SEDUCING CUSTOMERS WITH FOND MEMORIES: THE EFFECT OF NOSTALGIA ON CONSUMER SWITCHING BEHAVIOR

Zhongqiang (Tak) Huang,Xun (Irene) Huang,Yuwei Jiang 글로벌지식마케팅경영학회 2018 Global Marketing Conference Vol.2018 No.07

Nostalgia refers to the sentimental longing for the valued past (Sedikides, Wildschut, & Baden, 2004). It is considered a bittersweet emotion, involving both wistful joy and sadness (Sedikides et al., 2004). Nostalgia is also a social emotion. Nostalgic memories typically center on social activities involving the self and close others (Wildschut et al., 2010). Prior research has mainly focused on the social and emotional nature of nostalgic narratives, and researchers have only recently started to investigate the motivations triggered by the process of recalling nostalgic narratives. For example, recalling a nostalgic event can heighten people’s motivation to savor such an experience and prolong it (Huang, Huang, & Wyer, 2016). In the current research, we posit that thinking about nostalgic events can trigger another motivation, namely, a desire to revive the past. Whenever people experience nostalgic feelings, they are likely to perceive differences between the present and their memorable past and desire to go back in time (Hepper et al., 2012; Sedikides et al., 2004). This motivation, once activated, can lead people to take actions to change their current state in the hope of reviving the past (Koole & Jostmann, 2004; Kuhl, 1985). This tendency of taking actions to make changes may generalize to subsequent unrelated situations (Kruglanski et al., 2002), and consequently increase consumer switching behavior (Jiang, Zhan, & Rucker, 2014). These predictions were tested across five studies in various consumption contexts. Our findings contribute to consumer research in two important ways, (a) by demonstrating a novel motivational impact of nostalgia on consumer behavior, and (b) by delineating a systematic influence of an unexplored but pervasive emotional factor— nostalgia—on consumer switching behavior. This research also offers practical implications. Conventional wisdom suggests that nostalgia can make consumers prefer products reminiscent of the “old days”. Our findings show that nostalgia can have broader implications for consumer choices and marketers may use it to manage consumer switching behavior.

Curcumin suppresses oxidative stress via regulation of ROS/NF-κB signaling pathway to protect retinal vascular endothelial cell in diabetic retinopathy

Huang Jiang,Yi Quanyong,You Yuhong,Chen Yao,Niu Tongtong,Yi Li,Zhang Ji,Ji Xiaoyan,Xu Guoxu,Zou Weijie,Ji Fangfang,Luo Weifeng 대한독성 유전단백체 학회 2021 Molecular & cellular toxicology Vol.17 No.3

Background The retinal vascular endothelial cells can be damaged by oxidative stress even in the early stage of diabetic retinopathy (DR). This study aimed to investigate the protective effect of curcumin on the rat retinal vascular endothelial cells (RRVECs) in high glucose circumstance. Objective The cultured RRVECs were identified and characterized by both of vWF and CD31 immunofluorescence expression. The activation of ROS/NF-κB signal pathway was examined by electrophoretic Mobility Shift Assay (EMSA), immunohistochemistry and Western blot; the apoptosis of RRVECs was tested by flow cytometry. Results We found that curcumin reduced the reactive oxygen species (ROS) and relieved the apoptosis in RRVECs exposed to the high glucose by flow cytometry. It was revealed that the increased activity of NF-κB and phosphorylated NF-κB in RRVECs induced by high glucose concentration was significantly suppressed by curcumin. Conclusion We concluded that curcumin could suppress the oxidative stress via regulation of NF-κB signal to protect the RRVECs in DR. Background The retinal vascular endothelial cells can be damaged by oxidative stress even in the early stage of diabetic retinopathy (DR). This study aimed to investigate the protective effect of curcumin on the rat retinal vascular endothelial cells (RRVECs) in high glucose circumstance. Objective The cultured RRVECs were identified and characterized by both of vWF and CD31 immunofluorescence expression. The activation of ROS/NF-κB signal pathway was examined by electrophoretic Mobility Shift Assay (EMSA), immunohistochemistry and Western blot; the apoptosis of RRVECs was tested by flow cytometry. Results We found that curcumin reduced the reactive oxygen species (ROS) and relieved the apoptosis in RRVECs exposed to the high glucose by flow cytometry. It was revealed that the increased activity of NF-κB and phosphorylated NF-κB in RRVECs induced by high glucose concentration was significantly suppressed by curcumin. Conclusion We concluded that curcumin could suppress the oxidative stress via regulation of NF-κB signal to protect the RRVECs in DR.

The RCAN1.4-calcineurin/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discs

Huang Bao,He Yongqing,Li Shengwen,Wei Xiaoan,Liu Junhui,Shan Zhi,Huang Yue,Chen Jiang,Zhao Fengdong 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-

Calcipressin-1, also known as regulator of calcineurin 1 (RCAN1), can specifically bind calcineurin at or near the calcineurin A catalytic domain and downregulate calcineurin activity. However, whether RCAN1 affects the hypoxic intervertebral disc (IVD) phenotype through the calcineurin/NFAT signaling pathway remains unclear. First, we confirmed the characteristics of the degenerative nucleus pulposus (NP) by H&E, safranin O/fast green and Alcian blue staining, and detected increased RCAN1 levels in the degenerative NP by immunohistochemistry. Then, we demonstrated that the protein level of RCAN1.4 was higher than that of RCAN1.1 and progressively elevated from the control group to the Pfirrmann grade V group. In vitro, both hypoxia (1% O2) and overexpression of HIF-1α reduced the protein level of RCAN1.4 in rat NP cells in a dose- and time-dependent manner. We further found that miRNA-124, through a nondegradative pathway (without the proteasome or lysosome), suppressed the expression of RCAN1.4. As expected, calcineurin in NP cells was activated and primarily promoted nuclear translocation of NFATc1 under hypoxia or RCAN1.4 siRNA transfection. Furthermore, SOX9, type II collagen and MMP13 were elevated under hypoxia, RCAN1.4 siRNA transfection or NFATc1 overexpression. Using chromatin immunoprecipitation (ChIP) and a luciferase reporter assay (with mutation), we clarified that NFATc1 increasingly bound the SOX9 promotor region (bp −367~−357). Interaction of HIF-1α and NFATc1 promoted MMP13 transcription. Finally, we found that FK506 reversed hypoxia-induced activation of the calcineurin/NFAT signaling pathway in NP cells and an ex vivo model. Together, these findings show that the RCAN1.4-calcineurin/ NFAT signaling pathway has a vital role in the hypoxic phenotype of NP cells. RCAN1.4 might be a therapeutic target for degenerative disc diseases.

Effects of Alfalfa Meal on Growth Performance and Gastrointestinal Tract Development of Growing Ducks

Jiang, J.F.,Song, X.M.,Huang, X.,Zhou, W.D.,Wu, J.L.,Zhu, Z.G.,Zheng, H.C.,Jiang, Y.Q. Asian Australasian Association of Animal Productio 2012 Animal Bioscience Vol.25 No.10

A study was conducted to evaluate effects of alfalfa meal on growth performance and gastrointestinal tract development of growing layer ducks to provide evidence for application of alfalfa meal in the duck industry. Two hundred and fifty-six healthy Shaoxing 7-wk old growing layer ducks were selected and randomly allocated to 1 of 4 dietary treatments based on corn and soybean meal and containing 0, 3, 6, and 9% of alfalfa meal for 8 wks. Each treatment consisted of 4 replicates of 16 ducks each. Briefly, birds were raised in separate compartments, and each compartment consisted of three parts: indoor floor house, adjacent open area and a connecting water area. The results showed: i) Growing ducks fed alfalfa meal diet were not significantly different in average daily gain, feed intake and gain-to-feed ratio from those fed no alfalfa diet (p>0.05). ii) Alfalfa meal increased the ratio crop, gizzard to live weight, caecum to live weight, the caecum index of growing ducks (p<0.05). iii) Villus height in duodenum and jejunum of growing ducks increased significantly with the increase of alfalfa meal levels (p<0.05). Crypt depth in duodenum and jejunum of growing ducks decreased significantly with the increase of alfalfa meal levels (p<0.05). This experiment showed that feeding of alfalfa meal to growing layer ducks could improve gastrointestinal tract growth and small intestinal morphology without effect on performance. This experiment provides evidence that alfalfa meal is a very valuable feedstuff for growing layer ducks.

Porous Two-Dimensional Monolayer Metal–Organic Framework Material and Its Use for the Size-Selective Separation of Nanoparticles

Jiang, Yi,Ryu, Gyeong Hee,Joo, Se Hun,Chen, Xiong,Lee, Sun Hwa,Chen, Xianjue,Huang, Ming,Wu, Xiaozhong,Luo, Da,Huang, Yuan,Lee, Jeong Hyeon,Wang, Bin,Zhang, Xu,Kwak, Sang Kyu,Lee, Zonghoon,Ruoff, Rodn American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.33

<P>Rational bottorritup construction of two-dimensional (2D) covalent or nonCovalent organic materials with precise structural control at the: atomic or molecular level remains a challenge. The design and synthesis of metal organic frameworks (MOFS) based on new building blocks is of great significance in achieving new types of 2D monolayer MOF films. Here, we demonstrate that a complexation between copper(II) ions and tri(beta-diketone) ligands yields a novel 2D MOF siyucture, either-inthe form of a powder.or.as a monolayer filth. It has been Characterized by Fourier transform infrared, Raman, ultraviolet-visible, X-ray photoelectron, and electron paramagnetic-resonance spectroscopies. Selected area electron diffraction and powder X-ray diffraction results show that the MOF is Crystalline and has a hexagonal structure. A MOF-based membrane has been prepared by vacuum filtration of an aqueous dispersion of the MOF powder onto a porous Anodisc filter having pore-size 0.02 mu m. The porous MOF membrane filters gold nanOparticies with a cutoff of similar to 2.4 nm.</P>

Estimation of Energy Savings when Adopting Ultrasonic Vibration-assisted Magnetic Compound Fluid Polishing

Chen Jiang,Jialei Huang,Zhenyu Jiang,Dabing Qian,Xiaolan Hong 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.8 No.1

Reducing energy use is a major consideration in green manufacturing. Ultrasonic vibration has the advantage of improving machining performance. This work presents an experimental investigation on magnetic compound fluid (MCF) polishing with and without ultrasonic vibration and estimates reductions in polishing energy consumption and surface roughness due to ultrasonic vibration during the machining process. A series of ultrasonic vibration-assisted MCF polishing (UVAMP) tests was carried out for brass H62, and the normal and tangential polishing forces, surface roughness and material removal rate of the traditional MCF polishing (MP) and UVAMP of brass were investigated for various machining parameters. The polishing energy consumptions during traditional MCF polishing and UVAMP were calculated and analyzed from the perspective of the energy of the polishing process. Results indicate that the use of UVAMP considerably reduces energy consumption and surface roughness during the polishing of brass. The adoption of UVAMP therefore has the potential to improve the efficiency and quality of polishing processes and offers a practical solution for the greener manufacturing of brass.

Pyrotinib Combined with Vinorelbine in Patients with Previously Treated HER2-Positive Metastatic Breast Cancer: A Multicenter, Single-arm, Prospective Study

Kuikui Jiang,Ruoxi Hong,Wen Xia,Qianyi Lu,Liang Li,Jianhao Huang,Yanxia Shi,Zhongyu Yuan,Qiufan Zheng,Xin An,Cong Xue,Jiajia Huang,Xiwen Bi,Meiting Chen,Jingmin Zhang,Fei Xu,Shusen Wang 대한암학회 2024 Cancer Research and Treatment Vol.56 No.2

Purpose This study aims to evaluate the efficacy and safety of a new combination treatment of vinorelbine and pyrotinib in human epidermal growth factor receptor 2 (HER2)–positive metastatic breast cancer (MBC) and provide higher level evidence for clinical practice. Materials and Methods This was a prospective, single-arm, phase 2 trial conducted at three institutions in China. Patients with HER2-positive MBC, who had previously been treated with trastuzumab plus a taxane or trastuzumab plus pertuzumab combined with a chemotherapeutic agent, were enrolled between March 2020 and December 2021. All patients received pyrotinib 400 mg orally once daily plus vinorelbine 25 mg/m2 intravenously or 60-80 mg/m2 orally on day 1 and day 8 of 21-day cycle. The primary endpoint was progression-free survival (PFS), and the secondary endpoints included the objective response rate (ORR), disease control rate (DCR), overall survival, and safety. Results A total of 39 patients were enrolled. All patients had been pretreated with trastuzumab and 23.1% (n=9) of them had accepted trastuzumab plus pertuzumab. The median follow-up time was 16.3 months (95% confidence interval [CI], 5.3 to 27.2), and the median PFS was 6.4 months (95% CI, 4.0 to 8.8). The ORR was 43.6% (95% CI, 27.8% to 60.4%) and the DCR was 84.6% (95% CI, 69.5% to 94.1%). The median PFS of patients with versus without prior pertuzumab treatment was 4.6 and 8.3 months (p=0.017). The most common grade 3/4 adverse events were diarrhea (28.2%), neutrophil count decreased (15.4%), white blood cell count decreased (7.7%), vomiting (5.1%), and anemia (2.6%). Conclusion Pyrotinib plus vinorelbine showed promising efficacy and tolerable toxicity as second-line treatment in patients with HER2-positive MBC.

Effect of Solution-treated on Electrochemical Properties of AZ91 Magnesium Alloy Anode

Zhiquan, Huang,Yanjie, Pei,Renyao, Huang,Xiangyu, Gao,Jinchao, Zou,Lianyun, Jiang The Korean Electrochemical Society 2022 Journal of electrochemical science and technology Vol.13 No.4

The effect of solution-treated on the self-corrosion performance and discharge performance of AZ91 magnesium alloy as anode material was analyzed by microscopic characterization, immersion tests, electrochemical measurements, and discharge performance tests. The study shows that the β-phase in the AZ91 magnesium alloy gradually dissolved in the matrix with the increase of the solution temperature, and the electrochemical activity of the magnesium alloy anode was significantly improved. Through the comparison of three different solution-treated processes, it is found that the AZ91 magnesium alloy has the most vigorous activity and better discharge performance after solution-treated of 415℃+12 h. In addition, the proportion and distribution of β-phase AZ91 magnesium alloy have a direct impact on its discharge performance as an anode material.

A Review on Intelligent Scheduling and Optimization for Flexible Job Shop

Bin Jiang,Yajie Ma,Lijun Chen,Binda Huang,Yuying Huang,Li Guan 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.10

Flexible job shop scheduling problem is a NP-hard combinatorial optimization problem, which has significant applications in the field of workshop scheduling and intelligent manufacturing. Due to its complexity and significance, lots of attention have been paid to tackle this problem. This paper reviews some of the researches on this problem, by presenting and classifying the different criteria, constraints, and solution approaches. The existing solution methods for the flexible job shop scheduling problem in this literature are classified into exact algorithms, heuristics, and meta-heuristics, which are thoroughly reviewed. Particularly, the paper highlights the flexible job shop scheduling problem in the context of dynamic events and preventive maintenance. These dynamic events, such as machine breakdowns and unexpected changes in job requirements, present additional challenges to the scheduling problem. Furthermore, this paper analyzes the development trends in the manufacturing industry and summarizes detailed future research opportunities for the flexible job shop scheduling problem.

Risk Factors for Early Recurrence of HBV-related Hepatocellular Carcinoma Meeting Milan Criteria after Curative Resection

Zhu, Wen-Jiang,Huang, Chu-Ying,Li, Chuan,Peng, Wei,Wen, Tian-Fu,Yan, Lv-Nan,Li, Bo,Wang, Wen-Tao,Xu, Ming-Qing,Yang, Jia-Yin,Jiang, Li Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

Background: The prognosis of patients with hepatocellular carcinoma (HCC) after curative resection varies greatly. Few studies had investigated the risk factors for early recurrence (recurrence-free time ${\leq}$ 1 year) of hepatitis B virus (HBV)-related HCCs meeting Milan criteria. Methods: A retrospective analysis was performed on the 224 patients with HCC meeting Milan criteria who underwent curative liver resection in our center between February 2007 and March 2012. The overall survival (OS) rate, recurrence-free survival (RFS) rate and risk factors for early recurrence were analyzed. Results: After a median follow-up of 33.3 months, HCC reoccurred in 105 of 224 patients and 32 died during the period. The 1-, 3- and 5-year OS rates were 97.3%, 81.6% and 75.6% respectively, and the 1-, 3- and 5-year RFS rates were 73.2%, 53.7% and 41.6%. Cox regression showed alpha-fetoprotein (AFP) > 800 ng/ml (HR 2.538, 95% CI 1.464-4.401, P=0.001), multiple tumors (HR 2.286, 95% CI 1.123-4.246, P=0.009) and microvascular invasion (HR 2.518, 95% CI 1.475-4.298, P=0.001) to be associated with early recurrence (recurrence-free time ${\leq}$ 1-year) of HCC meeting Milan criteria. Conclusions: AFP > 800 ng/ml, multiple tumors and microvascular invasion are independent risk factors affecting early postoperative recurrence of HCC. In addition resection appears capable of replacing liver transplantation in some situations with safety and a better outcome.