Fluoxetine과 Haloperidol의 병합투여시 정신병리 및 추체외로 증상의 변화

이민수,한창수,김제원,원경식,곽동일,Lee, Min-Soo,Han, Chang-Su,Kim, Jae-Won,Won, Kyung-Sik,Kwak, Dong-Il 대한생물정신의학회 1997 생물정신의학 Vol.4 No.1

본 연구는 정신분열증 환자 38명을 대상으로 하여 haloperidol과 fluoxetine을 8주간 병합투여 하였고, PANSS, CGI, Simpson-Angus 척도를 투여전과 투여후 2, 4, 6, 8주에 시행하여 임상증상 및 추체외로 부작용을 평가하였다. 결과는 다음과 같다. 1) 8주간의 연구기간동안 양성, 음성증상의 유의한 변화가 없었다. 2) 8주의 연구기간동안 추체외로 부작용의 증가가 나타나지 않았다. 이는 기존 연구에서 fluoxetine에 의해 haloperidol의 혈중농도가 증가하여 효과 및 부작용이 증가한다는 연구보고와는 다르며, 이 결과는 haloperidol과 fluoxetine의 병합사용을 안전하게 할 수 있다는 것을 의미한다고 하겠다. Objectives : The authors have intended to know the drug interaction of fluoxetine and haloperidol when coadministering two drugs to the chronic schizophrenics by assessing the changes of positive, negative symptoms and extrapyramidal symptoms. Method : We selected 38 patients, the chronic schizophrenics with no physical problems. they are randomly assigned to placebo group and drug group. And then, placebo or fluoxetine 20mg were administered to the subjects of each group during 8 week period. We have assessed their psychopatholgy and extrapyramidal symptoms using Positive and Negative Syndrome Scale(PANSS), Clinical Global Impression(CGI), Simpson-Angus Scale at 0, 2, 4, 6, 8 week during the period. Results : 38 patients have completed the study during 8 weeks. 1) PANSS, CGI : no significant difference between groups and no significant change according to the times. 2) Simpson-Angus Scale : no significant changes. Conclusion : When co-administering fluoxetine and haloperidol, there were no significant changes of psychopathology and extrapyramidal symptoms. These results suggest that it is safe to coadminister fluoxetine to schizophrenic patients with haloperidol treatmemt.

워터드라이브 내부 유동 특성 파악을 위한 수치해석 연구

곽민희(Minhee Kwak),허남건(NahmKeon Hur),장춘수(Choon-Soo Chang),강남원(Nam-Won Kang) 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.2015 No.11

Water drive is one of the hydraulic coupling used for torque transmitting. This paper performs numerical analysis to investigate flow characteristics in water drive with different operating condition. Rotating speed of the primary wheel is fixed but that of the secondary wheel is changed. Also water volume fraction are changed. The realizable k-ε turbulence model and VOF method are used to simulate air-water two-phase flow inside the water drive. The simulation are conducted using the sliding grid. The results are presented in the form of flow patterns, torque values and circulation mass flow rate between the primary wheel and secondary wheel.

유산소 운동능력 향상을 위한 중량물 부가 신발의 기능성 평가

곽창수,김희석 한국운동역학회 2004 한국운동역학회지 Vol.14 No.3

C. S. KWAK, H. S. KIM. The Evaluation of an additional Weight Shoe's Function developed for the Improvement of Aerobic Capacity, Korean Journal of Sport Biomechanics, Vol. 14, No. 3, pp. 67-82, 2004. The purpose of this study was to evaluate the function and the safety of an additional weight shoe developed for the improvement of aerobic capacity, and to improve some problems found by subject's test for an additional weight shoe. The subjects employed for this study were 10 college students. 4 video cameras, AMTI force platform and Pedar insole pressure distribution measurement device were used to analyze foot motions. The results of the study were as follows: 1. The initial achilles tendon angle and initial rearfoot pronation angle of an additional weight shoe during walking were 183.7 deg and 2.33 deg, respectively, and smaller than a barefoot condition. Maximum achilles tendon angle and the angular displacement of achilles tendon angle were 185.35 deg and 4.21 deg, respectively, and smaller than barefoot condition. Thus rearfoot stability variables were within the permission value for safety. 2. Maximal anterior posterior ground reaction force of additional weight shoe was appeared to be 1.01-1.2 B.W., and was bigger than a barefoot condition. The time to MAPGRF of an additional weight shoe was longer than a barefoot condition. Maximal vertical ground reaction force of additional weight shoe was appeared to be 2.3-2.7 B.W., and was bigger than a barefoot condition in propulsive force region. But A barefoot condition was bigger in braking force region. The time to MVGRF of an additional weight shoe was longer than a barefoot condition. 3. Regional peak pressure was bigger in medial region than in lateral region in contrast to conventional running shoes. The instant of regional peak pressure was M1-M2-M7-M4-M6-M5 -M3, and differed form conventional running shoes. Regional Impulse was shown to be abnormal patterns. There were no evidences that an additional weight shoe would have function and safety problems through the analysis of rearfoot control and ground reaction force during walking. However, There appeared to have small problem in pressure distribution. It was considered that it would be possible to redesign the inner geometry. This study could not find out safety on human body and exercise effects because of short term research period. Therefore long term study on subject's test would be necessary in the future study.

삼풍 사고 생존자들의 정신과적 증상

이민수,한창수,곽동일,이준상 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.5

1995년 6월 29일 발생한 삼풍 백화점 붕괴사고의 생존자들을 정신과적으로 면담하여 이들의 정신적인 후유증의 여부와 증상의 빈도를 보고자 하였다. 1995년 11월에 안암병원에 내원한 삼풍사고 생존자 중, 정신과적 진찰을 받은 681명의 면담 자료를 대상으로 하여 기술통계 및 빈도분석을 실시하였다. 대상 환자들이 호소하는 증상 중 가장 흔한 증상은 수면장애로 전체환자의 54.2%가 호소하였다. 그 다음으로 두통(31.8%), 예민성(23.3%), 기억나는 상황에서의 심한 고통(24.2%)의 순으로 나타났다. 신체증상 중에는 두통, 흉부 불편감, 사지통, 요통, 소화기계 이상의 순으로 증상을 호소하였다. 위의 결과로 보아 내원 환자의 대부분이 정신과적 증상을 호소하고 있었다. 본 연구에서는 생존자들이 한국의 문화적, 사회적 배경에 따라 서구의 환자들과 다른 양상으로 신체 증상을 호소할 가능성을 고려하였으나, 결과는 서구의 연구결과와 큰 차이를 보이지 않았다. 향후 이 결과를 근거로 하여 외상후에 나타나는 증상들을 한국적 상황에 맞게 분별할 수 있는 자료를 제시할 수 있을 것이다. In order to evaluate psychiatric symptoms in survivors of the Sampoong accident, we interviewed 624 survivors of the accident. The most common complaint of the subjects was sleep disturbance(54.2%). And then, headache(31.8%), irritability and anger(23.3%), intense distress over reminders(24.2%) followed. Common somatic complaints were headache, chest discomfort, extremity pain, backache, and gastrointestinal discomfort. This study revealed that most of the subjects had various psychiatric symptoms after the Sampoong accident.

여자 500m 쇼트트랙 스피드 스케이팅의 스타트 기술분석

백진호,곽창수,정남주 한국운동역학회 2004 한국운동역학회지 Vol.14 No.3

J. H. BACK, C. S. KWAK, N. J. CHUNG. Analysis of the Female 500m Sprint Starting Motion in Short Track Speed Skating. Korean Journal of Sport Biomechanics, Vol. 14, No. 3, pp. 285-299, 2004. The purpose of this study is to identify female 500m sprint start motion by the center of gravity position in short track speed skating. The center of gravity position ratio was divided into three type(type A front : 80%-back : 20%, type B front : 70%-back : 30%, type C front: 50%-back : 50%). Three video cameras were used for 3D motion analysis with DLT method and the results were as follows: The elapsed time in starting motion was appeared that type B was the shortest and type A was the longest. It was appear that the stroke length of type A was longer than that type B and C during starting phase. This result was similar to displacement of center of gravity. It was appeared that skill type of center of gravity position ratio type B' ankle and knee joint angle were lower than that of type A and C. Observing these results it was conclusion that skill type B of center of gravity position ratio was more faster than that of type A and C. But it is important that these skill type needed to verifying more subjects.

緯度와 地形에 따른 溫帶中部 溪谷植生의 種多樣性 및 群集構造에 關한 硏究

尹相旭,辛壽哲,郭東勳,金昌浩 동국대학교 농림과학연구소 1994 農林科學 論文集 Vol.18 No.-

This study was Carried out to analyse species composition, species diversity and structure and variation trends of vegetation, of Mt. Odae, Mt. Sobaek, and Mt. Juwang following various latitudes and topographies which were in middle temperate zone in Korea. Obtained results are as follows : 1. As a result of the simple discriminant analysis, soil texture Showed the highest high percent contribution of each environmental factor to the discriminant of Studred area. And Mt. Odae showed high content of sand while Mt. Juwang Showed silt. 2. Mean stem density showed highest value in Mt. Juwang and mean D. B. H. was Mt. Odae, and on phisiographic locations showd high values of stem density and mean D. B. H in slow slope area, nothern aspect area, and high elevation area, in order. 3. Species that showed the highest importance value in each canopy-subtree-shrub layer in study area were Quercus mongolica-Acer pseudo-sieboldianum-Lindera obtusiloba were in Mt. Odae, Betula platyphylla var. japonica-Styrax obassia-Deutzia parviflora were in Mt. Sobaek, and Pinus densiflora-Acer pseudo-sieboldianum-Lindera obrusiloba were in Mt. Juwang. 4. Species that showed the highest importance value in each canopy-subtree-shrub layer on the physiographic location were Quercus mongolica-Acer pseudo-sieboldianum-Lindera obtusiloba in high elevation and southern aspect, Carpinus laxiflora-Acer pseudo-sieboldianum-Lindera obtusiloba in high elevation and southern aspect, Carpinus laxiflora-Acer pseudo-sieboldianum-Lindera obtusiloba in nothern slope, Carpinus laxiflora-Styrax obassia-Lindera obtusiloba in low elevation, and Betula platyphylla var. japonica-Styrax obassia-Deutzia parviflora in high elevation. 5. According to decrease of latitudes with going down from Mt. Odae to Mt. Juwang, the more Number of species and individuals were increased, and the deversity index was the highest value in Mt. Sobaek, the evenness was in southern aspect, and the dominance was in high elevation. 6. As a result of Cluster analysis, the study area were divided into 4 groups, Carpinus laxiflora community, Styurax obassia community, Deutzia parviflora community, and Quercus mongolica community. 7. As a result of COA analysis, communities of the study area were divided into Betula platyphylla var. japonica community, Deutzia parviflora community, Quercus mongolica-Acer pseudo-sieboldianum community, and species were divided into 4 groups as the major, the disturbed, the waterside, and the fertile. 8. As results of the simple discriminant analysis and the linear regression, sand and silt content, slope aspect, total nitrogen content, and elevation among environmental factors had high percent contribution to classification and ordination of vegetation communities of the study area. 9. Major tree species had the unstable layer structure due to lower importance values of canopies and subtrees than those of shrubs, and Pinus laxiflora and Betula platyphylla var. japonica were on the decline phase due to very low dominance and absence of next generation. while, Styrax obassia and Acer pseudo-sieboldianum were sustanable layer structure as being distributed on all the crown layer.

원발성 유방암에서 Sodium Iodide Symporter의 발현과 ^(99m)Tc-MIBI 유방스캔의 관계

석주원,김성장,곽희숙,이창훈,김인주,김용기,배영태,김동수 대한핵의학회 2002 핵의학 분자영상 Vol.36 No.6

목적: hNIS는 갑상선 조직 외에 다른 조직들에서도 발현된다고 알려져 있다. 유방암 세포는 그런 조직들 중에 하나이며, 그에 의한 유방암의 방사성옥소치료의 가능성이 제시되고 있다. 본 연구에서는 유방암 조직에서 hNIS의 발현정도를 알아보고, ^99mTc-MIBI 유방스캔과 hNIS의 발현 정도와의 관계를 조사하여 보았다. 대상 및 방법: 본 연구에서는 유방암으로 수술을 시행했던 56명의 환자를 대상으로 하였다. hNIS의 발현은 면역조직화학염색에 의해서 평가되었으며, 그 결과를 ^99mTc-MIBI 유방스캔의 판정 결과와 비교하였다. 결과: 전체 56명의 환자에서 hNIS의 발현율은 41.1%였다. 병리학적 진단에 의해 침윤성관상피암종이었던 49명에서의 발현율은 42.9%, 관상피내암종이었던 7명에서의 발현율은 28.6%였다. ^99mTc-MIBI 유방스캔에서 국소섭취 소견이 관찰되었던 41명에서의 hNIS의 발현율은 31.7%였다. 비정상적인 섭취 소견이 관찰되지 않았던 15명의 환자에서의 hNIS의 발현율이 의미있게 높게 관찰되었다(66.7%, p>0.05). 결론: 유방암 환자에서의 hNIS의 발현율은 그다지 높지 않았다. ^99mTc-MIBI 유방스캔에서 섭취증가 소견이 없을 때 hNIS의 발현율이 더 높았다. Purpose: Human Na^+/I- symporter (hNIS) is known to be expressed in many tissues other than thyroid gland. The breast cancer cells are one of them and the possibility of radioiodine therapy in treatment of the breast cancer may be suggested. We investigated the expression rate of hNIS and the relationship between the expression of hNIS and the finding of 99mTc-MIBI scintimammography in the breast cancer. Materials and Methods: Surgically proved 56 patients with breast cancer were the subjects of this study. The expression of hNIS were evaluated by immunohistochemistry and the results were compared to the findings of 99mTc-MIBI scintimammography. Results: Overall expression rate of hNIS was 41.1% in 56 patients. According to the pathologic diagnosis, it was 42.9% in 49 patients with invasive ductal carcinoma and 28.6% in the 7 patients with ductal carcinoma in situ. The expression rate of hNIS in the 41 cases with a focal increased uptake at he breast lesion on 99mTc-MIBI scintimammogram was 31.7%. That in the 15 cases without any abnormal uptake on the scan was significantly higher(66.7%, p<0.05). Conclusion: The expression rate of hNIS in the patients with breast cancer was not so high. The rate was higher in the patients with no increased uptake at the breast lesion on 99mTc-MIBI scintimammography. (Korean J Nucl Med 2002;36;325-32)

Comparison of postoperative changes in the distal and proximal segments between conventional and sliding mini-plate fixation following mandibular setback

Seong-Sik Kim,Kyoung-Ho Kwak,Ching-Chang Ko,Soo-Byung Park,Woo-Sung Son,Yong-Il Kim 대한치과교정학회 2016 대한치과교정학회지 Vol.46 No.6

Objective: The purpose of the present study was to evaluate the postoperative three-dimensional (3D) changes in the proximal segments after mandibular setback sagittal split ramus osteotomy and to compare the changes between the conventional mini-plate fixation and semi-rigid sliding plate fixation. Methods: Cone-beam computed tomography (CBCT) images were used to evaluate the postoperative 3D changes in the proximal segments during the healing process. CBCT images were superimposed using the symphysis and the lower anterior mandible as references. Results: There were no statistically significant differences between the conventional mini-plate and semi-rigid sliding plate groups (p > 0.05). With respect to the distribution of changes greater than 2 mm in the landmarks, the right condylion, right coronoid process, and left condylion showed ratios of 55.6%, 50.0%, and 44.4%, respectively, in the semirigid sliding plate group; however, none of the landmarks showed ratios greater than 30% in the conventional mini-plate group. Conclusions: There were no statistically significant differences in postoperative changes in the segments between the conventional mini-plate and semi-rigid sliding plate groups. Nevertheless, while selecting the type of fixation technique, clinicians should consider that landmarks with greater than 2 mm changes were higher in the semi-rigid sliding plate group than in the conventional mini-plate group.

색상 검출방식의 천이 액정법에서 색상 변화 시간 산정의 정확도 향상

신소민(Somin Shin),전창수(Chang Soo Jeon),곽재수(Jae Su Kwak),정용운(Yong Wun Jung) 대한기계학회 2007 大韓機械學會論文集B Vol.31 No.11

In this paper, different criteria for determining hue change time in the hue detection based transient liquid crystals technique were compared. Results showed that methods utilizing threshold of intensity or saturation gave many missing points and quality of the calculated results were strongly depends on the value of threshold. Wider bandwidth in the hue bandwidth method showed better distribution of calculated hue change time, but induced ambiguity in the hue change time. In the time-hue curve fitting method, the distribution of evaluated hue change time was smooth and reasonable, and, by the nature of curve fitting, the noise effect on the hue was successfully considered in calculating of the hue change time. Compared to other methods, it is expected that the time-hue curve fitting method would provide better and accurate hue change time in the hue detection based transient liquid crystals technique.

유기금속화학기상증착법에 의해 증착된 구리 핵의 기판과 전처리의 의존성

Kwak, Sung-Kwan,Lee, Myoung-Jae,Kim, Dong-Sik,Kang, Chang-Soo,Chung, Kwan-Soo The Institute of Electronics and Information Engin 2002 電子工學會論文誌 IE (Industry electronics) Vol.39 No.1

Si, SiO/sup 2/, TiN, W/sup 2/N 기판 위에 (hfac)Cu(VTMS) 유기금속 전구체로 증착된 구리 핵을 조사하였다. 증착온도가 증가함에 따라, 기판 종류에 상관없이 180。C에서 구리 핵이 클러스터링으로 성장하는 메커니즘을 관찰하였다. 또한, HF용액으로 세척한 TiN 과 SiO/sup 2/가 공존하는 기판에서 구리 핵의 선택성이 향상됨을 관찰하였다. TiN을 H/sup 2/O/sup 2/로 세척한 후 Dimethyldichlorosilane 처리했을 때 표면이 passivation됨을 확인하였다. The nucleation of copper(Cu) with (hfac)iu(VTMS) oganometallic precursor is investigated for Si, $Sio_2$, TiN, $W_2N$ substrates. As the deposition temperature is increased, the dominant growth mechanism is observed to change from the nucleation of Cu particles to the clustering of Cu nuclei around $180^{\ciec}C$, independent of the employed substrates. It is also observed that the cleaning of substrate surfaces with the diluted HF solution improves the selectivity of Cu nucleation between TiN and $Sio_2$ substrates. Dimethyldichlorosilane treatment is found to passivate the surface of TiN substrate, contrary to the generally accepted belief, when the TiN substrate is cleaned by $H_2O_2$ solution before the treatment.