갈색거저리(Tenebrio molitor) 유충의 냉장 저장 중 산화 안정성에 관한 연구

김소영,손양주,김수희,김안나,이금양,황인경,Kim, So-Young,Son, Yang-Ju,Kim, Soo-Hee,Kim, An-Na,Lee, Geum-Yang,Hwang, In-Kyeong 한국식품조리과학회 2015 한국식품조리과학회지 Vol.31 No.1

The purpose of this study was to evaluate the changes on the characteristics of the oxidative stability of Tenebrio molitor larvae during cold storage at $4^{\circ}C$. Pretreatment for T. molitor larvae was designed into three methods: raw (R), freeze-dried (F.D.), and pan-fried (P.F.). The water content of the raw sample (61.46%) was higher than those of other samples (F.D.: 5.02%, P.F.: 3.67%) and its high water content was expected to facilitate the oxidation of the raw sample. In our results, the peroxide value and the carbonyl value of all of the samples increased and the raw sample, after storage for 18 day, showed the highest value. The pan-fried sample had no significant increase in its lactic acid content, acid value, and thiobarbituric acid value; whereas those values were increased in the raw sample and the freeze-dried sample (p<0.05). The browning reaction was more progressed in the pan-fried sample than other samples at 0 day, but there was no significant change during the storage. The raw sample and the freeze-dried sample had their browning indexes increase with the increasing storage period (p<0.05). The pan-fried sample produced less oxidation products than the freeze-dried sample, indicating that the unheated sample was more susceptible to oxidation than the heated samples. In conclusion, heating treatment and low water content would be effective for improving the safety and stability of T. molitor larvae during cold storage.

진료를 받는 고혈압 환자의 혈압 조절과 관련된 의사 요인

김소영,조인숙,이재호,김지현,이은정,박종혁,이진석,김윤,Kim, So-Young,Cho, In-Sook,Lee, Jae-Ho,Kim, Ji-Hyun,Lee, Eun-Jung,Park, Jong-Hyock,Lee, Jin-Seok,Kim, Yoon 대한예방의학회 2007 예방의학회지 Vol.40 No.6

Objectives : Little is known about the physician-related factors that are associated with the management of Hypertension. The purpose of this study was to determine the physician-related factors associated with blood pressure control in hypertensive patients. Methods : We surveyed 154 physicians at 117 public health (subhealth) centers in Gyeonggi-do, Forty-one physicians completed the survey (response rates : 26.6%) and 31 physicians were finally included as the study subjects. Using the information obtained from the self-reported survey, we measured the physician-related factors associated with hypertension control, including their perception of hypertension, prescription patterns (combination prescription rates, specific antihypertensives prescription rates among patients with diabetes mellitus), and sociodemographic factors. We then collected data on blood pressure and medication use in patients seen by these physicians from the health center#s information system. We compared the physicians# perceived hypertension control rates with the actual rates, and then evaluated the rate of high overestimation (overestimation by more than 25% of the median degree of hypertension control rate overestimation) among the physicians. The physicians# antihypertensive prescription patterns were also evaluated. Multiple logistic regression analysis was used to evaluate the independent association between hypertension control and physician-related factors. Results : The physicians tended to overestimate the proportion of their patients with controlled blood pressure (79.5% perceived vs. 57.8% actual). The percentage of physicians with high overestimation was 35.5% (11 physicians). The physicians with lower control rates were more likely to highly overestimate their patients# control rates. Physicians with below-median actual control rates tended to prescribe fewer combination treatments for patients with uncontrolled blood pressure and angiotensin-converting enzyme inhibitors or fewer angiotensin receptor blockers for patients with diabetes mellitus. The rate of high overestimation by physicians was 1.31 times higher in patients with uncontrolled blood pressure than in patients with other conditions (OR=1.31, 95% CI : 1.17-1.48). Conclusions : Physicians have a tendency to overestimate the rates of hypertension control in their patients. Because physicians have a direct role in treatment outcomes, physicians# overestimation about hypertension management contributes to inadequate blood pressure control. Thus, interventions for improving physician# awareness regarding the management of patients with hypertension are needed.

다가불포화지방산의 공역이중결합 유도체가 흰쥐의 혈청 지질 성분에 미치는 영향

김소영,김성희,김경업,Kim, So-Young,Kim, Sung-Hee,Kim, Gyeong-Eup 한국식품영양과학회 2007 한국식품영양과학회지 Vol.36 No.9

n-6계 linoleic acid의 함량이 높은 옥수수유 및 n-3계 linolenic acid의 함량이 높은 들깨유와 함유된 다가불포화지방산을 공역이중결합 유도체화 처리한 옥수수유 및 들깨유가 흰쥐의 혈청 지질개선에 미치는 영향을 비교 검토하기 위하여 S.D.계 숫 흰쥐에게 돈지 식이를 대조군으로 하고 옥수수유 10%, 들깨유 10%, 유도체화 처리한 옥수수유 10% 및 유도체화 처리한 들깨유 10%을 급여하여 4주간 실험 사육한 후 혈청 지질성분을 분석하였다. 유도체화 처리한 옥수수유(TCO)는 가스 크로마토그래피에 의해 3개의 linoleic acid의 유도체가 확인되었고 유도체화 처리한 들깨유(TPO)에서는 5개의 linolenic acid의 유도체가 확인되었다. 체중증가량 및 식이섭취량은 유도체화 처리한 옥수수유 및 들깨유 급여군에서 유의성 있게 낮았다. 혈청 총콜레스테롤 농도는 대조군에 비해 전실험군에서 유의성 있게 낮았으며, 특히 유도체화 처리한 옥수수유 및 들깨유 급여군에서 더욱 낮았다. HDL-콜레스테롤 농도는 대조군에 비해 전실험군에서 유의적으로 높았다. 혈청 LDL 및 LDL-콜레스테롤 농도는 대조군에 비해 전실험군에서 유의성 있게 낮았으며 유도체화 처리한 옥수수유 및 들깨유 급여군에서 더욱 낮은 경향을 보였고, 특히 유도체화 처리한 들깨유 급여군에서 가장 낮았다. VLDL 농도는 대조군에 비해 전실험군에서 유의성 있게 낮았으며, chylomicron 농도는 유도체화 처리한 유지 급여군에서 유의성 있게 낮았고 특히 유도체화 처리한 들깨유 급여군에서 가장 낮았다. 혈청 유리콜레스테롤 농도는 대조군에 비해 전 실험군간에 유의적인 차이는 없는 반면 유도체화 처리한 옥수수유 및 들깨유 급여군에서 약간 낮았다. 혈청 중성지질 농도는 대조군에 비해 전실험군에서 유의성 있게 낮았으며, 특히 유도체화 처리한 들깨유 급여군에서 가장 낮았다. 인지질 농도는 옥수수유 급여군이 대조군에 비해 약간 높게 나타난 반면 유도체화 처리한 유지 급여군은 약간 낮은 수준이었다. 이상의 결과 n-6계 linoleic acid의 함량이 높은 옥수수유 및 n-3계 linolenic acid 함량이 높은 들깨유의 공역이중결합유도체의 섭취는 혈중 총콜레스테롤, LDL-콜레스테롤, chylomicron 및 중성지질 농도를 감소시킴으로써 혈청 지질 개선효과가 있는 것으로 나타났으며, 특히 n-3계 들깨유의 공역이중결합 유도체 급여군이 혈청 지질 개선효과가 가장 큰 것으로 나타났다. This study was designed to examine the effects of n-6 PUFA rich corn oil, n-3 PUFA rich perilla oil and their conjugated double bond derivatives on serum lipids status in rats. Experimental diets containing lard (control), corn oil (CO), perilla oil (PO), conjugated double bond derivatives of n-6 PUFA rich corn oil (TCO) and n-3 PUFA rich perilla oil (TPO) at the level of 10% (w/w) were fed to male Sprague Dawley rats for 4 weeks. TCO was found to have three derivatives of linoleic acid and TPO had five derivatives of linolenic acid by GC. Serum total cholesterol levels were significantly lower in the all experimental groups than in the control group, and particularly, the lowest in TCO and TPO groups. HDL-cholesterol concentrations were a little higher in the all experimental groups than in the control group, and TCO and TPO groups were not significantly different from CO and PO groups. Serum LDL, LDL-cholesterol, chylomicron and triglyceride concentrations were significantly lower in the all experimental groups than in the control group, remarkably lower in TCO group and particularly, the lowest in the TPO group. Serum free cholesterol and cholesteryl ester concentrations were lower in TCO and TPO groups than in CO and PO groups. From the above research, TCO and TPO groups were effective on the improvement of the lipid compositions in serum and particularly, TPO group was the most effective on the improvement of serum lipids.

태양광 물 분해를 통한 수소 생산용 Cu₂O/CuO 이종접합 광전극의 제작 및 광전기화학적 특성

김소영,김효진,홍순구,김도진,Kim, Soyoung,Kim, Hyojin,Hong, Soon-Ku,Kim, Dojin 한국재료학회 2016 한국재료학회지 Vol.26 No.11

We report on the fabrication and characterization of a novel $Cu_2O/CuO$ heterojunction structure with CuO nanorods embedded in $Cu_2O$ thin film as an efficient photocathode for photoelectrochemical (PEC) solar water splitting. A CuO nanorod array was first prepared on an indium-tin-oxide-coated glass substrate via a seed-mediated hydrothermal synthesis method; then, a $Cu_2O$ thin film was electrodeposited onto the CuO nanorod array to form an oxide semiconductor heterostructure. The crystalline phases and morphologies of the heterojunction materials were examined using X-ray diffraction and scanning electron microscopy, as well as Raman scattering. The PEC properties of the fabricated $Cu_2O/CuO$ heterojunction photocathode were evaluated by photocurrent conversion efficiency measurements under white light illumination. From the observed PEC current density versus voltage (J-V) behavior, the $Cu_2O/CuO$ photocathode was found to exhibit negligible dark current and high photocurrent density, e.g. $-1.05mA/cm^2$ at -0.6 V vs. $Hg/HgCl_2$ in $1mM\;Na_2SO_4$ electrolyte, revealing the effective operation of the oxide heterostructure. The photocurrent conversion efficiency of the $Cu_2O/CuO$ photocathode was estimated to be 1.27% at -0.6 V vs. $Hg/HgCl_2$. Moreover, the PEC current density versus time (J-T) profile measured at -0.5 V vs. $Hg/HgCl_2$ on the $Cu_2O/CuO$ photocathode indicated a 3-fold increase in the photocurrent density compared to that of a simple $Cu_2O$ thin film photocathode. The improved PEC performance was attributed to a certain synergistic effect of the bilayer heterostructure on the light absorption and electron-hole recombination processes.

고해상도 방사선 영상을 위한 $Gd_2O_3:Eu^{3+}$ 나노 형광체 제조 및 광학적 특성

김소영,강상식,박지군,차병열,최치원,이형원,남상희,Kim, So-Yeong,Kang, Sang-Sik,Park, Ji-Koon,Cha, Byung-Youl,Choe, Chi-Won,Lee, Hyung-Won,Nam, Sang-Hee 대한의용생체공학회 2007 의공학회지 Vol.28 No.1

In this paper, we have synthesized $Gd_2O_3:Eu^{3+}$ nano phosphor particle using a low temperature solution-combustion method. We have investigated the structure and the luminescent characteristic as the sintering temperature and europium concentration. From XRD(X-ray diffraction) and SEM(scanning electron microscope) results, we have verified that the phosphor particle was fabricated a spherical shape with $30{\sim}40nm$ particle size. From the photoluminescence results, the strong peak exhibits at 611 um and the luminescent intensity depends on europium concentration. $Gd_2O_3:Eu$ fine phosphor particle has shown excellent luminescent efficiency at 5 wt% of europium concentration. The phosphors calcinated at $500^{\circ}C$ have possessed the x-ray peaks corresponding to the cubic phase of $Gd_2O_3$. As calcinations temperature increased to $700^{\circ}C$, the new monoclinic phase has identified except cubic patterns. From the luminescent decay time measurements, mean lifetimes were $2.3{\sim}2.6ms$ relatively higher than conventional bulk phosphors. These results indicate that $Gd_2O_3:Eu$ nano phosphor is possible for the operation at the low x-ray dose, therefore, the application as medical imaging detector.

박태기나무의 잎으로부터 피부멜라닌 색소생성 억제성분의 분리

김소영,김진준,장태수,정시련,이승호,Kim, So-Young,Kim, Jin-Joon,Jang, Tae-Soo,Chung, See-Ryun,Lee, Seung-Ho 한국생약학회 1999 생약학회지 Vol.30 No.4

Tyrosinase plays an important role in the process of melanin polymer biosynthesis. Therefore, the enzyme inhibitors have been of great concern as cosmetics to have skin-whitening effects on the local hyperpigmentation. During the search for new inhibitory compounds on melanin polymer biosynthesis from natural sources, MeOH extracts of 589 higher plants were tested for the inhibitory effect on tyrosinase activity by the muschroom tyrosinase assay in vitro. Among plants tested, the leaves of Cercis chinensis exhibited potent inhibitory effect on mushroom tyrosinase activity. Subsequently seven active compounds were isolated from the ethyl acetate soluble part of acetone extract of the leaves of C. chinensis by the activity guided fractionation monitoring the inhibitory effect on tyrosinase activity. Their chemical structures were identified as $kaempferol-3-0-{\alpha}-L-rhamnoside$, quercitrin, $myricetin-3-0-{\alpha}-L-rhamnoside$, myricetin-3-0-(2'-O-galloyl)- ${\alpha}$ -L-rhamopyranoside (desmanthin), (-)-epicatechin-3-0-gallate, (-)-epigallocatechin-3-0-gallate, and methyl gallate on the basis of the speculation of spectral data and chemical reaction. Among the flavonol rhamnosides, myricetin-3-0-(2'-O-galloyl)- -L-rhamnoside(desmanthin) showed most potent inhibitory effect on tyrosinase activity and the structure of B-ring in flavonol moiety was related to the activity. (-)-Epigallocatechin-3-O-gallate having pyrogallol group in flavan-3-ol moiety exhibited more potent inhibitory effect than (-)-epicatechin-3-0-gallate having catechol group in flavan-3-ol moiety on mushroom tyrosinase activity.

만나고 싶었습니다-슈퍼컴퓨팅사업팀

김소영,Kim, So-Yeong 한국과학기술정보연구원 2006 지식정보인프라 Vol.21 No.-

천문우주, 생명과학과 같은 첨단 R&D에서부터 TV나 김치냉장고 같은 가전제품에 이르기까지 슈퍼컴퓨터의 활용영역이 급속히 확장되고 있다. 그리고 이제 한 나라의 과학기술 수준을 가늠하는 척도로까지 부각되고 있는 슈퍼컴퓨터. 이토록 중요성을 더해가는 슈퍼컴퓨팅의 모든 것을 처음부터 끝까지 이끌고 가다듬고 최적화하는 '슈퍼컴퓨팅의 브레인'들이 바로 KISTI 슈터컴퓨팅사업팀 사람들이다.

In Vitro Study on the Bond Strength Between 3D-Printed Resin and Resin Cement for Pediatric Crown Restoration

김소영,신유석,김익환,송제선,So Yung Kim,Yoosoek Shin,Ik-Hwan Kim,Je Seon Song Korean Academy of Pediatric Dentistry 2023 大韓小兒齒科學會誌 Vol.50 No.1

A 3D-printed resin crown is a novel option for esthetic crown restoration for primary teeth, which are typically bonded with resin cement. The purpose of this study was to evaluate the bonding ability of a 3D printing resin and compare it with other indirect resin materials for crown fabrication. The shear bond strengths of two 3D printing resin materials, Graphy (GP) and NextDent (NXT), and two indirect resin materials, VIPI Block (VIPI) and MAZIC Duro (MZ), were compared in the study. For all materials, the shear bond strength at the interface between the surface of the resin material and resin cement was measured. The mean shear bond strength values of GP, NXT, MZ, and VIPI were 23.29 ± 3.88, 26.14 ± 4.67, 25.41 ± 4.03, and 18.79 ± 4.26 MPa, respectively. There was no significant difference among the SBSs of GP, NXT and MZ except for VIPI. The result of this study indicates that the 3D printing resin meets the essential requirement for clinical use by showing clinically adequate bond strength.

신규간호사의 재직의도와 현실충격 및 극복력

김소영,현명선,Kim, Soyoung,Hyun, Myung-Sun 한국콘텐츠학회 2022 한국콘텐츠학회논문지 Vol.22 No.10

The purpose of this study was to identify factors influencing intention to stay among new graduate nurses. The participants were 127 new graduate nurses working at A University hospital in Gyeonggi Province. Data were analyzed by descriptive statistics, independent t-test, one-way ANOVA, Pearson's correlation coefficient, and multiple regression. The results showed that job satisfaction, reality shock, working period, and resilience were significant predictors of intention to stay and explained for 44.2% of the variance in intention to stay. The findings of this study suggest that interventions focusing on reducing the reality shock through pre-experiences or trainings in clinical situations and enhancing the resilience are needed to improve intention to stay for the new graduate nurses. Also it is necessary to establish a support system and work environment to improve nursing job satisfaction, and a long-term education program of more than 6 months is needed to help new nurses adapt to work.

1세 미만과 1세 이상의 가와사끼병 환아에서 급성기 임상양상 및 관상동맥 변화에 대한 비교

김소영,임성준,윤신원,이동근,최응상,Kim, So Young,Lim, Seong Joon,Yun, Sin Weon,Lee, Dong Keun,Choi, Eung Sang 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.6

목 적 : 기존의 진단기준을 모두 만족시키지 못하는 비정형적인 가와사끼병이 실제로 1세 미만에서 더 흔히 발생하는지 및 가와사끼병의 심혈관 합병증의 위험인자로 기존에 언급된 바 있는 1세 미만에 발병한 가와사끼병 환아에 있어서 1세 이상 가와사끼병 환아와 비교하여 급성기의 임상양상, 검사실 소견, 관상동맥 병변의 빈도에 차이가 있는지를 알아보고, 이들 비교 분석을 통해 가와사끼병의 발병연령에 따른 좀더 합리적인 진단기준 설정 및 조기치료의 필요성이 있는지에 대하여 알아보고자 하였다. 방 법: 1997년 4월부터 2001년 5월까지 49개월간 중앙대학교 용산병원 및 필동병원 소아과에 가와사끼병으로 입원하였던 환아 70례를 대상으로 발병연령이 1세 미만인 환아 17례와 1세 이상인 53례로 나누어 성별, 급성기 임상양상, 입원시 검사실 소견, 급성기, 아급성기 및 회복기의 심초음파 검사 소견 등에 대해 입원 기록지를 후향적으로 분석하였다. 결 과 : 1) 총 70례의 환아 중 1세 미만 환아는 24.3%를 차지하였고 발병연령은 최소 2개월에서 최대 8세였으며(평균연령 26.5개월) 전체 대상아의 남녀비는 1.3 : 1였고 1세 미만군의 남녀비는 3.3 : 1 및 1세 이상군의 남녀비는 1.0 : 1로 1세 미만 환아에서 통계적으로 유의하게 남아에서 호발하였다(P=0.04). 2) 발열시작부터 IVIG을 투여 받기까지의 총 발열일수($4.6{\pm}1.3$ 대 $6.2{\pm}2.5$일, P=0.004)와 발열시작부터 최초의 심초음파 시행까지의 일수($5.2{\pm}1.6$일 대 $7.1{\pm}2.6$일, P=0.01)는 1세 미만군에서 유의하게 짧았고, 5일 이상의 발열을 보인 경우(70.6% 대 92.5%, P=0.008)는 1세 미만군에서 유의하게 적었다. 경부림프절 비대를 보인 우(35.3% 대 66.0%, P=0.02)는 1세 미만에서 유의하게 적었다. 가와사끼병의 전형적 임상징후 5개를 모두 보인 경우(41.2% 대 75.5%, P=0.006)는 1세 미만군에서 유의하게 적었다. 비정형적 기타 임상증상 중 호흡기 증상의 빈도(23.5% 대 50.9 %, P=0.041)는 1세 이상군에서 유의하게 많았다. 3) 입원시 혈청 알부민($4.3{\pm}0.3g/dL$ 대 $3.8{\pm}0.5g/dL$, P=0.005)은 1세 이상군에서 유의하게 낮았고, 혈청 BUN($11.0{\pm}3.9mg/dL$ 대 $8.5{\pm}2.8mg/dL$, P=0.026)은 1세 미만군에서 유의하게 높았으며, 혈청 칼륨($4.8{\pm}0.4mEq/L$ 대 $4.1{\pm}0.4mEq/L$, P<0.001)은 1세 이상군에서 유의하게 낮았다. 4) 심초음파상 심염의 빈도는 급성기, 아급성기, 회복기 모두 두군간 차이가 없었다. 관상동맥확대 빈도는 급성기, 아급성기, 회복기 모두 1세 미만군에서 더 높았으나 통계적 유의성은 급성기(47.1% 대 17.0%, P=0.01)에만 있었고 가와사끼병으로 진단되어 IVIG를 투여한 후인 아급성기 및 회복기에는 두군간 유의한 차이를 보이지 않았다. 결 론 : 1세 미만에 발병한 가와사끼병 환아에서는 1세 이상군에 비해 전형적인 진단기준을 완전히 만족하지 못하는 경우가 유의하게 많으며 급성 발열기에 관상동맥변화가 나타남을 알 수 있었다. 따라서 1세 미만의 어린 영아에서 뚜렷한 원인이 없이 발열이 지속되는 경우에는 가와사끼병의 가능성을 항상 염두에 두고 심초음파 검사를 시행, 관상동맥 병변 유무를 확인하여 조기진단과 조기의 적절한 IVIG 투여가 필요할 것으로 사료된다. Purpose : To identify the necessity of more reasonable diagnostic criteria and the possibility of early prediction of coronary involvement in the higher risk group, we investigated and compared clinical and laboratory findings in the acute phase and coronary involvements in those younger (n=17) and older(n=53) than one year of age in Kawasaki disease(KD). Methods : Retrospective chart reviews were performed on 70 patients with KD who were admitted to the Chung-Ang University Hospital from April 1997 to May 2001. Results : Male were significantly higher in the younger age group(M : F ratio 3.3 : 1 vs. 1.0 : 1, P=0.004). Fever durations before intravenous immunoglobulin(IVIG) and echocardiography were significantly shorter in the younger group($4.6{\pm}1.3$ vs. $6.2{\pm}2.5$, P=0.004 vs. 0.01, respectively). Cases meeting typical diagnostic criteria were significantly less in the younger group(P=0.006). In the laboratory findings, serum albumin, BUN and $K^+$ levels in the acute febrile phase were significantly higher in the younger group(P=0.002, 0.006, <0.001, respectively) and incidences of coronary artery dilatation in the acute phase were significantly higher in the younger group(P=0.01). Conclusion : Although less met the typical diagnostic criteria of KD, infants younger than one year of age are more susceptible to coronary artery change in the acute febrile phase. Therefore, KD should be entertained as a diagnostic possibility in young infants with prolonged fever without distinct fever focus, and echocardiography should be considered as part of the evaluation of these patients, and then early diagnosis and prompt IVIG should be conducted.