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1996년도 제35차 대한소화기학회 추계학술대회 / 일반연제 : 위장관 ; 비궤양성소화불량환자에서 위배출시간지연과 자율신경기능실조의 임상적 의의
박수헌,김진일,나종순,채현석,김재광,한준열,최규용,정인식,정규원,선희식,박두호,손형선 ( Soo Heon Park,Jin Il Kim,Jon Soon Na,Hiun Suk Chae,Jae Kwang Kim,Jun Yul Han,Kyu Yong Choi,In Sik Chung,Kyu Won Chung,Hee Sik Sun,Doo Ho Park,Hyung Su 대한소화기학회 1996 대한소화기학회지 Vol.28 No.1
박수헌(Soo Heon Park),최명규(Myung Gyu Choi),조세현(Se Hyun Cho),한준열(Jun Yeul Han),최규용(Gyu Yong Choi),정인식(In Sik Chung),정규원(Kyu Won Chung),선희식(Hee Sik Sun),김부성(Boo Sung Kim),강창석(Chang Suck Kang) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.1
A 34-year old female was admitted to St. Mary Hospital because of indigestion. E,ndoscopy showed cobble stone appearance of gastric mucosa on the antrum. Computed tomography showed normal gastric wall thickness and no evidence of lymph node enlargement. Upper gastrointestinal barium study showed poorly defined granular depressed lesion on the antrum. Gastric mucosectomy specimen showed centrocyte-like cells of small lymphocytes, collection of lymphocytes infiltrating and partially destroying isolated glands(lymphoepithelial lesion). After the gastric resection, she was diagnosed as a malignant lymphoma of mucosa-associated lymphoid tissue(MALTOMA) with submucosal infiltration. In analogy to the early gastric cancer, early gastric lymphoma is defined as a tumor with a maximum depth of infiltration extending into the submucosa. After chernotherapy with a regimen of cyclophosphamide, vincrisiine, adriamycin, bleomycin, H-lone, procabazine, she was discharged with complete remission. Hence we present a case of MALT-lymphoma wilh literature. (Korean J Gastroenterol 1996;28: 111 - 117)
한국의 헬리코박터 유병률 개선에 따른 소화기질환의 변화
박수헌 ( Soo Heon Park ) 대한소화기학회 2015 대한소화기학회지 Vol.65 No.4
Helicobacter pylori can cause variety of upper gastrointestinal disorders such as peptic ulcer, mucosa associated lymphoid tissue (MALT)-lymphoma, and gastric cancer. The prevalence of H. pylori infection has significantly decreased in Korea since 1998 owing to active eradication of H. pylori. Along with its decrease, the prevalence of peptic ulcer has also decreased. However, the mean age of gastric ulcer increased and this is considered to be due to increase in NSAID prescription. Gastric cancer is one of the leading causes of cancer deaths in Korea and Japan, and IARC/WHO has classified H. pylori as class one carcinogen of gastric cancer. Despite the decreasing prevalence of H. pylori infection, the total number of gastric cancer in Korea has continuously increased from 2006 to 2011. Nevertheless, the 5 year survival rate of gastric cancer patients significantly increased from 42.8% in 1993 to 67% in 2010. This increase in survival rate seems to be mainly due to early detection of gastric cancer and endoscopic mucosal dissection treatment. Based on these findings, the prevalence of peptic ulcer is expected to decrease even more with H. pylori eradication therapy and NSAID will become the main cause of peptic ulcer. Although the prevalence of gastric cancer has not changed along with decreased the prevalence of H. pylori, gastric cancer is expected to decrease in the long run with the help of eradication therapy and endoscopic treatment of precancerous lesions. (Korean J Gastroenterol 2015;65:199-204)
한국인에서 Helicobacter pylori 중복 감염의 검출
박수헌(Soo Heon Park),최명규(Myung Gyu Choi),김재광(Jae Kwang Kim),정인식(In Sik Chung),선희식(Hee Sik Sun),박두호(Doo Ho Park),김병욱(Byung Wook Kim),이학성(Hak Sung Lee),최황(Hwang Choi),최규용(Kyu Yong Choi),이인석(In Seok Lee),한 대한소화기학회 2001 대한소화기학회지 Vol.38 No.6
Background/Aims: The aim of this study was to determine intra-variation of Helicobacter pylori (H. pylori) strains of each patient and to investigate the affection of multiple strains of H. pylori infection to the disease outcome in Korea. Methods: Thirty patients who were H. pylori-positive and had gastritis (n=10), duodenal ulcer (n=10) and gastric adenocarcinoma (n=10) were included in this study. Their disease were confirmed endoscopically and histologically. Their H. pylori were cultured. Five H. pylori colonies were picked randomly from the primary cultures. Using primer 1254, random amplified polymorphic DNA fingerprinting (RAPD) analysis was carried out. Restriction fragment length polymorphism (RFLP) patterns for the subtypes of ureC, cagA, and vacA were also investigated. Results: RAPD method confirmed that four of gastritis patients (40%), four of duodenal ulcer patients (40%), and five of gastric adenocarcinoma patients (50%) were infected with multiple strains of H. pylori. The intra-variation of RFLP patterns for the subtypes of ureC, cagA, and vacA were detected in the three groups. Conclusions: Multiple strains of H. pylori and the subtypes of cagA and vacA may not affect the outcome of the gastrointestinal disease. (Korean J gastroenterol 2001;38:411-418)
‘부대 속의 감자’ 또는 ‘혁명의 코러스’ : 마르크스의 농민관 재고찰
박수헌(Soo-Heon Park) 한국슬라브유라시아학회 2009 슬라브학보 Vol.24 No.3
Peasants cannot play an important role in Marx' general theory of capitalist development. They are doomed to disappear as a transitional intermediate class with the growth of the two major classes, capitalists and proletarians. However, the continued existence of the peasant class and the weakness of the workers' movements in Europe in the 19th century raised new questions that had not been dealt with in his general theories in appropriate way. Can the peasants be revolutionary during the period of their “transitional” existence? Is an alliance of the working class with the peasants possible against other “counter-revolutionary” forces? With regard to these serious issues in the development of theories and practices of socialism, Marx finds a strong revolutionary potential of the peasant class in his analysis of the revolutionary situations in the mid-19th century Germany and France. The peasants could contribute to the cause of the working class in allying with the latter, first, against the feudal landlords in making bourgeois revolutions, and then against the bourgeoisie in preparation for socialist revolutions. They could also be very instrumental in the proletariat's seizure of power and its maintenance. Despite this recognition of the revolutionary potential of the peasant class, however, the teleological implications in Marx's theory of historical development imposed certain basic restrictions in his evaluation of the nature and role of the peasantry. The peasants were understood by Marx as being able to be revolutionary from the viewpoint of their imminent transformation into the proletariat and as being led by the progressive force of the working class in the revolutionary situations. In other words, even though Marx saw a high degree of revolutionary potential in the peasants, the latter were approached by him not on the basis of a social composition equipped with its own developmental dynamics but from the ultimate standpoint of his historical materialism.
Omeprazole 투여시 위산분비 억제능에 대한 CYP2C19 의 영향
박수헌(Soo Heon Park),김종원(Jong Won Kim),이수연(Soo Youn Lee),최명규(Myung Gyu Choi),김재광(Jae Kwang Kim),정인식(In Sik Chung),정규원(Gyu Won Chung),선희식(Hee Sik Sun),박두호(Doo Ho Park) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.6
Background/Aims: CYP2C19 has an important role in the catabolism of several proton pump inhibitors. However, the relative contribution of CYP2C19-mediated metabolism varies among the different proton pump inhibitors. We investigate to determine the effect of CYP2C19 genotype status on intragastric pH during dosing with omeprazole. Methods: The subjects were 16 healthy volunteers. Their CYP2C19 genotype status was determined by a polymerase chain reaction-restriction fragment length polymorphism method. Twenty-four-hour monitoring of intragastric acidity were performed on the day without medication and day 4 after omeprazole administration. Results: A single dose of omeprazole significantly decreased 24 hour intragastric acidity (1.7±0.3 vs. 5.1±0.4). Subjects were divided into three groups on the basis of their CYP2C19 genotype status: homozygous extensive metabolizers (Ho-EMs, n=5), heterozygous extensive metabolizers (Ht-EMs, n=6), and poor metabolizers (PMs, n=5). Median 24 hour intragastric pH in the Ho-EM group was 3.1 compared with 5.5 in Ht-EM group and 5.9 in PM group(P<0.05). The median pH during omeprazole administration was influenced by CYP2C19 genotype. On the other hand, the Helicobacter pylori infection did not influence the median intragastric pH during omeprazole administration (p= NS). Conclusions: The effects of omeprazole on intragastric acidity is influenced by the CYP2C19 polymorphism. (Korean J Gastroenterol 2001;38:399-404)
박수헌(Soo Heon Park),박선숙(Sun Sook Park),최명규(Myung Gyu Choi),조세현(Se Hyun Cho),한준열(Jun Yeul Han),최규용(Gyu Yong Choi),정인식(In Shik Chung),선희식(Hee Sik Sun),김부성(Boo Sung Kim),강창석(Chang Suck Kang) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.2
A 58-year old man was admitted to our hospital because of right upper quadrant pain and tingling sensation of both wrists. On physical examination, liver was palpable below thie low costal margin at the right mid-clavicular line. Liver biopsy and gastric mucosal biopsy clemonstrated amyloid deposition. EMG showed the denervated pattern in both median nerves and partial muscular atrophy. On his hospital day, his renal function deteriorated with gastrocolic symptoms. Hemodialysis was initiated. But the patient's condition was not recovered and he died l week after initiation of hemodialysis. Hence, we reported a case of gastrointestinal amyloidosis with carpal tunnel syndrome with the literature. (Korean J Gastroenterol 1995;28: 286 - 291)
박수헌(Park Soo-Heon) 한국정치학회 1996 한국정치학회보 Vol.29 No.4
신생 러시아의 정당정치는 정치적 다원주의화, 시장경제화, 국가 재건설, 민족 정체성의 재규정 등을 포괄하는 구 소련체제로부터의 복합적인 이행과정 속에서 독특한 양태를 보이며 펼쳐지고 있다. 구 소련 말기에서 공산당 권력독점의 일당 체제의 붕괴를 거친 뒤 일종의 다당제 형태로 진행되고 있는 러시아의 정당정치는 93년 12월과 95년 12월의 두차례 총선을 거치면서 기본 윤곽이 잡혀가고 있다. 신속한 시장경제화와 다원주의를 주장하는 자유주의 개혁세력, 이에 맞서 사회주의 요소와 국가ㆍ민족 보전을 강조하는 좌파 및 민족주의 보수 반대파, 그리고 사회보호정책을 동반하는 완만한 변화를 지지하는 중도세력의 삼각구도가 형성되었다가, 우파 개혁세력의 약화, 좌파 반대세력의 강화, 정권 외부의 중도세력의 현저한 퇴조 및 친정부적 정치집단의 등장과 함께 정당정치의 전반적 내용에 상당한 변화가 일어나고 있다. 그러나 이와같이 전개되고 있는 러시아의 정당정치는 서구의 경험에 입각한 고전적, 근대적 정당정치의 관점에서 볼 때, 정당의 조직, 프로그램, 사회적 기반, 사회ㆍ정치적 영향력 등에 있어서 아직까지 상당히 미흡한 단계에 머물러 있다. 그 이유로는 유명인사를 중심으로 한 정당의 이합집산, 조직ㆍ기율의 미비, 높은 수준의 사회 유동성과 시민사회의 미성숙에 따른 사회세력과의 제도적 연계 부족, 정치 엘리트의 권위주의적인 통치행태와 권력집중적 통치구조, 선거제도의 문제점, 가부장적이고 집단주의적인 정치문화 성향 등을 꼽을수 있다. 이처럼 러시아 정당정치는 탈공산주의라는 러시아 특유의 상황에서 비롯되는 불안정한 다당정치의 보습을 보이고 있으며, 앞으로 근대적 정당정치로의 발전과 관련해 낙관적으로 보는 견해와 다소 비관적인 시각이 공존하고 있다. 지금까지의 전개내용으로는 부정적 요소가 더 부각되고 있으나, 역사적 초유의 경험이 이제 겨우 4-5년 지난 시점에서 이는 당연한 현상인지도 모른다. 또 70여년의 소련체제를 겪은 후의 복합적 체제 전환이라는 독특한 맥락에서 기존의 서구 정당정치와 다른 양태의 정당정치가 발전될 가능성도 절대적으로 부정할 수 만은 없다.