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최진은,( Yeon Kyung Na ),( Ji Young Park ),( Seung Soo Yoo ),( Shin Yup Lee ),( Hyo Sung Jeon ),( Dons Sun Kim ),( Jae Yong Park ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Introduction: Liver kinase 1 (LKB1) plays a critical barrier role in lung tumorigenesis by controlling initiation, differentiation and metastasis. We searched for genetic and epigenetic alterations of the LKB1 gene in Korean NSCLCs and correlated the results with clinicopathological features. We also investigated the relationship between genetic and epigenetic alterations of LKB1 and mutations in the TP53 gene and EGFR pathway genes. Methods: A total of 159 NSCLCs were analyzed for loss of heterozygosity (LOH) at microsatellite loci D19S886, and D19S878. Mutations and methylation status of LKB1 were examined by direct sequencing and a methylation-specific polymerase chain reaction, respectively. Results: A somatic mutation was found in one of the 159 tumors. LOH and promoter methylation was detected in 19.5% (31/159) and 13.2% (21/159) of the tumors, respectively. Four of the 159 tumors had concomitant LOH and methylation of LKB1. In total, 30.2% of the 159 NSCLCs harbored LKB1 LOH or promoter methylation, which were correlated with down-regulation of gene expression. LKB1 LOH was more frequent in males, smokers, and tumors with a TP53 mutation than in females, never-smokers, and tumors without a TP53 mutation, respectively. However, no significant correlation between LKB1 alterations and mutations in EGFR pathway genes was found. Conclusion: These results suggest that the prevalence of LKB1 genetic and epigenetic alterations in NSCLCs vary depending on patient ethnicity. Our results show that LKB1 alterations often occur simultaneously with mutations in EGFR pathway genes.
최진일(Jinil Choi),이상근(Sangkeon Lee),최재영(Jaeyoung Choi) 한국정보과학회 2005 한국정보과학회 학술발표논문집 Vol.32 No.2
워크플로우 시스템은 복잡한 복수의 작업을 사용자가 작성한 작업 플로우에 따라 자동으로 수행시킴으로써 작업의 효율성을 높이고자 하는 시스템이다. 특정 작업의 능률을 향상시키기 위한 목적으로 많은 연구기관에서 자체적인 워크플로우 시스템을 연구하고 있다. 이렇게 개발된 워크플로우 시스템은 각 연구기관에서 목적으로 하는 특정 작업 환경의 특성을 반영하는 시스템이지만 특정 작업이나 환경에 종속적인 특성을 가진다. 따라서 작업 환경이 확장 혹은 변경된다면 워크플로우 시스템도 수정하거나 처음부터 다시 개발해야 한다. 따라서 본 논문에서는 특정 작업이나 환경에 종속적인 워크플로우 시스템의 문제점을 해결하기 위한 방법으로 응용 프로그램 및 실행 환경에 독립적인 워크플로우 시스템 모델을 제안한다.
최진이(Choi, Jin Yi),장애경(Chang, Ae Kyung),이은주(Lee, Eunju) 대한근관절건강학회 2015 근관절건강학회지 Vol.22 No.3
Purpose: The purpose of this study was to examine factors related with the maintenance of physical activity in Korean old adults with hypertension based on the social cognitive theory. Methods: A cross-sectional survey of 300 old adults with hypertension from five public health centers in Korea was conducted using a self-reported questionnaire. Participants were designated as “maintainer” or “discontinuer” based on the reports to the Stages of Readiness to exercise Questionnaire. Results: One hundred seventeen participants (39%) were designated as maintainers. The predictors of the maintenance of physical activity were gender (OR=3.19, p=.049), education (OR=3.50, p=.049), outcome expectation (OR=1.21, p<.001), self-efficacy (OR=.22, p=.007), and physical activity planning (OR=1.19, p=.002). Conclusion: Findings from this study suggest that nursing interventions to improve the maintenance of physical activity in the hypertensive elderly should focus on increasing outcome expectation, self-efficacy, and physical activity planning strategies especially on the female elderly with lower education level.
레이저 각막절삭가공성형술 후 안압 상승에 의한 지연성 미만성 층판각막염 1예
최진,위원량,이진학,김미금,Jin Choi,Won Ryang Wee,Jin Hak Lee,Mee Kum Kim 대한안과학회 2006 대한안과학회지 Vol.47 No.10
Purpose: To report a case of post-laser in situ keratomileusis (LASIK) delayed diffuse lamellar keratitis (DLK) associated with elevated intraocular pressure (IOP). Methods: A retrospective review of the medical record for an eye with delayed-onset DLK. Results: In an eye treated with topical steroid eye drops after LASIK, DLK suddenly developed at 6 weeks postoperatively. No corneal epithelial defect was found, but IOP was observed to be high. Keratitis regressed as the IOP was controlled with topical antiglaucoma medications. However, DLK recurred at 3 months postoperatively with increasing IOP again caused by continued topical steroid application. Flap irrigation was performed. No microorganism was found on the interface. After discontinuation of topical steroid, IOP was lowered and DLK disappeared completely. Conclusions: Elevated IOP can be a causative factor of late-onset DLK after LASIK.
거골 골연골 병변의 수술적 치료 후 이차 관절경술 -자가 골연골 이식술과 미세 골절술의 결과 비교-
최진,이근배,조성범,정성택,박기헌,Choi, Jin,Lee, Keun-Bae,Cho, Seong-Beom,Jung, Sung-Taek,Park, Gi-Heon 대한족부족관절학회 2006 대한족부족관절학회지 Vol.10 No.2
Purpose: To evaluate the results of mosaicplasty and microfracture after surgical treatments for symptomatic osteochondral lesion of talus (OLT) by second-look arthroscopy. Materials and Methods: 7 cases of mosaicplasty and 7 cases of microfracture were reviewed who undertook second-look arthroscopy at 6 months or one year after undertaking mosaicplasty or microfracture for OLT between December 2004 and October 2005. The mean age at first operation was 43.6 years (Range, 20-59) (Mosaicplasty; 43.9 years, Microfracture; 43.4 years). The mean size of cartilage defect was $15.0{\times}7.7\;mm$ in mosaicplasty and $7.1{\times}6.6\;mm$ in microfracture. Clinical outcomes were evaluated by Freiburg ankle score. Cartilage healing state was evaluated by Insall's classification for chondromalasia during second-look arthroscopy. Results: By the Freiburg ankle score, 9 ankles (6 in mosaicplasty, 3 in microfracture) had excellent and 5 (1 in mosaicplasty, 4 in microfracture) had good results at the times of second-look arthroscopy. By Insall's classification, consistency of the osteochondral grafts and congruity between grafts and native cartilage (Grade I) were shown in 9 (6 ankles in mosaicplasty, 3 ankles in microfracture), a fissuring (Grade II) in one ankle of mosaicplasty, a fasciculation (Grade III) in one ankle of microfracture, and partial exposure of subchondral bone (Grade IV) in 3 ankles of microfractures. Conclusion: Mosaicplasty was more excellent in consistency and hardness of cartilage than microfracture. In some cases of microfracture, cartilage healing was incomplete at 6 months postoperatively, so second-look arthroscopy is necessary to identify. If incomplete cartilage healing was shown, additional procedure such as microfracture or mosaicplasty was needed.
요통환자의 근에너지 기법 시술 전과 후의 척추기립근 변화-경근전도를 통해
최진서 ( Jin Seo Choi ),안재민 ( Jae Min Ahn ),김주영 ( Choo Young Kim ),이재훈 ( Jae Hun Lee ),박동수 ( Dong Su Park ),정수현 ( Su Hyeon Jeong ),김순중 ( Soon Joong Kim ) 한방재활의학과학회 2013 한방재활의학과학회지 Vol.23 No.1
Objectives:To evaluate the clinical utility of MET in elector spinae muscle on low back pain patients.Methods:We compared electrical activity between a before MET and a after MET in elector spinae muscle on low back pain patients in same group(n=30) in dynamic flexion-reextension state during five seconds.We analyzed amplitudes and areas of electrical activity and asymmetry index(AI).Results:1.After MET in elector spinae muscle on low back pain patients were significantly decreased in Visual Analogue Scale(VAS) than before MET in elector spinae muscle on low back pain patients(p<0.05).2.After MET in elector spinae muscle on low back pain patients were lower electrical activity than before MET in elector spinae muscle on low back pain patients but it is not a pointless observation(p<0.05).3.AI of the after MET in elector spinae muscle on low back pain patients significantly decreased compared with before MET in elector spinae muscle on low back pain patients(p<0.05).Conclusions:According to above results, there is clinical effect MET on low back pain patients.
영종도 파라다이스시티 복합 리조트 개발이 지역 경제에 미치는 영향 분석
최진이(Choi, Jin-Yi),이성근(Lee, Sung-Gun) 한국부동산정책학회 2018 不動産政策硏究 Vol.19 No.2
The integrated resort is expected to have greater impact on the local economy by building infrastructure, including lodging, convention, shopping, restaurants, theme parks and performances, than on the simple casino hotel. The purpose of the project is to analyze the economic effects of the follow-up project in Incheon Paradise City. The research method was drawn by applying the regional industrial survey table and the input-output model, and the economic ripple effects were analyzed based on Incheon and Jung-gu. The analysis showed that the economic effect in Incheon City was 788.1 billion won for production inducement effects. The value added effect was estimated to be around 522.7 billion won, which could create 588 new employees within Incheon. The main implications of this study are : First, the integrated resortt industry has a huge ripple effect on the amount of investment. This proves that the integrated resort industry has a high income and employment capacity. Second, the integrated resort industry has excellent employment inducement and can contribute to creating youth jobs (dealers, hotel and resort management staff, etc.) that can be specialized through education. Third, the integrated resort industry has a large impact on the entire industry in terms of the related industry and can expect effects from its future operations.
PVK:Ir(ppy)₃ 발광층을 가지는 고분자 발광다이오드의 제작
이학민(Lee, Hak-Min),공수철(Gong Su-cheol),최진은(Choi, Jin-Eun),장호정(Chang Ho Jung) 한국산학기술학회 2008 한국산학기술학회 학술대회 Vol.- No.-
ITO 투명전극을 양극으로 사용하고 PEDOT:PSS 고분자 물질위에 PVK와 Ir(ppy)3를 각각 host와 dopant로 사용하여 고분자 발광다이오드를 제작하였다. 전자 수송층의 역할로 TPBI, 음극으로 Al을 증착하여 최종적으로 ITO/PEDOT:PSS/PVK:Ir(ppy)3/TPBI/LiF/Al 구조를 갖는 녹색 인광 고분자 유기발광 소자(PhPLED)를 제작하였다. 제작 된 소자의 발광부 dopant인 Ir(ppy)3도핑 농도에 따른 전기적 광학적 특성을 평가하였다. PVK:Ir(ppy)3를 host와 dopant system으로 dopant Ir(ppy)3의 도핑 양을 0.5 wt%에서 2.5 wt%까지 씩 변화시키면서 최적의 농도를 찾고자 하였다. TPBI를 전자 수송층으로 사용 하였을 경우 최대 휘도는 약 8600 cd/m2 (at 8V)이고, 전류밀도는 337mA/cm2 를 나타내었다.
TiAl합금의 Al 피복시 Al확산 피복층의 내고온산화성
이철형,최진일 ( C . H . Lee,J . I . Choe ) 한국열처리공학회 1997 熱處理工學會誌 Vol.10 No.2
The effect of variation of pack activators, compositions, temperature and time on the thickness and structure of aluminide coatings formed on the TiAl alloy was studied in one-step packs and two-step packs containing aluminum for the purpose of improvement of oxidation resistance. The thickness of coating layer was increased with increasing NH₄Cl content up to 3wt% and then it was saturated. Oxidation resistance of coating layers carried out at one step pack was superior to that of ones through of two step pack. The improvement of high temperature oxidation resistance was due to the formation of a protective Al₂O₃ surface layers and coating the alloys with TiAl₃phase.