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柴胡가 Alloxan投與家兎 血淸中 Cholesterol 含量 및 Transaminase 活性度에 미치는 影響
李京燮,姜孝信,鄭址昌 中央醫學社 1975 中央醫學 Vol.29 No.1
The effects of root of the Bupleurum falcatum L. on the serum transaminase (SGP-T, SGO-T) activities and the content of total cholesterol in serum from normal and alloxan-diabetic rabbits were observed. The Bupleuri Radix were extracted with methanol, and the extracted samples were orally administrated to the normal and alloxan-diabetic rabbits. The blood sugar levels, the amount of total cholesterol in serum and the serum transaminase activities of normal rabbits were significantly increased by intravenous administration of the alloxan 80mg/kg. The increased serum transaminase activities of the alloxan-diabetic rabbits were significantly decreased after 96 hours by administration of the extracted sample compared to that of control group. The increased content of total cholesterol in serum of the alloxan-diabetic rabbits were gradually decreased by administration of the extracted samples and returned to the control levels ,after 12 days. According to the above results, it is concluded that the extract of Bupleuri Radix have influence to the recovery of the increased contents of total cholesterol and serum transaminase activities by alloxan.
윤성우,이지영,하경호,이수경,한나,배효근,박선자 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2
Limy bile is a rare condition characterized by excessive precipitation of calcium carbonate in the gallbladder or bile duct. Recently we experienced two cases with obstructive jaundice in which limy bile in the common bile duct but not in the gallbladder for one case, and in the common bile duct and intra hepatic duct but not in the gallbladder for another case. The patients were treated by endoscopic sphincterotomy. Here, we report the cases and review the literature.
P42 Ebp1 functions as a tumor suppressor in non-small cell lung cancer
( Hyo Rim Ko ),( Truong Lx Nguyen ),( Chung Kwon Kim ),( Young Bin Park ),( Kyung Hoon Lee ),( Jee Yin Ahn ) 생화학분자생물학회(구 한국생화학분자생물학회) 2015 BMB Reports Vol.48 No.3
Although the short isoform of ErbB3-binding protein 1 (Ebp1), p42 has been considered to be a potent tumor suppressor in a number of human cancers, whether p42 suppresses tumorigenesis of lung cancer cells has never been clarified. In the current study we investigated the tumor suppressor role of p42 in non-small cell lung cancer cells. Our data suggest that the expression level of p42 is inversely correlated with the cancerous properties of NSCLC cells and that ectopic expression of p42 is sufficient to inhibit cell proliferation, anchorage-independent growth, and invasion as well as tumor growth in vivo. Interestingly, p42 suppresses Akt activation and overexpression of a constitutively active form of Akt restores the tumorigenic activity of A549 cells that is ablated by exogenous p42 expression. Thus, we propose that p42 Ebp1 functions as a potent tumor suppressor of NSCLC through interruption of Akt signaling.[BMB Reports 2015; 48(3): 159-165]
Aspiration pneumonia caused by fentanyl-induced cough -a case report-
Kyung Jee Lim,박은영,강매화,이수경,Hyo Min Lee,Man Ho Kim,Yi Seul Kim 대한마취통증의학회 2013 Korean Journal of Anesthesiology Vol.65 No.3
Although fentanyl-induced cough is generally transient and benign, it can give rise to serious problems in patients to whom increasing intracranial, intraocular or intraabdominal pressures may create dangerous situations. This case demonstrates aspiration pneumonia as a complication, exhibiting severe cough induced by intravenous injection of fentanyl.
Intraoperative blood loss and surgical time according to the direction of maxillary movement
Hyo Seong Kim,Ji Hwan Son,Jee Hyeok Chung,Kyung Sik Kim,Joon Choi,Jeong Yeol Yang 대한성형외과학회 2020 Archives of Plastic Surgery Vol.47 No.5
Background Excessive bleeding is one of the most severe complications of orthognathic surgery (OGS). This study investigated the associations of intraoperative blood loss and surgical time with the direction of maxillary movement. Methods This retrospective study involved patients who underwent OGS from October 2017 to February 2020. They were classified based on whether maxillary setback was performed into groups A1 and B1, respectively. Relative blood loss (RBL, %) was used as an indicator to compare intraoperative blood loss between the two groups. The surgical time of the two groups was also measured. Subsequently, the patients were reclassified based on whether posterior impaction of the maxilla was performed into groups A2 and B2, respectively. RBL and surgical time were measured in the two groups. Simple linear and multiple regression analyses were performed. P-values <0.05 were considered to indicate statistical significance. Results Eighteen patients were included. The RBL and surgical time for the groups were: A1, 13.15%±5.99% and 194.37±42.04 minutes; B1, 12.41%±1.89% and 196.50±46.07 minutes; A2, 13.94%±3.82% and 201.00±39.70 minutes; and B2, 9.61%±3.27% and 188.84± 38.63 minutes, respectively. Only RBL showed a statistically significant difference between the two groups (A2 and B2, P=0.04). Conclusions Unlike maxillary setback, posterior impaction of the maxilla showed a significant association with RBL during surgery. When performing posterior impaction of the maxilla, clinicians need to pay particular attention to surgery and postoperative care.
이효정(Hyo Jung Lee),심지연(Jee Youn Shim),오현숙(Hyun Suk Oh),장미란(Mi Ran Jang),이윤애(Yoon Ae Lee),이륜경(Ryun Kyung Lee),김민아(Min-A Kim),이상민(Sang Min Lee),조태용(Tae Yong Cho),강호일(Ho Il Kang) 한국식품과학회 2012 한국식품과학회지 Vol.44 No.1
본 연구에서는 주요섭취 가공식품(우유, 식용유지, 마가린) 3개 품목에 대한 납, 카드뮴, 비소의 기준ㆍ규격 설정을 위해 가공식품 총 287건을 전국 8개 권역(강원, 경기, 경남, 경북, 충청, 전남, 전북, 경남, 제주)에서 수거하고 각 시료를 microwave 분해법으로 전처리 하였다. 시료의 산분해 전처리 시 보다 객관화된 시료 전처리 방법의 확립을 위해 잔여 <SUP>12</SUP>C intensity를 ICP-MS로 측정하여 가장 분해정도가 우수한 조건(검체량, 질산량, 과산화수소량)을 선정하였다. 최적조건에서 전처리한 시료의 납, 카드뮴, 비소 함량은 ICP-MS로 분석하였다. 정량한계(Limit of quantification, LOQ)는 납의 경우, 우유 0.3 μg/kg, 식용유지, 마가린 0.61 μg/kg이었고, 카드뮴의 경우, 우유 0.15 μg/kg, 식용유지, 마가린 0.31 μg/kg이었다. 비소의 경우, 우유 0.45 μg/kg, 식용유지, 마가린 0.91 μg/kg이었다. 납, 카드뮴, 비소의 회수율은 납 92.6-98.0%, 카드뮴 91.2-98.9%, 비소 97.9-105.6% 수준 이었다 모니터링 결과, 가공식품의 납의 평균함량은 우유 2.395 μg/kg, 식용유지 7.656 μg/kg이었으며, 카드뮴의 평균함량은 우유 0.483 μg/kg, 식용유지 0.380 μg/kg이었다. 비소의 평균함량은 우유 0.781 μg/kg, 식용유지 1.241 μg/kg이었다. 가공식품의 Codex 납 기준 0.02-0.1 mg/kg, 카드뮴 0.1 mg/kg, 비소 0.1 mg/kg 수준과 비교해 볼 때, 모든 검체에서 기준보다 낮은 수준이었다. 2005년 국민건강조사 DB에서 조사대상 인구집단 전체를 대상으로 위해평가 한 결과 대상 식품들의 납, 카드뮴, 비소의 인체노출수준을 JECFA의 납, 카드뮴, 비소의 잠정주간섭취허용량으로 나누어 위해지수를 산출한 결과, 1.0 보다 훨씬 낮게 나타남으로 위해도는 매우 낮은 수준으로 판단된다. This research was carried out as a survey on the contents of lead, cadmium, and arsenic in processed foods (milk, vegetable oil, and margarine) in Korea. The limits of quantification (LOQs) were Pb 0.3 μg/kg, Cd 0.15 μg/kg, and As 0.45 μg/kg for milk and Pb 0.61 μg/kg, Cd 0.31 μg/kg, and As 0.91 μg/kg for vegetable oil and margarine. The recoveries were 92.6-98.0% for Pb, 91.2-98.9% for Cd, and 97.9-104.7% for As. The average levels of Pb were 2.395 μg/kg for milk, and 7.656 μg/kg for vegetable oil. The average levels of Cd were 0.483 μg/kg for milk, and 0.380 μg/kg for vegetable oil, and levels of As were 0.781 μg/kg for milk, and 1.241 μg/kg for vegetable oil. The results of this study showed that Pb, Cd, and As contents in the whole samples were less than the maximum residual levels in the processed foods that were specified by the Codex standard.