Evaluation of the Efficacy and Safety of DA-9601 versus Its New Formulation, DA-5204, in Patients with Gastritis: Phase III, Randomized, Double-Blind, Non-Inferiority Study

Choi, Yoon Jin,Lee, Dong Ho,Choi, Myung-Gyu,Lee, Sung Joon,Kim, Sung Kook,Song, Geun Am,Rhee, Poong-Lyul,Jung, Hwoon-Yong,Kang, Dae-Hwan,Lee, Yong Chan,Lee, Si Hyung,Choi, Suck Chei,Shim, Ki-Nam,Seol, KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.11

<P>This study compared the efficacy of DA-9601 (Dong-A ST Co., Seoul, Korea) and its new formulation, DA-5204 (Dong-A ST Co.), for treating erosive gastritis. This phase III, randomized, multicenter, double-blind, non-inferiority trial randomly assigned 434 patients with endoscopically proven gastric mucosal erosions into two groups: DA-9601 3 times daily or DA-5,204 twice daily for 2 weeks. The final analysis included 421 patients (DA-5204, 209; DA-9601, 212). The primary endpoint (rate of effective gastric erosion healing) and secondary endpoints (cure rate of endoscopic erosion and gastrointestinal [GI] symptom relief) were assessed using endoscopy after the treatment. Drug-related adverse events (AEs), including GI symptoms, were also compared. At week 2, gastric healing rates with DA-5204 and DA-9601 were 42.1% (88/209) and 42.5% (90/212), respectively. The difference between the groups was −0.4% (95% confidence interval, −9.8% to 9.1%), which was above the non-inferiority margin of −14%. The cure rate of gastric erosion in both groups was 37.3%. The improvement rates of GI symptoms with DA-5204 and DA-9601 were 40.4% and 40.8%, respectively. There were no statistically significant differences between the two groups in both secondary endpoints. AEs were reported in 18 (8.4%) patients in the DA-5204 group and 19 (8.8%) in the DA-9601 group. Rates of AE were not different between the two groups. No serious AE or adverse drug reaction (ADR) occurred. These results demonstrate the non-inferiority of DA-5204 compared to DA-9601. DA-5204 is as effective as DA-9601 in the treatment of erosive gastritis. Registered randomized clinical trial at ClinicalTrials.gov (NCT02282670)</P>

P164 : A clinical and statistical study of cutaneous premalignant lesions in Busan city and the eastern Gyeongnam province over 19 years

( Seung Hwan Choi ),( Seung Min Ha ),( Dong Yeob Ko ),( Ki Ho Kim ),( Ki Hoon Song ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: Premalignant lesions has recently continuously increased in Koreans. However, there has been little research into the distribution and incidence of cutaneous premalignant lesions in the south-eastern part of korea Objectives: To analyze recent trends in incidence and clinical patterns of cutaneous premalignant lesions in Busan city and the eastern Gyeongnam province Methods: We reviewed 1,292 cases (3,651 lesions) of cutaneous premalignant lesions that include actinic keratosis (AK) and bowen’s disease (BD) at the Department of Dermatology in Dong-A University Hospital Results: The average annual incidence of cutaneous premalignant lesions among total outpatients was 1.82% and has continuously increased from 0.70% to 4.25% over the last 19 years. The most common cutaneous premalignant lesionwas AK (75.85%), followed by BD (24.15%). The mean age of onset was 68.76 years. A major skin cancer was found in 15.79% of patients with cutaneous premalignant lesions, including SCC (11.54%), BCC (6.09%), and malignant melanoma (0.64%). Additionally, 59.13% of the patients had a single lesion, while 40.87% had multiple lesions. Age, occupation-related exposure to ultraviolet radiation, and a past history of skin cancer were higher in the patients with multiple lesions than single lesion Conclusion: The incidence of cutaneous premalignant lesions has gradually increased in Busan city and the eastern Gyeongnam Province, which was relatively higher than incidence in other areas

매복 과잉치 발거시의 전후방적 위치선정

최형준,손흥규,최병재,황동환 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.3

Surgical removal of impacted mesiodens can be performed easily when exact position of mesiodens is identified. This case report is argued about methodological approach of exact antero-posterior postioning of mesiodens using conventional cross-sectional occlusal film and periapical film. The author concludes, 1. Among various methods of positioning mesiodens, exact position of mesiodens can be determined with occlusal film and periapical film. 2. On operation, exact antero-posterior position of mesiodens can be determined with comparing occlusal images of adjacent teeth and anatomic structure to real ones. 3. It is important that exact removal course of mesiodens has to be determined in addition to exact determination of one's position, and that it has to be determined in regard to position, morphological basis, direction of impacted pattern of mesiodens and adjacent anatomic structure. 4. In 2 cases presented, both are mesiodens of inverted conical type, and impacted direction are class Ⅰ and Ⅲ respectively according to classification author suggested, and surgery can be performed with ease by different approach directions.

초기상담과 심리 검사

최동옥,김재환 漢陽大學校 學生生活硏究所 1990 大學生活硏究 Vol.8 No.-

AC8A-T6 알루미늄 合金材의 切削加工 特性에 關한 硏究

최현민,김경우,김우순,김용환,김동현,채왕석 한국공작기계학회 2002 한국공작기계학회 추계학술대회논문집 Vol.2002 No.-

In this study, examined the cutting characteristics of alumuminum alloy AC8A-T6 that is used to present car piston materials. And in been holding materials machining empirically escape as result that experiment comparison changing the cutting speed and feed on various condition to choose efficient machining condition. The following results can be summarized from this research. 1.As the cutting speed decreased, principal cutting force and thrust cutting force is increased, and reason that cutting force interacts greatly in the low cutting speed is thought by result by BUE's stabilization. 2.The feed speed and cutting speed increase, friction factor is decrescent and the cause appeared the thrust cutting force is fallen than cutting force relatively because chip flow according to increase of the feed rate is constraint. 3.Though specific cutting resistance grows cutting area and the feed rate are few, the cause was expose that shear angle decreases by rake face of tool gets into negative angle remarkably as wear of a cutting tool or defect part of workpiece is cut. 4.Cutting speed do greatly depth of cut is slow, surface roughness examined closely through an experiment that becomes bad, and know that it can get good surface that process cutting speed because do feed rate by 0.1㎜/rev low more than 250m/min to get good surface roughness can.

만삭 신생아의 기흉

최우경,홍찬의,이동진,허남진,이영환 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2

Background: This study was performed to evaluate the incidence and clinical characteristics of symptomatic pneumothorax in the full-term neonate. Materials and Methods: We retrospectively reviewed the medical records of 32 symptomatic pneumothorax patients in the full term neonates who admitted to the neonatal intensive care unit in Ulsan Dong Kang General Hospital from January, 2000 to December, 2004. The subjects were divided into two groups according to underlying causes; spontaneous pneumothorax group and secondary pneumothrax group, then each clinical characteristics were assessed. Result: Spontaneous pneumothorax patients were 10(31%) and secondary pneumothorax patients were 22(69%). Overall incidence of spontaneous pneumothorax was 0.4%. Most common cause of secondary pneumothorax was pneumonia. Twelve causes(54.5%) among secondary pneumothorax patients were associated with mechanical ventilator care. Clinical characteristics, courses and managements were similar between two groups, but more shorter duration of admission and chest-tube insertion in spontaneous pneumothorax group Conclusion: The patient with symptomatic pneumothorax needs careful observation and proper management with or without underlying respiratory diseases

다운 증후군 정신지체인의 시각적·언어적 자극에 대한 반응 시간

최승오,김동환 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

Previous research has indicated that individuals with Down Syndrome(DS) have difficulties processing auditory movement information relative to their peers with undifferentiated developmental disabilities. The present study was conduced to assess whether a model of atypical cerebral specialization could explain these findings. 13 adults with Down syndrome (8 men and 6 women), 14 adults with undifferentiated developmental disabilities (7 men and 7 women), and 14 adults without disabilities (8 men and 6 women) performed rapid aiming movements to targets under three conditions: a visual cue at the target location a visual cue remote from the target location or a verbal cue. Results revealed that, while the reaction times did not differ between the two groups with disabilities across conditions, the participants with DS, unlike their peers, had significantly longer movement times in the verbal than in two visual conditions. These results are consistent with the model of biological dissociation.

흰쥐의 파라쿼트 중독모델에서 폐손상에 대한 N-acetylcysteine과 Methylprednisolone의 효과

최태환,조건현,오동렬,김세경 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3

Background: This study evaluated the inhibitory effects of N-acetylcysteine(NAC) and methylprednisolone on lung injury in the paraquat-poisoned rat model. Methods: Sixty rats were divided into four groups(n=15 in each group) accordingly to the drug administered : group I, only intraperitoneally injected paraquat (20 mg/kg); group II, intraperitoneally injected paraquat and NAC(300 mg/kg); group III, intraperitoneally injected paraquat and methylprednisolone(60 mg/kg); and group IV, intraperitoneally injected paraquat, NAC(300 mg/kg), and methylprednisolone(60 mg/kg). On the 7th day after injection, the survival rate of experimental rats and the positive area of collagen fiber in the injured lung stained by Masson's trichroms were evaluated. Results: 1. There were no differences in the 7-day survival rates for the four groups. 2, The percent of collagen fiber for group II(6.3 ± 4.7%) was significantly decreased in comparison with that for group I (14.4±9.7%). 3. The percent of collagen fiber for Group III(13.2±5.9%) was not significantly different from that for group I(14.4±9.7%). 4. The percent of collagen fiber for Group IV(6.9±4.6%) was significantly decreased in comparison with that for group I, but was not different from that for group II. Conclusion: These results suggest that NAC protects against pulmonary fibrosis in paraquat-poisoned rats whereas methylprednisolone does not protect against pulmonary fibrosis.

한약수치에 관한 연구(제 9보) : 炒甘草 제법의 표준화 및 규격화(1) Preparing Standardization and Regulation of Stir-Frying Glycyrrhzia root(1)

최혁재,이우정,박성환,송보완,김동현,김남재 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

In this study, We carried out the preparing standardization and regulation of processed Glycyrrhizae Radix(PGR) which have been widely used in oriental medicines. Glycyrrhizae Radix(GR) have been generally prepared by the stir-frying, or mix-frying with honey for purpose of decreasing sweetness and augmenting vitality. Firstly, we tried to standardize PGR prepared by the stir-frying. We purchased 14 kinds of PGR and non-processed GR(NPGR) at oriental physician's offices and oriental pharmacies on a nation scale, respectively. The amounts of dry on loss, water extract, diluted ethanol extract, ether extract, total ash, acid insoluble ash, glycyrrhizin(GL), glycyrrhetic acid(GA) and liquiritin(LQ) of them were examined. The amounts of dray on loss, GL and LQ in commercial PGRs showed remarkable decrease, while GA showed increase as compared with NPGR. In order to standardize preparing method of PGR, the effect of heating time on physico-chemical parameters and biological activities were examined. Physico-chemical parameters such as dry on loss, extract amount, GL and LQ contents in PGRs showed decrease, however, GA was increased with heating time as compared with NPGR. Also, GA obtained form heat-treated GR, was found as an artifact in PGRs. PGR was more effective than NPGR in vitro test of DPPH scavenging effect and TBA-Rs reducing effect. PGR and NPGR showed potent hepatoprotective effect on CCl_(1)-intoxicated rats. Especially, PGR prepared by 80 min of heating was the most effective. Considering these results, the optimal condition for PGR preparation was 150℃ for 80min.

壓挫시킨 家兎 軟骨의 生存

최동원,송중원,한기환,강진성,정재홍 大韓成形外科學會 1990 Archives of Plastic Surgery Vol.17 No.2

The deviated nose regardless whether it is due to traumatic or congenital origin results in troublesome symptoms coming from airway obstruction. Numerous methods for straightening the severely deviated septum have been described by many authors but none is wholly satisfactory. A new method that the crooked septal cartilage is being flattened by crushing and reimplanting into the septal pocket is introduced. The authors are desirous of knowing about the fate of the crushed cartilage graft. Forty rabbits weighing 2 to 3 kg were divided into 2 groups, septal group and conchal group. The cartilages were obtained from the nasal septum and ear; these cartilages were placed under the paraspinal subcutaneous tissue. Prior to paraspinal iplantation the obtained cartilage was halved; one piece of cartilage being crushed by Cottle's cartilage crusher before its placement into the recipient site and the other was placed without crushing. The cartilage specimens were removed at 6 and 12 weeks postoperatively and these were examined by the naked eyes and light microscope. The results were as follows: 1. The fissures and cleavages of cartilage developed during crushing process are restored to normal by 6 weeks postoperatively. 2. All of the ujncrushed cartilages remained viable in the subcutaneous pockets. The crushed cartilages not only appeared viable but also induced a new cartilage formation beneath the perihondrium at 12 weeks postoperatively and the thickness being increased compaired to the cartilage before crushing. 3. Crushed cartilage remained flat at 12 weeks postoperatively. 4. The degree of strength of the crushed cartilage is increased due to new cartilage formation and fibrosis of perichondrium at 12 weeks postoperatively. These findings support the clinical impression that the crushed autogenous cartilage is viable and can be reshaped according to the contour of the recipient site.