산욕기에 발생한 뇌교출혈로 인한 마비성 사시 환자 치험 1례

김유경,김우성,강세영,심국진,윤지원,백동기,이종덕,원진희,이상관,김홍준,Kim, Yu-Kyung,Kim, Woo-Sung,Kang, Sei-Young,Sim, Kuk-Jin,Yoon, Ji-Won,Baek, Dong-Gi,Lee, Jong-Deok,Won, Jin-Hee,Lee, Sang-Kwan,Kim, Hong-Joon 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.3

Pregnancy related stroke is significant because it has dire impact on both mother and the fetus. Pregnant or puerperal women are reported to have about 13-fold more risk of stroke compared to non-pregnant women. Pregnancy-related stroke must be differentiated from stroke in elderly patients, because it is different in pathophysiological etiologies and recurrence rates and also diagnostic and therapeutic methods may affect the fetal health status. Because the VI cranial nerve manages lateral rectus muscles, it' s palsy causes sudden onset of double vision. The eyes turn medially. In this article, one case of paralytic strabismus resulting from pontine hematoma during puerperium is reported. It was treated with herb medicine and acupuncture. Symptoms improved. This case is submitted with a brief overview of related lit.

결핵성 흉막염 환자에서 항결핵제 투여중 발생한 결핵성 폐종괴: 단순흉부촬영 및 CT 소견

김유경,이선화,Kim, Yu-Gyeong,Lee, Seon-Hwa 대한영상의학회 2001 대한영상의학회지 Vol.45 No.6

목적: 결핵성 흉막염 환자에서 항결핵제 투여 중 발생하는 결핵성 폐종괴의 방사선학적 소견을 알아보고자 하였다. 대상과 방법: 2년간 결핵성 흉막염으로 확진된 134명의 단순흉부촬영을 후향적으로 분석하였다. 항결핵제 투여 중 추적검사상 발생한 폐종괴의 발생시기,단순흉부촬영소견,추적검사에서 의 변화를 기록하였다. 4명의 환자에서는 흉부 CT를 시행하였다. 종괴가 발생한 14명중 1명은 조직생검상, 나머지 13명은 임상적으로 결핵성 종괴로 진단하였다. 결과: 추적 단순흉부촬영상 총 29예의 종괴가 14명 (10.4%)의 환자에서 나타났다. 남자가 7명, 여자가 7명이었고, 연령분포는 21세에서 52세로 평균연령은 33세였다. 종괴가 나타난 시기는 흉막염 진단으로부터 1개월에서 7개월사이였고, 9명의 환자에서는 단일성으로 나머지 5명에서는 다발성으로 발생하였다. 모두 흉막 삼출이 있었던 흉곽내에 발생하였으며, 이중 21예는 흉막하폐 분포를 보였다. 4명의 환자에서 시행한 CT에서 총 14예의 종괴가 관찰되었고, 이중 10예는 흉막하폐 종괴로, 4예는 주변부폐 종괴로 관찰되었다. 흉막하폐 종괴 중 8예에서 종괴가 흉막하 지방 침범을 보였고, 6예에서 종괴 주변에 위성결절과 간유리상음영이 관찰되었다. 총 14예의 종괴 중 5예는 중심부 저음영을 동반한 주변부 조영증강을, 5예는 불균등한 조영증강을 나머지는 균등한 조영증강을 보였다. 모든 예에서 추적검사상 크기가 감소하였다. 결론: 결핵성 흉막염 환자에서 항결핵제 투여중 단일성 혹은 다발성의 결핵성 폐종괴가 나타날 수 있으며, 이는 특징적인 주변부폐 혹은 늑막하폐 분포와 CT상 불균등한 혹은 중심부 저음영을 동반한 주변부 조영증강, 늑막하 지방 침범, 위성 결절 및 간유리상 음영 동반을 보인다. Purpose: To evaluate the imaging findings of tuberculous pulmonary masses developing during antituberculous treatment of tuberculous pleurisy. Materials and Methods: The serial chest radiographs of 134 patients with tuberculous pleurisy were retrospectively assessed by two observers who recorded the presence of pulmonary masses observed on follow-up radiographs with their imaging findings. Four patients underwent chest CT scans. Results: On chest radiographs, 29 masses were observed in 14 patients (10.4%) comprising seven men and seven women aged 21-52(mean, 33) years. The interval between the onset of pleurisy and the development of masses varied between 1 and 7 months. The lesions were single in nine patients and multiple in five; all developed in the hemithorax affected by pleurisy and 21 were located subpleurally. The CT scans obtained in four patients, demonstrated 14 masses in the peripheral lung. The location of ten of these was subpleural; eight of the ten showed extrapleural extension, and associated satellite nodules and ground-glass opacity were observed in six. Contrast-enhanced CT scans showed that enhancement pattern was peripheral in five, heterogeneous in five and homogeneous in four. Follow-up radiography indicated that all masses had become smaller. Conclusion: Tuberculous pulmonary masses may develop during antituberculous treatment of tuberculous pleurisy as single or multiple masses. Characteristically, a peripheral or subpleural pulmonary location is noted, and the CT findings include heterogeneous or peripheral rim enhancement, extrapleural extension and associated ground-glass opacity or satellite nodules.

'글로벌 캐릭터 마케팅 사례' - 스마트미디어시장 확대에 따른 캐릭터마케팅 전략의 변화

김유경,Kim, Yu-Gyeong 한국스마트미디어학회 2012 It's Smart Media Vol.1 No.4

광합성세균 Rhodopseudomonas palustis 분리 및 IAA와 Carotenoid 생성에 관한 연구

김유경,조영윤,강호준,김정선,양성년,좌창숙,Kim, Yu-Kyoung,Cho, Young-Yun,Kang, Ho-Jun,Kim, Jung-Sun,Yang, Sung-Nyun,Jwa, Chang-sook 한국유기농업학회 2017 韓國有機農業學會誌 Vol.25 No.4

본 연구에서는 제주도 한라산 중산간 습지대 28개소에서 IAA 및 carotenoid 생성능이 우수한 광합성 세균 1종을 최종 선발하였으며, 16S rRNA 염기서열 분석과 생리학적 특성을 조사한 결과 Rhodopseudomonas palustris JK-1 균주로 동정하였다. JK-1 균주의 최적배양조건을 선발하기 위하여 pH, 온도, 빛 및 통기 등을 포함한 여러 가지 요인들이 균주의 생장과 IAA 및 carotenoid 등 광합성색소 생성에 미치는 영향을 조사하였다. 시험결과 JK-1 균주는 명/혐기조건에서 균생장, IAA 및 광합성색소 생성이 양호하였으며 암/혐기조건에서 균생장, IAA 및 광합성색소 형성이 모두 크게 억제되었다. 명/혐기조건에서 균생장, IAA 및 carotenoid 등 광합성색소의 생산을 위한 최적 pH, 온도 및 배양회전속도는 각각 7, $30^{\circ}C$, 150 rpm, 9, $30^{\circ}C$ 및 150 rpm, 그리고 6, $25^{\circ}C$ 및 50 rpm이었다. 그리고 명/호기조건(0.5~1 vvm)에서는 명/혐기조건(0 vvm)보다 균생장 및 IAA 합성이 양호하였으나 광합성색소 형성은 크게 억제되었다. 따라서 최적배양조건은 명/혐기조건에서 pH 7, 온도 $30^{\circ}C$ 및 회전속도 100 rpm을 선발하였으며, IAA 합성을 유도한 배양액을 생육촉진 효과검증에 이용하였다. 시험결과 R. palustris JK-1 균주를 열무에 3% (v/v) 처리 시 지상부 및 지하부 건물중이 무처리 및 배지처리구 대비 각각 20~58% 및 40-28% 증가하였다. The JK-1 isolate which was the best producer of indole-3-acetic acid and carotenoid among the 388 strains isolated from 28 wetlands in Jeju, was identified to be Rhodopseudomonas palustirs belongs to a typical group of non sulfur purple bacteria based on 16S sRNA sequencing. This study investigated the effect of different cultural conditions of pH, temperature, agitation, light and aeration on growth, IAA and carotenoid production of photosynthetic bacterium JK-1 for optimization of IAA and carotenoid production. It was found that growth, IAA, carotenoid, and bacteriochlorophyll production with light (3,000~3,500 Lux) and agitation (100 rpm) showed better results than those with dark/static or dark/agitation (100 rpm) in anaerobic conditions. The optimal pH, temperature and agitation speed for cell growth were 7, $30^{\circ}C$, 150 rpm, for IAA production were 9, $30^{\circ}C$, 150rpm and for carotenoid production were 6, $25^{\circ}C$, 50 rpm, cultured for 72 h under anaerobic light, respectively. The growth and IAA production were high in aerobic culture compared with anaerocic culture, whereas carotenoid and bacteriochlorophyll content were decreased extremely in aerobic condition (0.5~1 vvm). Subsequently, the optimal culture conditions for JK-1 were selected with pH 7, $30^{\circ}C$ and 100 rpm under anaerobic light and the effect on plant growth was tested by pot assay. Inoculation of JK-1 with 3% (v/v) level caused increase in shoot and root dry weigh that varied from 20%~58% to 40%~28% in young radish in camparison to uninoculated treatment at 50 days of growth. The study suggests that the JK-1 isolate may serve as efficient biofertilizer inoculants to promote plant growth.

젊은 과학자상 수상자

김유경,Kim, Yu-Gyeong 한국과학기술단체총연합회 2003 과학과 기술 Vol.36 No.1

'양자 초단면 이론' 으로 거울 대칭현상 해결/ '1조분의 1초'의 '초고속 현상' 연구 탁월/ 극미세 나노물질의 형성 원리 밝혀/ 인체 면역시스템을 분자적 수준서 규명/

소아 및 성인 마제신 환자들의 임상적 특징과 비교

김유경,권남희,강동일,정우영,Kim, Yu Kyong,Kwon, Nam Hee,Kang, Dong Il,Chung, Woo Yeong 대한소아신장학회 2013 Childhood kidney diseases Vol.17 No.2

목적: 마제신은 신장융합(renal fusion)을 가진 가장 흔한 신기형이다. 저자들은 단일병원에서 관찰된 마제신 환자들의 동반 질환을 포함한 임상적 특징을 조사하고자 하였다. 방법: 2000년 1월부터 2012년 12월까지 부산백병원에서 영상의학적 방법에 의해 마제신으로 진단된 환자 43명을 대상 (소아군 14례, 성인군 29례)으로 후향적으로 의무기록을 분석하였다. 또한 소아군과 성인군의 자료를 비교 분석하였다. 결과: 전체 환자의 진단당시의 평균 연령의 중간값은 34세이었고, 성별은 남자 17명 여자 26명 이었다. 소아군(<18세, 14명)의 평균연령은 $6.7{\pm}6.2$세, 남자가 5명이 있었다. 진단 시 혈뇨를 보인 1명을 제외한 대부분 동반 질환의 평가 도중 우연히 발견되었다. 동반된 질환으로는 터너증후군이 5례(36%)로 가장 많았고, 동반된 비뇨기계 기형으로는 2명(14.2%)에서 신우요관협착을 동반하였다. 신기능은 마지막 추적검사까지 모두 정상이었다. 성인군에서 진단된 29명의 진단 당시 연령 중간값은 48세이었고, 남자가 12명 여자 17명이 있었다. 진단 시 다른 질환의 평가 중 18명이 우연히 발견되었으며, 11명은 혈뇨 또는 결석으로 인한 복통 등이 있었다. 동반질환으로는 터너증후군이 5례로 가장 많았으며, 5명에서 신우요관협착이 동반되었고, 그 외 수신증, 과민성 방광 등을 동반하였다. 마지막 추적검사에서 6명(21%)에서 신기능감소(혈청Cr>1.5)가 관찰되었다. 결론: 마제신은 우연히 발견되는 경우가 대부분으로, 동반된 단일 질환으로는 터너증후군이 가장 많았다. 성인기로 이행 후 다양한 비뇨기과적 합병증의 위험이 높으므로 지속적인 추적 관찰이 필요하다. Purpose: We aimed to investigate the clinical characteristics and associated diseases in children with a horseshoe kidney and compared these data between children and adults. Method: We performed a retrospective analysis of the medical records and radiological findings of 43 patients diagnosed with a horseshoe kidney in the Busan Paik Hospital. The subjects were divided into the children's group (14 cases, age <18 years) and the adult group (29 cases, age ${\geq}18$ years). Results: The study group consisted of 17 males and 26 females with a median age of 34 years. In the children's group (14 cases), 5 subjects were male and 9 were female, with a mean age of $6.7{\pm}6.2$ years. Most of the subjects were asymptomatic and were incidentally diagnosed with horseshoe kidney during their evaluation for another disease. Among the associated diseases in the children's group, Turner syndrome was the most common (5 cases), whereas ureteropelvic junction (UPJ) stricture was observed in 2 cases (14.2%). None of the children exhibited abnormal renal function during the follow-up period. In the adult group (29 cases), 12 subjects were male and 17 were female, with a mean age of 48 years. Eighteen patients were incidentally diagnosed with horseshoe kidney during their evaluation for another disease, and 11 patients had hematuria or abdominal pain due to renal stones. Among the associated diseases in the adult group, Turner syndrome was the most common (5 cases), and UPJ stricture was observed in 5 cases; the other accompanying diseases included hydronephrosis and overactive bladder. Six patients exhibited decreased renal function (serum creatinine level >1.5) during the follow-up period. Conclusion: Horseshoe kidney is usually diagnosed incidentally in both children and adults. In the present study, we noted that Turner syndrome was the most common associated disease in children. In addition, most children were asymptomatic but had a high risk of urologic complications after the transition to adulthood. Therefore, children with horseshoe kidney require continuous follow-up.

청각장애 아동의 음운인식 능력과 단어확인 능력의 상관연구

김유경,김문정,안종복,석동일,Kim, Yu-Kyung,Kim, Mun-Jung,Ahn, Jong-Bok,Seok, Dong-Il 한국음성학회 2006 음성과학 Vol.13 No.3

Hearing impairment children possess poor underlying perceptual knowledge of the sound system and show delayed development of segmental organization of that system. The purpose of this study was to investigate the relationship between phonological awareness ability and word identification ability in hearing impaired children. 14 children with moderately severe hearing loss participated in this study. All tasks were individually administered. Phonological awareness tests consisted of syllable blending, syllable segmentation, syllable deletion, body-coda discrimination, phoneme blending, phoneme segmentation and phoneme deletion. Close-set Monosyllabic Words(12 items) and lists 1 and 2 of open-set Monosyllabic Words in EARS-K were examined for word identification. Results of this study were as follows: First, from the phonological awareness task, the close-set word identification showed a high positive correlation with the coda discrimination, phoneme blending and phoneme deletion. The open-set word identification showed a high positive correlation with phoneme blending, phoneme deletion and phoneme segmentation. Second, from the level of phonological awareness, the close-set word identification showed a high positive correlation with the level of body-coda awareness and phoneme awareness while the open-set word identification showed a high positive correlation only with the level of phoneme awareness.

들깨잎 폴리페놀 산화효소의 pH 및 온도에 의한 영향

김유경,김안근,Kim, Yoo-Kyung,Kim, An-Keun 대한약학회 2004 약학회지 Vol.48 No.6

Polyphenol oxidase-catalyzed oxidation of substrates (t-butylcatechol, 4-methylcatechol, chlorogenic acid, caffeic acid and pyrocatechol) were performed in the Ph range 4~8. Co ncentrations of substrate's major oxidation products were monitored by high performance liquid chromatograph. The nature and amounts of products formed were highly pH dependent. They also were ifluenced by kinds of substrates. Major oxidation product of 4-methylcatechol appeared the maxium value at pH 5, them of chlorogenic acid, caffeic acid and pyrocatechol at pH 6.0 and that of t-butylcatechol at pH 5~7. Time-dependent PPO activity was determined at $4^{\circ}C\;and\;30^{\circ}C$. PPO extracted by phosphate buffer containing triton X-114 (t-PPO) was more stable than PPO by phosphate buffer (b-PPO). The result of electrophoresis, at first PPO was showed only a band at 48 kd. After 1~3 days a partial degrade band was appeared in b-PPO and three partial degrade bands in t-PPO. No activity band was appeared in PPOs at $30^{\circ}C$ and b-PPO at $4^{\circ}C$ after 4 days. And a band (37 kDa) in t-PPO was remained finally and disappered. PPO from Perillae leaves has two activity bands at 48 and 37 kDa in previous paper. It was supposed that PPO in the leaves of Perilla frutescens was a protein having one molecular weight as 48 kDa. And 37 kDa protein, relatively proteolysis-resistant, was a proteolyzed form of a major form.

Denosumab (Prolia^®)의 투여 간격 및 칼슘·비타민 D 복합제제 처방 여부에 따른 임상적 결과 평가

김유경,김정현,도현정,정영미,이정화,이주연,김은경,Kim, Youkyeong,Kim, Junghyun,Doh, Hyunjeong,Jeong, Young Mi,Lee, Jeonghwa,Lee, Ju-Yeun,Lee, Euni 한국임상약학회 2022 한국임상약학회지 Vol.32 No.3

Background: Denosumab (Prolia®) is administered every 6 months for osteoporosis treatment. Co-administration of calcium and vitamin D is required to minimize hypocalcemia risk. We evaluated clinical outcomes based on the administration interval of denosumab and co-prescription with calcium-vitamin D combination products. Methods: A retrospective study was conducted using electronic medical records from 668 patients who started denosumab therapy between January 1 and December 31, 2018, at Seoul National University Bundang Hospital. Clinical outcomes, as measured by changes in T-score, were evaluated by the intervals and concurrent prescriptions with calcium-vitamin D combination products. Results: Of the 668 patients, 333 patients met the eligibility criteria. These patients were divided into two groups based on appropriateness of the administration interval: "Appropriate" (304 patients, 91.3%) and "Inappropriate" (29 patients, 8.3%). T-score changes were significantly higher in the "Appropriate" than in the "Inappropriate" group (0.30±0.44 vs. 0.13±0.37, p=0.048). At the beginning of the treatment, 221 patients (66.4%) were prescribed calcium-vitamin D combination products, but the changes in T-scores were not significantly different by the prescription status of the product (0.29±0.46 vs. 0.28±0.38, p=0.919). Conclusion: T-scores were significantly improved in patients with appropriate administration intervals. No significant changes in T-scores were observed by the prescription status with calcium-vitamin D combination products. For optimal treatment outcomes, prescribers should encourage adherence to the approved prescription information on dosage and administration, and pharmacists should provide medication counseling for patients.

Variable Pulmonary Manifestations in Hemodialysis Patients

김유경,이경수,오유환,Kim, Yu-Gyeong,Lee, Gyeong-Su,O, Yu-Hwan The Korean Radiological Society 2003 대한영상의학회지 Vol.49 No.2

혈액투석 환자에서 혈액투석이나 기존의 신장질환과 관계된 다양한 폐병변이 나타날 수 있다.이러한 폐병변은 크게 1)만성신부전과 관련된 병변;2)혈액투석의 합병증;3)폐감염;4)폐-신장 증후군 등으로 나누어 볼 수 있다.저자들은 혈액투석 환자에서 발생할 수 있는 다양한 폐병변에 대한 인식은 빠른 진단과 치료에 도움이 되리라 생각하고,이러한 다양한 폐병변의 방사선학적 소견을 보여주고자 한다. A wide variety of pulmonary disorders related to hemodialysis or pre-existing renal disease occurs in hemodialysis patients. The disorders may be classified as 1) pulmonary abnormalities associated with chronic renal failures; 2) pulmonary complications arising during hemodialysis; 3) pulmonary infection; or 4) pulmonary-renal syndrome. An awareness of the various possible pulmonary disorders arising in hemodialysis patients may be helpful for the proper and timely management of such patients. We describe and illustrate various radiographic and CT findings of variable pulmonary disorders in hemodialysis patients