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조영심 ( Young Shim Cho ),윤태영 ( Tea Young Yoon ),최웅 ( Woong Choi ),김경숙 ( Kyeong Sook Kim ),김미경 ( Mi Kyeong Kim ) 대한천식알레르기학회 2009 천식 및 알레르기 Vol.29 No.3
Polysorbates including polysorbate 80 is a solubilizing agents widely used in cosmetics and medical preparations such as vitamins, vaccines and anticancer agents. A 64-year-old woman experienced generalized urticaria, angioedema, hypotension and loss of consciousness during intravenous administration of aminoacid fluid with multivitamin. Skin prick test with multivitamin and its 15 ingredients including polysorbate 80 showed a strong positive reaction to polysorbate 80 only. Based on her symptoms and the result of skin prick test, we confirmed that she had polysorbate 80-induced anaphylaxis. (Korean J Asthma Allergy Clin Immunol 2009;29:204-207)
아미오다론 투여 후 동시에 발병된 간염과 갑상선 기능저하증
조영심 ( Young Shim Cho ),한정호 ( Joung Ho Han ),채희복 ( Hee Bok Chae ),김재수 ( Jae Su Kim ),강기만 ( Ky Man Kang ),박상민 ( Sang Min Park ),임준철 ( Jun Cheol Lim ) 대한소화기학회 2013 대한소화기학회지 Vol.62 No.1
Amiodarone is a di-iodated benzofuran derivative that is commonly used to treat patients with various cardiac arrhythmias. It is associated with side effects that involve the liver, thyroid, and other organs. Approximately 1-3% of patients treated with amiodarone suffer from symptomatic liver disease. Thyroid dysfunction occurs in 10% of patients treated with amiodarone. A 65-year-old woman with coronary heart disease and atrial fibrillation was administered with amiodarone. She developed nausea, vomiting, dyspepsia, and sweating within 9 months of amiodarone administration (200 mg orally once a day). Results of the laboratory finding showed increased hepatic enzymes, and low thyroid hormone levels. A liver biopsy showed irregular arrangement of hepatocytes and diffuse micro- and macrovesicular fatty changes. Electron microscopy findings showed pleomorphic mitochondria with crystalloid inclusions and membrane-bound lysosomal structures. The liver and thyroid functions returned to normal, after the amiodarone was stopped. We describe an unusual case in which amiodarone induced hepatitis and hypothyroidism simultaneously. Physicians should take a close look to the adverse event when using amiodarone which can cause adverse effects in multiple organs. (Korean J Gastroenterol 2013; 62:59-63)
이신영 ( Shin Young Lee ),주혜진 ( Hye Jin Joo ),조영심 ( Young Shim Cho ),전원중 ( Won Joong Jeon ),채희복 ( Hee Bok Chae ),박선미 ( Seon Mee Park ),윤세진 ( Sei Jin Youn ),성노현 ( Ro Hyun Sung ) 대한소화기학회 2009 대한소화기학회지 Vol.54 No.6
Acute cholangitis usually develops in congenital hepatic fibrosis (CHF), accompanied by cystic dilated bile ducts. However, it can also develop in simple CHF and may lead to critical course. A 30-year old man presented with recurrent acute cholangitis without bile duct dilatation. He visited the hospital for febrile sense and abdominal pain in the right upper quadrant. He had been admitted several times for hepatosplenomegaly and cholangitis since childhood and received a liver biopsy 15 years ago. Abdominal computed tomography (CT) and endoscopic retrograde cholangiopancreatography (ERCP) revealed hepatosplenomegaly and a mildly dilated bile duct without stones or biliary cysts. His condition improved after conservative treatment. However, during a two-month follow up period, the patient experienced three episodes of acute cholangitis. A liver biopsy was performed and showed periportal fibrosis and intrahepatic ductular dysplasia, characteristics of congenital hepatic fibrosis. The periportal fibrosis and the infiltration of inflammatory cells were aggravated compared to 15 years ago. There was no evidence of hepatic cirrhosis. He was diagnosed with congenital hepatic fibrosis with recurrent acute cholangitis without intrahepatic duct dilatation, and conservatively treated with antibiotics. (Korean J Gastroenterol 2009;54:404-408)
흥미영상 : FDG PET-CT에서 악성림프종처럼 보이는 복부 기쿠치병
한혜숙 ( Hye Suk Han ),김기현 ( Gi Hyun Kim ),조영심 ( Young Shim Cho ),주혜진 ( Hye Jin Joo ),이옥준 ( Ok Jun Lee ),류동희 ( Dong Hee Ryu ),이기형 ( Ki Hyeong Lee ),김승택 ( Seung Taik Kim ) 대한핵의학회 2009 핵의학 분자영상 Vol.43 No.4
Kikuchi`s disease is a self-limiting benign disease characterized by cervical lymphadenopathy, but it can be mistaken for malignant disease, and when involved lymph nodes are unusually located, diagnosis can be more difficult. The authors report the case of a 19-year-old man with Kikuchi`s disease, who had isolated intra-abdominal lymphadenopathy and increased 18-fluoro-deoxyglucose (FDG) uptake in positron emission tomography-computed tomography (PET-CT). Although its incidence is extremely rare, intra-abdominal Kikuchi`s disease with increased FDG uptake in PET-CT image should be considered in the differential diagnosis when constitutional symptoms mimic those of malignant lymphoma. (Nucl Med Mol Imaging 2009;43(4):363-365)
박재근 ( Jae Geun Park ),서의근 ( Eui Keun Seo ),조영심 ( Young Shim Cho ),장종순 ( Jong Soon Jang ),주혜진 ( Hye Jin Joo ),이승호 ( Seung Ho Lee ),김미경 ( Mi Kyeong Kim ) 대한내과학회 2010 대한내과학회지 Vol.78 No.5
Macrolides antibiotics synthesized by Streptomyces strains are prescribed widely and seldom produce hypersensitivity reactions, even when administered topically. Consequently, they are considered very safe drugs. We report the case of a 32-year-old woman who developed anaphylactic shock after ingesting erythromycin, which she had taken twice before. The previous exposure to erythromycin, clinical findings, and a positive skin intradermal test with erythromycin (10 mg/mL) support the postulate that anaphylaxis was induced by erythromycin. (Korean J Med 78:660-663, 2010)
흰쥐 결장운동에서 Neurotensin의 수축작용과 자율신경계의 영향
지정훈 ( Jeong Hoon Ji ),김성무 ( Sung Moo Kim ),서의근 ( Euikeun Seo ),조영심 ( Young Shim Cho ),유숙희 ( Suk Hee Yoo ),한정호 ( Joung Ho Han ),채희복 ( Hee Bok Chae ),박선미 ( Seon Mee Park ),윤세진 ( Sei Jin Youn ) 대한장연구학회 2010 Intestinal Research Vol.8 No.2
Background/Aims: Although neurotensin (NT) stimulates colon motility and the passage of intestinal contents, the associated mechanism of action remains unclear. The objective of this study was to investigate the effects of NT on colon motility using isolated rat colon. Methods: Intraluminal pressure was measured at both the proximal and distal portions of the isolated colon. An isolated rat colon was perfused with Krebs solution via the superior mesenteric artery. After stabilization, NT was administered in concentrations of 14, 28, 138 and 276 pM. After pretreatment with phentolamine, propranolol, hexamethonium, atropine or tetrodotoxin, NT was administered at a concentration of 276 pM, and then the intraluminal pressure was monitored. Results: NT significantly increased colon motility at concentrations of 14, 28, 138, and 276 in the proximal colon (25.1±6.5%, 175.4±117.0%, 240.8±115.1% and 252.3±110.6%, respectively) and in the distal colon (35.6±11.8%, 97.5±35.1%, 132.7±36.7% and 212.1±75.2%, respectively). The stimulant effect of NT was more potent in the proximal colon, in a concentration-dependent manner (P<0.05). The stimulant effect of NT was significantly inhibited by atropine at both the proximal and distal colon and by tetrodotoxin at the proximal colon, but not by tetrodotoxin at the distal colon and not by propranolol, phentolamine, or hexamethonium at both the proximal and distal colon. Conclusions: NT increased colon motility at both the proximal and distal portions of the rat colon. The effects were more prominent at the proximal portion. The results of this study suggest that the stimulant action of NT may be mediated by local cholinergic muscarinic receptors. (Intest Res 2010;8:162-171)
말기 신부전 환자에서 Acyclovir 사용 후 발생한 급성 뇌병증 2예
이승호 ( Seung Ho Lee ),장종순 ( Jong Soon Jang ),이신영 ( Shin Young Lee ),조영심 ( Young Shim Cho ),주혜진 ( Hye Jin Joo ),권순길 ( Soon Kil Kwon ),김혜영 ( Hye Young Kim ) 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.6
Acyclovir is an anti-viral nucleoside analogue that was discovered in 1972. Since it was put to use in clinical practice, some adverse events had been reported. Renal dysfunction and disturbance of central nervous system are the two major adverse effects. A 60-year-old man who was being treated with peritoneal dialysis was admitted for sudden onset of sensory-neural hearing loss. A 67-year-old man who was being treated with hemodialysis was also admitted for Bell`s palsy. After two days of treatment with intravenous acyclovir and oral prednisolone, they had hallucinations, myoclonus, disoriented mentality and agitation. Furthermore, the latter had stupor. We did some laboratory examination, brain MRI and electroencephalography (EEG), but there was no cause for neurologic abnormality. In the clinical suspicion of acyclovir neurotoxicity, we discontinued acyclovir and went on dialysis therapy. They fully recovered after several days. Our cases further reinforces the claim that the dose of acyclovir should be reduced in patients with renal failure and dialysis is a good form of treatment for overdosage.
내시경 절제술로 치료한 팽대부 주위 신경절세포 부신경절종
채희복 ( Hee Bok Chae ),박선미 ( Seon Mee Park ),성노현 ( Ro Hyun Sung ),전원중 ( Won Joong Jeon ),서의근 ( Eui Keun Seo ),주혜진 ( Hye Jin Joo ),조영심 ( Young Shim Cho ) 대한내과학회 2010 대한내과학회지 Vol.79 No.5
Gangliocytic paraganglioma is a rare tumor that is usually seen in the duodenum. This neoplasm generally behaves in a benign fashion, although instances of recurrence and lymph node metastasis have been described. We experienced a case of incidentally found gangliocytic paraganglioma treated with endoscopic resection. A 61-year-old man was referred because of submucosal tumor adjacent to the major papilla. Endoscopic biopsy revealed paraganglioma. Abdominal CT showed that there was no evidence of a duodenal mass or lymphadenopathy. This tumor was resected endoscopically by electrosurgical snare polypectomy. The excised tumor measured 1.0 cm in diameter. Histopathological examination revealed a benign gangliocytic paraganglioma and the resection margins were free of tumor. At the 6-month follow-up, the patient was still asymptomatic and no residual tumor was detected at the resection site. (Korean J Med 79:543-548, 2010)
푸마르산으로부터 숙신산 생물전환을 위한 Enterococcus faecalis RKY1 균체의 포괄담체에 의한 고정화
위영중,조영심,류화원 전남대학교 촉매연구소 2000 觸媒硏究 論文集 Vol.21 No.-
The Enterococcus faecalis RKY1 cells were immobilized within the polymer matrices such as agar, Ca-alginate, and k -carrageenan in order to investigate bioconversion characteristics of immobilized Enterococcus faecalis RKY1. Agar and k-carrageenan gels were prepared for cubic type, and Ca-alginate gels for bead type. When the seed volume of immobilized cells was adjusted to 10%(v/v), the optimum concentrations of agar, sodium alginate, and k -carrageenan for immo- bilization of Enterococcus faecalis RKY1 cells were 2%(w/v) for all. In this condition, the conversion ratios were 93.6, 96.4, 76.5%, respectively. Immobilized cells entrapped in agar, Ca-alginate, and k -carrageenan have all the optimum pH of 7.0. The optimum temperature of immobilized cells was 40℃ for agar gels, 35℃ for Ca-alginate gels, and 40℃ for k -carrageenan gels. Therefore, Ca-alginate gels were suitable for immobilization of Enterococcus faecalis RKY1 for succinate production.