제2형 당뇨병 환자에서 허혈성 뇌졸중 발생과 Interleukin-1 Receptor Antagonist 및 Peroxisome Proliferator-Activated $Receptor-{\gamma}2$ 유전자 다형성과의 관계

장원만,이병철,안세영,두호경,안영민,Jang, Won-Man,Lee, Byung-Cheol,Ahn, Se-Young,Doo, Ho-Kyung,Ahn, Young-Min 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.2

Objective : It has been reported that two-repeats ($IL1RN^{\ast}2$) of interleukin-1 receptor antagonist (IL-1Ra) gene is associated with ischemic stroke, and that Ala allele of the common Pro12Ala polymorphism in $PPAR-{\gamma}2$ isoform is associated with reduced risk for type 2 DM and its complications. The aim of the present study is to assess the association of IL-1Ra and $PPAR-{\gamma}2$ Pro12Ala polymorphism with the presence of ischemic stroke in the case of diabetic and non-diabetic patients. Methods : Genomic DNA was obtained from 373 healthy subjects, 157 DM subjects without ischemic stroke (known DM duration ${\ge}10$ years) and 302 ischemic stroke patients (including with DM). IL-1Ra polymorphism was analysed by polymerase chain reaction (PCR), and $PPAR-{\gamma}2$ polymorphism by restriction fragment length polymorphism after PCR. Results : $IL1RN^{\ast}1/IL1RN^{\ast}2$ genotype was associated with significantly increased risk for DM (OR=2.86, P = 0.0008) and ischemic stroke (OR=2.74, P = 0.0016). Pro/Ala genotype was associated with the reduced risk for DM (OR=0.53, P = 0.0491) and ischemic stroke (OR=0.38, P = 0.0039). They were also associated with the reduced risk for ischemic stroke in the DM patients compared with DM without ischemic stroke (OR=0.25, P = 0.0321). Conclusions : $IL1RN^{\ast}2$ allele could be an accelerating factor, not a predictive marker for ischemic stroke in type 2 DM. The Pro/Ala genotype of $PPAR-{\gamma}2$ Pro12Ala polymorphism may be associated with reduced risk for ischemic stroke with type 2 DM. Therefore it could be a useful predictive marker for ischemic stroke in Korean type 2 DM.

韓国人日本語学習者の漢字表記上の問題について

長原成功 한국일본근대학회 2010 일본근대학연구 Vol.0 No.28

선진국 환경프로그램의 실태와 우리의 나아갈 방향

장원 한국방송학회 1998 한국방송학회 학술대회 논문집 Vol.- No.-

메틸말로닌산혈증에 의한 신생아 고암모니아혈증에서 지속적 정정맥 투석 여과법 시행 1례

장원경,한혜원,신영림,박현경,김애란,유한욱,박영서,Jhang Won-Kyoung,Hahn Hye-Won,Shin Young-Lim,Park Hyun-Kyung,Kim Ai-Rhan,Yoo Han-Wook,Park Young-Seo 대한소아신장학회 2003 Childhood kidney diseases Vol.7 No.1

저자들은 methymalonic acidemia로 진단된 체중 2.4 kg의 생후 5일된 여아에서 지속적 정정맥 투석 여과법(CVVHDF)을 이용하여 혈역학적 불안정 상태나 특별한 후유증 없이 체내 암모니아를 효과적으로 제거하였기에 보고하는 바이다. Acute hyperammonemia is a medical emergency in the newborn. Efficient, prompt removal of serum ammonia is essential in preventing irreversible brain damage in order to prevent the profound central nervous system dysfunction due to hyperammonia. We report a case of 2.3 kg, 5-day old girl with methylmalonic acidemia who presented with severe hyperammonemia and was successfully treated with continuous venovenous hemodiafiltration(CVVHDF). CVVHDF is an effective and safe method of ammonia removal in the newborn.

「~たばかり」と「~たところ」の時間語との共起関係 ー青空文庫を中心にー

長原成功 한국일본근대학회 2012 일본근대학연구 Vol.0 No.37

This study discussed possible views on time-related words and co-occurrence of '~tabakari' and '~tatokoro' that were considered through 'Aozora' and reached the following results. First of all, considerably strong co-occurrence was found in '~tabakari' and '~tatokoro' in terms of relation of 'ima', a time-related word. Comparing with other time-related words including utterance time, however, ‘~tabakari' co-occurred with time-related words such as ‘saikin’, and ‘kotoshi’ that showed a relatively wide time gap while '~tatokoro' showed co-occurrence with time-related words close to utterance time. In terms of relation with time-related words indicating 'pre-' when utterance happened, ‘~tabakari' co-occurred with time-related words such as ’konomae‘, and ’kyonen‘ that indicated considerably long past before the utterance happened, when '~tatokoro' showed strong co-occurrence with time-related words that are not far from utterance time. In addition, both ‘~tabakari' and '~tatokoro' showed co-occurrence in relation to 'yatto', and 'youyaku', but personal intervention was engaged in both cases. Particularly, looking into relation with 'mada', ‘~tabakari' showed 78 cases of co-occurrence whereas there was none of this case found in '~tatokoro', which indicated that ‘~tabakari' was more likely to make utterance equipped with speaker's personal intervention than '~tatokoro'.

지각된 조직문화가 인터넷 수용에 미치는 영향

장원경,김태균 한국경영교육학회 2004 경영교육연구 Vol.34 No.-

Technology Acceptance Model(TAM) is very influential model in information technology adoption and usage research. TAM proposes that Perceived ease of use(Peou) and Perceived usefulness(Pu) predict Information System(IS)/Information Technology(IT) adoption in many studies, but only Peou and Pu can't help suggesting cyber space or community culture with internet characteristics. So, social variables are needed in internet adoption. This paper examines the role of perceived organizational culture(POC) and subjective norm(SN) on predicting internet adoption and usage. The model is tested by structural equation model analysis with the small and medium enterprises' employees. This research results may provide a extended TAM to understand including social variables. 정보시스템(Information System) 수용(Adoption)과 이용(Usage)연구에서 가장 영향력 있는 모형 중 하나는 TAM(Technology Acceptance Model)이다. 지각된 이용용이성(Perceived Ease of Use)과 지각된 유용성(Perceived Usefulness)은 TAM의 가장 중요한 변수로 정보시스템의 수용과 이용에 영향을 미치는 변수임이 많은 연구를 통해서 확인되었다. 인터넷의 보편적 보급으로 시작된 인터넷 수용과 이용에 관한 연구들은 인터넷의 고유한 특성인 가상공간과 공동체적 문화로 인해서 지각된 이용용이성과 지각된 유용성변수만으로는 만족할 만한 결과를 얻을 수 없었다. 따라서 지각된 이용용이성과 지각된 유용성변수 이외의 변수, 특히 사회적변수의 적용이 필요함을 인식하게 되었다. 본 연구는 사회적 영향변수인 지각된 조직문화와 주관적 규범이 인터넷의 수용과 이용에 영향을 주는가를 분석하고자 하였다. 중소기업의 종업원을 대상으로 설문을 수집하여 이를 구조방정식 모형으로 분석하였다. 연구의 결과, 인터넷 수용과 이용에 있어서 사회적 영향 변수를 포함한 확장TAM의 가능성을 제시하였다.

비밥 재즈 즉흥연주의 무작위적 4음열의 원리

장원국 ( Won Guk Chang ) 한국음악학회 2009 한국음악학회논문집 음악연구 Vol.42 No.-

비밥 재즈에 대한 기존의 분석은 실용적 견지에서 고전 화성의 분석법을 적용하는 정도에 머물러 왔으나, 그 이면에 숨은 분석 불가능한 추상성이야말로 재즈의 아름다움의 본질이라 할 수 있다. 본 연구에서는 이러한 추상성의 기원과 의미라는 주변적 양상을 논구함으로써 재즈의 추상성의 본질에 대한 통찰을 제공하고자 한다. 비밥 재즈인들이 사용하는 즉흥연주의 구성단위인 두 세 마디 길이의 릭(lick)은 보다 작은 단위인 네 개의 8분음표의 그룹의 합으로서 분석되어질 수 있으며 이러한 4음 그룹은 무작위적 음고를 가지려는 경향이 있다. 포스트 밥(post bop) 시대에는 이러한 4음 그룹의 경향이 더욱 증대하여, 릭의 개념이 거의 사라지고, 4음 그룹이 생각의 단위가 되어가는 모습도 나타난다. 이러한 무작위적 4음열의 기원과 의미라는 다음과 같이 정리되어질 수 있다. 첫째로, 이러한 4음 그룹의 무작위성은 서구 고전 음악에 그 기원을 두고 있으며, 그러한 의미에서 현대 12음열 음악의 무작위성과 재즈의 무작위성은 동일한 전통에서 유래한다고 해석할 수 있다. 둘째로, 이러한 무작위적 4음열의 그룹을 기본 단위로 삼아 즉석에서 조립하는 방식의 즉흥연주 기법이 곧 비밥이라는 혁신적인 조성음악의 한 장르를 탄생시켰다고 볼 수 있으며, 이것은 조성음악의 논리성과 현대적인 추상성이 하나로 융합되는 결과를 낳았다는 점에서 역사적 의미를 가진다. 본 연구에서는 수학적 도구의 도움을 받아 이러한 해석을 유도해 보도록 하겠다. The analysis on the bebop jazz improvisation so far has been confined within the boundary of the classical harmony, but the unanalyzable abstractness behind the harmonic structure can be said to be the essential element of the beauty of bebop jazz. This thesis discusses the peripheral aspects of the abstract beauty, such as its origin and historical significance, hopefully being able to provide with the insight into its essence. The so-called "licks" that bebop musicians use are units of melodies that have length of a few measures. These licks can be further analyzed into groups of four eighth notes, and these four notes always tend to form a random pitch group. In the post-bop era, the tendency for the musicians to think in terms of four-note groups becomes even more prominent, and the lick is not used anymore. This idea of random four-note group can be conceptualized and signified as follows: Firstly, this randomness of four notes can be said to have been originated from western european classical music, especially chromatic ornamental phrases such as in Chopin. In that sense, modern 12 tone music can be said to be from the same origin as jazz music. Secondly, the technique of assembling these four-note groups in various ways has put the art of improvisation to new heights. This can be of historical significance because it successfully combined the logical structure of classical tonal music and the modern abstractness. This thesis tries to induce this kind of interpretation using the aid of some mathematical tools.

A Successful Primary Percutaneous Coronary Intervention Twelve Days After a Cabrol Composite Graft Operation in Marfan Syndrome

장원일,정진옥,안계택,박형서,박재형,김송수,이재환,최시완,성인환 대한심장학회 2010 Korean Circulation Journal Vol.40 No.5

The Cabrol procedure is one of several techniques used for re-implantation of a coronary artery. After replacement of the ascending aorta and aortic valve using a composite graft, second Dacron tube grafts are used for anastomosis between the ascending aortic graft and the coronary arteries. Ostial stenosis is one of the complications associated with the Cabrol operation. However, there have been no reported cases of acute thrombosis of a Cabrol graft. Here we report a case with acute ST elevation myocardial infarction due to thrombotic total occlusion of a right Cabrol graft-to-right coronary artery (RCA) twelve days after surgery in a patient with Marfan syndrome. He was successfully treated with primary percutaneous coronary intervention (PCI).

우주방사선과 암발생 위험도

장원일,김미숙 한국항공우주학회 2015 한국항공우주학회 학술발표회 논문집 Vol.2015 No.4

고에너지 하전 입자의 형태의 전리 방사선으로 주로 구성되는 우주방사선은 우리가 지표면이나 저궤도에서 노출되는 방사선과는 다른 특징을 가지고 있다. 우주방사선에 의한 생물학적 영향의 정도와 형태 또한 기존 감마선이나 엑스선과는 다른 특징을 가질 것으로 생각된다. 하지만 우주비행사를 제외한 대부분의 인간은 이런 우주방사선 노출에 대한 경험이 없으며, 암발생 위험을 비롯한 인체에 미치는 영향 또한 제한적으로 연구되었을 뿐이다. 우주방사선의 암발생 위험도에 대한 연구를 진행하고 및 이에 대한 불확실성을 해소하는 것은 향후 도래할 우주시대의 필수적인 부분이라고 할 수 있다. 우리나라에서도 현재 개발 중인 중입자가속기를 이용하여 머지않은 미래에 우주방사선의 인체 영향에 대한 연구에 참여할 수 있을 것으로 기대해 본다. Space radiation, that is configured mainly with ionizing radiation in the form of high-energy radiation and charged particles, have different characteristics from radiation that are exposed at the surface and a low-earth orbit. It is considered that the extent and type of the biological effects caused by space radiation are also different from conventional X-ray and gamma-ray. However, the most of humans except for astronauts has no experience with space radiation exposure, the effects on human body including cancer risk has been based on only limited studies. It is the essential part of the Space Age to come in the future to study cancer risk induced by space radiation and resolve uncertainty. In the near future, we expect to be able to participate in studies on the health effects of space radiation, using heavy-ion accelerators under development in Korea.

Subarachnoid hematoma after spinal anesthesia - A case report -

장원,조용현,이동현,김선희 대한마취통증의학회 2018 Anesthesia and pain medicine Vol.13 No.2

Spinal subarachnoid hematoma is a very rare complication of spinal anesthesia. This complication can, and is, often overlooked and dismissed as a fatal neurological consequence of (what amounts to) delayed diagnosis. In this case, a 59-year-old female patient with no specific medical history underwent right knee arthroscopy under spinal anesthesia. The arthroscopic surgery concluded without complications but, on the first postoperative day, the patient complained of lower back pain, headache, nausea, vomiting. On the fifth postoperative day, magnetic resonance imaging was taken and it revealed evidence of a subarachnoid hematoma involving the L3 and L4 vertebral levels. Hematoma evacuation was performed, and the patient recovered without sequelae. Here, we report this case that lumbar spinal subarachnoid hematoma was found five days after spinal anesthesia which was done in a patient without coagulopathy