양극성장애와 새로운 항경련제의 효과

남범우,서정석,정헌종,최진영 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.13 No.-

Bipolar disorder, like epilepsy and migraine, is episodic in nature and psychiatric illness requiring lifelong treatment. So, it should not be surprising that anticonvulsants such as carbamazepine and valproate have proven efficacy as mood stabilizers. The newer anticonvulsants such as lamotrigine, gabapentin, topiramate, oxcarbazepine, tiagabine, and zonisamide may also be effective treatments for bipolar disorder. Identifying an anticonvulsant for use in bipolar disorder should take into account not only the pathophysiology of bipolar disorder but also the mechanism of action of the anticonvulsant. Evidence for effectiveness of these novel antiepileptic drugs in treating acute mania and depression as well as in preventing the recurrence of mania and depression is reviewed. In conclusion, although the novel anticonvulsants appear to be clinically useful, more controlled trials are needed to assess the effectiveness in bipolar disorder.

병원폐기물의 발생 및 거동에 관한 조사

차병훈,김남천 서울보건대학 1999 서울보건대학 부설 병원경영연구소 논문집 Vol.4 No.2

This study was performed to examine the current management of hospital wastes and to investigate the contents. rules and systems concerning management of hospital wastes to find out the countermesures by the subjects. The amount and the present storage of hospital wastes and the collection. conveyance and handling of the consignment treatment company were investigated according to the examiration. the suitable treatment of hospital wastes has not been carrid out for the defect of the current management and handling capacity. To take charge of hospital wastes effectively and sanitarily. at the first place. a professional should understand the contents of wastes correctly and manage all systems by the characteristics. The improvement of storage and conveying container is required absolutly for sanitary management. An air-tight vessel should be used for storage container it should make a unification of a bicameral system.

Mastoparan B의 항균 활성 및 용혈 작용에 미치는 소수성도와 양친매성의 영향

이봉헌,김광호,장태식,박남규,박장수,강신원 부산대학교 유전공학연구소 1998 분자생물학 연구보 Vol.14 No.-

Tetradecapeptide인 Mastoparan B(MP B)와 이의〔Ala〕-MP B유도체들을 합성하고 항균 활성 및 용혈 작용을 측정하여 MP B의 활성에 미치는 소수성도(hydrophobicity)와 양친매성(amphiphilicity)의 영향을 비교하였다. 그 결과 MP B와 소수성도가 MP B 보다 큰〔Ala^2〕-,〔Ala^4〕-MP B유도체가 큰 항균 활성을 나타내었으며, 소수성도가 MP B보다 작은〔Ala^6〕-MP B유도체의 활성은 MP B와 비슷하거나 작게 나타나 소수성도가 큰 유도체일수록 항균활성을 크게 나타내었다. 그러나 MP B보다 소수성도가 큰 유도체인〔Ala^9〕-MP B는 Ala에 의한 Trp의 치환때문에 MP B보다 작은 활성을 나타내었다.용혈 활성 측정 결과 MP B보다 소수성도가 큰〔Ala^2〕-,〔Ala^4〕-MP B유도체가 각각100.0%와 69.4%로써 용혈 작용을 크게 나타냈으나, 소수성도가 작은〔Ala^6〕-MP B유도체는 6.1%로써 가장 작은 용혈 작용을 나타내었고 Trp대신 Ala으로 치환한 소수성도가 큰 유도체인〔Ala^9〕-MP B는 MP B보다 작은 26.0%의 용혈 작용을 나타내었다. 그러므로 용혈 작용은 소수성도가 클수록 증가하였으며 양친매성이 활성에 미치는 영향은 적었다. Tetradecapeptide.Mastoparan B(MP B)and its〔Ala^2 〕-,〔Ala^4〕-,〔Ala^6〕-,〔Ala^9〕-MP Bderivatives were synthesized, and then their antibacterical and hemolitic were to examine the effect of hydrophobicity and ampiphilicity on the MP B-induced those activities. MP B and more hydrophobic〔Ala^2 〕-,〔Ala^4〕-MP B showed stronger antibacterical activity and less hydrophobic〔Ala^6〕-MP B than MP B did similar or weaker activity, so more hydrophobic〔Ala〕-MP B derivative had stronger activity. But more hydrophobic〔Ala^9〕-MP B than MP B showed weaker activity because of its Trp subsitution by Ala. On the other hand,〔Ala^2 〕-and〔Ala^4〕-MP B showed 100.0% and 69.4% hemoiytic activity, but〔Ala^6〕-MP B did the weakwst activity(6.1%)and〔Ala^9〕-MP B, weaker activity(26.0%) than MP B.Therefore, more hydrophobic〔Ala〕-MP B derviative had stronger activity and the effect of ampiphilicity on the activity was weak.

제주도 해수욕장의 자연조건에 관한 기초조사

김남형,장성훈 제주대학교 해양연구소 2000 해양자원연구소연구보고 Vol.24 No.-

Bathing beaches may be the one of the resorts in popular, which peoples can easily access in summer. Three beaches located in Jeju island are observed on natural conditions using coastal engineering technique. Also the satisfaction indexs of the sand size. wave height. water temperature. transparency and bottom slope are surveyed. The results obtained can be utilized making an artificial bathing beach.

체외형 자동 제세동기(AED)와 심전도계(ECG)를 위한 통신 프로토콜의 설계 및 사용자 인터페이스 구현

김남훈,권희중,권호열,나학록 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.A

In this paper, we studied Automated External Defibrillator and Electro- Cardiogram System. Proposed System, CU-EX1, is a PC-based AED/ECG system that manages the data acquired by Paramedic CU-ER1. The system controls the transfer of data from the Paramedic CU-ER1 and the storage of the data in a local host computer. Patient data could be entered as soon as the rescue data is stored in a local computer. The system also displays the data on a local computer and facilitates review of rescue events.

閉塞性 換氣障碍 疾患에 있어서 動脈血가스 分析과 肺換氣機能 檢査에 關한 硏究

金獻男,崔仁善,朴炅玉 全南大醫大 1986 전남의대학술지 Vol.23 No.1

VDT작업별 정신사회적 스트레스와 근골격계 장애에 관한 연구

백남종,강종두,주영수,배인근,권호장,박종만,조수헌,김돈규,김재용,최홍렬 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.4

It has been hypothesized that jobs that have both high psychological demands and low decision latitude("job strain") can lead to musculoskeletal disorder. The objective of this study was to test whether job strain was correlated with the presence of work-related musculoskeletal disorder, especially myofascial pain syndrome(MPS). Information on demographic factors, confounders such as household load and taking care of children or not, and scores for decision latitude, job demand, and social support was obtained by self-administered questionnaire, which had been developed in Korean language, by adopting NIOSH instrument and Extended Karasek Model(16 items). All subjects were also examined by rehabilitation medicine specialists for musculoskeletal disorders. Subjects(n=370) could be categorized into 4 groups, these were, housewives(n=89), shipyard CAD workers(n=89), general female workers(n=79; nurses, insurance counselors, public officials, clerks, etc), and telephone directory assistance operators(n=113). Results from univariate analyses indicated that all demographic factors, all confounders, scores for decision latitude and social support were not associated with the risk of musculoskeletal disorder. However, score for job demand was higher in musculoskeletal disorder cases than others. In subgroup analysis, this association was convinced again, in telephone directory assistance operators. Job strain model showed that the group of telephone directory assistance operators was high-stain group, and OR of musculo skeletal disorder was 2.446(95% C. I. : 1.174, 5.096), when comparing this with the low strain group. In conclusion, job strain is a risk factor for work-related musculoskeletal disorder.

p-Amino-diphenylamine으로부터 N-phenyl-N'-iospropyl-p-phenylene-diamine의 합성 및 특성

변헌수,전남석 여수대학교 1998 論文集 Vol.13 No.2

We were studied to the preparation and property of N-phenyl-N'-isopropyl-p-phenylene-diamine from p-amino-diphenylamine with the various type of precious metal catalyst : 3% platinum on activated carbon. 5% palladium on activated carbon. In this study, we were obtained to the optimum conditions of reaction step in Lab. The data of Lab test were as follows : the purity of N-pheny-N'-isoprophyl-p-phenylene-diamine from p-amino-diphenyl-amine was 97.0% and the yield of N-phenyl-N'-isoprophyl-p-phenylene-diamine from p-amino-diphenylamine was 97.5%.

비강 및 부비동 종양에서의 종양혈관형성에 관한 면역조직화학적 연구

도남용,노용훈,박선홍 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

Background and Objectives : Angiogenesis is essential for the growth of solid tumors. Microvessel density(MVD), which represent a measure of tumor angiogenesis, have been found to have prognostic significance in many tumor types for predicting an increased risk of metastasis. However, the significance of angiogenesis in sinonasal malignant tumor remains controversial. The purpose of this study was to asses the tumor vascularity using the highly specific endothelial cell marker CD34, and the expression of its related protein p53, in sinonasal malignant tumors. Materials and Methods : The study samples were obtained after surgical removal of 27 cases of inverted papilloma(IPs), 5 cases of IPs with malignant transformation(IP-MT), 16 cases of squamous cell carcinoma(SCC) in sinonasal cavity. Microvessels were stained with anti-CD34 and p53 expressions were assessed by immunohistochemical staining. Results : The degree of tumor angiogenesis in squamous cell carcinoma group was higher than in inverted papilloma group, and which reached at highest level in IP-MT(p<05). The p53 expressions were increased as tumor progressed, which was statistically significant also(p<05). Significant correlation between MVD and p53 expressions was observed in IP(p<05) but there were no correlation in IP-MT and SCC. Conclusions : These results suggest that overexpression of p53 and MVD in the sinonasal tumors seemed to be associated with tumorigenesis but further studies on tumor angiogenesis of sinonasal tumors are needed before it can be adopted as a prognostic marker.

비정형 기관지 유암종에 의한 이소성 ACTH 증후군 1례

이창훈,천남일,홍세인,정진욱,윤인석,조동혁,강호철,정동진,정민영 全南大醫大 2001 전남의대학술지 Vol.37 No.2