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SnO<sub>2</sub>센서의 ZnO 첨가량에 따른 di(propylene glycol) methylether (DPGME)에 대한 반응 특성
차건영,백원우,윤기열,이상태,최낙진,이덕동,허증수,Cha G. Y,Baek W. W,Yun K. Y,Lee S. T,Choi N. J,Lee D. D,Huh J. S 한국재료학회 2004 한국재료학회지 Vol.14 No.3
Respectively the powder made of ZnO added $SnO_2$ was prepared by coprecipitation method and the thick film gas sensor was fabricated by screen-printing technique, The morphology and phase of the powder and film was investigated by SEM and XRD. The specific area of the particle was linearly increased with ZnO contents. Target gas was di(propylene glycol) methylether ($CH_3$($OC_3$$H_{6}$ )$_2$OH, DPGME), which is simulant gas of blister gas. The gas sensing characteristics for DPGME were examined with flow type measurement system and the concentrations of target gas were controlled from 500 ppb to 1500 ppb. ZnO (2 wt%) added $SnO_2$ showed maximum sensitivity to DPGME at $300^{\circ}C$.
이태성,조치흠,차순도,서영욱,정철재,권건영 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.5
Primary malignant melanoma of the vagina are believed to arise from melanocytes which may be present in the epithelium of the vagina. These tumors are very rare and comprise less than 0.5% of all vaginal malignancies, which are the worst prognosis compared to other malignant vaginal neoplasms. We present a case of primary malignant melanoma of the vagina with brief review of literature.
Sabarish Ramachandran,권건영,신소진,권상훈,차순도,배인수,조치흠 대한의학회 2008 Journal of Korean medical science Vol.23 No.4
The molecular mechanism of the cell-cycle machinery in uterine leiomyoma has not yet been fully elucidated. Among the various types of cell-cycle regulators, p27Kip1 (p27) is considered to be a potent tumor suppressor. To provide further molecular basis for understanding the progression of uterine leiomyoma, our objective was to evaluate the expression level of p27 in normal myometrium and uterine leiomyoma tissue and its effect on cytogenic growth. Western blot analysis, real-time polymerase chain reaction (PCR) and immunohistochemical staining revealed that p27 protein and messenger RNA were down-regulated in uterine leiomyoma tissue and cultured cells compared to normal myometerium. Full-length human p27 cDNA was transferred using a replication-deficient recombinant adenoviral vector (Ad.p27) into uterine leiomyoma cells and evaluated the effect on cell proliferation. Transfection of Ad.p27 into uterine leiomyoma cells resulted in the induction of apoptosis, reduction in viability and proliferation of uterine leiomyoma cells. Our results suggest a new paradigm that down-regulated p27 protein expression is the possible underlying mechanism for the growth of uterine leiomyoma and over-expression of p27 induces cell death. This study provides better understanding of the control exerted by p27 in regulating growth and disease progression of uterine leiomyoma.
조치흠(Chi Heum Cho),차순도(Soon Do Cha),백원기(Won Ki Baek),권건영(Kun Young Kwon),배인수(In Soo Bae) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.5
N/A Objective : Apoptosis or programmed cell death is a normally physiological cell suicide program that is highly conserved among all animals. We previously evaluated overexpression of c-IAP1(Inhibitor of Apoptosis Protein) in ovarian carcinomas compared with normal ovaries. In this study, we demonstrate evidence for the involvement of c-IAP2 in ovarian carcinomas. Methods : Fresh 9 normal ovaries, 5 benign ovarian cysts and 13 ovarian carcinomas were obtained from routine gynecologic surgeries carried out for benign and malignant ovarian tumors. They were examined for the presence of c-IAP2 by RT-PCR(Reverse Transcriptase Polymerase Chain Reaction), Western blot analysis and immunohistochemical stains. Results : Nine of 14 normal and benign ovarian tumors were negative and 11 of 13 ova rian carcinomas were positive for c-IAP2 by RT-PCR. Positive RT-PCR for c-IAP2 was seen in 11/13 of ovarian carcinomas, a significantly higher percentage than in normal and benign ovarian tumors(5/14). All of these tumors showed strong positive for c-IAP2 by western blot and immunohistochemical staining. Whereas negative RT-PCR for c-IAP2 was seen in 9/14 of normal and benign ovarian tumors, a significantly higher percentage than ovarian carcinomas(2/13). Of these 9 negative samples, 6 had positive Western blot and immunohistochemical stains. There was weak concordance of the result. But expression of c-IAP2 in normal ovarian tissue was localized exclusively in the corpus luteum. Therefore, c-IAP2 may play important role in determining the fate of the follicular destiny. There was no expression in normal ovarian stroma cells for c-IAP2. Conclusions : These findings suggest that c-IAP2 is expressed in ovarian carcinomas and emerging role in cancer. The c-IAP2 expression has been investigated in the normal ovary, where apoptosis is thought to play an important role in ovulation.
Talc를 이용한 늑막유착술 후 발생한 급성 호흡곤란증후군 1례
김기업 ( Kim Gi Eob ),차건영 ( Cha Geon Yeong ),한상훈 ( Han Sang Hun ),윤여일 ( Yun Yeo Il ),박성우 ( Park Seong U ),김도진 ( Kim Do Jin ),나문준 ( Na Mun Jun ),어수택 ( Eo Su Taeg ),김용훈 ( Kim Yong Hun ),박춘식 ( Park Chun Sig 대한결핵 및 호흡기학회 2001 Tuberculosis and Respiratory Diseases Vol.51 No.3
ZrO2 첨가된 SnO2를 이용한 신경 및 수포작용제 검지에 대한 연구
윤기열 ( Ky Youl Yun ),차건영 ( Gun Young Cha ),최낙진 ( Nak Jin Choi ),이덕동 ( Duk Dong Lee ),김재창 ( Jae Chang Kim ),허증수 ( Jeung Soo Huh ) 한국센서학회 2004 센서학회지 Vol.13 No.5
N/A N-type semi-conducting oxides such as SnO₂, ZnO, and ZrO₂ have been known for the detecting materials of inflammable or toxic gases. Of those materials, SnO₂-based sensors are well known as high sensitive materials to detect toxic gases. And the sensitivity is improved if catalysts are added. Detecting toxic gases, especially DMMP (di-methyl-methyl-phosphonate) and DPGME (Dipropylene glycol methyl ether), was performed by a mixture of Tin oxide (SnO₂) and Zirconia (ZrO₂). The films consist of each three different mass% of Zr (from I mass% to 5 mass%). and they were tested by XRD. SEM. TEM, BET. Nano-structure, pore and particle size was controlled to verify the sensor`s sensing mechanism. The sensors was evaluated at five different degrees (from 200℃ to 400℃) and three different concentrations (from 500 ppb to 1500 ppb). The sensors had good sensitivity of both simulants, and high selectivity of DMMP.
자궁경부암 및 난소암에서 세포자멸사 억제인자인 c-IAP1과 c-IAP2의 발현 양상
조준형,조치흠,권상훈,백원기,권건영,박준철,이정호,김종인,윤성도,차순도 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.1
목적 : 처음 baculoviruses에서 동정된 세포자멸사 억제단백들(inhibitor of apoptosis proteins;IAPS)은 바이러스가 복제하는 동안 숙주 세포의 생존을 유지하는 기능을 하고 다양한 자극에 의한 세포자멸사를 억제하는 것이 보고 되었으나 암화 과정에 관여하는 기전은 아직까지 정확히 알려져 있지 않다. 난소 암 및 자궁경부암과 그들의 정상조직에서 IAPS의 발현을 비교하여 암화과정에서의 역할을 알아보았다. 연구 방법 : 난소 암 10예와 자궁경부암 10예를 대상군으로, 정상 난소 및 양성 난소 낭종 10예, 정상 자궁 경부조직 10예를 대조군으로 사용하였다 c-lAPl, 2의 mRNA에서의 변화를 보기 위해 RT-PCR을 시행하였고 RNA의 변화를 단백질에서 검증하기 위해 Western blot을 시행하였다. 결과 . c-lAPl, 2단백질의 발현은 난소 암에서 정상 난소 조직에서 보다 높은 발현이 있었고, 정상 자궁 경부조직에서는 c-lAPl 2단백질이 전 예에서 높게 발현되었다. RNA의 변화를 단백질에서 검증하기 위해 Western blot을 시행한 결과 c-lAPl,2 단백질이 난소암에서 일관되게 높게 발현되었다. 자궁경부 조직에서의 c-lAPl 단백질의 발현은 정상 자궁경부에서 자궁경부암보다 일관된 증가를 보여 주었고, c-lAP2 단백은 RT-PCR에서 보여준 일관된 정상 자궁경부에서의 증가가 없이 자궁암에서도 증가가 나타났다. 조직에서의 정확한 발현부위를 알기 위해 면역조직화학염색을 시행하여 난소 암에서 c-lAPl 단백은 암세포의 세포질에 정확히 침착되나 정상 난소에서는 발현이 일어나지 않음을 관찰하였다 c-lAP2단백은 난소암과 양성 난소 낭종인 자궁내막종과 황체에서 발현을 보였다. c-lAPl 단백은 자궁경부암에서 암세포에서는 발현이 없었으며 주위 정상 조직에서는 발현을 나타내었고, 정상 자궁경부 조직에서도 상피세포에서 발현을 나타내었다 그러나 c-lAP2 단백은 자궁경부암이나 정상 조직에서 일관된 결과를 보이지 않았다. 결론 이상의 연구 결과로 보아 난소 암에서는 c-lAPl,2의 증가가, 자궁경부암에서는 c-lAPl의 감소가 암화 과정에 관여한다고 추정할 수 있다. Objective : The inhibitor of apoptosis proteins (IAPs) constitutes a family of highly conserved apoptosis suppressor proteins that were originally identified in baculoviruses. Although IAP homologs have recently been demonstrated to suppress apoptosis in mammalian cells, their expression and role in human gynecologic cancers are unknown. In this study auther used ovarian and cervical cancer tissues to examine the role of IAP in the regulation of apoptosis in cervical and ovarian cancers compared with normal tissues. Methods : Fresh tissues were retrieved from 10 cases each with ovarian cancers, cervical cancers and 4 normal ovarian tissues, 6 benign ovarian tumors, and 10 normal cervical tissues. Expression of mRNA was determined by RT-PCR. Western blot analysis was also used for asseessment of protein expression. Results : The overexpression of c-IAP1,2 was identified in ovarian cancers compare with normal ovaries. All cases of cervical cancer tissues were negative and normal cervical tissues were positive for c-IAP1,2 by RT-PCR assay. Using Western blot analysis, the overexpression of c-IAP1,2 was observed in ovarian cancer tissues compared with normal ovarian tissues and overexpression of c-IAP1 in normal cervical tissues. However differences were not observed with expression of c-IAP2 in cervical cancer tissues. On immunohistochemical results, the expression of c-IAP1,2 was observed in ovarian cancer tissues, normal corpus luteum, and normal cervical tissues, whereas c-IAP1 was not shown in cervical cancer tissues. There was no correlation in c-IAP2 expression between cervical cancer and normal cervical tissues. Conclusion : These results suggest that c-IAP1,2 are important elements in growth of ovarian cancers, whereas c-IAP1 may play role of down regulation to cervical carcinogenesis.
기포성 말기 폐질환에서 발생한 allergic bronchopulmonary aspergillosis (ABPA) 1 례
김동원,이영목,한상훈,홍기영,이준혁,김용훈,박춘식,차건영,어수택 대한알레르기학회 2001 천식 및 알레르기 Vol.21 No.3
Allergic bronchopulmonary aspergillosis(ABPA) is a syndrome seen in patients with asthma and cystic fibrosis. It is characterized by chronic cololinization of the airways with a ubiquitous fungus, Aspergillus fumigatus. Clinically, it is a syndrome characterized by recurrent episodes of wheezing, mucus production, pulmonary infiltrates, and elevated levels of serum IgE. ABPA patients are also accompanied with bronchiectasis in 89% and observed in 10% of cystic fibrosis that show the features of end-stage lung pattern. There are few reports of ABPA associated with bullae. We will report here a case of ABPA developing in an old cicartrical and bullous lesion of a lung.