신경세포 이주장애의 발작 양상 및 뇌파 소견과의 상관관계에 대한 연구

김영준(Yooung Jun Kim),김규영(Kyu Young Kim),손동우(Dong Woo Kim),박경희(Kyung Hee Park),김기중(Ki Joong Kim),황용승(Yong Seung Hwang) 대한소아신경학회 1997 대한소아신경학회지 Vol.5 No.1

목적 : 대뇌신경세포의 발달과 이주 및 조직화 과정의 이상으로 발생하는 신경세포 이주장애는 형태학적으로 활택뇌증, 피질이형성증, 회색질이소증, 열두기형 그리고 반구거대뇌증 등으로 나눌 수 있다. 최근 신경세포 이주장애는 소아에 있어서 신경학적 이상의 중요한 원인중의 하나로 알려지고 있으나, 동반될 수 있는 간질성 발작에 관한 연구는 아직 부족한 실저이다. 이에 저자는 신경세포 이주장애를 가진 환아에서 형태졀로 간질 발작의 임상적 양상을 알아보고 뇌파 소견의 특성 및 뇌자기공명 영상상의 병변과의 상관관계를 알아보고자 본 연구를 시작하였다. 방법 : 1990년 1월부터 1996년 8월까지 서울대학교 어린이병원 소아과를 방문하여 뇌 자기공명영상상 신경세포 이주장애로 진단된 환아 중 간질발작의 증상을 가진 60명의 환아를 대상으로 병력지 고찰을 통해 상기 5가지 형태학적 분류에 따른 간질 발작의 임상적 양상과 뇌파 소견의 특성 및 병변과의 관계를 비교 분석하였다. 결과: 1) 간질발작의 발현시기는 신경세포 이주장애의 형태에 따라 유의한 차이를 보였는데, 활택뇌증, 반구거대뇌증 그리고 피질이형성증에서 다른 형태의 장애군에서보다 빨랐다(P<0.05). 2) 영아연축을 포함한 전신 발작이 모든 형태의 군에서 주된 발작의 형태였고, 부분발작은 국소성피질이형성증과 회색질이소증 그리고 열두기형에서 상대적으로 높은 빈도를 보였다. 3) 뇌파검사가 시행된 55례중에서 자기공명 영상상 병변으로 보이는 부위를 중심으로 간질파와 배경활동이상이 관찰된 경우는 각각 28례와 25례였고, 정상으로 보이는 부위에서 간질파와 배경활동의 이상소견이 보인 경우는 각각 14례와 8례였으며, 나머지에서는 뇌파검사상 이상소견이 관찰되지 않았다. 4) 추적관찰을 받은 환아 48례중에서 6개월 이상 간질발작이 조절되었던 경우는 35례였으며, 항경련제의 치료효과는 신경세포 이주장애의 각 형태군에서 차이를 보이지는 않았다. 결론: 본 연구를 통하여 신경세포 이주장애의 형태학적 분류에 따른 간질발작의 발현시기 및 발작의 임상적 형태가 다소 차이가 있음을 알 수 있었고, 일부 진단적 가치를 가진 뇌파소견에 대하여 관심을 가질 수 있게 되었다. 뇌파검사상 이상 뇌파 소견과 자기공명 영상상 병변의 분포와 범위를 비교 분석한 연구의 결과들은 향후 수술을 포함한 간질발작의 치료방침을 결정하는데 도움을 줄 것으로 기대되는 바이다. Purpose: Neuronal migration disorder(NMD) is a heterogeneous disorder of the development and organization of cerebral cortex with a variety of subtypes including lissencephaly, cortical dysplasia, heterotopias, schizencephaly, and hemimegalencephaly. NMD is becoming increasingly recognized as a cause of neurologic abnormalities in children, but the informations about the epileptic seizures in this disorder are not fully available yet. So the author reviewed the clinical, electroencephalography(EEG) and magnetic resonance imaging(MRI) features in patients with NMD Methods : The study group is composed of 60 patients who had epileptic seizures and diagnosed as NMD by magnetic resonance imaging at Seoul National University children’s Hospital Neurology Clinic from Jan. 1990 to Aug. 1996. The findings were analyzed and compared according to the 5 subtypes of the disorder. Results : Clinical epileptic seizures began significantly earlier in the patients with lissencephaly, hemimeglencephaly and cortical dysplasia than in the patients with schizencephaly and heterotopias at the mean age of onset : 1.0, 1.4 and 2.2 yr versus 3.5, 4.8 yr, respectively. Generalized seizure including infantile spasm was a major clinical seizure type at first seizures in all subtypes and partial seizures were observed relatively often in focal cortical dysplasia, heterotopias and schizencephaly comparing with lissencephaly and hemimegalencephaly. The location and extent of abnormal findings on interictal scalp EEG were not exactly correlated to those of the lesion defined by MRI. Among 55 cases of EEG examination, epileptiform discharges and background activity abnormalities were observed in the area of the lesion in 28 and 25 cases, in the area remote from the lesion in 14 and 8 cases respectively, and the remainders did not show any abnormalities. Clinical seizures were well controlled by conventional antiepileptic drugs for more than 6 months in 35 out of 48 patients whose follow-up durations were at least 1 year. Conclusion : This study showed that the types and the ages of the first seizures varies according to the subtypes of NMD; the epileptic seizures were not so intractable; the EEG abnormalities were not confined to the area of the lesion on MRI. The latter observations seem to provide some clues to the further investigation of the epileptogenesis and the determination of the treatment plan for the epileptic seizures in NMD including surgery.

진통산(痛散)이 흰쥐의 adjuvant 유발 관절염 및 척수내 C-fos 발현에 미치는 영향

손동우 ( Dong Woo Son ),김순중 ( Sun Jung Kim ),서일복 ( Il Bok Seo ) 한방재활의학과학회 2005 한방재활의학과학회지 Vol.15 No.3

Objectives : This study was carried out to investigated the anti-pathogenetic and curative effects of Jintong-san(Chentong-san) on Complete Freund`s Adjuvant(CFA) induced arthritis in rats. Methods : In experiment, Thirty male rats were divided into non-treated normal group(n=12), control group(n=12) is distilled water treated for 15 days after onset of arthritis by CFA, treated group(n=6) is Jintong-san(Chentong-san) treated for 15 days after onset of arthritis by CFA. Body weight, paw edema volume, and thickness of ankle joint were measured at 0, 5, 10, 15 days after treatment. At 15 days after treatment, IL-1β, IL-6 and PGE2 level in Paw Exudate were analysed for anti-inflammatory effect, C-fos immunoreactive cells measurement for analgesic effect, and histopathological examination was performed on the ankle joint. Results : Paw edema volume, thickness of ankle joint, IL-1β, IL-6, PGE2, C-fos immunoreactive cells number of treated group was significantly decreased compared with control group and histopathologically, destructive lesions of articular cartilage and subchondral bony tissue, and degree of fibrous ankylosis in treated group were alleviated compared with those of control group. Conclusions : These results indicated that Jintong-san(Chentong-san) has inhibitory effects on the progression of CFA arthritis in rats, by it`s lowering effects on the secretion of IL-1β, IL-6 and PGE2, and analgesic effect by C-fos immunoreactive cells decrease.

인공지능을 이용한 클라이밍 홀드 인식 모델 및 객체화 시스템

손동우(Sohn, Dong Woo),김건우(Kim, Gonu),양경모(Yang, Kyeong Mo),곽재경(Kwak, Jae Kyung) 한국IT서비스학회 2020 한국IT서비스학회 학술대회 논문집 Vol.2020 No.-

스크린 클라이밍 시스템에 있어서 인공암벽에 부착된 홀드의 형태와 위치 데이터는 다양한 정보로 활용되지만 사람이 수작업 으로 계산하기에는 어려움이 따른다. 홀드의 형태가 각기 다르며, 인공암벽에 부착된 홀드의 수가 보 통 수백 개 이상 되기 때문이다. 따라서 제안하는 인식 기술을 통하여 자동으로 홀드의 형태와 위치 데이터를 계산할 수 있게 한다. 홀드의 형태는 스네이크 알고리즘으로 윤곽선을 추출해 인식하며, 홀 드의 위치는 추출된 윤곽 데이터의 무게중심 점을 계산하여 인식한다. 본 논문에서는 인공암벽에 부착된 홀드의 형태 및 위치인식 시스템을 제안한다.

응급실로 내원하는 급성중독환자의 원인물질 분석을 위한 중독 분석실 이용 현황 및 이용 만족도 조사: 전국 권역 및 지역응급의료센터 설문조사

손동우 ( Dong Woo Son ),강지훈 ( Ji Hun Kang ),김양원 ( Yang Weon Kim ),박철호 ( Chul Ho Park ),윤유상 ( Yoo Sang Yoon ),지재구 ( Jae Gu Ji ) 대한임상독성학회 2021 대한임상독성학회지 Vol.19 No.2

Purpose: The purpose of this study is to find out the current status of toxicology laboratory operated by six locations nationwide and to investigate the satisfaction of emergency medical professionals who working at local and regional emergency medical centers. Methods: This survey was conducted prospective. It was conducted on 665 emergency medical professionals working at regional and regional emergency medical centers across the South Korea. Among them, the analysis was conducted with data that 510 emergency medical professionals who respond to this survey. The questionnaire was conducted on an online basis for a month. To ensure statistical significance, consider a dropout rate of 10% based on a minimum response recovery rate of 70%. 506 people were selected for the survey. Results: According to a survey on the status of addiction analysis room usage, the average monthly usage of addiction test rooms among respondents were 406 cases.71.0 cases (17.4%) of toxicology laboratory in Seoul and 71 cases (17.4%) in Gwangju. 32 cases (7.8%), 118 cases (29.0%) requested by toxicology laboratory in Busan, and the toxicology laboratory in Daegu. Eighty two cases (20.1%), Daejeon area 25 cases (6.1%), Wonju area toxicology laboratory was 78 (19.6%). According to a survey on the satisfaction of the addiction analysis room,Seoul (4.9±2.71) and Gwangju (4.8±2.52) showed high satisfaction. Conclusion: Due to the limited operation time of the four addiction analysis rooms currently in operation, the satisfaction level of addiction analysis by emergency medical professionals in the area is low due to the delay until the result is notified.

산전 진단된 폐외분리증 2예

김현영,손동우,김석영,김지은,하승연,Kim, Hyun-Young,Son, Dong-Woo,Kim, Seok-Yong,Kim, Jee-Eun,Ha, Seung-Yeon 대한소아외과학회 2009 소아외과 Vol.15 No.2

Congenital thoracic malformations such as intra- and extra-pulmonary sequestration, cystic adenomatoid malformation, congenital pulmonary airway malformation, malinosculation, bronchogenic cyst, reduplication cyst, and foregut cyst are frequently detected on routine prenatal ultrasound. There are some controversies about treatment for postnatally persistent pulmonary sequestration. Some authors recommend expectant long term follow up but most authors advocate elective surgical excision because of complication such as respiratory distress, infection, intrathoracic bleeding, haemoptysis, cardiac failure, and potential risk of malignancy. We experienced 2 cases of prenatally diagnosed extrapulmonary sequestration which were located in the subdiaphragmatic retroperitoneum. Resections were performed at 2 months and 4 months of age using intraabdominal approach. There were no complications. In conclusion, if the prenatally diagnosed extrapulmonary sequestration remained postnatally, early operation might reduce morbidity related to extrapulmonary sequestration and parental anxiety without any postoperative complication.

난소종양으로 수술한 환자의 임상 조직학적 양상 및 수술 전 CA 125의 의미

김창래 ( Chang Rae Kim ),구천회 ( Chun Hoe Ku ),전인상 ( In Sang Jeon ),손동우 ( Dong Woo Son ),이지성 ( Ji Sung Lee ) 대한폐경학회 2013 대한폐경학회지 Vol.19 No.1

Objectives: The aim of this study is to confirm the clinical and histopathologic findings of ovarian tumors and determine the malignancy before operation. It will attribute to early diagnosis, determining direction of treatment and improving prognosis of malignant ovarian tumor. Methods: Seven hundred sixty-five patients who had an operation for ovarian tumors in the department of Obstetrics and Gynecology of Gachon University Gil Medical Center from April 2007 to December 2009 were enrolled as subjects. A retrospective analysis of age, parity, menopausal status, preoperative CA 125, histology, ultrasound, and treatment method was done. Results: 1. Among benign ovarian tumors, endometrial cyst (211 cases, 30.1%) was most common and had the highest preoperative CA 125 (76.07 U/mL). 2. Among borderline ovarian tumors, mucinous type (16 cases, 62.5%) was most common, but preoperative CA 125 was higher in serous type (144.38 U/mL) than mucinous type (82.59 U/mL). 3. Among malignant ovarian tumors, serous adenocarcinoma (14 cases, 29.8%) was most common, and undifferentiated carcinoma had the highest preoperative CA 125 (500.0 U/mL). 4. The preoperative CA 125 showed a tendency to increase in relation to stage in malignant ovarian tumors. 5. Age, preoperative CA 125, menopausal status and ultrasound finding were identified as discriminating factors for malignancy and relative risk of them were 7.19, 7.90, 5.56 and 61.43, respectively. Conclusion: Using the combination of age, menopausal status, preoperative CA 125 and ultrasound to diagnose ovarian tumors before the operation will be a help to early diagnosis and determining the treatment and improve prognosis. (J Korean Soc Menopause 2013;19:26-35)

후두기관지폐렴으로 진단된 소아 환자들의 임상 양상과 원인: 크룹 환아와의 비교

김은진 ( Eun Jin Kim ),남혜나 ( Hyena Nam ),선용한 ( Yong Han Sun ),차한 ( Hann Tchah ),류일 ( Eell Ryoo ),조혜경 ( Hye Kyung Cho ),조혜정 ( Hye Jung Cho ),손동우 ( Dong Woo Son ) 대한천식알레르기학회(구 대한알레르기학회) 2017 Allergy Asthma & Respiratory Disease Vol.5 No.5

Purpose: Croup, a common childhood respiratory illness with various severities, has many unanswered questions. Laryngotracheo-bronchopneumonitis (LTBP) is a disease entity considered to be an extension of croup to the lower respiratory tract. The object of this study was to compare epidemiology, clinical characteristics, and viral etiologic spectrum between croup and LTBP. Methods: Patients hospitalized with croup at Gachon University Gil Hospital from January 2010 to April 2016 were recruited. LTBP was defined as pneumonia confirmed on radiographs of patients with croup. Clinical findings and demographic data were re-viewed of patients whose nasopharyngeal swabs were done for viral analysis. Results: A total of 371 patients with only croup and 63 patients with LTBP were included. Croup was found to be significantly associ-ated with parainfluenza virus type 1 (P=0.006). LTBP was related to parainfluenza virus type 3, respiratory syncytial virus, and hu-man bocavirus (P=0.001, P=0.030, and P=0.019, respectively). The duration of fever was longer in patients with LTBP than in those with croup (3.87±1.85 days vs. 2.86±1.80 days, P<0.001). Conclusion: Specific etiologic viruses might be associated with the progression from croup to LTBP. Pronged fever is also associated with progression from croup to LTBP. (Allergy Asthma Respir Dis 2017;5:274-279)

인천 지역에서 급성 세기관지염의 치료 실태

김정선 ( Jung Sun Kim ),인두교 ( Doo Kyo In ),선용한 ( Yong Han Sun ),홍희주 ( Hee Joo Hong ),조강호 ( Kang Ho Cho ),손동우 ( Dong Woo Son ),전인상 ( In Sang Jeon ),차한 ( Hann Tchah ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2006 소아알레르기 및 호흡기학회지 Vol.16 No.2

목 적 : 급성 세기관지염은 영아기에 가장 흔한 하기도 감염이지만 치료에 있어 임상적 효과가 있다고 확실하게 입증된 약물 요법이 없다. 본 조사를 통해 인천 지역에서 소아과 의사의 급성 세기관지염에 대한 치료 실태를 알아보고자 하였다. 외국과 국내의 결과를 비교 분석하여 국내의 치료 실태를 알아보고자 하였다. 방 법 : 인천의 소아과 전문의를 대상으로 설문지를 통해 급성 세기관지염의 치료에서 약제 사용을 빈도에 따라 조사하였다. 결 과 : 전체 131명 중 80명(61%)으로부터 설문지를 회수하였다. 흡입 기관지 확장제는 90%가 사용하고 있었으며, 41%는 항상, 43%는 간헐적으로 사용하고 있었다. 스테로이드는 93%에서 사용되고 있었으며, 65%는 간헐적으로, 23%는 항상 사용하고 있었다. 타국가 비교시, 약물 요법을 진료 지침이 시행되고 있는 호주에 비해서 많이, 그렇지 않은 스위스에 비해서 비슷하게 사용하는 경향을 보였다. 결 론 : 인천 지역 소아과 의사는 급성 세기관지염 치료에 약물 요법을 많이 사용하고 있었다. 최근에 전세계적으로 비용과 효과를 고려하여 급성 세기관지염에서 약물 요법의 사용을 줄이려는 노력이 있는데 국내의 치료 실태를 파악하여 향후 긍정적인 방향으로 변화하는데 도움이 되고자 하였다. Purpose : Although acute bronchiolitis is the most common lower respiratory tract infection in the first year of life, the use of pharmaceutical agents has been debated. The purpose of this study was to examine the current management practice of acute bronchiolitis by pediatricians in Incheon and to compare this with management internationally. Methods : We sent postal questionnaires to all pediatricians in Incheon to assess their current practice for treating acute bronchiolitis. We analyzed the frequency of bronchodilators, steroids, xanthines use. These results were compared with international management. Results : Of a total 131 questionnaires, 80(61 percent) were returned. Ninety percent of pediatricians used bronchodilator inhalation, either routinely(41 percent) or occasionally(43 percent). Steroid were used by 93 percent of the respondents, always(23 percent) or sometimes (65 percent). Pediatricians in Incheon tended to use pharmaceutical agents more frequently than Australian pediatricians who have consensus guidelines for the management of acute bronchiolitis, and as frequently as Swiss pediatricians who do not. Conclusion : Pharmaceutical agents are frequently used in the management of acute bronchiolitis by pediatricians in Incheon. Better therapeutic approaches are needed for bronchiolitis care. [Pediatr Allergy Respir Dis(Korea) 2006;16:150-161]

증례 : 감연된 두혈종 1례의 증례에 대한 문헌 고찰로 조사한 천자적응증

이현미 ( Hyun Mi Lee ),손동우 ( Dong Woo Son ),김규영 ( Kyu Young Kim ) 대한주산의학회 1998 大韓周産醫學會雜誌 Vol.9 No.1

태아 모체간 대량수혈의 임상적 고찰

김혜경 ( Hea Kyoung Kim ),최문영 ( Moon Young Choi ),윤혜선 ( Hye Sun Yoon ),윤보영 ( Bo Young Yun ),배선환 ( Sun Whan Bae ),손동우 ( Dong Woo Son ) 대한주산의학회 2001 大韓周産醫學會雜誌 Vol.12 No.3