산업체 근로학생의 자각증상과 이의 처리에 관한 연구

민해숙 한국지역사회간호학회 1992 지역사회간호학회지 Vol.2 No.1

산업체 근로학생의 자각증상과 이의 처리에 관한 연구

민해숙,Min, Hae-Suk 한국지역사회간호학회 1990 지역사회간호학회지 Vol.2 No.1

확장된 선형회귀 모형에서의 회귀진단에 관한 연구

민해숙,강은미 성신여자대학교 기초과학연구소 1993 基礎科學硏究誌 Vol.10 No.-

In a given data set of linear regression model, detecting influence and multicollinearity are very important part in regression diagnostics. we examined leverage, C(i), and AP(i) which are statistics for identifying influential observations. And we also examined VIF, condition index, and collinearity index which are statistics for identifying multicollinearity. Then we obtained ?? and ?? by applying C(i) and AP(i) to linear regression model augmented by arbitrary variable. As the result, ?? and ?? diagnosed simultaneously multicollinearity and influnce in variable selection.

Association of an Anti-inflammatory Cytokine Gene IL4 Polymorphism with the Risk of Type 2 Diabetes Mellitus in Korean Populations

고민진,민해숙,이종영,김성수,김연정 한국유전체학회 2011 Genomics & informatics Vol.9 No.3

Chronic inflammation has been implicated as one of the important etiological factors in insulin resistance and type 2 diabetes mellitus (T2DM). To investigate the role of anti-inflammatory cytokines in the development of T2DM, we conducted a case-control study to assess the association between IL4/IL4R polymorphisms and disease risk. We firstly identified single nucleotide polymorphisms (SNP) at IL4 and IL4RA loci by sequencing the loci in Korean participants. Case-control studies were conducted by genotyping the SNPs in 474 T2DM cases and 470 non-diabetic controls recruited from community-based cohorts. Replication of the associated signals was performed in 1,216 cases and 1,352 controls. We assessed effect of IL4 -IL4RA interaction on T2DM using logistic regression method. The functional relevance of the SNP associated with disease risk was determined using a reporter expression assay. We identified a strong association between the IL4 promoter variant rs2243250 and T2DM risk (OR=0.77; 95% CI,0.67∼0.88; p=1.65×10-4 in the meta-analysis). The reporter gene expression assay demonstrated that the presence of rs2243250 might affect the gene expression level with ∼1.5-fold allele difference. Our findings contribute to the identification of IL4 as a T2D susceptibility locus, further supporting the role of anti-inflammatory cytokines in T2DM disease development.

Replication of genomewide association studies on age at menarche in the Korean population

홍경원,김청식,민해숙,박선주,박재경,안영진,김성수,김연정 한국유전학회 2013 Genes & Genomics Vol.35 No.1

Early menarche is associated with adverse health outcomes, including breast cancer, endometrial cancer,obesity, type 2 diabetes, and cardiovascular disease. Recently, a genomewide association study (GWAS) of age at menarche (AAM) in 104,533 individuals of European ancestry was reported by the ReproGen consortium. They identified 42 loci known and novel loci that were linked to age at menarche. Because age at menarche varies between ethnic groups, we decided to investigate if these results would be replicated in the Korean population. To this end, we examined the association of the SNPs reported in the ReproGen GWAS with AAM in 3,194 individuals from the Korean Genome and Epidemiology Study (KoGES) cohort. Genotype data for total 17 SNPs (6 genotyped SNPs and 11imputed SNPs) were available for the association analysis using linear regression analysis for age at menarche with controlling current age, waist-to-hip ratio, and body mass index as the covariates. We found replication of the Repro-Gen study in two SNPs; one SNP (rs466639) in the retinoic acid receptor gamma gene (RXRG), showing a significant association with early menarche (beta = -0.224 ± 0.065,p value = 5.2 9 10-4, Bonferroni-corrected p value =0.009), and the other (rs10899489), in GRB2 (growth factor receptor bound protein 2)-associated binding protein 2(GAB2), linked to late menarche (beta = 0.140 ± 0.047,p value = 2.8 9 10-3, Bonferroni-corrected p value =0.049). This result possibly suggests that genetic factors governing AAM in the Korean population would be distinct from those in the Europeans, implying roles of modulating or interacting factors in determining AAM, including environmental factors such as nutritional status.

Prevalence of Atrial Fibrillation in Middle-Aged People in Korea: The Korean Genome and Epidemiology Study

이광수,최순자,박성희,김형재,민해숙,박현영 대한심장학회 2008 Korean Circulation Journal Vol.38 No.11

Background and Objectives: The prevalence of atrial fibrillation (AF), the most common sustained arrhythmia, is expected to rise with the aging population, but very few studies have reported on the prevalence and risk factors of AF in Korea. Subjects and Methods: We analyzed 10,012 Korean adults (4,750 men and 5,262 women), 40-69 years old, who were enrolled in the Korean Genome and Epidemiology Study. AF was diagnosed by single electrocardiogram recording in a baseline survey (2001-2003). Results: The estimated prevalence of AF was 0.4% {95% confidence interval (CI), 0.28-0.52} in adults 40-69 years old, and increased to 1.0% in individuals 60-69 years old. The prevalence rate for men (0.6%) was higher than for women (0.2%) across all age groups. In multiple logistic regression analysis, AF was significantly associated with old age {odds ratio (OR), 8.15; 95% CI, 3.06-21.71}, male gender (OR, 4.04; 95% CI, 1.90-8.61), diabetes mellitus (OR, 2.15; 95% CI, 1.05-4.44), and congestive heart failure (OR, 14.11; 95% CI, 2.56-77.70). Obesity, however, did not show an association with AF. Conclusion: The prevalence of AF in Korean adults aged 40-69 years is approximately 0.4%, lower than that in Western populations. Age, male gender, diabetes, and heart failure are associated with AF. Further research in a larger population is necessary to verify for our results. Background and Objectives: The prevalence of atrial fibrillation (AF), the most common sustained arrhythmia, is expected to rise with the aging population, but very few studies have reported on the prevalence and risk factors of AF in Korea. Subjects and Methods: We analyzed 10,012 Korean adults (4,750 men and 5,262 women), 40-69 years old, who were enrolled in the Korean Genome and Epidemiology Study. AF was diagnosed by single electrocardiogram recording in a baseline survey (2001-2003). Results: The estimated prevalence of AF was 0.4% {95% confidence interval (CI), 0.28-0.52} in adults 40-69 years old, and increased to 1.0% in individuals 60-69 years old. The prevalence rate for men (0.6%) was higher than for women (0.2%) across all age groups. In multiple logistic regression analysis, AF was significantly associated with old age {odds ratio (OR), 8.15; 95% CI, 3.06-21.71}, male gender (OR, 4.04; 95% CI, 1.90-8.61), diabetes mellitus (OR, 2.15; 95% CI, 1.05-4.44), and congestive heart failure (OR, 14.11; 95% CI, 2.56-77.70). Obesity, however, did not show an association with AF. Conclusion: The prevalence of AF in Korean adults aged 40-69 years is approximately 0.4%, lower than that in Western populations. Age, male gender, diabetes, and heart failure are associated with AF. Further research in a larger population is necessary to verify for our results.

Current Status, Challenges, Policies, and Bioethics of Biobanks

강병학,박재선,조상연,이미희,김남희,민해숙,이수연,박옥,한복기 한국유전체학회 2013 Genomics & informatics Vol.11 No.4

Many biobanks were established as biorepositories for biomedical research, and a number of biobanks were founded in the1990s. The main aim of the biobank is to store and to maintain biomaterials for studying chronic disease, identifying riskfactors of specific diseases, and applying personalized drug therapies. This report provides a review of biobanks, includingKorean biobanks and an analysis of sample volumes, regulations, policies, and ethical issues of the biobank. Until now, thetop 6 countries according to the number of large-scale biobanks are the United Kingdom, United States, Sweden, France, theNetherlands, and Italy, and there is one major National Biobank of Korea (NBK) and 17 regional biobanks in Korea. Manycountries have regulations and guidelines for the biobanks, and the importance of good management of biobanks isincreasing. Meanwhile, according to a first survey of 456 biobank managers in the United States, biobankers are concernedwith the underuse of the samples in their repositories, which need to be advertised for researchers. Korea Biobank Network(KBN) project phase II (2013‒2015) was also planned for the promotion to use biospecimens in the KBN. The KBN iscontinuously introducing for researchers to use biospecimens in the biobank. An accreditation process can also beintroduced for biobanks to harmonize collections and encourage use of biospecimens in the biobanks. KBN is preparing anon-line application system for the distribution of biospecimens and a biobank accreditation program and is trying toharmonize the biobanks.

지역사회 코호트 여성의 요골과 경골에서의 골다공증 유병률과 관련 요인 분석 -Quantitative ultrasound 방법을 이용하여-

박선주,조남한,박찬,김규찬,안윤진,민해숙,오경수 대한지역사회영양학회 2005 대한지역사회영양학회지 Vol.10 No.4

tHIS STUDY WAS CONDUCTED TO INVESTIGATE OSTEOPENIA AND OSTEOPOROSIS PREVALENCE OF RADIUS AND TIBIA USING QUANTITATIVE ULTRASOUND (QUs) AND TO IDENTIFY AFFECTING FACTORS OF OSTEOPOROSIS. a TOTAL OF 4,340 WOMEN AGED 40 - 69 YEARS, LIVING IN aNSUNG (RURAL) AND aNSAN (MID-SIZED) AREA, AND FREE OF ILLNESSES AFFECTING BONE METABOLISM PARTICIPATED IN THE COMMUNITY-BASED COHORT STUDY. aMONG THEM 4,059 SUBJECTS MEASURED RADIUS BONE DENSITY AND 4,089 MEASURED TIBIA. tHE t-SCORE THRESHOLD, DEFINED AS , -1.0 AND ≤ -2.5, WAS USED TO IDENTIFY SUBJECTS WITH OSTEOPENIA AND OSTEOPOROSIS BY fiHo CRITERIA. tHE CRUDE PREVALENCE OF OSTEOPOROSIS IN RADIUS AND TIBIA WAS 8.4$ AND 23.3$ RESPECTIVELY; AFTER ADJUSTMENT FOR AGE, IT CHANGED 6.3$ AND 18.8$. iN SIMPLE LOGISTIC REGRESSION ANALYSIS, THE PREVALENCE OF OSTEOPOROSIS INCREASED BY AGING, NON-MARITAL STATUS, LOW EDUCATION, LOW INCOME. oTHERWISE, HIGH INTAKES OF ¢A⁄P, THIAMIN, RIBOFLAVIN,VITAMIN b6, AND VITAMIN e WERE DECREASED OSTEOPOROSIS PREVALENCE. ¢OMPARED TO THE NORMAL bmi (BODY MASS INDEX)GROUP (18.5 ≤ bmi , 23), THE ODDS RATIO (orS) OF THE LOW bmi GROUP (bmi , 18.5), AND HIGH bmi GROUPS (bmi 25 -30, bmi ≥ 30) WERE SIGNIFICANTLY INCREASED. tHE or OF OSTEOPOROSIS DECREASED ACROSS INCREASING QUARTILES OF INTAKES OF ¢A, P AND ¢A⁄P. tHEREFORE, MAINTAINING NORMAL bmi AND INCREASING ¢A INTAKE AND ¢A⁄P RATIO MAY HAVE A BENEFICIAL EFFECT ON BONE HEALTH OF KOREAN WOMEN. (KOREAN J ¢OMMUNITY nUTRITION 10(4) : 536 ~ 545, 2005)

40대 이상 농촌 및 중소도시 성인의 식품섭취 패턴 (Pattern)과 질환별 유병위험도 : 한국인유전체역학조사사업 일부 대상자에 대해

안윤진(Ahn Younjhin),박윤주(Park Yun-Ju),박선주(Park Seon-Joo),민해숙(Min Haesook),곽혜경(Kwak Hye-Kyoung),오경수(Oh Kyung-Soo),박찬(Park Chan) 韓國營養學會 2007 Journal of Nutrition and Health Vol.40 No.3

Recently, dietary pattern analysis was emerged as an approach to examine the relationships between diet and risk of chronic diseases. This study was to identify groups with population who report similar dietary pattern in Korean genome epidemiology study (KoGES) and association with several chronic diseases. The cohort participants living in Ansung and Ansan (Gyeonggi province) were totally 10,038. Among those, 6,873 subjects with no missing values in food frequency questionnaire were included in this analysis. After combining 103 food items into 17 food groups, 4 dietary factors were obtained by factor analysis based on their weights. Factor 1 showed high factor loadings in vegetables, mushrooms, meats, fish, beverages, and oriental-cereals. Factor 2 had high factor loadings in vegetables, fruits, fish, and factor 3 had high factor loadings in cereal-oriental, cerial-western and snacks. Factor 4 showed positive high factor loadings in rice and Kimchi and negative factor loadings in mushrooms and milk and dairy products. Using factor scores of four factors, subjects were classified into 3 clusters by K-means clustering. We named those 'Rice and Kimchi eating' group, 'Contented eating' group, and 'Healthy and light eating' group depending on their eating characteristics. 'Rice and Kimchi eating' group showed high prevalence in men, farmers and 60s. 'Contented eating' group and 'Healthy and light eating' group had high prevalence in women, people living in urban area (Ansan Citizen), with high-school education and above, and a monthly income of one million won and more. 'Contented eating' group appeared lower distribution proportion in the sixties and 'Healthy and light eating' group does higher in the fifties. 'Contented eating' versus 'Rice and Kimchi eating', odds ratio for hypertension, diabetes, metabolic syndrome and obesity significantly decreased after adjusting age and sex (OR = 0.64, 0.73, and 0.85 respectively, 95% CI). Although our results were from a cross-sectional study, these imply that the dietary patterns were related to diseases. (Korean J Nutr 2007; 40(3): 259~269)