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실험실적 간질환에 있어서 P450 2El의 Molecular Regulation
박선미,박은전,고건일,손동환 圓光大學校 藥品硏究所 1993 藥品硏究所報 Vol.8 No.1
Cytochrome P450 2El is involved in the metabolic activation of many xenobliotics involved with human toxicity. The molecular mechanism of cytochrome P450 2El reduction in acute CCl_4 treatment and cirrhosis models were examined by measuring its enzymi activity, immunoreactive protein contents, and mRNA levels. Ⅰ. Acute CCl_4 treatment Aniline hydroxylase and the amounts of immunoreactive P450 2El were rapidly decreased in 24-48h and recovered in 72-96h after a single dose of CCl_4. The activities of pentoxyreasorufin-0-dealkylase and ethoxyresorufin-0-deethylase were also suppressed in 24h and begun to repair in 48h. The decline in the P450 1A content correspond to the inhibition pattern of P450 1A enzyme acitivity. However the decrease in immunoreactive P450 2C content wasn't observed. The decreases in P450 2El enzyme activity and immunoreactive protein by acute CCl_4 treatment were accompanied by a decline in its mRNA levels. The data thus suggested a pre-translational reduction of P450 2El by acute CCl_4 treatment probably due to destruction of the P450 2El gene by its own substrate. Ⅱ. Cirrhosis models In CCLl_4-induced cirrhosis, aniline hydroxylase, pentoxyreaorufin-0-dealkylase, and ethoxyresorufin-0-deethylase were suppressed and the amounts of immunoreactive P450 2El, and P450 1A were rapidly decreased. In contrast, the changes or reduction in the immunoreactive amounts of P450 2C was not so apparent as the inhibition of the corresponding catalytic activity. In bile duct ligation/scission(BDL)-induced cirrhosis, aniline hydroxylase and pentoxyresorufin-0-dealkylase were decreased, but ethobyresorufin-0-deethylase wasn't changed. No change were observed in the amounts of immunoreactive P450 2El, P450 2C, and P450 1A. In dimethylnitrosamine(DMN)-induced cirrhosis, only pentoxyresorufin-0-dealkylase was decreased and aniline hydroxylase and ethoxyresorufin-0-deethylase weren't suppressed. No change were observed in the amounts of immunoreactive P450 2El, P450 2C, and P450 1A. The decreases in P450 2El enzyme activity and immunoreactive protein by CCl_4-induced cirrhosis were accompanied by a decline in its mRNA levels. The data thus suggested a pre-translational reduction of P450 2El by CCl_4-induced cirrhosis probably due to destruction of the P450 2El gene by its own substrate.
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박선미,임희주 한국문화융합학회 2024 문화와 융합 Vol.46 No.-
본 연구의 목적은 스포츠전공학생이 영어영상 콘텐츠를 기획하고 제작하는 과정에서 학생들의 영어학습에 대한 정의적 측면을 알아보는데 있다. 이를 위하여 충청남도 소재 대학에 재학 중인 3, 4학년 48명을 대상으로 설문을 실시하였다. 설문은 영어학습 정의적 측면과 관련하여 자신감, 학습태도, 학습흥미그리고 학습동기에 대한 문항으로 구성되었다. 본 연구의 결과로, 영어에 대한 선호도나 영어학습 태도는 긍정적인 결과를 보였지만, 영어학습에 대한 자신감은 낮은 것으로 나타났다. 또한 영어에 대한 흥미나 동기는 긍정적으로 나타났지만 자기주도학습이나 학습에 대한 몰입에서는 어려움을 보였다. 마지막으로 협동학습에 있어서 팀원들과의 친밀도와 협동심, 그리고 영어실력의 향상 등을 장점으로 언급했고 영상물 제작, 편집과정의 어려움, 팀원 간의 상호작용의 문제 등을 단점으로 지적했다. 본 연구 결과를 통해, 교수자는 콘텐츠 제작 과업 절차에 대한 명확한 가이드라인을 제공해야한다. 또한 전문분야의 직무와 관련된 영어능력을 갖출 수 있는 영어교육과정의 개설이 필요하다는 것을 시사하고 있다. The purpose of this paper is to examine sports major students’ affective aspects on English learning during planning and producing English video contents. Forty eight juniors and seniors who enrolled in an university in Chungcheongnam-do participated in the study. After having the students complete their team project, a survey was conducted. The survey consisted of questions about confidence, attitude, interests, and motivation related to the students’ affective aspects of English learning. As a result, preference and attitude about their English learning were positive; however, their overall confidence in learning English was low. In addition, while the students’ interests and motivation for English learning were positive, most of the participants mentioned about their difficulties in self-directed or emersion learning. Finally, in cooperative learning, intimacy, cooperation with team members, and improvement of English proficiency were mentioned as advantages. On the other hand, video shooting and editing process, interaction among team members were pointed out as disadvantages. Based on the results, it can be said that specific guidelines for the process of content production tasks should be provided. Additionally, it is necessary to establish practical English courses in which students can learn job-related English skills and investigate their future careers.
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내시경 시술 관련 예방 항생제, 항응고제 및 항혈소판제의 사용
박선미 대한소화기내시경학회 2010 Clinical Endoscopy Vol.40 No.4
This review provides general recommendations, based on the literature, on antibiotic prophylaxis, anticoagulants and antiplatelets for GI endoscopy. Antibiotic prophylaxis is recommended for patients at high risk of infection - ERCP with incomplete drainage, ERCP with sterile pancreatic fluid collection (which communicates with the pancreatic duct), pancreatic pseudocyst drainage, EUS-FNA of cystic lesions, percutaneous endoscopic feeding tube placement and cirrhosis with acute GI bleeding. Prophylactic antibiotics are no longer recommended for GI endoscopy to prevent infectious endocarditis. To decide how to manage anticoagulants and antiplatelets during endoscopic procedures, the risk of an adverse ischemic event or a thromboembolic complication and the risk of bleeding must be weighed. For a low-risk procedure, no adjustments in anticoagulation and antiplatelets need to be made. For a high risk procedure, it is recommended to discontinue warfarin 3 to 5 days before the procedure and clopidogrel 7 to 10 days before. Low molecular weight heparin may be used as a bridge before endoscopy in patients with a high risk of a thromboembolism. In the absence of a pre-existing bleeding disorder, endoscopic procedures may be done in patients taking aspirin or other NSAIDs. Further controlled clinical studies are needed to clarify aspects of these recommendations. 내시경 시술시 예방 항생제, 항응고제, 항혈소판제의 사용법에 대한 권고 사항을 알아보았다. 예방 항생제는 ERCP를 할 때 불완전 배액이 예상되거나 췌관과 교통하는 췌액 저류가 있을 때, 췌장 가성낭종을 배액하거나 낭종성 병변을 EUS-FNA할 때, 경피적 위루 혹은 공장루 튜브 삽입시, 간경변증 환자에서 급성 위장관 출혈이 있을 때 사용할 것을 권고하고 있다. 모든 내시경 시술시 감염성 심내막염 예방을 위한 예방 항생제는 권고하고 있지 않다. 항응고제나 항혈소판제를 복용하는 환자들에서 내시경 시술을 할 때, 약제들을 어떻게 할 것인가의 문제는 약제 중단시 허혈이나 혈전색전증의 위험성과 약제를 지속하고 내시경 시술을 할 때 출혈의 위험성을 고려해서 결정하여야 한다. 일반적인 추천은 저위험 시술시 모든 약제를 중단하지 않으며, 고위험 시술은 아스피린과 NSAIDs는 유지하고 와파린은 3∼5일 전에 clopidogrel은 7∼10일 전에 중단한다. 혈전색전증의 위험성이 높은 경우에는 LMWH으로 bridging therapy를 시행한다. 향후 권고 사항의 유용성을 검증하기 위한 적절한 임상 연구가 필요하다.
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박선미,김선욱,지재환,정지영,조윤영,손서영,진상만,허규연,김재현,정재훈,민용기,이문규 대한골대사학회 2014 대한골대사학회지 Vol.21 No.3
Background: The average dietary sodium intake of Koreans is 2.6 times higher than theWorld Health Organization’s recommended amount. The effect of a diet high in sodiumon the skeletal system, especially osteoporosis, has not previously been examined in Ko-rean postmenopausal women with low bone mass. We assessed the daily sodium in-take, and determined the impact of sodium intake on urinary calcium excretion andbone resorption marker. Methods: A retrospective review of medical records was per-formed for 86 postmenopausal subjects who were initially diagnosed with osteopeniaor osteoporosis at the health promotion center. They were subsequently referred to theDivision of Endocrinology and Metabolism between 2010 and 2013. All subjects com-pleted a modified food frequency questionnaire. Twenty-four hour urine collection forsodium, calcium and creatinine excretion, and serum C-terminal telopeptides of type Icollagen (CTX-I) were also obtained. Results: The average amount of daily sodium andcalcium intake were 3,466 mg and 813 mg, respectively. Average dietary sodium intakeand 24-hour urinary sodium excretion showed significant positive linear correlation (r=0.29, P=0.006). There was also a significant positive linear correlation between 24-hoururine sodium and calcium excretion (r=0.42, P<0.001); CTX-I and 24-hour urinary calci-um excretion (r=0.29, P=0.007). Conclusions: Excessive sodium intake assessed by 24-hour urine specimen is associated with high calcium excretion in urine. High calcium ex-cretion is also related to increasing bone resorption marker.
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