포스타 전시 발표 : 신장 ; 신이식 환자에서 혈청 호모시스틴 농도의 변화

김여경,마성권,고정희,김수완,김남호,최기철 대한내과학회 2001 대한내과학회 추계학술대회 Vol.61 No.-

Prognostic significance of nucleophosmin mutations and FLT3 internal tandem duplication in adult patients with cytogenetically normal acute myeloid leukemia

김여경,Hee-Nam Kim,Se Ryeon Lee,Jae-Sook Ahn,Deok-Hwan Yang,이제중,이일권,Myung-Geun Shin,김형준 대한혈액학회 2010 Blood Research Vol.45 No.1

Background Nucleophosmin (NPM1) gene and fms-like tyrosine kinase 3 gene-internal tandem duplication (FLT3-ITD) mutations are the most frequent mutations in patients with cytogenetically normal (CN)-AML. We analyzed the prognostic impact of these mutations and their interactions in adults with CN-AML. Methods NPM1 mutation (NPM1mut) and FLT3-ITD mutation (FLT3-ITD+) were analyzed by GeneScan and PCR assays of bone marrow samples obtained from 121 adult patients with CN-AML (age≤60 years at diagnosis). Results The incidence of FLT3-ITD+ was higher in the NPM1mut group than in the wild-type NPM1 gene (NPM1wt) group. The patients were divided according to their mutation status into the NPM1mut/FLT3-ITD (isolated NPM1mut), NPM1mut/FLT3-ITD+ or NPM1wt/FLT3-ITD-, and NPM1wt/FLT3-ITD+ (isolated FLT3-ITD+) groups. The isolated NPM1mut group showed significantly better clinical outcomes in terms of relapse rate, 5-year relapse-free survival (RFS), and overall survival (OS) than the other groups. In contrast, the isolated FLT3-ITD+ group had a higher relapse rate and shorter RFS and OS than the other groups. The 5-year RFS rate was much higher among the patients who underwent allogeneic stem cell transplantation (alloSCT) than among those treated with high-dose cytarabine chemotherapy (HDAC) only as consolidation therapy in the isolated NPM1mut group and the NPM1mut/FLT3-ITD+ or NPM1wt/FLT3-ITD- group. Conclusion Adult patients with CN-AML carrying isolated NPM1mut and isolated FLT3-ITD+ exhibit different clinical outcomes than those with NPM1mut/FLT3-ITD+ or NPM1wt/FLT3-ITD-. Although isolated NPM1mut leads to favorable clinical outcomes of CN-AML, the role of alloSCT in such patients remains to be considered.

포스타 전시 발표 : 혈액종양 ; 중추신경계를 침범한 혈구탐식성 림프조직구증 1례

김여경,이제중,조상희,황호인,양태영,정익주,박형천,김형준 대한내과학회 2001 대한내과학회 추계학술대회 Vol.61 No.-

필라델피아 염색체 양성 급성골수성백혈병에서 Imatinib Mesylate로 분자학적 관해를 유도한 후 성공적인 자가 말초혈액 조혈모세포이식이 시행되었던 1예

김여경,이제중,이병환,변정래,조덕,이일권,정익주,양동욱,김형준 대한조혈모세포이식학회 2003 대한조혈모세포이식학회지 Vol.8 No.1

저자들은 필라델피아 염색체 양성 급성골수성백혈병 환자에서 복합항암화학요법으로 혈액학적 완전관해를 유도하고, imatinib mesylate를 이용하여 분자학적 관해를 유도한 후, 성공적으로 자가 말초혈액조혈모세포이식을 시행하였던 1예를 경험하였기에 이를 보고하는 바이다. Philadelphia chromosome (Ph¹)-positive acute myeloid leukemia (AML) is very rare disease, comprising 3~4% of the AML, and is a clinically distinct entity with poor clinical outcome with conventional chemotherapy. We report a case of Ph¹-positive AML who underwent successful autologous peripheral blood stem cell transplantation after achieving a molecular remission with imatinib mesylate.

한옥의 벽과 창호의 조형미를 활용한 여성복디자인 연구

김여경,조문희 한국니트디자인학회 2013 패션과 니트 Vol.11 No.1

The recent rapid development of the media has greatly our society overall, bringing up much change in our life. The world has become able to communicate each other in one space through various media and through this, we have become able to share cultures of each country. Thus the recent culture is shared by majority of the people from different countries through various media and has emerged as a new different culture. Due to this phenomenon, the cases of borrowing other cultures by the world’s best designers are found in large quantities in the fashion area too, and the fast fashion of multi-national corporations are already encroaching upon the world market. Thus, the necessity for the Korean-type of design based on the identity of our culture has become much more urgent. The fashion is something that appears in the image of the environment where the designer belongs showed as various types of clothes, and through these, the fashion communicates with the customers. The understanding of the culture where the designer belongs is very important to development a unique design of the modern fashion. This research intend to develop the woman's wear design, range of 35∼45 years old, utilizing the aesthetic value that shows in the windows and doors of the Korean traditional house from the Joseon Dynasty that was influenced by the environment and culture of the era. The results of this research are as follows. First, The development of the woman's wear design utilizing the aesthetic characteristics that show in the walls and doors and windows of traditional Korean houses is more than enough to create modern design. Second, The develop various and creative types of items by utilizing the aesthetic values which are nonstructure, roughness, naturalness, shape of lines and shapes from the walls, and Ja-kyung, Cha-kyung, Jang-kyung, Jung-chup, collage, framed, roll screen, rice paper from doors and windows of the Korean traditional houses. Third, we can develop various modern woman's wear designs according to the representation method, printing, embroidery, material, texture, 3-dimensional structure, weaving, overlapping to create the images from the walls and doors and windows of the Korean traditional houses. Fourth, The development of the woman's wear design utilizing the aesthetic characteristics from the walls and doors and windows of the Korean traditional houses extend the choice for the customers and the territory of fashion businesses. The superiority of our culture by developing the design utilizing the aesthetic characteristics that show in the wall and doors and windows of Korean houses can contribute to create modern design for the globalera.

공공도서관의 공간구성비 변화에 관한 연구 : 대구광역시 공공도서관을 중심으로 focused on the Public Library in Daegu

김여경,정지석,최무혁 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(계획계)

In line with the fast development of the modern society, the basic function of the public library has been changing to meet the present user's needs and social requests. Such multiple library organizations have been continuously and rapidly changed. This study suggests to analyze the changes in the space composition of the public library in Daegu. It explains the relationship of the multiple programs for public library and users who need new requests. The results of this study are as follows : The changes for new needs and requests are 1) to extend lecture rooms and auditorium, 2) to offer a reading room more open for public users, 3) to extend internet data and clipping data. These changes are attended with various problems.

Gene Expression Profile Associated with the Differentiation of Osteoblasts from Human Mesenchymal Stem Cells

김여경,김희남,이일권,박경수,양덕환,조상희,이제중,정익주,김순학,김형준,Kim Yeo-Kyeoung,Kim Hee-Nam,Lee Il-Kwon,Park Kyeong-Soo,Yang Deok-Hwan,Cho Sang-Hee,Lee Je-Jung,Chung Ik-Joo,Kim Soon-Hag,Kim Hyeoung-Joon Korean Society of Life Science 2006 생명과학회지 Vol.16 No.2

인체의 골수내에 존재하는 중간엽 줄기세포는 성장인자나 환경적 요인에 의해 지방세포, 골아세포, 연골모세포 및 연골세포 등으로 분화됨이 알려져 있다. 본 연구에서는 정상 인체의 골수으로 얻어진 중간엽 줄기세포로부터 골아세포의 분화 가능성을 알아보고 이에 관여하는 유전자의 발현을 조사하였다. 정상 골수의 중간엽 줄기세포를 골유도성 자극보조제로서 $\beta$-glycerol phosphate, L-ascorbic acid 및 dexamethasone을 첨가하여 골아세포로의 분화를 유도한 세포와 골유도성 자극보조제를 첨가하지 않은 세포를 배양하여 일정 간격으로 cDNA microarray를 이용하여 각각의 단계에서 발현되는 유전자를 검사하고 이로 인해 얻어진 유전자의 발현량을 분석하기 위해 real time quantitative RT-PCR 을 시행하였다. 골유도성 자극보조제를 첨가한 군에서 첨가하지 않은 군에 비하여 정상적인 골아세포로의 성장이 유도되었고, 분화과정에서 36개의 유전자의 발현이 증가되었고, 59개의 유전자의 발현이 억제되었다. 주로 골 생성 과정과 연관이 있다고 알려진 osteoprotegerin, LRP5 및 metallothionein 2A 등의 유전자들이 분화과정에서 발현 증가되어 나타났고, 줄기세포로부터 분화될 수 있는 조직들 중 근육, 지방, 연골, 혈관 및 신경 조직과 연관된 유전자들은 분화 후기에 감소하거나 혹은 전분화 과정 동안 발현이 억제되었다. 본 연구에서는 골아세포의 분화와 연관된 유전자 발현을 확인함으로써 특정 조건하에서 중간엽 줄기세포로부터 골아세포로의 분화가 가능함을 확인할 수 있었고, 이 과정에 관련된 특정 유전자의 발현 양상을 밝힐 수 있었다. Human mesenchymal stem cells (hMSCs) in bone marrow (BM) can be induced to differentiate into a variety of mesenchymal tissues, including adipocytes, osteoblasts and chondroblasts, under the influence of certain growth or environmental factors. In this study, we analyzed the differentiation process and the associated gene expression profiles inherent to the process by which hMSCs differentiate into osteoblasts. We conducted a comparison of gene expression profiles of the normal human BM MSCs, using human 8K cDNA microarray, incubated in media containing either a combination of $\beta$-glycerol phosphate, L-ascorbic acid, and dexamethasone, or in medium lacking these osteogenic supplements. During the osteoblastic differentiation process, 36 genes were determined to be up-regulated, and 59 genes were shown to be down-regulated. Osteoprotegerin, LRP5, and metallothionein 2A, all of which are associated with the osteogenetic process, were up-regulated, and genes associated with the differentiation of MSCs into other lineages, including muscle, adipose tissue and vascular structure were down-regulated. The set of differentially expressed genes reported in this work should contribute to our current understanding of the processes inherent to the differentiation of MSCs into osteoblasts.

조국이란 무엇인가 : 귀국1.5세 재일탈북자의 구술사를 중심으로

김여경 한국구술사학회 2017 구술사연구 Vol.8 No.1

재일탈북자는 주로 식민지시대에 도일하여1959년부터 1984년까지의 귀국사업으로 북한에 귀환한 재일조선인이나 그 가족들로, 1990년대 중반 이후에 탈북하여 일본에 정주한 사람들이다. 이들은 ‘식민지조선-일본-북한-일본’이라는 경로를 세대에걸쳐 이주해왔다. 본고는 유년시절 일본에서 북한으로 건너갔다가 탈북 후, 다시 일본에 정주한 귀국1.5세 재일탈북자3인의 구술을 통해, 이들의 이주 경로를 중심으로 한각 사회의 부조리에 주목한다. 연구참여자 K씨의 어머니의 도일계기는 ‘제주4.3사건’이라는 냉전체재 아래의 국가의 폭력이 있었고, C씨와 S씨의 가족이 북한으로의 귀국한 요인에는 일본사회의 재일조선인 차별이 존재한다. 지금까지 밝혀진 것처럼 북한에서도 정치적 사회적으로귀국자를 차별해 왔다. 더욱이 탈북 후 일본생활에서도 정주상의 어려움뿐만 아니라‘북한에서 왔다’는 사실을 이야기하지 못하는 환경 속에 놓여지게 되며, 귀국 이전에속해있었다고 할 수 있는 재일조선인 사회에도 융화되기 어려운 부분이 있다. 본고는 한국과 북한, 일본 사회의 재일탈북자를 향한 편견과 차별에 내재되어 있는부조리에 대해 주목하고 그 어느 곳도 이들에게 ‘조국’과 같은 장소가 되지 못한 것을지적한다. 오히려 정치적인 대립 속에서 ‘필요’에 따라 이들의 존재가 ‘소비’되거나‘망각’되는 사회시스템의 문제에 대하여 논한다. 이러한 이유 중의 하나로 식민주의와냉전체제 아래에서 형성된 사회시스템의 ‘폭력’이 존재하기 때문이며 이러한 문제가재일탈북자와 관련된 모든 사회에 존재하고 있다고 할 수 있다. This article is about the life histories of Japan’s community of returnee-refugees (dappoku-kikokusha; zainichi-dappokusha). The returneerefugees usually migrated from Korea to Japan during the Japanese colonial period, returned back to North Korea between 1959 and 1984, and then sought asylum in Japan after the middle of the 1990s. During three generations, they followed the route of ‘Korea (Chosen)-Japan-North Korea-Japan’. This article particularly focuses on the life histories of three members who migrated to North Korea as youths and returned back to Japan after spending most of their life in North Korea. The Jeju uprising was the reason ‘K’s mother initially evacuated to Japan, while racial discrimination in Japan was the reason ‘C’ and ‘S’ families returned to North Korea. ‘K’ who received aids from the North Korean government experienced more discrimination than ‘S’ did. According to K’s report, there was discrimination towards immigrants from Japan in North Korea; however, the interview with ‘S’ indicates that there were some differences in their general conditions in North Korea. In addition, the returnee-refugees had a difficult time living in Japan because they received no support from the Japanese government, and could not even mention North Korea as their country of origin due to the its image. It was also difficult for them to assimilate with the old-timer Korean society in Japan. This article explores the irrationality and violence of social systems under colonialism and the Cold War toward the returnee-refugees. It points out that the returnee-refugees have been exploited or forgotten in political perspectives without considering other social sides the refugees encountered with. Therefore, the article focused on prevalent social irrationality, and investigated further to discover the problems of the social systems affecting the lives of the returnee-refugees by interviewing three returnee-refugees in depth. Furthermore, it emphasized the irrationality of the social system accounted by the life histories of three returnee-refugees while taking into account their immigration routes and sensed absence of ethnic roots.

2000년 이후 대중매체에 나타난 고구려 복식 연구

김여경,홍나영 한국의류학회 2008 한국의류학회 학술대회논문집 Vol.2008 No.1

임상강좌_Clinical decision making session: case-oriented : 쉽게 멍드는 환자

김여경 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.2