국어교육과 학교도서관

이종록,Lee, Jong-Rok 한국도서관협회 1966 圖協月報 Vol.7 No.1

현호색(玄胡索)과 초초현호색(醋炒玄胡索)의 여드름균에 대한 항균효과 비교

이종록,박숙자,김영우,조일제,변성희,김상찬,Lee, Jong-Rok,Park, Sook-Jahr,Kim, Young-Woo,Cho, Il-Je,Byun, Sung-Hui,Kim, Sang-Chan 대한한방안이비인후피부과학회 2011 한방안이비인후피부과학회지 Vol.24 No.3

Objectives : Corydalis tuber has been used for promoting blood circulation and for relieving pain in Oriental medicine. In the present study, we focused on the antimicrobial activity of Corydalis tuber and compared its antimicrobial activity with the processed Corydalis tuber. Methods : Processing of Corydalis tuber was accomplished by immersing in 5% of acetic acid for 12 h and then by roasting at $250^{\circ}C$ for indicated time periods(0-30 min). Minimum inhibitory concentration(MIC) and the zone of growth inhibition were determined against Propionibacterium acnes(P. acnes). Results : The methanolic extracts of Corydalis tuber showed potent antimicrobial effect(MIC 62.5 ${\mu}g/ml$). Its alkaloidal component, dehydrocorydaline, also exhibited antibacterial activity(MIC 25.0 ${\mu}g/ml$). After processing of Corydalis tuber, its inhibitory effect on the growth of P. acnes was significantly enhanced compared with that of unprocessed Corydalis tuber. Furthermore, elevated content of dehydrocorydaline was found in the processed than the unprocessed Corydalis tuber. However, the different roasting minutes effected on antimicrobial activity. The best roasting time of Corydalis tuber was 10 min, while roasting for the time above 15 min resulted in diminishing antimicrobial activity. Thus, it was concluded that the standardized processing condition of Corydalis tuber should be established to obtain enhanced antimicrobial(P. acnes) activity. Conclusion : For antimicrobial effect against P. acnes, the best processing condition of Corydalis tuber is immersing in 5% of acetic acid for 12 h and by roasting at $250^{\circ}C$ for 10 min.

감초 지표성분 분석법 확립 및 liquiritigenin의 함량 증대를 위한 감초의 수치에 관한 연구

이종록,조미정,박상미,김상찬,박숙자,Lee, Jong-Rok,Jo, Mi-Jeong,Park, Sang-Mi,Kim, Sang-Chan,Park, Sook-Jahr 대한한의학방제학회 2010 大韓韓醫學方劑學會誌 Vol.18 No.1

Objective : Licorice has been used for treating digestive disorder and also recommended as a detoxification agent. Liquiritigenin, a component of licorice, has been reported to have various biological activities. In this study, we aimed to establish the analytical method for liquiritigenin content in licorice and the processing method for the enhancement of liquiritigenin content in licorice. Methods : Processing was accomplished by roasting licorice at $250^{\circ}C$ for indicated time periods (5-20 min). Analysis of liquiritigrnin from roasted licorice was conducted using UPLC(Ultra Performance Liquid Chromatography). Results : We established UPLC method for the analysis of liquiritigenin using water : acetonitrile gradient as mobile phase. Furthermore, we standardized the processing condition of licorice to enhance liquiritigenin content using UPLC method. Processing of licorice was accomplished by roasting at $250^{\circ}C$ for indicated time periods (5-20 min) and by pretreating with 50% of acetic acid or 30% ethanol for 24 h. By roasting licorice, the liquiritigenin contents in the licorice were increased. The best roasting time of licorice was 6 min, while roasting for the time above 8 min resulted in diminishing liquiritigenin contents. Moreover, pretreatment with 50% of acetic acid or 30% ethanol picked up liquiritigenin contents in roasted licorice. Conclusion : The adequate processing condition of licorice for the enhancement of liquiritigenin contents was obtained by pretreating licorice with 50% of acetic acid or 30% ethanol for 24 h and then by roasting at $250^{\circ}C$ for 6 min.

쑥갓 잎에서 터펜노이드계 화합물의 분리 및 동정

이경동 ( Kyung Bong Lee ),하태정 ( Tae Joung Ha ),이병원 ( Byong Won Lee ),이종록 ( Jong Rok Lee ),이준 ( Jun Lee ),황선우 ( Sun Woo Hwang ),조동령 ( Dong Young Cho ),남상해 ( Sang Hae Nam ),양민석 ( Min Suk Yang ) 한국응용생명화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.1

Three terpenoids were isolated from the leaves of Chrysanthemum coronarium L. by silica gel chromatography and recrystalization. The structure of compounds 1, 2, and 3, using various spectroscopic data, were identified as to be terpenoid derivatives of dihydrotulipinolide, loliolide, and 5α, 8α-peroxyergosterol, respectively. The presence of these 3 is the first time reported in this plant. The cytotoxic activity of 5α, 8α-peroxyergosterol showed strong activities against human cancer cell lines such as A549, PC-3, and HCT 116.

탈(脫)세속화시대와 기독교 보수주의

이종록(Jong Locke Lee) 한국종교학회 2005 宗敎硏究 Vol.39 No.-

연구논문 : 요시야의 개혁에서 드러나는 지지와 반대의 역학관계 -역대하 34:1-7을 중심으로-

이종록 ( Jong Lock Lee ) 한국종교학회 2008 宗敎硏究 Vol.51 No.-

구강미생물에 대한 고삼의 항균효과

이종록 ( Jong Rok Lee ),박숙자 ( Sook Jahr Park ),김상찬 ( Sang Chan Kim ) 대한본초학회 2010 大韓本草學會誌 Vol.25 No.2

Objectives: Sophorae Radix (SR), the dried root of Sophorae Flavescens Aiton, has been used to treat atherosclerosis, arrhythma and skin diseases including scabies and eczema. The present study was examined to evaluate antimicrobial activities of SR extracts against oral microorganism. Methods: Antimicrobial properties of SR extracts were determined by agar diffusion method and minimum inhibitory concentration (MIC) against Streptococcus mutans, Streptococcus sobrinus and Actinomyces viscosus. Analysis of kurarinone from SR extracts was conducted using UPLC (Ultra Performance Liquid Chromatography). Results: The ethanolic extracts of SR showed stronger antimicrobial effect than methanolic extracts, while the aqueous extracts of SR had no activity. In addition, the higher content of kurarinone was found in ethanolic extracts than methanolic extracts. The purified kurarinone from ethanolic extracts showed potent antimicrobial activity with the MIC value of 3.9~7.8㎍/㎖. Conclusion: An ethanolic extract of SR showed antimicrobial properties against several oral microorganisms, and kuranrinone contributed to antimicrobial action of SR. Thus, ethanolic extracts of SR or purified kurarinone should be beneficial for the preparation of the useful agent for treating oral disease including anticaries.

대두, 홍삼, 진피로 구성된 발효 추출물의 항염증 효능에 관한 연구

이종록 ( Jong Rok Lee ),김영우 ( Young Woo Kim ),변성희 ( Sung Hui Byun ),김상찬 ( Sang Chan Kim ),박숙자 ( Sook Jahr Park ) 대한본초학회 2015 大韓本草學會誌 Vol.30 No.5

Objectives: Fermentation of herbs has been known to be helpful in improving the immune systems and protecting body against disease. The present study was conducted to evaluate anti-inflammatory effects of the fermentation extracts (FE) consisting of soybean, red ginseng and Citrus Unshiu Peel in lipopolysaccharide (LPS) -activated Raw264.7 cells. Methods: FE were prepared by the fermentation with Bacillus Subtilis and then by extraction with ethanol (95%; prepared by the fermentation process). Cell viability was measured by MTT assay. Nitric oxide (NO) production was measured in culture media by Griess assay. The expression of nuclear factor (NF)-κB and inhibitory kappa B alpha (IκBα) was determined by Western blot. Results: LPS-induced production of NO and PGE2 was dose-dependently decreased by the treatment of FE in Raw264.7 cells. These suppressive effects of FE on NO and PGE2 production were related to the inhibition of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression. FE inhibited LPS-induced production of pro-inflammatory cytokines, TNF-α, IL-6, and IL-1β in a dose-dependent manner. Furthermore, FE inhibited the NF-κB signaling pathway through the prevention of LPS-induced degradation of IκBα in cytosol and the nuclear translocation of NF-κB. Conclusions: These findings suggest that FE could have anti-inflammatory effects on LPS-induced inflammatory responses in macrophages.

공포극과 예언

이종록(Lee, Jong-Lock) 한국종교학회 2010 宗敎硏究 Vol.59 No.-

This thesis is to study on horror by the divine vision in chapter 1 verses 15-21 of the book of Ezekiel. God addresses his will and plan for the future of Israel to his prophets by showing the scenes that will occur sooner or later as the form of play. God makes a plan of that play and directs it as a producer of play. Ezekiel experienced the divine vision by the form of play and the content of that play is very fearful. The horror by the divine vision appears more definitely in chapter 9. Therefore we call it the horror play. I consult the art theory of Martin Heidegger and other philosophers in order to clarify the meaning of the prophecy as horror play. Ezekiel might be seized with the panic by seeing that horror play directed by God in chapter 1 and chapter 9. Then, it is very problematic that the horror play in chapter 1 and chapter 9 of the book of Ezekiel is not the simple play. The play God plans and directs will be reproduced really in the life of the Israelites and the tragedy of that play will actually occur without fail. Therefore, readers of the book of Ezekiel cannot do anything but being frightened. The fear is amplified more and more during reading and imagining the tragic scenes. Horror play should give dread to spectators. And because fear has strong contagiousness, it is easily spreaded and amplified. But the horror play God plans and directs makes only one person, Ezekiel, horrified and does not make fear spread at all. The content of that play is the divine judgment for the Israelites but the Israelites are unconcerned with that play and does not feel any fear. They are not afraid of their tragic future by the divine judgment. Then, it is very strange that God does not intend that effect on them and even does not want it. God calls them the rebellious people and he thinks that they have no chance to be redeemed from the tragic judgment. And God never shows any pity to them. He will judge them without any mercy as the cruel scene in the book of Ezekiel. Thus, the divine play becomes the real horror play in their lives than any other plays.

산화스트레스를 유발한 위 상피세포에서 수치 치자의 세포 보호 효과

이종록 ( Jong Rok Lee ),김상찬 ( Sang Chan Kim ),박숙자 ( Sook Jahr Park ) 대한본초학회 2023 大韓本草學會誌 Vol.38 No.1

Objective : Gardeniae Fructus (GF) has bitter and cold nature. Thus, it has been traditionally prescribed in processed form roasted with ginger juice for patients with a weak stomach. This study investigated the effects of processed GF in tert-butyl hydroperoxide (tBHP)-treated gastric epithelial cells. Methods : Processed GF was made by applying 40% ginger juice or 10% ethanol for 24 h and then roasting at 150℃ for 5 minutes. Apoptosis was determined by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Mitochondrial membrane potential (MMP) was monitored by flow cytometry using the membrane permeable fluorescent dye Rh123. Protein expression was measured by Western blot analysis. Results : Cell viability was reduced by tBHP and restored by ethanol extract of GF (GFE). In the TUNEL assay, it was found that cell death by tBHP was due to apoptosis, and GFE had an anti-apoptotic effect. Processed GF roasted with ginger juice showed the best anti-apoptotic effect. Processed GF also inhibited MMP loss and restored tBHPinduced changes in expression levels of apoptosis-related proteins. Increased ROS production and GSH depletion after tBHP treatment were significantly reduced by processed GF. In addition, tBHP-induced activation of mitogen-activated protein kinase (MAPK) was inhibited by processed GF. Conclusion : These results demonstrate that the processed GF is able to protect gastric epithelial cells from oxidative stress-induced cell death with antiapoptotic and antioxidant activity. In addition, it shows that the processing of GF, which have been traditionally used for gastrointestinal protection, partially have scientific validity.