이미다졸의 양성자 친화도에 미치는 치환기 효과에 대한 이론적 연구

이현미,이갑룡,Lee, Hyeon Mi,Lee, Gap Ryong 대한화학회 1994 대한화학회지 Vol.38 No.1

이미다졸 고리를 포함하는 lexitropsin에서, DNA minor grooved의 염기쌍(G-C sequence)과 결합하는 부분인 치환이미다졸의 양성자 친화도를 확장분자궤도함수법으로 조사하였다. 그 결과 메틸이미다졸의 경우 염기중심 질소의 $\alpha$위치에 치환된 이미다졸이 N에 치환된 이미다졸보다 양성자 친화도가 약간 더 크게 나타났으며 다른 치환이미다졸의 경우에는 N에 치환된 이미다졸이 ${\alpha}$위치에 치환된 이미다졸보다 양성자 친화도가 더 크게 나타났다. 예상한 바와 같이 이미다졸의 N에 전자를 미는기가 치환될 때 모두 양성자 친화도가 증가함을 알 수 있었다. The proton affinities of substituted imidazoles, relevant to the binding of lexitropsins that contain imidazole ring to the base pair (G-C sequence) of minor groove of DNA, are studied with the aid of EHT calculations. It is shown that proton affinity of imidazole substituted at position $\alpha$ to the basic nitrogen is slightly larger than that of imidazole substituted at N for the methylimidazole. Proton affinities of N-substituted imidazoles are found to be larger than those of imidazoles substituted at position ${\alpha}$ for a selected set of the other derivatives. As predicted the proton affinity increases when electron-donating group is attached at position N of imidazole.

2004 한국과학영재올림피아드 참가 수학영재와 과학영재의 실천지능 비교

이현미(Hyeon Mi Lee) 한국교육심리학회 2005 敎育心理硏究 Vol.19 No.3

시설 호스피스에 있어서 가족지지가 말기 암 환자의 삶의 질에 미치는 영향

강승계,김수호,김신수,박희명,송근옥,원주희,이명숙,이성옥,이은의,이채영,이현미,Gang Seung-Gye,kim Su-Ho,kim Sin-Su,park Hui-Myeong,song Geun-Ok,Won Ju-Hui,Lee Myeong-Suk,Lee Seong-Ok,Lee Eun-Ui,Lee Chae-Yeong,Lee Hyeon-Mi 한국호스피스협회 2003 호스피스 학술지 Vol.3 No.1

Background: The purpose of this study is to assess the effectiveness of family support on the quality of life in patients admitted to the hospice facility at Saemmul Hospice. Method: The subjects of this study were 152 terminal cancer patients that were admitted to the hospice facility at Saemmul hospice between January 2002 and February 2003. Their each quality of life were assessed at admission, one, three, five and seven weeks at Saemmul Hospice using a questionnaire prepared by the Saemmul hospice and were anlalyzed by means of T-test. Result: There was no difference in the quality of life score between patients with family support and patients without family support in terms of physical, psychosocial, and spiritual aspects in the admission. There was no difference in the quality of life score between the patients with frequent family member's visit(>=8) and less frequent family visit(<=7), and between the patients whose family members stayed at the facility for 24hrs and the patients without staying family members. There was no difference in the quality of life score between the patients in low-middle and low-high class among 9 classes of familial economic status(high-high, high-middle, high-low, middle-high, middle-middle, middle-low, low-high, low-middle, low-low). There was no difference in the quality of life score between the patients whose familial religion were Christianity and the patients with other religions. After 1, 3, 5, 7 weeks assessment, the scores in the physical, psychosocial, spiritual aspect of quality of life were increased. Conclusion: The results suggest that family support is important to improve the quality of life in hospice patients and hospice care team is needed to replace 24 hours of family care. There is a urgent need of trained hospice care teams, so training programs for physicians, nurses, clergies, social workers, and volunteers are necessary.

신앙이 말기 암환자 삶의 질에 미치는 영향

강승계,김수호,김신수,박희명,송근옥,원주희,이명숙,이성옥,이은의,이채영,이현미,Gang Seung-Gye,kim Su-Ho,kim Sin-Su,Park Hui-Myeong,Song Geun-Ok,Won Ju-Hui,Lee Myeong-Suk,Lee Seong-Ok,Lee Eun-Ui,Lee Chae-Yeong,Lee Hyeon-Mi 한국호스피스협회 2002 호스피스 학술지 Vol.2 No.2

Background: The purpose of this study is to find out to how much influence religion had on the quality of life in patients admitted to the hospice facility at Saemmul's House. Terminal cancer patients were assessed one to two weeks after admittance to Saemmul's House. Metohd: The subjects of this study were numbered at 75 patients and were admitted to the hospice facility at Sammul's house between January 2002 and July 2002. The data regarding quality of life was collected using a questionnaire prepared by the sammul Hospice and were analyzed by means of ANOVA and T-test. Result: As a result of this study, there was no noticeable difference in quality of physical, psychosocial life between the patients with conviction of salvation and the other patients. However, it shows that the former enjoyed a higher spiritual quality of life than the latter. In case of baptized patients and unbaptized patients, there were no differences in terms of physical and psychosocial quality of life, but the baptized patients demonstrated a higher spiritual quality of life. After admittance, patients were grouped by duration of conviction of salvation I.e., those that believed more than 5 years and those that believed less than 5 years. In terms of physical, psychosocial quality of life, there was little difference between the two groups. However, those who believed more than 5 years demonstrated a higher spiritual quality of life. However, there was no difference in quality of life among patients, regardless of their belief in God, after receiving spiritual care at the hospice. Conclusion: We got a few conclusions in accordance with result gained by this study. First, spiritual support is very important to improving quality of patients' lives in hospices. Second, hospice programs are needed keenly and spiritual support for patients from trained experts is needed 24 hours a day. Third, because trained experts(ministry) are urgently needed to lend spiritual support, hospice courses must be taught at all colleges of theology. Fourth, a hospice program must provide a proper atmosphere that can give spiritual support and therefore all hospices must build such as environment. Fifth, a tool for spiritual support of hospice must be developed.

4-크로로-4'-메톡시-2-니트로디페닐아민의 X-선 결정 및 분자구조 결정

남궁해,유재혁,이현미,Nam, Gung-Hae,Yu, Jae-Hyeok,Lee, Hyeon-Mi 한국결정학회 1991 韓國結晶學會誌 Vol.2 No.2

4-크로로-4'-메톡시-2-니트로디페닐아민, (C12H11N2O3CL, FW=278.70)의 단것세포 상수는 a=8,169(3), b=8.883(1), c=9.150(1) h, α =82. 98(1), β=104.80(2), y=101.43(2)", V=627.3 A3, F(000)=288.0, Dc=1.48g/cm3, u=3.06cm-1, 7=295" K, 공간군 Pi, 번호 2, 삼사 정계 이며, Z=2이다. λ (Mo-Ka)=0.7107A을 사용 하여 수집한 독립적인 회절 반점 1541개로 구조분 석한 최종 신뢰도 값은 각각 R=0.032, Rw=0.033 이며, S=0.46이다. 본 화합물은 암모니아의 두개 의 수소 대신에 4-크로로-페닐기와 4-메톡시-페닐기로 치환된 물질로써, 질소와 두 페닐기 사이의 각과 결합거리 들은 각각 125.42", 1.362 및 1.428 A 인바 수소와 함께 SP2_혼성결합을 하고있다. 질소를 포함한 두 면간 각은 63.29"이다. 분자간 어 떠 한 수소결합을 하고 지지 않다.

Bis(N-Methylphenazinium) Bis(Oxalato)Palladate(Ⅱ)의 결정구조

김세환,남궁해,이현미,Kim, Se Hwan,NamGung, Hae,Lee, Hyeon Mi 대한화학회 1994 대한화학회지 Vol.38 No.11

(N-methylphenazinium) bis(oxalato)palladate(II)$((C_{13}H_{11}N_2)_2[Pd(C_2O_4)_2])$의 착이온 및 결정의 구조는 X-선 회절법으로 연구하였다. 이 결정은 사방정계이고 공간군은 P1 (군번호 = 2)이다. 단위세포 길이는 a = 7.616(8), b = 9.842(3), c = $20.335(7)\AA$, $\alpha$ = 103.53(3), $\beta$ = 90.00(5), $\gamma$ = $112.38(5)^{\circ}이며$, $V = 1363(2){\AA}^3,\;F_w = 672.93,\;D_c = 1.639\;gcm^{-3},\;F(000) = 680.0,\;{\mu} = 7.3\;cm^{-1},\;Z = 2$이다. 회절반점들의 세기는 흑연 단색화 장치가 있는 자동 4축 회절기로 얻었으며 $Mo-K\alpha$ X - 선(${\lambda}$= 0.7107 $\AA)$을 사용하였다. 구조분석은 중금속법으로 풀었으며, 최소자승법으로 정밀화하였고, 최종 신뢰도 값들은 3120개의 회절반점에 대하여 $R = 0.069,\;R_w = 0.050,\;R_{all} = 0.069$ 및 S = 5.45였다. 착이온들은 근본적인 평면구조로써, 이들의 충진구조는 착음이온들을 두개의 양이온들이 거의 평행하게 둘러싸고 있는 삼중체들을 형성하고 있다. 양이온과 음이온들의 이면각들이 각각 6.3(6)과 $57.06(6)^{\circ}$인 삼중체들이 b축을 따라서 배열되어 있으나, 삼중체면의 배향은 두 가지 착음이온의 이면각이 $59.08(9)^{\circ}$을 이루는 방향이다. 삼중체내의 면간거리는 각각 3.328와 3.463 $\AA$이었다. The crystal structure of bis(N-methylphenazinium) bis(oxalato)palladate(II) has been determined by X-ray crystallography. Crystal data: ((C_{13}H_{11}N_2)_2[Pd(C_2O_4)_2]) $M_w$ = 672.93, Triclinic, Space Group P1 (No = 2), a = 7.616(8), b = 9.842(3), c = $20.335(7)\AA$, $\alpha$ = 103.53(3), $\beta$ = 90.00(5), $\gamma$ = $112.38(5)^{\circ}$, Z = 2, $V = 1363(2){\AA}^3\;D_c = 1.639\;gcm^{-3},\;{\mu} = 7.3\;cm^{-1},\;F(000) = 680.0$. The intensity data were collected with $Mo-K\alpha$ radiation (${\lambda}$= 0.7107\;\AA)$ on an automatic four-circle diffractometer with a graphite monochromater. The structure was solved by Patterson method and refined by full matrix least-square methods using Killean & Lawrence weights. The final R and S values were $R = 0.069,\;R_w = 0.050,\;R_{all} = 0.069$ and S = 5.45 for 3120 observed reflections. Both cation and anion complexes are essentially planar and have dihedral angles of 6.3(6) and $57.06(6)^{\circ}$ between their planes. The planar complex anions are sandwiched between slightly bent cations. The interplanar separations of two triads are 3.328 and 3.463 $\AA$, respectively. The triads are stacked along b-axis, but their orientations are different based on dihedral angle $59.08(9)^{\circ}$ of two complex anions.

사용자 잠재선호특성을 고려한 스마트 주차서비스 설계요건 연구

장정아(Jeong-Ah Jang),이현미(Hyun-Mi Lee),이원우(Won-Woo Lee),김현미(Hyeon-Mi Kim),김태형(Tae-Hyung Kim) 한국전자통신학회 2021 한국전자통신학회 논문지 Vol.16 No.6

본 연구는 주차장 검색 및 사전예약서비스가 가능한 스마트 주차서비스에 대한 것으로, 요금(예약요금, 위약금) 등과 관련된 사용자의 선호선택 모형에 관한 연구이다. 스마트 주차서비스에 대한 응답설문을 구성하여 로짓 모형형태의 사용자 선호도 모형을 두 가지를 구축하였다. 첫 번째는 스마트주차장을 선택하는 모형으로 이용요금과 비용과의 관계에서 일반 주차장보다 선택확률이 높아지는 상황을 제시하였다. 두 번째는 주차권 예약할인 선택모형으로 예약금액과 위약금과의 관계 모형을 통하여 스마트주차서비스 선택확률을 분석하였다. 사용자의 선호도를 고려한 정교하고 다양한 형태의 스마트 주차서비스가 가능한 설계 요구사항으로 활용이 가능할 것으로 판단된다 This study suggests the user s needs for a smart parking service that enables parking lot search and advance reservation service, and is a study on the user s preference selection model related to fees (reservation fee, penalty fee), etc. Two types of user preference models in the form of logit models were constructed by composing a response questionnaire for smart parking service. The first is a model for selecting a smart parking lot, which suggests a situation in which the probability of selection is higher than that of a general parking lot in the relationship between usage fee and cost. The second is a parking ticket reservation discount selection model, and the smart parking service selection probability was analyzed through the relationship model between the reservation amount and the penalty. It can be used as a design requirement that enables sophisticated and various types of smart parking service considering users preferences.

Levenberg-Marquardt알고리즘을 이용한 시내버스 지연요소 추정

이진우(Jin-Woo Lee),이현미(Hyun-Mi Lee),이현수(Hyeon-Soo Lee) 한국전자통신학회 2017 한국전자통신학회 논문지 Vol.12 No.3

최근 국내·외에서 버스운행의 효율화 및 D2D(: Door to Door)서비스, 대중교통의 자율주행을 위해 교통데이터를 분석하여 다양한 분석결과를 도출해내고 있다. 하지만 대중교통, 특히 버스 지연시간의 예측을 위해 다양한 연구가 수행되고 있으나 단순분석, 데이터 취득의 한계로 현재까지의 연구는 미흡한 상태이다. 본 연구에서는 버스의 운행정보를 기반으로 요일, 날씨, 시간대 등의 데이터를 추가적으로 수집·가공하여 지연시간 추정을 수행하였다. 본 논문에서 제안하는 방법은 향후 변수를 추가하여 정확도를 향상시킴으로써 자율주행 대중교통 및 대중교통 관제시스템에 활용이 가능하다. Recently, traffic data is analyzed for efficiency of bus operation, D2D(: Door to Door) service, and self-driving of public transportation. However, various studies have been carried out to predict the delay time of public transportation, especially buses, but the research to date has been insufficient due to limitations of simple analysis and data acquisition. In this study, delay time estimation is performed by collecting and processing data such as day of the week, weather, and time of day based on bus operation information. The proposed method in this paper can be applied to autonomous public transport and public traffic control system by improving the accuracy by adding variables in the future.

트레드밀 운동과 타우린 섭취가 streptozotocin 유도 당뇨쥐의 체중, 혈당, 인슐린 및 콜레스테롤 농도에 미치는 영향

김세종 ( Kim Se Jong ),서혜림 ( Seo Hye Lim ),이현미 ( Lee Hyeon Mi ),염종우 ( Yeom Jong U ),김경환 ( Kim Gyeong Hwan ),장은숙 ( Jang Eun Sug ),백영호 ( Baeg Yeong Ho ),전병학 ( Jeon Byeong Hag ) 한국운동영양학회 2003 Physical Activity and Nutrition (Phys Act Nutr) Vol.7 No.3

Exercise and taurine has been known to be benficial to the diabetic patients. But it combinatory effect has not been studied. This study aims to understand whether taurine intake has a repressive effect on blood levels of glucose, insulin and lipids of the streptozotocin-induced hyperglycemic diabetic rat, and also whether combinational treatment of taurine intake and low-intensity exercise has a synergistic repressive action. Taurine was freely supplied as 1 % solution. The blood glucose level was not suppressed in the taurine-intake diabetic rat, but the blood levels of insulin and lipid such as total colesterol, HDL-cholesterol, LDL-cholesterol and triglyceride was reverted. Exercise (25 mill/day, 5 time/week,15 m/min) alone has a repressive effect on the hyperglycemic index. The combinatory effect of taurine and exercise before and after streptozotocin injection was examined. When taurine was supplemented with exercise before streptozotocin injection, the blood glucose level was surprisingly unchanged. but the blood levels of insulin and lipids were mildly recovered. When taurine was supplemented with exercise after streptozotocin injection, the blood glucose level was also unchanged, but the blood levels of insulin and lipids were mostly recovered. These results suggest that taurine itself has no beneficial effect on the blood glucose level and no combinatory effect with exercise, although it has a positive effect on the blood insulin levels and also serum lipids.

부산시 고등학교 교사들의 환경교육 의식에 관한 연구

이상준,이현미 부산대학교 환경문제연구소 1994 環境硏究報 Vol.12 No.-

This study was attempted to analyze teacher's consciousness for environment in high schools. In order to achieve this purpose, a method of questionaire was administered to obtain some information helping to investigate and analyze the next problems from the total of 455 high school teachers (distribute 480;94%) selected from 24 public and private high schools in 12 districts in Pusan city. There were some survey questions as follows, experience and knowledge of environmental education, necessity for environmental education, and the actual conditions of environmental education and teachers' consciousness. The results obtained to analyze the data based upon present study were as follows. 1) The results show that there are far more teachers not having the environmental education in past (72.3%) than ones having it (27.7%). Among those who have experience of environmental education, science teachers (41.9%) command an (overwhelming) majority. Most of them pointed out the teacher's workshop(33.3%) where they were educated. It is shown to have more relative importance to afford an opportunity of environment education. 86.5% of the responding teachers recognized helping of experience of having the environmental education in the past to educate students practically, 62.0% wanted a little more knowledge, because they recognize the need of the informations about environmental education. 2) 52.6% answered "normal" to the question of environmental problems of his residential district, secondary majority (28.1%) stated "serious" to the question. 3) 96.9% of high school teachers recognized the need of the systematic environmental education, 45.3% of them thought the environmental education do well to be included in curriculum for primary, middle and high schools. As the most suitable subject of environmental education in charge, 73.7% of teachers stated "Science", 50.1% gave their approval to a new establishment of independent subject, namely "environmental science". Teachers obtained most knowledge about environmental problems in newspaper of maganzines (45.8%). As for the most important materials for environmental education, video tapes got 73.2%. 4) Teachers having environmental education often lectured on the subject (82.5%) but, most of them have still taught current curriculum. 5) Most of them told that the role of teachers to change the students' attitude toward environment is very important (73.8%), and teachers in the high school showed deep interests(94.5%) in environmental problems. They also stressed the positive aid of government, specially the urgent need of reference books or audio-visual materials(53.2%) to carry out more effective environmental education under present inferior circumstance.