『동의보감(東醫寶鑑)』에 수록된 파킨슨병 치료 처방(處方) 후보군 선별 연구

황민섭,박혜진,김시원,백진웅,Hwang, Min-Seob,Park, Hye-Jin,Kim, Si-Won,Baek, Jin-Ung 대한한의학방제학회 2018 大韓韓醫學方劑學會誌 Vol.26 No.1

Objectives : This study aims to sort out prescription candidates for four major symptoms of Parkinson's disease from Korean traditional medical publication, "Dongeuibogam". Methods : Medical terms related to four major symptoms of Parkinson's disease were primarily selected from "Dongeuibogam". Prescriptions that include at least one or more medical terms which are selected above were classified by the four major symptoms of Parkinson's disease, and finally analyzed to sort the most effective candidates. Results & Conclusions : 1. There are 18 medical terms in efficacy ($ch{\grave{i}}$ $z{\grave{o}}ng$, $j{\bar{u}}$ $lu{\acute{a}}n$, $j{\bar{i}}ng$${\check{u}}$ $ju{\check{a}}n$($ju{\check{a}}n$, $qu{\acute{a}}n$) $lu{\acute{a}}n$, $j{\bar{i}}ng$${\check{u}}$ $lu{\acute{a}}n$($lu{\acute{a}}n$) $t{\grave{o}}ng$, $j{\bar{i}}n$ $lu{\acute{a}}n$, $j{\bar{i}}n$ $t{\grave{i}}$, $sh{\check{o}}u$ $zh{\grave{e}}n$, $y{\acute{a}}ng$ $sh{\check{o}}u$, $lu{\acute{a}}n$ $j{\acute{i}}$, $lu{\acute{a}}n$ $b{\grave{i}}$, $r{\grave{o}}u$ $r{\acute{u}}n$, $zh{\grave{a}}n$ $di{\grave{a}}o$, $zh{\grave{a}}n$ $y{\acute{a}}o$, $zh{\grave{i}}$ $z{\acute{u}}$, $ch{\grave{e}}$ $t{\grave{o}}ng$, $ch{\bar{o}u}$ $ch{\grave{e}}$, $f{\bar{e}}ng$ $ch{\grave{u}}$, $ch{\grave{u}}$ $nu{\grave{o}}$) related to tremor, one of four major symptoms of Parkinson's disease. 2. There are 9 medical terms in efficacy ($qi{\acute{a}}ng$ $j{\acute{i}}$, $qi{\acute{a}}ng$ $zh{\acute{i}}$, $qi{\acute{a}}ng$ $t{\grave{o}}ng$, $j{\bar{u}}$ $j{\acute{i}}$, $j{\bar{i}}n$ $j{\acute{i}}$, $sh{\bar{e}}n$ $qi{\acute{a}}ng$, $lu{\acute{a}}n$ $j{\acute{i}}$, $y{\bar{a}}o$ $j{\acute{i}}$ $qi{\acute{a}}ng$, $xi{\grave{a}}ng$ $qi{\acute{a}}ng$) related to rigidity, one of four major symptoms of Parkinson's disease. 3. 38 prescription candidates (jiaweishouxingyuan, jiaweilonghusan, gehuajiexingtang, qiangfutang, qianghuoxuduantang, dawugongsan, duhuojishengtang, mahuangzuojingtang, fangfengbaizhumulitang, fangfengtongshengsan, baizhutang, buxinwan, fulingtang, binsusan, xieqingwan, sanbitang, shengdiqinliantang, shujinbaoansan, xingxiangsan, xiaotanfulingwan, shengjunwan, shenmizuojingtang, wuyaoshunqisan, yuzhenwan, wenjingyiyuantang, yiziqingjinsan, ziyinningshentang, shaoyaogancaotang, dingtongsan, zhushazhijiasan, cangzusan, chuanxiongfulingtang, tiedanyuan, choubaowan, duomingsan, xuanhusuosan, xuefengtang, huoluodan) were selected for tremor, one of the four major symptoms of Parkinson's disease. 4. 21 prescription candidates (qianghuoshengshitang, guizhiqianghuotang, guizhifuzitang, jiuweiqianghuotang(qianghuochonghetang), xiongzhixiangsusan, daqianghuotang, mahuangguizhitang, muguajian, fuzilizhongtang, shenzhusan, lianqiaobaidusan, yuzhensan, niuhuangjinhudan, renshenbaidusan, shaoyaogancaotang, jiuzhumuguazhou, cangzusan, shenxiangtianmatang, xiangjiaosan, xuefengtang, huishousan) were selected for rigidity, one of the four major symptoms of Parkinson's disease. 5. The results in this study ought to be verified by subsequent studies and clinical trials.

경근이론(頸筋理論)에 대한 연구(硏究)

황민섭,윤종화,Hwang, Min-sub,Yoon, Jong-hwa 대한침구의학회 2005 대한침구의학회지 Vol.22 No.1

Objective : This study was performed to understand about the concept of Meridian muscle which is the method explaining the muscular system in the Oriental Medicine. Methods : To reveal the concept and the course of formation of Meridian muscle, we have compared the route and symptoms of meridian muscle with the Meridian route and Symptoms of <<Zubi shi yi mai jiu jing(足臂十一脈灸經)>>, <<Yin yang shi yl mai jiu jing(陰陽十一脈灸經)>> and <<Jing Mai(經脈)>>. Results & Conclusion : 1. The concept of "Keun(筋)" reported in the <<Huangdi-Naijing(黃帝內經)>> include muscle, tendon, superficial vein and nerve. and in the <<Kyung keun(經筋)>>, it means muscle and tendon. 2. The route of the Meridian muscle is facing toward the heart or head from the limbs, and the symptoms is mostly muscle spasm or pain according to the route, therefore the symptoms of the Meridian muscle are similar to the meridian symptoms of <<Zu hi shi yi mai jiu jing(足臂十一脈灸經)>>. 3. The twelve-Meridian muscle had been made by classifying the whole muscle into twelve sections with making reference to the Meridian system.

도시화가 1인당 탄소 배출에 미치는 영향

황민섭 ( Minsup Hwang ),이응균 ( Eungkyoon Lee ) 한국환경영향평가학회 2016 환경영향평가 Vol.25 No.5

본 연구는 도시화가 1인당 탄소 배출에 미치는 영향을 도시화와 소득 수준 간의 교호 작용을 중심으로 분석하였다. 이를 위해 84개 국가에 대한 패널 자료를 고정효과 모형을 통해 회귀분석하고 동시에 Pooled LS 모형 및 패널 GLS 모형과도 비교하였다. 그 결과 1인당 탄소배출과 도시화는 비선형적 관계를 이루는 것으로 나타났다. 즉 저소득 국가에서 도시로의 인구 집중이 1인당 탄소 배출을 증가시키는 반면, 고소득 국가에서는 오히려 반대의 효과가 나타났다. 이러한 본 연구의 결과는 도시의 압축성(compactness)과 에너지 소비 패턴에 대한 논의로 확장할 수 있으며, 이를 통해 지속가능한 도시개발을 위한 연구와 정책개발의 토대를 제공할 수 있다. This research examines the impacts of urban population growth on per capita CO₂ emissions with particular focus on the interaction effect between urbanization and income levels. Employing the Panel Fixed Effects model together with the Pooled LS and Panel GLS models, the research reported here analyzes the relevant data on 84 countries. The statistical results show a nonlinear( an inverted-U) relationship between urbanization and per capita CO₂ emissions; that is, while the urban agglomeration leads to increases in per capita CO₂ emissions for low income countries, this adverse impact does not hold true for high income countries. The research findings can contribute to addressing broad issues of urban compactness and patterns of energy consumption that should be considered by those concerned about the sustainable urban development.

황금 추출물의 신경병증성 통증 유발 흰쥐에 미치는 영향

황민섭(Min Sub Hwang),강석용(Seok Yong Kang),강안나(An Na Kang),김수진(Su Jin Kim),정효원(Hyo Won Jung),박용기(Yong Ki Park) 한의병리학회 2018 동의생리병리학회지 Vol.32 No.1

연안습지관리의 경제적 파급효과: 순천만습지 사례분석

황민섭(Hwang, Minsup),이명균(Lee, Myung Kyoon) 한국지역개발학회 2017 韓國地域開發學會誌 Vol.29 No.1

Suncheon Bay Wetland is a good example of a successful implementation of a sustainable development policy. This study adopts an inter-regional input-output analysis to see the economic impacts of restoration and conservation of Suncheon Bay Wetland and suggests a sustainable way of coastal wetland management. The survey from the visitors of Suncheon Bay Wetland in 2015 shows KRW 85,019 of per capita expenditure. The highest share of visitors’ expenditure goes to meals and 47.5% of total expenditure is disbursed in Suncheon. Using the inducement coefficients of tourism in Jeonnam Province, total KRW 203.4 billion of a production inducement effect is generated and 4,494 of jobs are generated within the region. Policy implications are suggested as follows: in order to enhance economic impacts of eco-tourism, the increase in visitor’s expenditure is a better way than the increase in the number of visitors; in order to increase efficiency of investment in eco-tourism, recommended is investment in the sectors with a high share of visitor’s expenditure and high inducement coefficients which are restaurants and hotels.

포부자추출물의 갑상선기능저하증 흰쥐모델에서의 한열조절작용에 의한 개선효능 연구

황민섭 ( Min Sub Hwang ),황지혜 ( Ji Hye Hwang ),강석용 ( Seok Yong Kang ),강안나 ( An Na Kang ),노효선 ( Hyo Sun Roh ),박용기 ( Yong-ki Park ) 대한본초학회 2016 大韓本草學會誌 Vol.31 No.6

Objective : To suggest a scientific evidence of Aconitum carmichaeli Debx. (Aconiti Lateralis Radix Preparata: ALRP) as one of cooling and heating medicines on the regulation of body temperature, we investigated the effects of ALRP water extract on hypothyroidism. Methods : Hypothyroidism was induced by intradermal injection with PTU for 4 weeks in SD rats. ALRP extract or L-thyroxine as a control drug was orally administrated for 2 weeks with PTU injection in rats. The physiological and serological parameters were measured in rats. The histological change of thyroid tissues was observed by H&E staining, and also the expression of thermo-regulating proteins was determined by Western blot in dorsal root ganglia and brain tissues of rats. Results : The administration of ALRP extract in PTU-induced hypothyroidism rats was significantly increased body temperature, but did not changes on body weight, food and water intake. ALRP extract did not effect on the levels of TSH and T4 in the hypothyroidism rats. ALRP extract significantly decreased the levels of GPT, glucose, HDL-cholesterol, LDL-cholesterol, and total cholesterol in the hypothyroidism rats. In histological observation, the enlarged epithelium and atrophic follicles with higher concentration of follicular cells on hypothyroidism were improved by ALRP extract. In addition, ALRP extract increased the expression of TRPV1 and TRPM8 ion channel proteins in hypothyroidism rats. Conclusion : These results indicate that ALRP extract can improve PTU-induced hypothyroidism through regulation of body temperature and lipid accumulation. The action mechanism of ALRP extract is related with body temperature control by thermoregulation with TRP ion channels.

순천만 생태복원에 따른 경제적 가치 평가

황민섭 ( Min Sup Hwang ),이명균 ( Myung Kyoon Lee ),정태용 ( Tae Yong Jung ) 한국환경복원기술학회 2014 한국환경복원기술학회지 Vol.17 No.4

Coastal wetlands are among the most productive biomes in the Earth. The economic values include the direct use of a coastal wetland`s ecosystem services, such as food, raw materials, recreation, and tourism. Other values comprise the indirect use of a coastal wetland`s ecosystem services, such as carbon sequestration, waste-water treatment, and erosion prevention. In particular, Suncheon Bay is recently attracting attention as the most successful case of the preservation and restoration. This study applies Travel Cost Method (TCM) to estimate the economic value by drawing the demand curve for trips to Suncheon Bay. The TCM is an approach used for economic valuation of non-market goods and services. Based on the results of TCM, this study shows that the economic benefit from recreational uses of the site adds up to .174.7 billion per year. It is also significant in the sense that monetary information is suggested to help local policy makers evaluate the realistic values of coastal wetlands.

${\ll}$상한론(傷寒論)${\gg}$ 소음병(少陰病) 제망(製網)을 이용(利用)한 침구학적(鍼灸學的) 정증(定證) 및 분경(分經)의 운용(運用) 방법(方法)에 관한 연구(硏究)

이성수,황민섭,이준범,윤종화,Lee, Seong-Su,Hwang, Min-Sub,Lee, Jun-Beom,Yoon, Jong-Hwa 대한침구의학회 2005 대한침구의학회지 Vol.31 No.4

Objectives : The following study was undertaken in order to seek the acupuncture operation method of ${\ll}$Sang Han Lun(傷寒論)${\gg}$ Liu-Jing-Bian-Zheng(六經辯證). Methods : Based on the documents quoted in ${\ll}$Sang Hang Za Bing Lun Xu Wen(傷寒雜病論 序文)${\gg}$ of 'Zhang, Zhong-Jing(張仲景)', the relativity of the theory of Jin-Mai(硬脈) and Liu-Jing-Bian-Zheng of convalescence, and from the Liu-Jing-Bing(六經病), the origin and implication that caused so-Yin-Bing(少陰病) to form was studied on the basis of acupuncture medicine publications and the commentary writing of ${\ll}$Sang Han Lun${\gg}$. Results : 1. ${\ll}$Sang Han Lun${\gg}$ Liu-Jing-Bian-Zheng has succeeded and was developed based on Liu-Jing-Fen-Zheng(六經分證) Of ${\ll}$Su Wen Re Lun(素問 熱論)${\gg}$. In addition, the summary of Liu-Jing-Bing became the general principle of Fen-Jing(分經) and Ding-Zheng(定證) that may be applicable to Fenghan(風寒), Wenre(溫熱), Lili(疫?) and Eating(雜病). 2. Most commentators of ${\ll}$Sang Han Lun${\gg}$ in the Song, Ming and Ching Dynasties of ${\ll}$Sang Han Lun${\gg}$ interpreted the so-yin-Bing in physiological and pathological aspects of Rong-Wei(榮衛) as the disease of the Heart and Kidney meridian. 3. From the Liu-Jing-Bing of ${\ll}$Sang Han Lun${\gg}$, the region of acupuncture treatment of So-yin-Bing is treated with the needle from the point of view of Bing-Zheng-Lun-Zhi(辨證論治) with the basis of the important region of acupuncture of the heart of meridian Kindey of meridian.

fMRI를 이용한 조해혈(照海穴)(KI6) 자침(刺針)이 대뇌피질(大腦皮質) 운동영역(運動領域)의 활성변화(活性變化)에 관(關)한 연구(硏究)

윤종화,황민섭,배건태,이수홍,이승덕,장준혁,김경호,장용민,변우목,김갑성,Yoon, Jong-Hwa,Hwang, Min-Sup,Bae, Geon-Tae,Lee, Soo-Hong,Lee, Sung-deok,Jang, Jun-Hyeok,Kim, Kyoung-Ho,Jang, Young-Min,Byun, Wu-Mok,Kim, Gap-Sung 대한침구의학회 2001 대한침구의학회지 Vol.18 No.5

Objective : Recent studies Suggested that there is a strong correlation between acupuncture stimulation and its related cortical activation. Anther study showed that either positive or negative BOLD effects could be observed depending on anatomical structure in acupuncture. Material and Methods : 1) Subjects and paradigms : Two separate stimulation paradigms were performed on five healthy (aged 22-23 yrs) in this study. First, the paradigm of acupuncture stimulation was that the acupuncture needle was inserted in acupoints KI6(照海), which is located in lateral side of the foot and then continuously twisted(補瀉를 除外한 捻轉法) for 70 seconds for 10 cycles of activation. During rest period (70 seconds), the needle was completed removed from acupoint. Total 60 cycles were performed and 10 images were obtained per cycle. Second, non-acupoint was randomly selected and the same paradigm was performed as acupoint stimulation. The stimulation protocol comprised 10 cycles of alternating activation and rest (10 images per cycle). Total 60 cycles were performed and each cycle take about 1.5 sec for motor task. Subjects take an at least 15 minutes break before starting anther paradigm. Conclusion : In this study, I investigated a new acupoint KI6(照海) which was known as motor - related acupoint and obtained an evidence that the stimulation of KI6(照海) resulted in negative BOLD response to stimulation.

고대(古代)의 경맥진단법(經脈診斷法) 중(中) 십이경표본맥진법(十二經標本脈診法)에 관(關)한 연구(硏究)

이동휘,황민섭,윤종화,Lee, Dong-hee,Hwang, Min-seob,Yoon, Jong-hwa 대한침구의학회 2004 대한침구의학회지 Vol.21 No.1

Objective: A study on $\ll$Lingchui, 靈樞 Weiqi, 衛氣$\gg$ which descripted Twelve meridian Biaoben(標本) pulse diagnosis method. Methods: A study on Twelve meridian Biaoben(標本) pulse diagnosis method which has the cognizance of Biaoben(標本) on upper and low twelve meridian as linear upper and low pulse diagnosis point. Results: Twelve meridian Biaoben(標本) pulse diagnosis method is derived from using each twelve meridian pulse diagnosis and it can be explained that the ben(本) pulse point on wrist ankle and the biao(標) pulse point on thorax axillary neck head face correspond to upper and low part of meridian for diagnosis and treatment which become the theory of "treat upper disease on low part, treat low disease on upper part". Conclusions: Twelve meridian Biaoben(標本) pulse diagnosis method started confirming the general concept of Jue-symptom(厥症) and Jue-symptom(絶症) and developed upper and low pulse diagnosis point or acupuncture point to treatment.