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- 저자 : Sung-Joon Lee (검색결과 13,609 건)
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Eun-Do Kim,Jin-Kwon Lee,Jin-Kyu Cho,Jae-Myung Kim,Ji-Ho Park,Ju-Yeon Kim,Sang-Ho Jeong,Young-Tae Ju,Chi-Young Jeong,Eun-Jung Jung,Young-Joon Lee1,Soon-Chan Hong,곽승진 대한종양외과학회 2019 Korean Journal of Clinical Oncology Vol.15 No.2
Purpose: Whether subtotal or total colectomy with primary anastomosis (PA) is safer than Hartmann procedure (HP) for left-sided colon cancer obstruction or perforation remains controversial. The purpose of this study was to compare postoperative morbidity, mortality, and defecation frequency between PA and HP for left-sided colon cancer obstruction or perforation. Methods: This retrospective study enrolled 54 patients from January 2014 to February 2018 who underwent emergency surgery due to left-sided colon cancer obstruction or perforation. Results: PA was carried out in 20 patients while HP was performed for 34 patients. Thirty-day mortality did not show significant difference between the two groups (15.0% vs. 14.7%, P=1.000). No anastomotic leakage occurred in PA group while three (8.8%) cases of stump leakage occurred in HP group. Stoma repair was performed for 13 cases (44.8%) and stoma reformation was performed for one case in HP group (7.7%). Stoma related complications occurred in five cases (17.24%). For patients after stoma repair, defecation frequency at 3 months after operation was 2.91±2.88 times per day in PA group and 2.86±2.63 times per day in HP group. At 1 year after operation, defecation frequency was changed to 1.40±1.12 times per day in PA group and 1.17±0.39 times per day in HP group. Conclusion: Primary ileosigmoid or ileorectal anastomosis for left-sided colon cancer obstruction or perforation is safe, and shows similar outcome of defecation frequency compared to H
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Lee, Jae Hyun,Yang, Joon Seon,Lee, Sang-Hak,Moon, Myeong Hee Elsevier 2018 Journal of chromatography. B, Analytical technolog Vol.1099 No.-
<P><B>Abstract</B></P> <P>A comprehensive lipid analysis was performed at the plasma lipoprotein level in patients with acute coronary syndrome (ACS) and stable coronary artery disease (CAD). Because the lipids in lipoproteins are related to the pathology of the cardiovascular system, lipoprotein-specific lipid analysis can be useful for understanding the mechanism of lipid-associated cardiovascular diseases. Lipoproteins were size-sorted into high density lipoproteins (HDL) and low density lipoproteins (LDL) using asymmetrical flow field-flow fractionation, then lipids of each lipoprotein were analysed using nanoflow ultrahigh performance liquid chromatography-electrospray ionization-tandem mass spectrometry. A total of 365 lipids were structurally identified and quantified by selected reaction monitoring method. Two high abundance lysophosphatidylcholines (16:0 and 18:0) were significantly increased only in the HDL of the ACS group (vs. the stable CAD group). Phosphatidylethanolamines (38:5 and 40:5) significantly increased in ACS by >2-fold in both lipoproteins. (18:0, 22:6)-diacylglycerol increased in ACS by 3.5-fold only in LDL; however, most high abundance triacylglycerols decreased 2-fold in both lipoproteins. The present study revealed the usefulness of lipoprotein-specific analysis of lipids in distinguishing ACS from stable CAD, and the selected lipids analysed in this study may be useful in the development of lipid markers for the early detection of ACS.</P>
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Lignin for white natural sunscreens
Lee, Sang Cheon,Tran, Thi Minh Thu,Choi, Joon Weon,Won, Keehoon Elsevier 2019 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.122 No.-
<P><B>Abstract</B></P> <P>Long-time exposure to the sun's ultraviolet (UV) radiation is harmful and causes various skin problems. Natural sun blockers have been drawing considerable attention recently. Even though lignin, an abundant aromatic polymer from plants, is a natural UV screening agent, its unfavorable dark color hinders its high value-added applications in sunscreens and cosmetics. In this study, we separate lignin under mild conditions (at room temperature with neutral solvents) in order to prevent darkening occurring during delignification and apply the resultant lignin as a natural sunscreen ingredient for the first time. Lignins isolated from <I>Miscanthus sacchariflorus</I> (MWL-M) and from <I>Pinus densiflora</I> (MWL-P) are compared with organosolv lignin (OL), which showed the best sunscreen performance, in color and UV protection. MWLs separated under mild conditions were light in color unlike conventional lignins extracted under harsh conditions. UV absorption of light-colored MWL-M was revealed to be as high as dark-colored OL. MWLs also showed synergistic effects with a commercial sunscreen; exposure of the MWL-added sunscreen to UVA radiation greatly enhanced the sun protection factor (SPF) value of the sunscreen.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Lee, Jaegi,Lee, Jimin,Ryu, Dongmin,Lee, Hochan,Ye, Sung-Joon Institute of Physics in association with the Ameri 2018 Physics in medicine & biology Vol.63 No.19
<P>A Fano cavity test was performed for four general-purpose Monte Carlo codes, EGSnrc, PENELOPE, MCNP6 and Geant4 to evaluate the accuracy of their electron transport algorithms in magnetic fields. In the simulations, a plane-parallel ionization chamber was modelled as a circular gas disk sandwiched between two circular solid wall disks. It was assumed that an isotropic and uniform line source per unit mass along the central axis of the gas and solid emits mono-energetic electrons with energies 0.01, 0.1, 1.0 and 3.0 MeV at different magnetic field strengths 0, 0.35, 1.0, 1.5 and 3.0 T in the electron transport mode (no Bremsstrahlung). The relative difference between the calculated dose to the gas region and the initial total energy of emitted electrons per unit mass was defined as the accuracy of Monte Carlo codes. In all results, EGSnrc with the enhanced electric and magnetic field (EEMF) macros was not considerably sensitive to the step size parameters and showed accuracy less than 0.18% ± 0.06% with a coverage factor <I>k</I> = 2. The other codes could not achieve competent accuracy with their default settings of step size parameters, compared to EGSnrc with the EEMF macros. With the step size parameters carefully selected, the accuracy of PENELOPE and MCNP6 was within 1.0% and 0.4%, respectively. However, Geant4 showed accuracy within 1.7% except in 3.0 T. EGSnrc with the EEMF macros achieved the best accuracy for the Fano test at the electron energies and the magnetic field strengths investigated in this study and thus, would be recommended to simulate dose responses of ionization chambers in the presence of magnetic fields.</P>
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Lee, Sung-Sahn,So, Sang-Yeon,Jung, Eui-Yub,Kim, Hyun-Jun,Lee, Byung Hoon,Wang, Joon Ho Elsevier 2019 Arthroscopy Vol.35 No.6
<P><B>Purpose</B></P> <P>To identify risk factors for patellofemoral degenerative progression after opening-wedge high tibial osteotomy (HTO) and to investigate the effect of patellofemoral degeneration on the patellofemoral specific patient-reported outcomes.</P> <P><B>Methods</B></P> <P>Between March 2010 and June 2016, 94 knees (86 patients) underwent hardware removal with second-look arthroscopy at 21.4 months after opening-wedge HTO with first-look arthroscopy (mean follow-up duration, 49.8 months). Predictive factors for patellofemoral degeneration, including demographics, preoperative and postoperative mechanical axis (MA) of the lower limb (positive and negative MA indicating varus and valgus, respectively), tibial slope, and modified Blackburne-Peel ratio, were evaluated. Patients were divided into the progression and nonprogression groups according to their patellofemoral degenerative progression from first to second arthroscopy. Clinical outcomes, including the Kujala score and Knee Injury and Osteoarthritis Outcome Score, and radiographic outcomes were compared between the 2 groups.</P> <P><B>Results</B></P> <P>Postoperative MA (adjusted odd ratio, 0.62; <I>P</I> < .001) was the most significant predictive factor for progressive change in the patellofemoral joint (<I>R</I> <SUB>n</SUB> <SUP>2</SUP> = 0.31). Twenty-eight knees (30%) showed patellofemoral degenerative progression. Mean postoperative Kujala score (progression group 60.5 vs nonprogression group, 72.3; <I>P</I> = .005) and Knee Injury and Osteoarthritis Outcome Score scales (except for the symptom subscale) were lower in the progression group. Postoperative MA was significantly more corrected in the progression group (progression group –5.1° ± 2.7° vs nonprogression group –2.4° ± 2.3°; <I>P</I> < .001).</P> <P><B>Conclusions</B></P> <P>Postoperative MA, which might be related to overcorrection, is correlated with patellofemoral degenerative progression after opening-wedge HTO. Patients with patellofemoral degenerative progression showed inferior patient-reported outcomes.</P> <P><B>Level of Evidence</B></P> <P>Level IV, case series with subgroup analysis.</P>
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Lee, Changkeun,Hong, Seongjin,Noh, Junsung,Lee, Junghyun,Yoon, Seo Joon,Kim, Taewoo,Kim, Hosang,Kwon, Bong-Oh,Lee, Hanbyul,Ha, Sung Yong,Ryu, Jongseong,Kim, Jae-Jin,Kwon, Kae Kyoung,Yim, Un Hyuk,Khim, Elsevier Applied Science Publishers 2019 Environmental pollution Vol.252 No.1
<P><B>Abstract</B></P> <P>While various bioremediation techniques have been widely used at oil spill sites, the in situ efficiency of such techniques on recovering the benthic communities in intertidal areas has not been quantified. Here, the performance of several bioremediation tools such as emulsifiers, multi-enzyme liquid (MEL), microbes, and rice-straw was evaluated by a 90-days semi-field experiment, particularly targeting recovery of benthic community. Temporal efficiency in the removal of sedimentary total petroleum hydrocarbons (TPH), reduction of residual toxicity, and recovery of bacterial diversity, microalgal growth, and benthic production was comprehensively determined. Concentrations of TPH and amphipod mortality for all treatments rapidly decreased within the first 10 days. In addition, the density of bacteria and microphytobenthos generally increased over time for all treatments, indicating recovery in the benthic community health. However, the recovery of some nitrifying bacteria, such as the class Nitrospinia (which are sensitive to oil components) remained incomplete (13–56%) during 90 days. Combination of microbe treatments showed rapid and effective for recovering the benthic community, but after 90 days, all treatments showed high recovery efficiency. Of consideration, the “no action” treatment showed a similar level of recovery to those of microbe and MEL treatments, indicating that the natural recovery process could prevail in certain situations.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Residual hydrocarbons and amphipod toxicity rapidly decreased within 10 days. </LI> <LI> Quick recovery found for most of the bacteria, but some remained incomplete at >90 d. </LI> <LI> Microphytobenthos community took more than 90 days to recover against oil exposure. </LI> <LI> Combination of microbe treatments were effective for recovering the benthic community. </LI> <LI> “No action” showed comparable recovery to others, indicating prevailing natural recovery. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Analysis of Fifty Hotspot Mutations of Lung Squamous Cell Carcinoma in Never-smokers
Lee, Ha Youn,Lee, Se-Hoon,Won, Jae-Kyung,Lee, Dong Soo,Kwon, Nak-Jung,Choi, Sun Mi,Lee, Jinwoo,Lee, Chang-Hoon,Lee, Sang-Min,Yim, Jae-Joon,Yoo, Chul-Gyu,Kim, Young Whan,Han, Sung Koo,Park, Young Sik KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.3
<P>Smoking is the major risk factor for lung squamous cell carcinoma (SCC), although a small number of lung SCCs occurs in never-smokers. The purpose of this study was to compare 50 hotspot mutations of lung SCCs between never-smokers and smokers. We retrospectively reviewed the medical records of patients newly diagnosed with lung SCC between January 1, 2011 and December 31, 2013 in the Seoul National University Hospital. Formalin-fixed, paraffin-embedded tumor samples were used for analysis of hotspot mutations. Fifty cancer-related genes in never-smokers were compared to those in ever-smokers. Of 379 lung SCC patients, 19 (5.0%) were never-smokers. The median age of these 19 patients was 67 years (interquartile range 57–73 years), and 10 of these patients were women (52.5%). The incidence rates of stage I, II, III, and IV disease in this group were 26.4%, 5.3%, 31.6%, and 36.8%, respectively, and sequencing was performed successfully in 14 cases. In the 26 lung SCC tumor samples (12 from never-smokers and 14 from ever-smokers) sequenced using personal genome machine, the most common mutations were in <I>TP53</I> (75.0%), <I>RAS</I> (66.7%), and <I>STK11</I> (33.3%), but mutations were also found in <I>EGFR</I>, <I>KIT</I>, and <I>PTEN</I>. The distribution of hotspot mutations in never-smokers was similar to that in ever-smokers. There was no significant difference in overall survival between the 2 groups. The 50 hotspot mutations of lung SCC in never-smokers were similar to those of ever-smokers.</P>
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Lee, Dae Woon,Kang, Yeongkwon,Jo, Bong Hyun,Jeon, Gyeong G.,Park, Jaehong,Yoon, Sang Eun,Zheng, Jian,Ahn, Tae Kyu,Park, Hui Joon,Kim, Bong-Gi,Kim, Jong H. Elsevier 2019 ORGANIC ELECTRONICS Vol.64 No.-
<P><B>Abstract</B></P> <P>Near-infrared (NIR) photodetectors sensitive to 860 nm light were fabricated through a solution process using two different conjugated polymers (CPs) that share a similar conjugated backbone consisting of a diketopyrrolopyrrole (DPP) moiety. The two CPs had a comparable conjugated nature, but their detection capabilities were significantly different depending on the applied linker units, namely thiophene for PDPP-T and fluorinated thiophene for PDPP-FBT. First, we revealed that employing an additive during active film preparation was beneficial for achieving an optimum film morphology for both CPs, which could suppress dark current and provide enhanced detectivity. In addition, when a highly electronegative fluorine atom, which induces a surface dipole, was introduced into the conjugated skeleton, it was clearly demonstrated via transient photovoltage measurements that the charge recombination time was lengthened, which implies an increase in the probability of charge extraction in actual devices by suppressing charge recombination. Thus, PDPP-FBT exhibited higher external quantum efficiency and responsivity across all wavelengths. Our results indicated that the management of both film morphology and surface dipoles of CPs are equally important for achieving high detectivity and responsivity in organic NIR photodetectors.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Solution-processed NIR photodetectors based on two conjugated polymers are demonstrated. </LI> <LI> Additives reduced the dark current by optimizing the morphology of photoactive layers. </LI> <LI> Surface dipoles in the conjugated polymer improved external quantum efficiency of the photodetectors. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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