Facile Synthesis of HKUST-1@ Dual Porosity Carbon Hybrid Materials for Enhanced Carbon Dioxide Adsorption Capacity under Steaming Condition

정헌종,김지만 한국공업화학회 2014 한국공업화학회 연구논문 초록집 Vol.2014 No.0

영유아의 발달장애의 평가

정헌종,김정은 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

This article shows the differences between normal development and abnormal development at the evaluation of milestones in infancy and early childhood. The assessment tools of abnormal developmental milestones have been used the korean developmental test of the infancy and childhood and neurodevelopmental evaluation by keyages which are simplified diagnostic method since the 2002 year. The korean developmental test of the infancy and childhood are composed by gross motor, fine motor, personal-social, language and cognitive-adaptive. The neurodevelopmental evaluation by keyages are evaluated by the ages which are 1month, 4 month, 7month, l0month and 18month. The each specified ages show the critical specified neuronal development. This diagnostic tool has been assessed by the simplified neurodevelopmental state. Finally, when we assess the delayed neurodevelopmental growth of the infancy and childhood, we should know that the neurodevelopmental growth rate of the infancy and childhood in person are each different. The normal neurodevelopmental growth of the infancy and childhood should not misdiagnosis as the abnormal neurodevelopmental growth of the infancy and childhood.

아침

정헌종 우리신학연구소 2008 갈라진 시대의 기쁜소식 Vol.- No.862

요중 마뇨산과 관련된 연령, 근무년수, 혈액학적검사, 성별 및 생활행태에 관한 연구

정헌종,김근회 대한산업의학회 2008 대한직업환경의학회 학술대회 논문집 Vol.41 No.-

국내 직업성암의 언더라이팅

정헌종,Chung, Hun-Jong 한국생명보험의학회 2008 保險醫學會誌 Vol.27 No.2

Now, we have experienced that the loss ratio of cancer insurance with prevalence of cancer increased. The insurance companies interest how the loss ratio of cancer insurance decrease. To decrease the loss of ratio of cancer, underwriting is very important. The underwriting of cancer are very important factors which are family history, habitual behavior and past history. We have spend the most of time under the occupational situation. Occupation may be very important factor causing cancer. But we neglect the occupation history. This article show how the underwriting of the occupational cancers in the field of occupation are managed Generally, Occupational cancers show special characteristic features. We know the characteristics of occupational cancer under the variety of occupation. For the underwriting of occupational cancer in Korea, we also understand the epidemiology of Korean occupational cancer with the varieties of occupation This article shows the characteristics of occupational cancer and epidemiology of Korean occupational cancers.

실험계획법을 활용한 항공기 연료량 측정 정확도에 대한 연구

정헌종,이민구,홍성훈,권혁무 한국품질경영학회 2019 한국품질경영학회 학술대회 Vol.2019 No.-

본 연구에서는 항공기 연료량 측정 시스템을 소개하고, 항공기 자세 중 Pitch, Roll, 연료량 높이를 입력 변수로 선정하였으며 출력 변수는 연료량으로 선정하여 3인자 완전 요인 실험을 실시하였다. 1차 실험 결과 연료량 측정 정확도를 만족 못함을 확인하여 연료탱크 DB를 보완 후 2차 실험을 실시하였고 실험데이터를 활용하여 연료량의 예측 모형을 설정하였다. 재현성 검증(3차 실험)을 통해 예측 모형의 유효성을 입증하였다. 본 연구를 통해 기존에 1,200회 이상 측정하고 3개월 이상의 시간과 많은 비용이 소요되는 실험 방법을 개선하여 81 회의 실험 수행만으로 연료량 측정 정확도 기준 만족 여부를 입증할 수 있음을 확인하였다. 본 연구는 실험계획법을 활용한 연료량 측정 정확도 입증방법을 향후 무인기, 고정익기, 회전익 항공기 등 항공 무기체계 개발단계뿐만 아니라 양산단계에서 납품검사 실험에 활용한다면 연료량 측정 정확도 입증 기간 단축, 비용 및 인력 절감이 가능함을 확인한 것에 의미가 있다.

CI보험중 '중대한 암'(Critical cancer)의 정의에 관한 Medical Underwriting의 제한적요소에 관한 고찰

정헌종,Chung, Hun-Jong 한국생명보험의학회 2006 保險醫學會誌 Vol.25 No.-

The definition of 'critical cancer' in critical insurance(CI) is more insurance meanings than medical meanings. The difference between critical cancer of insurance and critical cancer of medical cancer is made difficult problem to the underwriting of insurer, contractor and medical doctor. The limited factors of underwriting in critical cancer of critical insurance as follows: (1) the limitation factors in the definition of 1st item critical cancer in CI 1) the definition differences of meanings in insurer, contractor, and medical doctor 2) the meanings of "the table of malignance" 3) the definition difference between 'critical cancer' and 'a large of medical expense cancer' (2) the limitation factors in the definition of second item critical cancer in CI 1) The limitation in the change of cancer character 2) The missing malignancy in pathological result due to localized cancer 3) The differences in the test result of hospital (3) the limitation factors in the definition of third item critical cancer in CI. 1) the lower items disobey the higher items 2) clinical malignancy of benign cancer pathologically 3) others: (1) low grade of malignant melanoma (2) early prostate cancer. (3) malignancy related HIV (4) all skin cancer excepted malignant melanoma (5) accepted clinically and a medical certificate by medical doctor as critical cancer of premalignant lesion, carcinoma-in-situ, and borderline cancer.

가토모델에서 배양 구강상피를 이용한 점막근조직판의 형성에 관한 연구

신영민,정헌종,안강민,박희정,성미애,김성민,황순정,김명진,장정원,김성포,양은경,송계영,이종호 대한악안면성형재건외과학회 2005 Maxillofacial Plastic Reconstructive Surgery Vol.27 No.4

백서 설신경 압박손상모델에서 신경성장인자 유전자 주입이 신경재생에 미치는 영향

고은봉,정헌종,안강민,김성민,김윤희,장정원,이종호,Gao, En-Feng,Chung, Hun-Jong,Ahn, Kang-Min,Kim, Soung-Min,Kim, Yun-Hee,Jahng, Jeong-Won,Lee, Jong-Ho 대한악안면성형재건외과학회 2006 Maxillofacial Plastic Reconstructive Surgery Vol.28 No.5

Purpose: Lingual nerve (LN) damage may be caused by either tumor resection or injury such as wisdom tooth extraction, Although autologous nerve graft is sometimes used to repair the damaged nerve, it has the disadvantage of necessity of another operation for nerve harvesting. Moreover, the results of nerve grafting is not satisfactory. The nerve growth factor (NGF) is well-known to play a critical role in peripheral nerve regeneration and its local delivery to the injured nerve has been continuously tried to enhance nerve regeneration. However, its application has limitations like repeated administration due to short half life of 30 minutes and an in vivo delivery model must allow for direct and local delivery. The aim of this study was to construct a well-functioning $rhNGF-{\beta}$ adenovirus for the ultimate development of improved method to promote peripheral nerve regeneration with enhanced and extended secretion of hNGF from the injured nerve by injecting $rhNGF-{\beta}$ gene directly into crush-injured LN in rat model. Materials and Methods: $hNGF-{\beta}$ gene was prepared from fetal brain cDNA library and cloned into E1/E3 deleted adenoviral vector which contains green fluorescence protein (GFP) gene as a reporter. After large scale production and purification of $rhNGF-{\beta}$ adenovirus, transfection efficiency and its expression at various cells (primary cultured Schwann cells, HEK293 cells, Schwann cell lines, NIH3T3 and CRH cells) were evaluated by fluorescent microscopy, RT-PCR, ELISA, immunocytochemistry. Furthermore, the function of rhNGF-beta, which was secreted from various cells infected with $rhNGF-{\beta}$ adenovirus, was evaluated using neuritogenesis of PC-12 cells. For in vivo evaluation of efficacy of $rhNGF-{\beta}$ adenovirus, the LNs of 8-week old rats were exposed and crush-injured with a small hemostat for 10 seconds. After the injury, $rhNGF-{\beta}$ adenovirus($2{\mu}l,\;1.5{\times}10^{11}pfu$) or saline was administered into the crushed site in the experimental (n=24) and the control group (n=24), respectively. Sham operation of another group of rats (n=9) was performed without administration of either saline or adenovirus. The taste recovery and the change of fungiform papilla were studied at 1, 2, 3 and 4 weeks. Each of the 6 animals was tested with different solutions (0.1M NaCl, 0.1M sucrose, 0.01M QHCl, or 0.01M HCl) by two-bottle test paradigm and the number of papilla was counted using SEM picture of tongue dorsum. LN was explored at the same interval as taste study and evaluated electro-physiologically (peak voltage and nerve conduction velocity) and histomorphometrically (axon count, myelin thickness). Results: The recombinant adenovirus vector carrying $rhNGF-{\beta}$ was constructed and confirmed by restriction endonuclease analysis and DNA sequence analysis. GFP expression was observed in 90% of $rhNGF-{\beta}$ adenovirus infected cells compared with uninfected cells. Total mRNA isolated from $rhNGF-{\beta}$ adenovirus infected cells showed strong RT-PCR band, however uninfected or LacZ recombinant adenovirus infected cells did not. NGF quantification by ELISA showed a maximal release of $18865.4{\pm}310.9pg/ml$ NGF at the 4th day and stably continued till 14 days by $rhNGF-{\beta}$ adenovirus infected Schwann cells. PC-12 cells exposed to media with $rhNGF-{\beta}$ adenovirus infected Schwann cell revealed at the same level of neurite-extension as the commercial NGF did. $rhNGF-{\beta}$ adenovirus injected experimental groups in comparison to the control group exhibited different taste preference ratio. Salty, sweet and sour taste preference ratio were significantly different after 2 weeks from the beginning of the experiment, which were similar to the sham group, but not to the control group.

가토모델에서 배양 구강상피를 이용한 근-점막 피판의 형성에 관한 연구

신영민,정헌종,안강민,박희정,성미애,김성민,황순정,김명진,장정원,김성포,양은경,송계영,이종호,Shin, Young-Min,Chung, Hun-Jong,Ahn, Kang-Min,Park, Hee-Jung,Sung, Mi-Ae,Kim, Soung-Min,Hwang, Soon-Jung,Kim, Myung-Jin,Jahng, Jeong-Won,Kim, Sung-P 대한악안면성형재건외과학회 2005 Maxillofacial Plastic Reconstructive Surgery Vol.27 No.3

Purpose : Extensive defect of oral and maxillofacial area is usually reconstructed with composite flap including skin paddle. However, if the defects are lined with only skin components, the mucosa's role in mastication and texture are not restored. Furthermore, stiffness and hair-growing prevent denture rehabilitation and good oral hygiene. This study was performed to overcome the disadvantages of composite soft tissue flaps including the skin and to make a model for myo-mucosal flaps. Materials and methods : Buccal mucosa sized $0.5\times1.0\;cm^2$ from New Zealand rabbit (around 1.5kg) was harvested and cultivated by the modification of Rheinwald and Green's keratinocyte culture method. Cultured mucosa was grafted on the fascia of latismus dorsi as form of mucosal sheet. After 7, 10, 14 days, the myomucosal flap was excised and evaluated under light microscope with H & E and immunohistochemical staining. As control group, harvested buccal mucosa from rabbit was transplanted to gracilis muscle(n=6). Results : From 7 days after prelamination, the basal layer of the grafted mucosa resembled that of normal mucosa. As control group, transplanted mucosa had original shape but there's slight inflammatory reaction. Prelaminated mucosa has 19.8$\pm$4.59 cell layers and some samples have more than 20 layers. The expression rate of PCNA was relatively strong (42.9%$\pm$14.1) at the basal layer of grafted mucosa and the laminin was found at the basal layer. On the contrary, prelaminated mucosa at 10 days showed moderate expression rate of PCNA(32.4%$\pm$4.62). We found the mucosal layer was somehow disappeared and there is strong inflammatory reaction. After 14 days prelamination, the grafted oral keratinocytes were almost disappeared and expression of PCNA was not observed. Conclusion : We can make 75 fold large mucosal($3850mm^2$) sheet from small samples of mucosa $(50mm^2)$. Epithelial sheet that grafted on the fascia of muscle underwent differentiation and proliferation. But after 10, 14 days, there was strong inflammatory reaction and the grafted mucosa was destroyed from surface layer. In rabbit model, transfer of fascio-mucosal flap should be done from 7 to 10 days after prelamination.