후두 및 하인두 암종에서 p53단백 발현과 Espstein-Barr Virus 검출

최영환,도남용,나한조,이도용,노용훈,김완수,최종선 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : When p53 cancer suppressor gene, occurs gene deletion or point mutation, malignancy develops by loss of p53 function with abnormal p53 protein. The Epstein-Barr virus (EBV) is the causative agent of certain type of lymphoma and undifferentiated nasopharyngeal carcinoma. However, the role of EBV as a causative factor in other head &eck tumors is not fully elucidated except nasopharyngeal carcinoma. This study, the author examined that p53 expression and detection rate of EBV correlate to development of laryngeal and hypopharyngeal squamous cell carcinoma(SCC) and play the possible role of prognostic indicators. Materials and Methods : Formalin-fixed, paraffin-embedded tissue specimen from 32 cases of larynx and hypopharyngeal squamous cell carcinomas were studied by immunohistochemical staining for p53 and EBV. The results of analysis were compared with clinicopathological parameters. Results : p53 expression was 56.3% (18 cases) and the detection rate of EBV was 43.6% (14 cases) of 32 cases in laryngeal and hypopharyngeal squamous cell carcinomas. p53 expression was correlate with histologic grade (p<05) only. Detection of EBV was not correlate with clinicopathological parmeters. Conclusion : These results suggest p53 expression and the detection of EBV may be related with development of laryngeal and hypopharyngeal squamous cell carcinoma. And, the expression of p53 protein can be used as a prognosticator in laryngeal and hypopharyngeal squamous cell carcinoma under certain limitation.

수중의 영양염류 제거를 위한 세라믹 소재 개발

이용환(Yong-Hwan Lee),최인호(In-Ho Choi) 한국환경관리학회 2006 環境管理學會誌 Vol.12 No.4

본 연구는 수중에 용해된 인과 질소 제거효과를 갖는 세라믹소재를 개발하기 위하여 수행되었다. 감람석을 이용한 인의 제거효과는 “이”와 “최”의 연구에서 수행된바 있으며, 제올라이트를 이용한 질소제거에 관한 연구는 국내외적으로 많이 수행되어 왔다. 본 연구에서는 감람석(Olivine)과 제올라이트(Zeolite)를 서로 다른 부피 혼합비에 따라 혼합한 후 소성하여 얻어진 세라믹을 이용하여 수중에 용해된 총인(Total-Phosphorus)과 총질소(Total-Nitrogen)의 제거효과를 회분식 실험(batch reactor system)을 통해 분석하였다. 연구결과 총인의 경우 감람석과 제올라이트의 부피 혼합비가 1:2의 경우 최고의 제거효율을 보였으며, 시험개시 30분 일 때 96.0%, 4시간일 때 95.1% 의 인이 제거되었다. 총질소의 경우 감람석과 제올라이트가 1:6일 때 시험개시 30분일 때 93.6%, 4시간일 때 97.4%의 질소가 제거되었다. This study was performed to develop ceramic material to be able to eliminate phosphorus and nitrogen in water. Olivine was found to remove phosphorus in aqueous phase, which was demonstrated by Lee and Choi.1) The nitrogen removal using zeolite has been demonstrated by many researchers.2,3) Hence, utilization of mixed-typed material of Olivine and Zeolite is expected to achieve simultaneous elimination of phosphorus and nitrogen in water. In this study, the removal efficiencies of T-P(Total phosphorus) and T-N(Total nitrogen) were investigated using ceramic material in batch reactor system, which was produced by incinerating after mixing Olivine and Zeolite with different ratio. The highest removal efficiency of phosphorus was achieved under the condition of 1: 2 mixing volume ratio of Olivine to Zeolite. The phosphorus of 93.6% and 97.4% (as T-P) was removed for 0.5hr and 4hr, respectively. For the nitrogen, the nitrogen removal efficiencies of 93.6% and 97.4% (as T-N) were obtained under the condition of 1:6 mixing volume ratio of Olivine and Zeolite.

rhBMP-2가 저칼슘식이 투여 백서의 골결손부 이유에 미치는 영향

최용석,황의환,이상래 大韓口腔顎顔面 放射線學會 2004 Imaging Science in Dentistry Vol.34 No.1

Purpose : To investigate the effect of rhBMP-2 on the healing of bone defect in the low calcium diet rat. Materials and Methods : To prepare the experimental model, control group was fed a normal diet and experimental group was fed a low calcium diet for 3 weeks. And then, 4 mm bicortical perforated bone defect was made on mandibular body of each rats. Experimental group was subdivided into two groups; experimental group 1 (rats given a low calcium diet before and after bone defect) and experimental group 2 (rats given a low calcium diet before and after bone defect with rhBMP-2 application). At 1, 3, 5 and 7 weeks after bone defect formation, the rats Were terminated. The healing of bone defect was assessed by three-dimensional computerized tomography, soft xray radiography, and histopathological examination. Results : The wound healing of the bone defect for control group, experimental group 1, and experimental group 2 showed a increase from 3 weeks after bone defect formation. The experimental group 2 showed a more increase in healing amount than control group and experimental group 1 from 5 weeks after bone defect formation and the experimental group 2 showed a complete recovery of bone defect at 7 weeks after bone defect formation. Conclusion : The healing process of bone defect is accelerated by rhBMP-2 application in the low calcium diet rats.

양극산화와 절연파괴로 형성한 인산칼슘 함유 티타늄 산화피막의 특성

최원호,이용승,김동환,권용훈,배태성 大韓齒科器材學會 2003 대한치과재료학회지 Vol.30 No.1

This study was performed to investigate the surface properties of electrochemically oxidized pure titanium by anodic spark deposition technique. Titanium plates of 10×10×1 ㎜ were polished sequentially from # 300 to # 1,000 emery paper. They were ultrasonically washed in ethyl alcohol and acetone for 5 min and dried in a desiccator. Titanium plates and titanium screw implants were anodized in an electrolytic solution that was dissolved calcium and phosphate in water. The electrolytic voltage was set in the range of 190-340 V and the current density was 30 ㎃/㎠. The surface oxide film was characterized by X-ray deffractometer(XRD), scanning electron microscope(SEM) and X-ray photoemission spectroscopy(XPS). The main crystal structure of the titanium oxide was anatase type as analyzed with thin-film X-ray diffractometery. The diameter of micropores increased with increasing the spark forming voltage. The porous coatings showed the growth of cell structure and more compact texture with increasing the spark forming voltage. Microcracks were examined in the coating formed at voltage of 340 V. Ca/P ratio in coatings was increased with increasing the voltage.

손등 정맥 패턴의 회전 왜곡을 보상한 개인 식별 알고리즘의 연구

최환수,안장용 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-

This paper proposes an enhanced algorithm for person identification system utilizing hand vein pattern. The conventional algorithm does not cope with distortion caused by image rotation caused by misplaced hands on the imaging device. A straightforward approach to consider the rotaional compensation required too much computational load, thus, we devised an approach to expect the rotation direction along with image translation, reducing the compuational requirement dramatically. In this paper, we present the detail of the algorithm with experimental results with the new algorithm.

용도지역 적용방식별 비교ㆍ평가 연구 : 도시지역내 2이상의 용도지역에 걸치는 대지를 대상으로 A Case of the Lots Divided by Zoning-Line in the Urban Area

최찬환,황용연,최준순 대한건축학회 2004 대한건축학회논문집 Vol.20 No.2

This study is focusing on analyzing the effect and meaning of the zone on the lot divided by zoning line which is run by the current law to get rational solutions. Each evaluation applies to realistic and applicable methods according to regulations. The three ways of application methods on the zone of the selected lot divided by zoning appear are Land Area Method, Building Area Method, and Zone Method. All three ways have their own meanings and limitations to apply, but according to the analysis result, we could decide that Region Method is the most effective way. However, it has sever limitations when we design site plan, building-use and building form in a land, so complements are required for each of provisions. Therefore, We suggest new approach about the building development scale, and for building-use and a right to enjoy sunshine, We suggest complementary methods for each case. First, We apply for a complex method for deciding on the building development scale. Second, for determination of the building uses, We permit the mixed-usage when a building sets on the lot divided by zoning line, and for a right to enjoy sunshine, We select the application method for the bigger land.

SS41 용접재의 피로크랙 진전거동에 관한 연구

최병기,권택용,정환규 朝鮮大學校 機械技術硏究所 2000 機械技術硏究 Vol.3 No.1

SS41 is welded automatically and is investigated some effects of the welding residual stress in the growth and propagation of fatigue crack, so as to study the fatigue behaviour in the welding residual stress field. The summarized results are as follows; 1) In case of the load range is constant, as the stress ratio is changing to 0.1, 0.33 and 0.5 the propagation life is constant but the growth life decreases. And than, when maximum load or minimum load is constant, as the stress ratio increases the growth life and propagation life. 2) It was shown that the fatigue crack propagation ratio da/dN was almost constant regardless of the stress ratio change at constant load amplitude and that the larger stress ratio, the slower was the fatigue crack propagation ratio. 3) The opening ratio U is influenced by Kmax but it isn't only the function of Kmax because data range is very large. 4) The growing and propagation fatigue crack in the welding residual stress field is similar to original specimen after passing the original residual stress field.

클래스 유사도에 의한 분류방법에 관한 연구

최영신,김용환,최성 호서대학교 반도체제조장비국산화연구센터 2001 반도체장비학술심포지움 Vol.2001 No.-

게임 제작 도구의 핵심 구성 요소가 되는 클래스 라이브러리 개발을 위해 게임 객체와 수 있는 클래스 분류방법이 필요하다.클래스 분류방법에는 Enumerative 분류 방법과 클러스터링 방법을 적용한다.본 논문에선 클래스의 시공간 개념 분석을 하고 유사도 값에 의한 클러스터링을 한다.유사도 값에 의한 클래스 클러스터링이 게임 클래스 객체들의 행위들을분류할 카테고리에 없는 경우 Enumerative분류 방법을 하여 게임 클래스 라이브러리를 연구하였다.

마이크로머시닝을 이용한 Bump형 Probe Card의 제조

최원익,김용대,심준환,이종현 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

Probe card is the most important part of testing IC chips. This work was related to silicon vertical probe card which enabled to simultaneously test multiple semiconductor chips. We presented Bump-type vertical probe card. It was fabricated by dry etching using RIE technique, isotropic etching, and bulk-micromachining on SDB wafer. The process used in this work was very simple and reproducible, which had good controllability in the probe card dimension and spacing. It is expected that the fabricated probe card can reduce testing time, can promote productivity and enables bum-in test.

Molecular subtypes of triple-negative breast cancer: understanding of subtype categories and clinical implication

Yong‑Moon Lee,Man Hwan Oh,Jai‑Hyang Go,Kyudong Han,Song‑Yi Choi 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: Triple-negative breast cancer (TNBC) is a heterogeneous entity that encompasses several subtypes with distinct molecular characteristics. The patients with TNBCs show unpredictable response to the chemotherapy, and further there is the lack of effective agents. Thus, many studies have been underway to discover targeted therapy suitable for patients with specific genetic alterations in each molecular subtypes. TNBCs are classified as four major molecular subtypes according to the gene expression patterns. These are luminal androgen receptor (LAR), mesenchymal-like, immunomodulatory (IM), and basal-like types. Conclusion: Here, we discuss the unique molecular features of each subtype as well as promising targets for anti-cancer therapy.