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이철진,김민정,안상준 대한임상건강증진학회 2020 Korean Journal of Health Promotion Vol.20 No.1
비만과 감염은 서로 상호작용하는 관계이다. 감염은 비만을 야기시키고, 비만은 감염의 발생 및 악화에 기여한다. 비만을 일으키는 감염원에는 아데노바이러스, 장내 바이러스등의 바이러스, 장내 미생물 등의 세균, 기생충이 포함되며이러한 미생물들의 변화를 초래하는 항생제도 영향을 미친다. 위의 위험인자들이 인체의 만성 염증 반응을 일으켜 비만을 유발시키고, 이와 더불어 나쁜 식생활 습관이 동반되면 비만이 더욱 가속화된다. 비만한 사람에서 잘 발생하고상태를 악화되는 감염으로는 인플루엔자바이러스, 코로나바이러스 등의 각종 바이러스 감염과 요로 감염이나 치주감염을 유발하는 세균 감염이 있으며, 기관지염, 폐렴 등의호흡기 감염, 원내 감염, 수술 부위의 감염이 있다. 비만에서감염이 동반되면 합병증을 증가시키고, 항생제와 백신의 효과를 떨어뜨린다. 비만과 감염 사이의 기전은 만성 염증 증가에 따른 면역력의 저하이다. 비만과 감염이 서로 원인과결과가 되며 상호작용을 한다는 근거에 따라 비만의 예방및 치료에도 이를 활용할 수 있겠다. 비만 백신의 개발과 건강한 장내 미생물 유지와 연관된 연구들이 진행되고 있어향후 비만 감소와 예방을 위한 효과가 기대된다. 결과적으로 비만이 줄게 되면 감염의 위험성과 악화를 줄일 수 있을 것이다. Obesity and infection are interacting with each other. Infection causes obesity, and obesity contributes to the occurrence and deterioration of infection. The sources of infection that cause obesity include viruses such as adenovirus, intestinal viruses, bacteria such as intestinal microbes, parasites, and the antibiotics that cause these microbes to change. The above risk factors cause chronic inflammatory reactions in the body, and in addition, obesity is further accelerated when bad eating habits are accompanied. Among the infections that occur often in obese people and worsen their condition are various viral infections such as influenza viruses and coronavirus, bacterial infections that cause urinary tract infections or periodontal infections, respiratory infections such as bronchitis, pneumonia, floor infections and infections in surgical areas. Infection in obesity increases complications, and reduces the effectiveness of antibiotics and vaccines. The mechanism between obesity and infection is a decrease in immunity resulting from increased chronic inflammation. Based on the evidence that obesity and infection cause and effect each other and interact with each other, it can be used for prevention and treatment of obesity. Studies related to the development of obesity vaccines and the maintenance of healthy intestinal microbes are under way, which is expected to reduce obesity and prevent future prevention. As a result, reducing obesity will reduce the risk and deterioration of infection.
Solution Structures and Molecular Interactions of Selective Melanocortin Receptor Antagonists
이철진,윤지혜,임승길,이원태 한국분자세포생물학회 2010 Molecules and cells Vol.30 No.6
The solution structures and inter-molecular interaction of the cyclic melanocortin antagonists SHU9119, JKC363,HS014, and HS024 with receptor molecules have been determined by NMR spectroscopy and molecular modeling. While SHU9119 is known as a nonselective antagonist,JKC363, HS014, and HS024 are selective for the melanocortin subtype-4 receptor (MC4R) involved in modulation of food intake. Data from NMR and molecular dynamics suggest that the conformation of the Trp9 sidechain in the three MC4R-selective antagonists is quite different from that of SHU9119. This result strongly supports the concept that the spatial orientation of the hydrophobic aromatic residue is more important for determining selectivity than the presence of a basic, ‘‘arginine-like’’ moiety responsible for biological activity. We propose that the conformation of hydrophobic residues of MCR antagonists is critical for receptor-specific selectivity.
관광호텔의 기능적 부대시설과 호텔이미지, 고객충성도 간 관계
이철진,홍정화 관광경영학회 2019 관광경영연구 Vol.93 No.-
The purpose of this study was to provide basic guidelines for the differentiation strategy of functional facilities according to the recent growth of the hotel culture. It was confirmed that the characteristics of various functional facilities contribute to the image formation and customers’ loyalty of the hotel. A wide variety of variables have been examined in the past literature. As a result, functional facilities were embodied as banquet and convention, shopping and duty free shop, casino and amusement facility, swimming pool and fitness center, shuttle bus and parking lot. A total of 246 samples were obtained from customers and potential customers who have recently used the hotel. The SPSS 25.0 and AMOS 22.0 were used to test the suitability of the sample, reliability and validity of the scale, and hypothesis test. The findings were as follows. First, the factors related to the cognitive perception of customers in the image formation of the hotel were found to be mainly caused by banquet and convention, swimming pool and fitness center, shuttle bus and parking lot. Second, the attractiveness of the swimming pool and fitness center was found to be significant in the emotional image of the customer about the hotel. Moreover, much research has been conducted on the emotional response of customer so importance of swimming pool and fitness facilities was explained when the emotional image response to the hotel. Lastly, building hotel image through functional facilities had a significant effect on customer loyalty, of which emotional image was significant. This study differed from previous studies since it has evaluated the importance of each facility in terms of building hotel image through functional facilities. However, major limitation of the study was not distinguished by hotels’ grade or operating characteristics and tourists’ segments.