EMG 신호의 패턴 분류를 위한 간단한 SOM 방식

임중규,엄기환,Lim, Joong-Kyu,Eom, Ki-Hwan 대한전자공학회 2001 電子工學會論文誌-SC (System and control) Vol.38 No.4

본 논문에서는 근육의 움직임에 의해 유발되는 전기적 선호인 근전도(EMG) 신호를 신경회로망을 통해 분류하여 인체의 움직임을 파악하는 방법을 제안한다. 신호분류를 위한 신경회로망으로 학습에 의해 스스로 출력뉴런을 구성하는 SOM을 사용하였으며, 기존의 방식과 다르게 전처리 과정 없이 신호자세를 SOM의 입력으로 사용하여 패턴을 분류하는 간단한 방식이다. 실험과 시뮬레이션을 통해 제안한 방식의 유용성을 확인하였다. In this paper we propose a method of pattern classification of the hand movement using EMG signals through Self-organizing feature map. Self-organizing feature map is an artificial neural network which organizes its output neuron through learning and therefore it can classify input patterns. The raw EMG signals become direct input to the Self-organizing feature map. The simulation and experiment results showed the effectiveness of the classification of EMG signal using the Self-organizing feature map.

미세단백뇨를 보인 인슐린비의존성 당뇨병환자에서 혈압 및 맥박의 일중변동의 변화

김승준(Seung Jun Kim),배원엽(Won Yeop Bae),임석환(Seok Hwan Lim),이윤호(Yun Ho Lee),전인표(In Pyo Jeon),김순호(Sun Ho Kim),조상기(Sang Kee Cho),임중규(Joong Kyu Im),허진득(Jin Deuk Hur) 대한내과학회 1997 대한내과학회지 Vol.52 No.3

Objectives: In diabetics the disturbance of circardian variation of blood pressure and heart rate has been supposed to be related to diabetic autonomic neuropathy and diabetic nephropathy. We performed this study to evaluate the circardian variation of blood pressure and heart rate and the difference of affecting factors between normoalbuminuric patients and microalbuminuric patients. Methods: We studied 50normotensive NIDDM patients without overt nephropathy, divided two grooups, which are normoalbuminuric patients(D1 group) and microalhuminuric patients(D2 group), according to the urinary albumine excretion rate(AER) on 24-h urine collection. We simultaneosly measured 24-hour blood pressure and heart rate by using of ambulatory 24-hour blood pressure monitoring (ABPM). Results: 1) In group Kb, 24-h systolic and diastolic blood pressure were significantly higher than in C(normal control group) and D1 2) 24-h heart rate values did not significantly differ between the groups, but night heart was significantly elevated in group D2 than C and D1. 3) The night/day ratio of SBP(systolic blood pressure) and HR(heart rate) was significantly higher in D2 than C and D1, but the night/day ratio of DBP(diastolic blood pressure) was significantly higher in D2 compaired with C only. 4) The night/day ratio of SBP correlated significantly with duration of diabetes, log of AER, HDL, HbAlc and 24-h DBP. The determinants selected in a multiple stepwise regression were duration of diabetes and HbAlc. 5) The night/day ratio of DBP was related to duration of diabetes, log of AER, 24-h DBP and night HR. The determinants selected in a multiple stepwise regression were duration of diabetes and 24-h DBP. 6) The night/day ratio of HB was related to neuropathy, 1/creatinine, HDL, night SBP, duration of diabetes and log of AER. The determinants selected in a multiple stepwise regression were neruopathy and night SBP. Conclusion: In this study, the normal circardian variation of blood pressure was disturbed in a group of micoralbuminuric patients. But it seems that AER was not a principle independent factor and circardian variation of blood pressure and heart rate were affected by different several factors identified in this study. The nocturnal heart rate was significantly elevated in microalbuminuric group, suggesting the possibility of the presence of parasympathetic neuropathy which is supposed to be related with sudden cardiac death. So it is thought that blunted circardian variation of blood pressure and heart rate can be a prognostic indicator and further prospective study is necessary.

그레이브스병에 있어서 항갑상선제와 티록신 병합요법의 효과

조장현(Jang Hyun Cho),오기창(Ki Chang Oh),김명원(Myung Won Kim),김원석(Won Seok Kim),추진호(Jin Ho Choo),조형철(Hyung Cheol Cho),김순호(Soon Ho Kim),임중규(Joong Kyu Lim),허진득(Jin Duk Huh) 대한내과학회 1998 대한내과학회지 Vol.54 No.2

Objectives: It was recently reported that the administration of T during antithyroid drug(ATD) therapy resulted in a significant decrease of antibodies to TSH receptors as well as the rate of recurrence of active Graves' disease following discontinuance of ATD treatment. But, there is still controversy whether combination therapy is efficient. Therefore, the present study was undertaken to evaluate the effect of T4 administration of patient with Graves' disease who were being treated with ATD. Methods: We studied 56 patients received methimazole(MMI) alone(Group 1) and 48 patients received methimazole plus T4(Group 2). They are diagnosed active Graves' disease at department of internal medicine, Kwang ju Christian Hospital from January, 1994 to December, 1995. AU the patients were treated initially with 30mg of methimazole daily for one month after then, in the Group 1(methimazole alone), the dose of methimazole was adjusted as necessary to achieve normal serum concentrations of T3, T4, and TSH. The patients of Group 2(methimazole plus T4) continue to receive the combination of T4 at a dose of 100 μg daily. Simultaneously, we estimated the serum concentratio n of T3, T4, TSH and Thyroid-stimulating immunoglob ulin(TSI) antibody at every three months. Results : We obtained the following result. In the group 1, mean TSI values were 50.1%(first visit), 30.6%(6months), and 24.7%(1year). And, in the group 2 mean TSI values were 51.8%(first visit), 33.6%(6months), and 22.7% (1year). After 6 months of discontinuing of therapy, the recurrence rate was no significant difference in the two groups (the recurrence rate were 55.4%, 50.0%, respectively P>0.05). Conclusion : These results suggest that T4 administration in combination with MMI therapy have no significant effect in a decrease in levels of TSH receptors antibodies and recurrence rate within 6 months discontinuing MMI therapy as compared with MMI treatment alone.

특발성 경련질환으로 오인된 원발성 부갑상선기능저하증 1례

신성하,최정영,김준기,고영춘,조상욱,김순호,임중규 全南大醫大 2001 전남의대학술지 Vol.37 No.1

양성 단일 갑상선 결절의 갑상선 호르몬 억제요법

김순호,오기창,추진호,임중규,조형철,조장현,허진득 대한내분비학회 1997 Endocrinology and metabolism Vol.12 No.1

Background: Clinically apparent thyroid nodule is a very common disease in adults. Patients are often treated with thyroxine in order to reduce the size of the nodule, but the efficacy of thyroxine-suppressive therapy with thyroxine remains uncertain. We investigated the efficacy of thyroxine-suppressive therapy and the hormonal characteristics during thyroxine therapy to find out whether such measurement could be used to determine the effectiveness of this therapy in patients with benign solitary thyroid nodule proved by aspiration biopsy. Methods: In this study, 54 patients were randomly assigned to receive L-thyroxine(Group I, n=24) or placebo(GroupII, n=30) for 1 year. High resolution ultrasonography(10MHz) was used to measure the size of the nodules at six month intervals. Thyroid hormones and thyroglobulin assay and FNA(fine needle aspiration) was done at the same time. The dose of thyroxine was 200ug/day. Patients were followed at 6 month intervals. Results: The results were as follows: 1) 13(54.1%) out of 24 Group I patients after adequate TSH suppression had a statistically significant reduction of nodule size and before-to-after nodule volume ratios were significantly different between the Group I and Group II patients. 2) In the responders among Group I patients, the before-to-after therapy ratio of the nodule volume was not related to the pretreatment nodule size, thyroid hormones and thyroglobulin levels. Conclusion: Thus we concluded that an adequate suppressive dose of L-thyroxine significantly altered the volume of the benign solitary thyroid nodules 12 months later. ( J Kor Soc Endocrinol 12:45-52, 1997)

그레이브스병에 있어서 methimazole에 의한 인슐린 자가면역 증후군 1예

김순호,강성진,우용안,임중규,유성식,홍건영,박종서 대한내분비학회 1998 Endocrinology and metabolism Vol.13 No.4

Insulin autoimmune syndrome (IAS) includes fasting or reactive hypoglycemia, hyperinsulinemia and the presence of insulin-binding antibodies in patients who have never been exposed to exogenous insulin. This report concems a 29-year-old male patient with Graves disease who had history of having taken methimazole for two months, without any consequence, 6 months previously. However, when methimazole was administered again for three weeks, the patient suffered hypoglycemia during the next fourth week. He denied history of diabetes mellitus (DM), of taking any oral hypoglycemic agent or of having received insulin injection. Laboratory data showed total serum insulin level > 300 pu/mL, C-peptide reactivity (CPR) 8.0ng/mL and insulin antibody 89%. After stopping methimazole, he was treated with radioiodine (131I). There was no episode of hypoglycemic attack during 8 months of follow-up (J Kor Soc Endocrinol 13:612-616, 199S)

원발성 항인지질 증후군에 병발한 IgA 신증 1예

박종서,이현순,유성식,김순호,강성진,우용안,임중규,홍건영 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.5

The antiphospholipid antibody syndrome is characterized by antibodies directed against either phos-pholipids or plasma proteins bound to anionic phospholipids. These antibodies have been characterized by lupus anticoagulants and anticardiolipin antibodies. Patients with the antiphospholipid antibody syndrome may display a constellation of clinical features including venous and arterial thrombosis, recurrent fetal losses, and thrombocytopenia. Although the majority of patients reported have a thrombotic microangiopathy, some have also seen membranous nephopathy as well as IgA nephropathy in a patient with anti-phospholipid antibody syndrome accompanying glo-merulonephritis. Authors experienced a 37-year-old male patient who presented with generalized edema at the moment of follow-up for primary antiphos-pholipid syndrome accampanying systemic thrombotic events. Anticardiolipin antibody-IgM positivity was detected by seroligic test but no evidence for systemic lupus erythematosus was found. Kidney biopsy showed mesangial IgA deposition without th throm-botic microangiopathy of gomerular capillaries and was diagnosed finally as primary antiphospholipid syndrome with IgA nephropathy. Patient's symptom was relieved with steroids and anti platelete agents and now he is being follow-up to out patient department. This case suggests some possibility that anticardiolipin antibody may induce the IgA nephropathy. Therefore clinician should have concern about the relationship between antiphospholipid antibody and immune mediate glomerulonephritis.

당뇨병환자에서 미세단백뇨의 선별검사로서 단회뇨 검사의 의의

이윤호,김승준,김순호,배원엽,임석환,전인표,위대철,임중규,허진득 대한당뇨병학회 1994 Diabetes and Metabolism Journal Vol.18 No.3