변색 실활치에 대한 carbamide peroxide gel의 표백효과

박선아,김선호,황윤찬,오병주,윤창,박영준,정선와,황인남,오원만 大韓齒科保存學會 2002 Restorative Dentistry & Endodontics Vol.27 No.4

The bleaching of discolored nonvital teeth is conservative treatement that satisfy the cosmetic desire. The most common method for this treatement, walking bleaching, is using 30% hydrogen peroxide and sodium perborate. Many alternatives are suggested for preventing the external cervical root resorption that is the common complication of the nonvital teeth bleaching with 30% hydrogen peroxide. The same extent of oxidation reactions as that resulted by the bleaching with the application of 30% hydrogen peroxide and sodium perborate can also be acquired more safely by materials that contain 10% carbamide peroxide, used primarily for the bleaching of vital teeth. Therefore, this study was performed to evaluate the efficacy of 10% and 15% carbamide peroxide bleaching gel in nonvatal teeth bleaching. The internal bleaching of intentionally discolored teeth was performed in vitro with 10% carbamide peroxide (Group 1), 15% carbamide peroxide (Group 2), mixture of distilled water and sodium perborate (Group 3), and mixture of 30% hydrogen peroxide and sodium perborate (Group 4). The bleaching materials were refreshed following 3, 6, 9 and 12 days. To evaluate the bleaching effect, the color change of the crowns was measured at 1, 2, 3, 4, 7 and 15 days of bleaching using the colorimeter. The results were as follows : 1. L^* and ΔE^* values were increased with time in all bleaching agents(p<0.01). 2. There was no significant difference in L^* and ΔE^* value among bleaching agents. 3. Δ^* value higher than 3 was shown after 3 days of bleaching with 10% carbamide peroxide gel, 1 day with 15% carbamide peroxide gel, 4 days with mixture sodium perborate and distilled water and 4 days with mixture sodium perborate and 30% hydrogen peroxide, respectively. These results revealed that the use of 10% and 15% carbamide peroxide bleaching gel in non-vital teeth bleaching is as effective as mixture of distilled water and sodium perborate and mixture of 30% hydrogen peroxide and sodium perborate. Accordingly, carbamide peroxide could be used clinically to bleach discolored non-vital teeth.

악성 점막하 종양과의 구별이 어려웠던 Gastritis Cystica Profunda 1예

선제형,박진석,한민석,김수항,김우진,박인형,이숭,유종선,박찬국 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Gastritis cystica profunda (GCP) is a rare disease characterized by gastric foveolae elongation along with hyperplasia and cystic dilatation of the gastric glands extending into the tissue beneath the submucosa. GCP mainly develops at the gastroenterostomy stoma but can arise in a stomach that has not undergone surgery. The proposed pathogenesis is related to chronic inflammation, ischemia and the presence of a foreign body. GCP may present as a submucosal tumor, Polyp or a giant gastric mucosal fold. Endoscopic ultrasonography (EUS) is an effective diagnostic method for differentiating GCP from protruding and elevated gastric lesions. We report a case of GCP along with the endoscopic and EUS findings that were indistinguishable from a malignant submucosal tumor.

TQM과 파트너링을 활용한 개념적 건설품질관리모델

박찬식,장선호 중앙대학교 생산공학연구소 1997 생산공학연구소 논문집 Vol.6 No.2

국내 건설업의 품질관리는 현장 중심의 관리와 전통적인 설계시공 분리계약으로 인해 적절히 수행되지 못해왔다. 효율적인 품질관리를 위해서는 프로젝트의 모든 단계에 걸쳐 발주자의 요구사항을 만족시키기 위한 새로운 개념의 품질관리 시스템이 적용되어야만 한다. 이를 위하여 첫째, 시공전 단계에서 적절한 조달유형의 선택과 품질관리위원회의 조직이 필요하고, 둘째, 시공 단계에서 TQM과 파트너링(partnering)에 근거한 품질관리가 이루어져야 하고, 마지막으로 시공후 단계에서는 품질관리위원회를 유지시키고 미래의 프로젝트를 위한 피드백 체계가 형성되어야 한다. 이와 함께 참여주체간의 커뮤니케이션의 확보, 지속적인 훈련과 교육, 강한 리더쉽 등이 요구된다. The quality management of the Korean construction industry has not been performed properly, since the industry has preferred the site driven quality management approach due to the traditional contracting system-design/bid/build. In order to enhance the industry's quality level, new concept of quality management should be applied to all project phases to meet the owners desire and requirements. The paper suggests the following: ⅰ) to choose right contract method and forming quality committee in the pre-construction stage; ⅱ) to utilize and relate the partnering and TQM concepts to site QA/QC system in the construction phase, ⅲ) to keep organizing the quality committee for future projects. More on that, this paper proposes the flexible communication relation within organization, continuous training and education, and strong leadership.

폐외소세포암

선길홍,윤찬영,정춘해,박치영 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Background: Small cell carcinomas (SCC) are most commonly seen in the lung, approximately 2.5-4% of all SCC occur in extrapulmonary sites. This study aimed to review the clinical features, therapy and natural course of patients with extrapulmonary small cell carcinoma (EPSCC) in single-institution series. Methods: We retrospectively reviewed the medical records of patients with SCC between December 2002 and November 2005. Study eligibility required that patients had pathologically proven SCC in sites other than lung with normal radiological findings of the chest and normal sputum cytology or negative bronchoscopic findings. Result: Eight patients with EPSCC were identified and their primary sites were various such as esophagus (4 cases), kidney (1 case), thymus (1 case), stomach (1 case) and unknown primary supraclavicular lymph node (1 case). The 4 patients were classified as limited disease (LD) and 2 patients were as extended disease (ED) at initial staging work-up. But 2 patients were undetermined. The 3 patients with EPSCC of LD were treated with operation and adjuvant chemotherapy or chemotherapy and radiotherapy and one received only supportive care. They showed favorable clinical courses with a median overall survival of 23 months. EPSCC of ED and undetermined group received only supportive care. They had aggressive clinical courses with a median overall survival of 3 months, Conclusions: EPSCC was identified in various sites with the most common primary site being the esophagus, It was predominantly occurred in old male patients and associated with smoking like as SCC of the lung. Since EPSCC is a relalively rare disease that mimics SCC of the lung in its response to treatment and survival pattern, it would appear advisable to follow similar treatment guidelines. Although recurrence within short terms was observed, a significant survival benefit was obtained in EPSCC of LD received treatment (chemotherapy, operation and radiation therapy). Thus, EPSCC is usually a fatal disease with meidan overall survival of 18 months. 연구배경: 소세포암의 가장 흔한 발생부위는 폐이며, 폐외소세포암은 전체 소세포암의 2.5~4%를 차지하는 매우 드문질환이다. 본 연구의 목적은 단일 기관에서 진단된 폐외소세포암의 임상적 특징, 치료와 자연경과를 보고하고자 하였다. 방법: 조선대학교부속병원에서 2002년 12월 부터 2005년 11월 사이에 소세포암으로 진단된 66명의 의무기록을 검토하였다. 폐외소세포암은 흉부 단순 몇 전산화단층 촬영, 객담세포 검사, 기관지경 검사에서 폐병번이 없으면서 폐와 병변의 조직학적 생검에서 소세포암으로 증명된 경우로 하였으며, 총 8명이였다. 결과: 본 연구에서 식도가 전체 폐외소세포 암 환자의 50%(4례)로 가장 많은 원발병소를 보였으며 그 외 흉선, 신장, 위가 1례씩 있었으며 쇄곧상부 림프절에서 소세포암이 발견되었으나 원발 병소를 발견 못한 경우가 1례 관찰되었다. 4명의 환자는 제한 병기를 보였으며 2명은 광범위 병기를 보였지만 나머지 2명은 위내시경으로 식도에서 소세포암이 조직학적으로 진단되었으나 보전적 치료만을 받길 원하여 병기결정을 위한 검사는 시행할 수 없었다. 제한 병기의 폐외소세포암 환자는 4명이었다. 2명은 수술적 절제후 보조항암화학요법을 받았으며, 1명은 항암화학요법후 방사션치료를 받았고, 나머지 한명은 보전적 치료만 시행하였다. 제한 병기의 폐외소세포암 환자틀은 양호한 임상 경과를 보였으며 중앙 생존기간은 23개월이었다. 하지만 광범위 병기의 폐외소세포암 환자와 병기를 분류할 수 없던 환자에 대해서는 항암화학요법 등의 적극적 치료는 시행하지 않고 보존적 치료만 시행하였다. 그들의 임상경과는 빠르게 악화되었으며 중앙 생존 기간은 3개월이었다. 결론: 본 연구에서 폐외소세포암은 다양한 장기에서 발견될 수 있으나 가장 흔한 곳은 식도였다. 소세포폐암과 유사하게 고령, 남성 및 흡연과 관련을 보였었다. 제한 병기에서 국소 치료, 항암화학요법은 생존기간의 연장을 보였으나 쉽게 다른 장기로 전이가 되거나 재발하는 매우 치명적인 질환임을 확인할 수 있었다. 전체 중앙 생존기간은 18개월 이었고 항암 화학요법등의 치료를 받은 군이 보존적 치료를 받은 군에 비해 의미있는 생존기간 (p=0.040)의 연장을 보였다. 본 연구는 단일기관의 상대적으로 적은 수의 소규모 연구이지만 폐외소세포암의 제한 병기에서 국소치료 및 항암화학요법은 생존기간의 연장을 보였고 쉽게 다른 장기로 전이가 되거나 재발하는 매우 치명적인 질환임을 확인 할 수 있었다.

복합레진의 조건등색에 관한 연구

박기정,황윤찬,김선호,오원만,황인남 大韓齒科保存學會 2003 Restorative Dentistry & Endodontics Vol.28 No.5

This study was done to present a criterion in selection of the most proper light sources and materials by measuring metamerism index(MI) of the light curing composite resins with spectrocolorimeter. Metamerism is defined when two objects appear to be the same color in one illuminant but different in another. This is due to the fact that they have different spectral curves that fail to match under the second illuminant. In this study, A1 & A3 shade of five light curing composite resins (Esthet-X, Filteck Z250, Filteck A110. Charisma. Vitalescence) were chosen based on Vita shade. Five samples were made for shade of each product with Teflon mold (diameter: 15mm, thickness: 2mm). Metamerism index of each samples on a Barium sulfate plate(L^(*)=96.54, a^(*)=0.19, b^(*)=0.01) prepared for sample fixation were measured with spectrocolorimeter(Miniscan XE plus. Model 4000s. Hunter Lab. USA) by applying standard light source D_(65), C. Fcw, TL84 and A. Standardization was done with reference standard(X=80.8, Y=85.7, Z=90.8) and light trap. The results were as follows. 1. Different resins with same Vita shade showed recognizable color difference (ΔE^(*)>2). 2. All composites had MI below accepted value 0.5 between standard illuminant(D_(65), C, & A) and below 1.5 under fluorescent condition (Fcw & TL84). 3. MI value between D_(65) and A showed higher value than MI value between other source of light(p<0.01). 4. All resins except Z250 showed MI value that A3 is higher than A1 between D_(65) and A(p<0.05).

복합 병렬 전단벽 접합부의 전단강도

박완신,한병찬,황선경,윤현도,이재연,이원호 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

An theoretical study of the strength of hybrid coupled shear wall connections is achieved. The bearing stress at failure in the concrete below the steel coupling beam section is related to the concrete compressive strength and the ratio of the width of the steel coupling beam section to the width of the hybrid coupled shear wall. Also experimental studies are achieved to revise shear transfer strength across connections between coupled shear walls and steel coupling beam. The main test variables were auxiliary details of stud bolts. In this studies. these proposed equations are shown to be in good agreement with the test results reported in the paper and with other test data in the literature.

The Efficacy and Safety of 4-n-butylresorcinol 0.1% Cream for the Treatment of Melasma: A Randomized Controlled Split-face Trial

( Sun Young Huh ),( Jung Won Shin ),( Jung Im Na ),( Chang Hun Huh ),( Sang Woong Youn ),( Kyoung Chan Park ) 대한피부과학회 2010 Annals of Dermatology Vol.22 No.1

Background: Melasma is a common acquired symmetrical hypermelanosis that occurs on sun-exposed areas, and it is frequently observed among women. Various treatment modalities have been tried, but none are completely satisfactory. 4-n-butylresorcinol, which is a resorcinol derivative that has an inhibitory effect on both tyrosinase and tyrosinase-related protein-1, was introduced in 1995 and it has received increasing attention as a new hypopigmenting agent. However, the hypopigmenting effect of 4-n-butylresorcinol in human subjects has only been shown in a few studies. Objective: The aim of this study was to investigate the hypopigmenting efficacy and safety of 4-n-butylresorcinol 0.1% cream for the treatment of melasma. Methods: Twenty patients with melasma were enrolled to this randomized, double-blind, vehicle-controlled, split-face comparative study. The patients were instructed to apply 4-n-butylresorcinol 0.1% cream or vehicle to each side of the face twice daily for 8 weeks. Mexameter measurements were performed along with photography at baseline, 4 weeks and 8 weeks. Adverse events were observed and recorded throughout the study. Results: All the patients completed the study. Mexameter measurements demonstrated that the melanin index of the treated side showed a significant decrease when compared with that of the vehicle-treated side after 4 weeks (p=0.006) and after 8 weeks (p<0.0005). All the adverse reactions were mild and transient. Conclusion: 4-n-butylresorcinol 0.1% cream showed rapid efficacy and it was well tolerated when used for the treatment of melasma. (Ann Dermatol 22(1) 21∼25, 2010)

공공부문 정보화사업의 소프트웨어 개발비용 예측에 관한 연구

박찬규,구자환,김성희,신수정,송병선 한국경영과학회 2002 經營 科學 Vol.19 No.2

As the portion of information systems (IS) budget to the total government budget becomes greater, the cost estimation of IS development and maintenance projects is recognized as one of the most important problems to be resolved for scientific and efficient management of IS budget. Since IS budget makes much effect on the delivery time, quality and productivity of IS projects, the exact cost estimation is also necessary for the successful accomplishment of IS projects. The primary concern in the cost estimation of IS projects is software cost estimation, which requires the measurement of the size of softwares. There are two methods for sizing software : line-of-code approach, function point model. In this paper, we propose a function-point-based model for estimating software cost. The proposed model is derived by collecting about fifty domestic IT projects in public sector and analyzing their relationship between cost drivers and development effort. Since the proposed model is developed by simplifying the function point model that can be used only when detailed user requirements are specified, it can be also applied at project planning and budgeting phase.

Inhibitory Effect of Clavicepitaceae on Serotonin Release out of Human Platelets and Human Platelet Aggregation

박화진,--,--,--,--,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2004 Journal of biomedical laboratory sciences Vol.10 No.1

We have investigated the effects of hypha-water extracts (HWE), fruit body-water extracts (FWE) and cordycepin from Cordyceps militaris on serotonin release out of human platelets and human platelet aggregation. HWE and FWE inhibited the release of [^(3)H]-serotonin from human platelet stimulated by thrombin (2 U/ml) or collagen (20 ㎍/ml) in a dose-dependent manner. Furthermore, cordycepin, a major component of Cordyceps militaris, inhibited the human platelet aggregation induced by collagen (10 ㎍/ml) in a dose-dependent manner. These results suggest that cordycepin containing in HWE and FWE may inhibit the serotonin release by suppressing the collagen-induced human platelet aggregation. Accordingly, our data demonstrate that HWE and FWE containing much cordycepin might have antithrombotic and antimigrainous functions.

개 원발성 면역매개성 혈소판 감소증 증례

유찬,임수정,이선희,박형진,김태신,송은식,김덕환,송근호 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2009 動物醫科學硏究誌 Vol.16 No.1

A 13-year-old, castrated male, Maltese-dog was admitted to the Veterinary Medical Teaching Hospital of Chungnam National University with the history fo petechiae. On physical examination, she had petechiae and ecchymoses at her back, bilateral inguinal region, and inner part of ear pinna. CBC indicated neutrophilia and severe thrombocytopenia. A few platelets, no autoagglutination of RBC, and no spherocyte were observed. Coagulation profile demonstrated normal PT, and aPTT. No significant findings was not found on serum biochemical profile and electolytes test. FNA of a splenic mass which was found on the abdominal radiograph and sonograph demonstrated extramedullary hematopoiesis, Proteinuria was observed on urinarysis. Primary immune-mediated thrombocytopenia was diagnosed by ruling out of other underlying disease, severe thrombocytopenia, and response to immunosuppressive therapy. Prednisone and antibiotics were administered orally and parenterally, respectively. After altering prednisone to azathioprine, the number of platelets was recovered to normal range and petechiae and ecchymoses were improved.