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P148 : A clinical study of skin diseases on vulvar
( Hye Rim Ko ),( So Min Kim ),( Chae Young Won ),( Hyung Jin Hahn ),( Young Bok Lee ),( Jin Wou Kim ),( Dong Soo Yu ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Vulvar diseases are not rare in dermatology, however the clinical investigations of the vulvar lesions are insufficient. Objectives: The purpose of this study was to investigate the epidemiological aspects of the vulvar diseases, and to highlight the clinical features of dermatoses of the vulvar with the brief review of the common vulvar diseases. Methods: The retrospective clinical study was performed by reviewing charts, pathologic slide, and clinical photographs of 37 patients who had received skin biopsy for vulvar lesions at Uijeongbu St. Mary’s Hospital between February 2009 and September 2013. Results: The mean age was 47.3 years. The most frequent vulvar diseases were epidermal cyst, lichen sclerosus, lichen simplex chronicus, herpes simplex infection and condyloma accuminatum in the decreasing order of frequency. Except for the 11 asymptomatic patients, the rest of the patients complained of various symptoms such as a pain, prickling sensation, tenderness and pruritus. Of the 37 cases, 14 had patches or plaques, 11 had papules or nodules, 6 had erosions or ulcers and 6 had vulvar mass. Conclusion: We retrospectively studied 37 cases of vulvar diseases. The results of this study are similar to previousreports on the clinical features of vulvar diseases. This study suggests that various conditions can affect the vulvar. Further investigation with a larger group of patients is necessary to better understand the epidemiology of vulvar diseases.
Lichen striatus following Blaschko lines
( Hye Rim Ko ),( Ji Won Yun ),( Hyung Jin Hahn ),( Young Bok Lee ),( Dong Soo Yu ),( Jin Wou Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Lichen striatus is an uncommon self-limiting dermatosis that occurs mostly in children and rarely in adults. It presents as linear, erythematous, lichenoid papules distributed along Blaschko lines usually on the extremities and rarely on the trunk and face. It is important to distinguish lichen striatus from many conditions following Blaschko lines, particularly the adult “blaschkitis” initially described as a distinct entity from lichen striatus. Blaschkitis is more common in adults, consists of papules and vesicles in multiple lines usually on the trunk, is more recurrent, and histologically shows a spongiotic rather than a lichenoid pattern. However, it is still not clear whether lichen striatus and blaschkitis are two distinct diseases or variations of the same entity. A 45-year-old male presented with pruritic, linear, brownish papules on the back for 1 month. The lesions showed the pattern of a v on the spine, suggesting the distribution along Blaschko lines. Histopathological findings showed minimal spongiosis and lichenoid lymphohistiocytic infiltrates in the upper dermis and around the sweat ducts in the deep dermis. After 6 months, the lesions improved with topical steroid preparations although pigmentation persisted. The clinical features and histologic findings suggested the diagnosis of lichen striatus. Herein, we report a case of lichen striatus distributed along Blaschko lines on a trunk in an adult patient.
The Role of MCP 1 and IL 6 on the Progress of Crescentic Glomerulonephritis
( Hye Won Hahn ),( Eun Young Um ),( Il Soo Ha ) 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.4
Purpose: Growing data on the relationship between cytokine expression and the progression of renal diseases make these cytokines potential targets for therapeutic interventions. Weexamined the helper T1-cell- and macrophage-associated cytokines in anti-glomerular basement membrane (GBM) antibody-induced nephritis in mice and their temporal relationships with renal tissue fibrosis. Methods: Kidneys were harvested on days 1, 3, 7, 11, and 16 after glomerulonephritis was induced with anti-GBM antibody. The progression of renal fibrosis was serially monitored to quantitate the accumulation of cortical extracellular matrix, and various cytokines were measured simultaneously. Results: A single injection of anti-GBM antibody successfully produced severe crescentic glomerulonephritis. Proteinuria increased abruptly and both mesangial matrix expansion and interstitial fibrosis progressed rapidly. Cortical fibronectin and type III collagen increased continuously, reaching a peak on day 7, and the deposition of type III collagen followed the same pattern, in parallel with that of urinary transforming growth factor 1 (TGF-1) expression. Serial cytokine measurements revealed a sustained increase in interleukin (IL) 6 and monocyte chemoattractant protein 1 (MCP1) from day 3, but neither IL12, IL18, nor interferon changed significantly. Real-time polymerase chain reaction confirmed these features at the transcription level. Conclusion: MCP1 and IL6 correlated with the progression of renal fibrosis, with no increase in Th1-inducing cytokines. This confirms MCP1 and IL6 as attractive therapeutic targets for renal fibrosis in crescentic glomerulonephritis.
Genetics of kidney development: pathogenesis of renal anomalies
Hahn, Hye-Won The Korean Pediatric Society 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.7
Congenital anomalies of the kidney and urinary tract (CAKUT) account for more than 50% of abdominal masses found in neonates and involve about 0.5% of all pregnancies. CAKUT has a major role in renal failure, and increasing evidence suggests that certain abnormalities predispose to the development of hypertension and cardiovascular disease in adulthood. To understand the pathogenesis of human renal anomalies, understanding the development of kidney is important. Diverse anomalies of the kidney corresponding to defects at a particular stage of development have been documented recently; however, more research is required to understand the molecular networks underlying kidney development, and such an investigation will provide a clue to the therapeutic intervention for CAKUT.
(Eun Hye Shin,(Yong Cheol Yoo,(Sang Won Lee,(Tae Ryong Hahn 한국응용생명화학회 2001 Journal of Applied Biological Chemistry (J. Appl. Vol.44 No.4
A cDNA fragment encoding the chloroplastic fructose-1, 6-bisphosphatase (FBPase) was cloned via PCR from the cDNA library of pea leaves. The cloned cDNA, about 1.05 kbp without signal sequence, was introduced into a pET-28a vector for expression in E. coli
한혜원,Hahn, Hye-Won 대한소아신장학회 2011 Childhood kidney diseases Vol.15 No.1
Hypertension is a major risk factor of atherosclerosis which results in cardiovascular disease, and remains a major health problem worldwide. While children are more likely to have secondary hypertension, recent studies support the theory that the prevalence of essential hypertension in children and adolescents is increasing with the global epidemic of childhood obesity, and close attention is needed. Evaluation of hypertension in the pediatric age group should be guided by the age at presentation, and renal diseases must be considered in every child with hypertension, because of the prevalence of renovascular and renal parenchymal disorders as the etiology in any age group. The majority of children with chronic kidney disease are hypertensive, and many have associated end organ damage. Thus, once hypertension has been confirmed, end organ care as well as pharmacologic therapy must be continued. In renovascular hypertension, as cure could be gained with surgical/endovascular intervention, accurate diagnosis is important and it is recommended that every suspected child should undergo angiography.