전립선비대증에 대한 α₁-아드레날린 수용체 차단제와 5α-환원효소 억제제 병합요법의 효과

노준화,오봉렬,박양일 大韓泌尿器科學會 1998 Korean Journal of Urology Vol.39 No.12

백서에서 척수손상이 뇌하수체-고환호르몬 축에 미치는 영향

박양일,노준화,오봉렬,유명식 大韓泌尿器科學會 1998 Korean Journal of Urology Vol.39 No.10

폴리(스타이렌-b-아이소부틸렌-b-스타이렌) 삼블록 공중합체 아이오노머의 기계적인 성질

나연화,김희석,김준섭,유지강,박기주,이영관 조선대학교 생산기술연구소 1998 生産技術硏究 Vol.20 No.2

The dynamic mechanical properties of poly(styrene-b-isobutylene-b-styrene) and its sulfonated ionomers were investigated. The triblock copolymer showed a tan δ peak at ca. -25℃, which is ascribed to the T_(g) of polyisobutylene blocks. The copolymer also showed a shoulder on a tan δ curve at ca. 50℃, which is probably associated with crystallization and/or melting of the crystalline polyisobutylene blocks. Above 100℃, the copolymer started to flow. In the cases of ionomers, well developed rubbery plateaus, extended to ca. 150-160℃, were seen in modulus-temperature plots. A tan δ peak for the T_(g) of the polyisobutylene blocks and a shoulder peak were also observed for the tetramethylammonia neutralized sulfonated ionomer. However, the shoulder peak became smaller and shifted to low temperatures, which implies that the ionic interactions in this system reduces the ability of crystallization or/and melting of the polyisobutylene blocks. For the K neutralized ionomer sample, only a tanδ peak for the T_(g) of the isobutylene blocks was seen. This different result in these two ionomers is believed to be due to the difference in the strength of ionic interactions.

Styrene-co-lithium methacrylate ionomer의 기계적인 성질에 미치는 LiCl의 영향

나연화,김준섭,유지강,박기주 조선대학교 생산기술연구소 1999 生産技術硏究 Vol.21 No.2

The effect of LiCl salt added to styrene-co-lithium methacrylate ionomer on the mechanical properties of ionomers was studied dynamic rnschanically. When the LiCl salt was added to a 100% Li-neutralized ionomer, the amount of added salt. in the range of 100-300% to ionic groups of the ionomer, did not change the mechanical properties of the ionomers, This implies that the added salt may form isolated LiCl salt aggregates in the polymer matrix. However, when LiCl was added to a 200% neutralized ionomer, the cluster T_(g) shifted to a low temperature and then the sample started to flow. This result suggests that in this case the LiCl salts reside in and near the multiplets, resulting the weakening of ionic interactions between ionic groups in multiplets.

Alcohol이 마우스 소뇌의 조롱박신경원의 미세구조에 미치는 영향

장병준,윤화중,박창현 건국대학교 1996 學術誌 Vol.40 No.2

Effects of acute exposure to alcohol on fine structures of cerebellar Purkinje cells were investigated with electron microscope. ICR mice were injected orally by 18ml/kg b.w. of ethanol, and 30 minutes,2 hours, 6 hours, 24 hours, 3 days, 7 days after administration, mite were sacrificed with perfusion fixation. Specimens of each group were obtained by routine electron microscopic tissue preparation and were observed with transmission electron microscope. Dilatation of cisternae of rough endoplasmic reticulum, multiplication and cisternal dilatation of smooth endoplasmic reticulum, morphologic changes and cisternal dilatation of Golgi complex, swelling of mitochondria, increase of lysosome were prominent findings in the groups of 30 minutes and 2 hours after alcohol administration. These findings were getting recovered with the lapse of time. The territorial regions of astrocytes were prominently extended, and the synaptic vesicles of auto-somatic synapses were reduced in all experimental groups. These findings were also recovered gradually with the lapse of time, but these observations even in the group of 7 days after alcohol administration were not completely similar to that of control group.

알레르기 환자에서 특이알레르겐 항체 양성율과 관련요인

이선화,남해선,이성수,안현철,황규윤,박준수,,박춘식 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.2

Recently, allergic diseases are very prevalent in Korea, resulting in physical and economic losses during the life. It is well-known that the principle therapy is identification, eradication, and desensitization of allergens. There are many allergic diagnostic tools for identification of specific-allergens. However, none of them is satisfied with its efficiency due to lack of validity. Recently MAST-CLA has been widely used in the allergic clinical fields because of its simplicity and simultaneous identification of allergens. This study was designed to determine the positivity of allergen-specific antibodies using MAST-CLA in patients with allergic diseases, and evaluate the efficacy for allergen detection, compared to results of skin prick test. During June 2000 - September 2001, 325 study subjects visited Soonchunhyang University Chunan Hospital for the evaluation of allergic problems. Among them, 289 subjects were diagnosed with allergic disease and included for the study. Thirty four subjects visited children's allergic unit were evaluated specific allergens using a skin prick test at the same time. Our result as follows; 1. The positive rates of allergen-specific antibodies and total IgE were 51.2% and 73.4%, retrospectively. 2. There was significant difference in positive rate in age group, showing highest in teen ages(73.6%), but insignificant difference in sex in allergen-specific antibodies. 3. The positive rate was 60.4% in allergic rhinitis, 51.3% in allergic dermatitis, 46.9% in bronchial asthma, and 39.1% in urticaria in order(P=0.073). 4. Significant difference in month or season was observed, with highest rate in April(78.1%) and May(72.1%). The highest season was in spring(62.7%), and then summer(52.8%), fall(50.3%), and winter(41.4%) in order (P=0.04). 5. The three highest allergen-specific antibodies were D. pteronyssinus(39.3%), D. farinae(38.3%), and house dust(24.3%) in Korean inhalant pannel, However, in food pannel types of allergen-specific antibody were different as D. farinae(18.5%), Alternaria(18.5%), house dust(17.3%). 6. There were significant agreements between MAST-CLA and Skin prick test (D. farianae Kappa=0.636;D. pteronyssinus Kappa=0.78, both P<0.001) In conclusion, MAST-CLA could detect allergen-specific antibodies in patients with allergic diseases as a simple and valid tool of screening of allergy. Especially, it could be a useful measure of multiple allergens simultaneously in children However, more detailed allergens and valid assay for unmeasured allergens should be identified for Korean-specific allergens.

포타슘 술포네이트 폴리스타이렌 아이오노머의 기계적인 성질에 미치는 Crown ether의 영향

나연화,조규성,이법원,김준섭,유지강,박기주 조선대학교 생산기술연구소 1999 生産技術硏究 Vol.21 No.1

The effects of crown ether on the dynamic mechanical properties of potassium sulfonated polystyrene ionomer were investigated. As expected, it was found that when crown ether molecules were added to the ionomer, the crown ether molecules interacted with K^(+) cations and weakened the ionic interaction between K^(+)/sulfonate ion pairs of the ionomer significantly. Thus, no multiplets were present, and, in turn, no clustering was found. When the ether was added to interact with 50% of K^(+) cations, weak clustering was observed: the clustering was slightly stronger than that of a 50% neutralized ionomer. From this result, it was speculated that in the 50% neutralized sample H^(+) ⇔ K^(+) cation exchange occurs rapidly between -SO₃H and -S0₃K groups in multiplets. which weakens ionic interactions. In the 50% crown ether-added sample, however, -S0₃- group, instead of -S0₃H, is present, and thus no cation exchange is expected to occur.

스타이렌 아이오노머의 기계적인 성질에 미치는 혼합 양이온의 영향

김희석,나연화,이용혁,이법원,유지강,박기주,김준섭 조선대학교 생산기술연구소 1998 生産技術硏究 Vol.20 No.1

The styrene-co-methacrylate ionomers neutralized with Na +, Ba2 +, and mixed cation of both were prepared. The dynamic mechanical properties of two cation-containing ionomers were measured and compared to those of the ionomers neutralized with only one type of cations. We found that in the ionomers with one type of cations the difference in the type of cation does not change the glass transition temperatures. It was found, however, that the cluster Tg of the mixed cation ionomer is lower than that of the single cation ionomers. Thus it was postulated that in the two-cation system the two cations in a solution have sufficient dynamics to form new type of multiplet containing both cations, which may be slightly bigger than that found in the single cation multiplet. The mechanical properties also imply that the strength of ion interactions in the multiplets of the two cation ionomer is thought to be weaker than that of the one cation ionomers. These two effects are believed to contribute the lower in the cluster glass transition of mixed cation system.

에틸 아크릴레이트 아이오노머의 성질에 미치는 양이온 크기의 영향

조규성,나연화,김희석,김준섭,박기주 조선대학교 생산기술연구소 1999 生産技術硏究 Vol.21 No.1

The effects of the size of cations on the properties of polyfethyl acrylate-co-metal acrylate) ionomers containing 3.8 mol% of ionic moiety were investigated. It was found that with changing cations, matrix T_(g)s seem to remain constant; however, cluster T_(g)s increase with decreasing the size of cations. Since ion-hopping occurs at a cluster T_(g) and the electrostatic force of ion pairs decreases with the size of ions increasing, it was suggested that the effect of the size of cation on a cluster T_(g) is operative, but not on a matrix T_(g). It was also found that activation energies for a cluster T_(g) were decreased with decreasing the size of cations; which means that the activation energy values for a cluster T_(g) are not directly related to the cluster T_(g)s. In the present study, the highest value of a cluster T_(g) for the Li ionomer may be one of the reasons why the Li ionomer has the lowest value for an activation energy.

장티푸스 진단에 있어서 Vi-Indirect Fluorescent Antibody Test의 민감도 및 특이도

장경희,류동렬,박성하,박병규,이준구,염준섭,최영화,송영구,김현숙,정윤섭,김준명 대한감염학회 1998 감염 Vol.30 No.4

목 적 : 장티푸스는 체액의 세균배양검사에서 Salmonella typhi의 분리로 확진하지만 조기진단을 위해서는 혈청학적인 검사가 도움이 된다. 저자 등은 1989년 이후 장티푸스진단에 S. typhi의 Vi항원을 이용한 간접형광항체법 (Vi-indirect fluorescent antibody test : Vi-IFAT)을 도입하였다. 이에 지난 7년간의 검사결과를 토대로 Vi-IFAT의 민감도 및 특이도를 규명하고자 하였다. 방 법 : 1989년부터 1996년까지 연세대학교 의과대학 세브란스 병원에 발열을 주소로 내원하여 Vi-IFAT가 의뢰된 환자 중 발열의 원인이 확진된 744명의 환자를 대상으로 하였으며, Vi-IFAT에 있어서 양성반응은 1:64이상으로 하였다. 결 과 : 1) 세균배양검사에서 확진된 장티푸스 환자 178예 중 168예에서 양성반응을 보여 민감도는 94.4%이었다. 항체가는 1:64가 89예, 1:128이 36예, 1:256이 27예, 그리고 1:512가 16예이었다. 위음성이었던 10예의 항체가는 1:32가 7예, 1:16이하가 3예이었다. 2) 발열을 주소로 내원한 환자 중 장티푸스 이외의 다른 질환으로 확진된 566예 중 538예에서 음성반응을 보여 특이도는 95.1%이었다. 항체가는 1:32가 117예, 1:16이하가 421예이었다. 위양성이었던 28예의 항체가는 1:64가 23예, 1:128이 5예이었으며, 장티푸스 이외의 살모넬라증이 4예, 요로계감염이 10예, 소화기계감염이 6예, 호흡기 계감염이 5예, 악성 종양이 2예, 그리고 바이러스 감염이 1예이었다. 3) Vi-IFAT 양성인 196예 중에서 장티푸스는 168예로 양성예측율은 85.7%이었으며, Vi-IFAT 음성인 548예 중 장티푸스 이외의 발열질환은 538예로 음성예측율 98.2%이었다. 4) 배양검사와 Widal test 사이의 일치율 (Kappa value)는 0.28로 poor agreement를 보였으며 Vi-IFAT와 Widal test 사이의 Kappa value는 0.74로 good agreement를 보였다. 그러나 배양검사와 Vi-IFAT 사이의 Kappa value는 0.86으로 excellent agreement를 보여 일치율이 가장 높은 검사는 배양검사와 Vi-IFAT라 할 수 있겠다. 5) 장티푸스 환자에 있어서 Vi-IFAT의 양성율은 발열기간이 1중 미만인 환자에서는 68%, 1내지 2주인 환자에서는 89.5%, 2주이상인 환자에서는 100%이었다. 결 론 : Vi 항원을 이용한 간접형광항체법 (Vi-IFAT)은 장티푸스 진단에 높은 민감도 및 특이도를 가지며, 또한 조기진단에 있어서도 임상적으로 유용함을 확인할 수 있었다. Background : Typhoid fever is diagnosed by culture or serological study. The confirmative diagnosis of typhoid fever is made by culture of the causative organism usually from body fluids. Serological test is a supportive diagnositic tool, which is useful for early diagnosis. In Severance Hospital, Vi-indirect foluorescent antibidy test(Vi-IFAT) using the Vi-antigen of Salmonella typhi has been used in the diagnosis of typhoid fever since 1989. We investigated the test results from the past 7 years, in order to clarify the sensitivity and specificity of Vi-IFAT. Methods : A retrospective study was done on patients whose chief complaint was fever and who were tested using Vi-IFAT in the Severance Hospital from 1989 to 1996. The positive value for Vi-IFAT was defined as 1:64 or higher. Results : The sensitivity and specificity of Vi-IFAT for typhoid fever was 94.4% and 95.1%, respectively. The positive and negative predictive values were 85.7% and 98.2% respectively. Positive rates of Vi-IFAT after fever onset increased with time and 68% were positive before the first week. From the first to the second week, 89.5% were positive and after the second week, 100% were positive. Conclusion : Vi-IFAT is not only a valuable serologic test for the diagnosis of typhoid fever, but also useful in the early diagnosis of the disease.