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조형등대와 건축적 표상에 관한 연구 : 통영 문학기념 조형등대의 디자인 기술을 중심으로
안웅희(Ahn Woong-Hee),송민성(Song Min-Sung),고신채(Ko Sin-Chai),한창수(Han Chang-Soo) 한국항해항만학회 2007 한국항해항만학회 학술대회논문집 Vol.1 No.춘계
등대는 전통적인 기능과 역할에 충실한 항로표지일 뿐만 아니라 사람들의 향수와 해양문화의 기억들이 묻어있는 공간이다. 최근에는 적절한 해양문화공간으로 개발함으로써 해양문화에 대한 인식을 높이고, 지역관광에 공헌을 하고 있는 추세이다. 특히, 해양수산부는 2006년 "희망의 빛 조형등대 설치계획"을 통하여 마산지방해양수산청 소속의 통영시 도남항 동방파제 등대를 건설하였다. 지역과 문화적 특색을 살릴 수 있는 기념등대로 개발하고자 하였으며, 이에 따라 통영의 훌륭한 문화적 성과를 기념대상으로 지정하였다. 이에 현상공모를 통해 한국해양대학교의 안웅희 교수의 작품이 당선되었다. 본 연구는 기존의 등대의 형태에서 벗어난 추상적이면서 기하학적인 형상을 통해 통영 일대의 문화적, 관광적 요소에 미치는 영향을 살펴봄으로써, 향후 등대건축의 방향성을 제시하고, 다양하게 검토되어야 할 논제들을 밝히는 것에 그 목적이 있다. The Lighthouse is not only functioning as a traditional aids to navigate for the vessel, but also space that has memory about marine culture and man's nostalgia. Recently, it contributes to regional tourism and makes a new meaning about marine culture through the development of lighthouse to a proper space of ocean culture. Especially, MOMAF has constructed the sculpture lighthouse in Tongyeong as "the light of hope-sculptural lighthouse project". They hoped to develop the memorial lighthouse that represents characteristic of the region and culture and it became a symbol of the great culture in Tongyeong. Through the competition, prof. Ahn Woong-Hee's design won the project, and constructed. For this situation, we intended to reveal in this study that all the issues which relate to the design for lighthouse in the future through the abstract, geometrical form of lighthouse that deviated the traditional design.
( Woong Hyun Kim ),( Hyun Ok Song ),( Chun Mei Jin ),( Jong Moon Hur ),( Hwa Sung Lee ),( Han Yong Jin ),( Sung Yeon Kim ),( Hyun Park ) 한국응용약물학회 2012 Biomolecules & Therapeutics(구 응용약물학회지) Vol.20 No.1
In the present study, the inhibitory effect of neem leaf extract (NLE) on lipopolysaccaride (LPS)-induced nitric oxide (NO) and tumor necrosis factor-α (TNF-α) production was examined both in vitro and in vivo. In vitro study revealed that NLE treatment (100 μg/ml) inhibits LPS (100 ng/ml)-induced NO production by 96% and TNF-α production by 32%. The reduction in NO production is probably conferred by the complete suppression of inducible nitric oxide synthase (iNOS) expression. Interestingly, in vivo NLE significantly improved the survival rate of mice in an experimental sepsis model. Administration of NLE (100 mg/kg) 24 h before LPS treatment (20 mg/kg) improved the survival rate of mice by 60%. The inhibition of plasma NO and TNF-α production by NLE is likely to account for the improved survival of mice. Our results suggest that NLE may present a promising avenue in the development of therapeutic agents for the treatment of inflammatory diseases.
Sang-Yeon Lee,Hyun Been Choi,Mina Park,Il Soon Choi,Jieun An,Ami Kim,Eunku Kim,Nahyun Kim,Jin Hee Han,Min young Kim,Seung min Lee,Doo-Yi Oh,Bong Jik Kim,Nayoung Yi,Nayoung, K. D. Kim,Chung Lee,Woong-Y 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Loss-of-function variant in the gene encoding the KCNQ4 potassium channel causes autosomal dominant nonsyndromic hearing loss (DFNA2), and no effective pharmacotherapeutics have been developed to reverse channel activity impairment. Phosphatidylinositol 4,5-bisphosphate (PIP2), an obligatory phospholipid for maintaining KCNQ channel activity, confers differentialpharmacological sensitivity of channels to KCNQ openers. Through whole-exome sequencing of DFNA2 families, we identified three novel KCNQ4 variants related to diverse auditory phenotypes in the proximal C-terminus (p.Arg331Gln), the C-terminus of the S6 segment (p.Gly319Asp), and the pore region (p.Ala271_Asp272del). Potassium currents in HEK293T cells expressing each KCNQ4 variant were recorded by patch-clamp, and functional recovery by PIP2 expression or KCNQ openers was examined. In the homomeric expression setting, the three novel KCNQ4 mutant proteins lost conductance and were unresponsive to KCNQ openers or PIP2 expression. Loss of p.Arg331Gln conductance was slightly restored by a tandem concatemer channel (WT-p.R331Q), and increased PIP2 expression further increased the concatemer current to the level of the WT channel. Strikingly, an impaired homomeric p.Gly319Asp channel exhibited hyperactivity when a concatemer (WT-p.G319D), with a negative shift in the voltage dependence of activation. Correspondingly, a KCNQ inhibitor and chelation of PIP2 effectively downregulated the hyperactive WTp. G319D concatemer channel. Conversely, the pore-region variant (p.Ala271_Asp272del) was nonrescuable under any condition. Collectively, these novel KCNQ4 variants may constitute therapeutic targets that can be manipulated by the PIP2 level and KCNQregulating drugs under the physiological context of heterozygous expression. Our research contributes to the establishment of a genotype/mechanism-based therapeutic portfolio for DFNA2.
A New Optimal Current Excitation Scheme of Brushless DC Motor
Sung-Jun Park,Han-Woong Park 한국정보과학회 1999 Journal of Electrical Engineering and Information Vol.4 No.5
In this paper, the novel optimal excitation scheme of BLDCM producing loss-minimized ripple-free torque based on the d-q-0 reference frame is presented including 3-phase unbalanced condition. The optimized phase current waveforms that are obtained by the proposed method can be reference values and the motor winding currents are forced to track it by using the delta modulation technique. As a result, it can be shown that the proposed work provides a simple and clear way of obtaining and controlling optimal motor excitation current. Simulation and experimental results prove the validity and practical applications of the proposed control scheme.
Functional Genomics Approach Using Mice
Sung, Young-Hoon,Song, Jae-Whan,Lee, Han-Woong Korean Society for Biochemistry and Molecular Biol 2004 Journal of biochemistry and molecular biology Vol.37 No.1
The rapid development and characterization of the mouse genome sequence, coupled with comparative sequence analysis of human, has been paralleled by a reinforced enthusiasm for mouse functional genomics. The way to uncover the in vivo function of genes is to analyze the phenotypes of the mutant animals. From this standpoint, the mouse is a suitable and valuable model organism in the studies of functional genomics. Therefore, there have been enormous efforts to enrich the list of the mutant mice. Such a trend emphasizes the random mutagenesis, including ENU mutagenesis and gene-trap mutagenesis, to obtain a large stock of mutant mice. However, since various mutant alleles are needed to precisely characterize the role of a gene in vivo, mutations should be designed. The simplicity and utility of transgenic technology can satisfy this demand. The combination of RNA interference with transgenic technology will provide more opportunities for researchers. Nevertheless, gene targeting can solely define the in vivo function of a gene without a doubt. Thus, transgenesis and gene targeting will be the major strategies in the field of functional genomics.
A Case of Acute Intermittent Porphyria with Psychiatric Manifestations
Han, Sang Yup,Oh, Min Woong,Kim, Hun Suk,Choi, Soo Ho CATHOLIC MEDICAL CENTER 1973 Bulletin of the Clinical Research Institute Vol.1 No.1
This is a brief report on a case of Acute intermittent Porphyria observed in the St. Mary's Hospital, Catholic Medical College, Seoul, Korea.