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이종접합 Gate 구조를 갖는 수평형 NiO/Ga<sub>2</sub>O<sub>3</sub> FET의 전기적 특성 연구
이건희 ( Geon-hee Lee ),문수영 ( Soo-young Moon ),이형진 ( Hyung-jin Lee ),신명철 ( Myeong-cheol Shin ),김예진 ( Ye-jin Kim ),전가연 ( Ga-yeon Jeon ),오종민 ( Jong-min Oh ),신원호 ( Weon-ho Shin ),김민경 ( Min-kyung Kim ),박철환 ( 한국전기전자재료학회 2023 전기전자재료학회논문지 Vol.36 No.4
Gallium Oxide (Ga<sub>2</sub>O<sub>3</sub>) is preferred as a material for next generation power semiconductors. The Ga<sub>2</sub>O<sub>3</sub> should solve the disadvantages of low thermal resistance characteristics and difficulty in forming an inversion layer through p-type ion implantation. However, Ga<sub>2</sub>O<sub>3</sub> is difficult to inject p-type ions, so it is being studied in a heterojunction structure using p-type oxides, such as NiO, SnO, and Cu<sub>2</sub>O. Research the lateral-type FET structure of NiO/Ga<sub>2</sub>O<sub>3</sub> heterojunction under the Gate contact using the Sentaurus TCAD simulation. At this time, the VG-ID and VD-ID curves were identified by the thickness of the Epi-region (channel) and the doping concentration of NiO of 1 × 10<sup>17</sup> to 1 × 10<sup>19</sup> cm<sup>-3</sup>. The increase in Epi region thickness has a lower threshold voltage from -4.4 V to -9.3 V at I<sub>D</sub> = 1 × 10<sup>-8</sup> mA/mm, as current does not flow only when the depletion of the PN junction extends to the Epi/Sub interface. As an increase of NiO doping concentration, increases the depletion area in Ga<sub>2</sub>O<sub>3</sub> region and a high electric field distribution on PN junction, and thus the breakdown voltage increases from 512 V to 636 V at I<sub>D</sub> =1 × 10<sup>-3</sup> A/mm.
( Ga Young Lee ),( Hyung-jun Kim ),( Myung Jin Song ),( Yeon Wook Kim ),( Byung Soo Kwon ),( Sung Yoon Lim ),( Yeon-Joo Lee ),( Jong Sun Park ),( Ho Il Yoon ),( Jae Ho Lee ),( Choon-taek Lee ),( Young 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background As cases of pneumothorax have been reported in coronavirus disease 2019 (COVID-19) patients, it is suspected as a complication of COVID-19. However, it has not been proven whether COVID-19 is associated with causing pneumothorax by comparing non-COVID-19 pneumonia under mechanical ventilation (MV). The purpose of this study was to evaluate the impacts of COVID-19 on pneumothorax development in mechanically ventilated patients. Methods A retrospective cohort study was performed in an intensive care unit (ICU) at tertiary, academic hospital, from February 2020 to March 2021. Occurrence of pneumothorax between COVID-19 and non-COVID-19 pneumonia group was assessed including their baseline clinical characteristics. Risk factors of pneumothorax and association with COVID-19 were analyzed by logistic regression model. Results Of the 135 patients, 48 (35.5%) patients were diagnosed with COVID-19. In COVID-19 patients, 30 (63.5%) were male, median age was 66.5 years and 10 (20.8%) developed pneumothorax, which occurred only 4 (4.6%) in non-COVID-19 (P=0.008). Compared to non-COVID-19, COVID-19 patients had lower P/F ratio at ICU admission (84.1 [69.8;126.1] vs. 144 [104.2;217.2], P=0.001) and higher MV settings [positive end expiratory pressure (PEEP) 10.0 [10.0;12.0] vs. 8.0 [6.0;10.0], P=0.001, pressure above PEEP 16.6 ± 5.2, 17.0 ± 4.0, P=0.068]. Co-morbidities tended to be more various in non-COVID19 patients. In the univariate analysis for the risk factors of pneumothorax, PEEP (OR 1.26, P<0.01,) and COVID-19 (OR 5.46, P=0.001) were significantly associated with the development of pneumothorax, where only COVID-19 (OR 14.0, P=0.030) was an exclusive risk factors in the multivariate analysis. Conclusions In patients with pneumonia who underwent MV, COVID-19 could be a decisive risk factor on the occurrence of pneumothorax.
Ga Yeon Kim,Jin Kyoung Kim,Young Ki Lee 대한구강악안면병리학회 2015 대한구강악안면병리학회지 Vol.39 No.2
S. aureus is reported as a major cause of nosocomial infections after dental care and involved in endocarditis, bacteremia, osteomyelitis, peritonitis, and soft tissues etc. It is very important to identify the distribution and the diversity of toxin gene associated with the S. aureus expression in dental care patients with periodontitis directly for an effective prevention and treatment of dental diseases. Fifty four strains of S. aureus were isolated from the saliva of 129 patients who were diagnosed with periodontitis at dental clinics and hospitals located in Seoul. The distribution of the virulence gene and the genetic diversity of the strains were studied using the polymerase chain reaction with isolated strains. The enterotoxin test showed Seb was the most frequent gene with 88.9%. The hemolysin gene of Hla, Hib and Hld were the most frequently gene with 98.1% (53 strains), leukocidins gene of lukM showed 90.7% (49 strains), and laminin binding protein gene of Eno showed 100% (54 strains), respectively. The diversity of the enterotoxin gen was held as Seb-Seg-Sei gene of 35.2% (19 strains), the diversity of hemolysin gene of Hla-Hlb-Hld gene was 98.1% (53 strains) and the diversity of leukocidins gene of LukD-LukM were 88.9% (48 strains), respectively. Patients with dental disease showed somehow high toxin gene expression so that S. aureus in dental care area is judged to show very highly pathogen with a high and infection rate. In the future, additional studies for these toxin genes seem to be required.
Lee Ga Young,Shin Gi Won,Park Young Mi,Lee Anbok,Park Ha Young,Lee Yoo Jin,Han Ji-Yeon 대한영상의학회 2021 대한영상의학회지 Vol.82 No.6
Post-partum galactocele is a common benign disease among breastfeeding women, whereas retromammary and peri-implant galactocele are relatively rare conditions. Herein, a 34-yearold, 1 month-postpartum female, who had augmentation mammoplasty and a 1-month history of breast pump use, presented with left breast enlargement for 2 weeks. An initial left breast US revealed hyperechoic peri-implant fluid collection. Additional US-guided fine needle aspiration was done using a 21G-needle, draining the milk component in the process, and cytologic results revealed numerous crystals, suggestive of galactocele. Various diseases, especially breast implant-associated anaplastic large cell lymphoma, can cause peri-implant fluid collection in an augmented breast. Thus, correlating imaging features with clinical information and cytologic analysis plays an important role in appropriate management.
Glycosylation study of phenolic complunds by amylosucrase
Ga Yeon Noh,Jihye Baek,Jin Woo Lee,Jong Won Song,Hun Sang Lee,Jae Kyung SohngH 한국당과학회 2018 한국당과학회 학술대회 Vol.2018 No.01
The purpose of this experiment is to investigate the glycosylation using enzymes. E. coli BL21 (DE3) was used as a host for protein overexpression. Phloroglucinol (PG) is used as an antiseptic and the treatment of gallstones, cramps and gastrointestinal disorders. According to HPLC results, the glycosylation of PG quickly generated in a few hours. Pyrogallol is a medicinal product that is used in psoriasis and antimicrobial agents. We progressed this reaction with ascorbic acid which is antioxidant for reaction stability of phloroglucinol and pyrogallol. 2,4-dihydroxybenzoic acid are belong to flavor modulators. The pharmacological action of 2,5-dihydroxybenzoic acid has a wide range of biological activities such as anti-inflammatory, antirheumatic and antioxidant properties. When salicylic acid is glycosylated, we anticipate both antivirus and antipyretic effects against influenza. In the case of p-aminosalicylic acid, when glycosylated, we anticipate alleviation of various side effects mentioned above as a result of enhanced water solubility of drug. The glycosylation of salicylic acid by amylosucrase was not detected, but we observed through HPLC that the level of glycosylation of p-aminosalicylic acid, 2,4-dihydroxybenzoic acid, and 2,5-dihydroxybenzoic acid, although slow in reaction rate, increased over a time period.
Role of Soluble ST2 as a Marker for Rejection after Heart Transplant
Ga Yeon Lee,Jin-Oh Choi,Eun-Seon Ju,Yoo-Jung Lee,Eun-Seok Jeon 대한심장학회 2016 Korean Circulation Journal Vol.46 No.6
Background and Objectives: Endomyocardial biopsy is obligatory during the first year after heart transplant (HTx) for the surveillance of acute rejection. Previous attempts using cardiac biomarkers for the detection of rejection failed to show enough evidence to substitute endomyocardial biopsy. Therefore, this study sought the possibility of using soluble ST2 (sST2), a novel cardiovascular marker, as a surrogate marker for acute allograft rejection after HTx. Subjects and Methods: A total of 494 blood samples acquired at the time of endomyocardial biopsy were analyzed in 67 HTx cases from September 2006 to August 2014. Significant rejection was defined as International Society of Heart and Lung Transplant (ISHLT) score ≥2R and humoral rejection accompanied by hemodynamic instability. Results: Twenty cases of HTx with 22 blood samples showed significant rejection in endomyocardial biopsy at 4.0 (2.0-9.0) months after HTx. The level of sST2 showed positive correlation with cardiac troponin I, and N-terminal pro-B-type natriuretic peptide (all p<0.001), and negative correlation with post-HTx months (p<0.001). The levels of sST2 according to the ISHLT scores were 36 (19-98), 28 (18-62), 15 (16-37), and 191 (85-343) ng/mL, consecutively 0R, 1R, 2R, and 3R+ (3R plus hemodynamically-unstable humoral rejection) (p=0.003). However, when we studied within-subject effects of sST2 using a mixed model, the sST2 level according to the predefined time point was not different according to the presence of significant rejection (p for interaction=0.94). Conclusion: Although sST2 is known as a promising predictor for cardiovascular events, its role in HTx patients to predict acute allograft rejection seems to be limited.