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김봉석(Bong Seog Kim),김서운(Seo Woon Kim),이영현(Young Hyun Lee),조희준(Hee Jun Cho),이춘택(Choon Taek Lee),도영수(Young Soo Do),김효윤(Hyo Youn Kim),조재일(Jae Ill Zo),심영목(Young Mog Shim),이진오(JIn Oh Lee),강태웅(Tae Woong Kang 대한내과학회 1994 대한내과학회지 Vol.46 No.4
N/A Objective: For curative surgical treatment of esophageal cancer the resectability from the tracheobrochial tree would be the most important factor. Although CT scan has been used for the determination of the resectability of esophageal cancer, it has a limitation on the detection of esophageal cancer invasion to tracheobronchial tree We have performed flexible bronchoscopy in the patients with esophageal cancer to detect and classify the tracheobronchial tree alterations and to find the relation of bronchoscopic findings with the resectability. Method: From April 1990 to October 1992, 133 patients with esophageal cancer had received bronchoscopy. Bronchoscopic findings were classified into three groups: [Group I: normal, Group II: indirect effects (hyperemia and compression-mild, moderate, severe), group III: invasion). CT findings were a]so classified into three classes: [Class A: tumor separated from tracheobronehial tree, Class B: abutting tree, Class C: compressing tree]. We investigated the resectability of esophageal cancer according to bronchoscopic and CT findings. Results: 1) Among 133 patients, the bronchscopic findings were Group I in 41(30.8%), Group II in 66(49.6%), and Group III in 26(19.6%) patients. 2) Abnormal bronchoscopic findings were mainly found in trachea and left main bronchus and frequently found in upper and middle esophageal cancer patients, 3) The resection rate from tracheobronchial tree was 96.8% in group I and 75% in group II bronchoscopic finding. 4) The resections from tracheobronchial tree could be performed in 94.6% of Class A, in 70% of Class B and in 53.8% of Class C of CT scan patients. 5) Six of twelve unresectable patients belonged to Class C of CT scan finding If we excluded Class C in Group II patients, resectability would be increased to 87.5%. Conclusion: We could recommend the operation in esophgeal cancer patients with Group I and minimal Group II bronchoscopic finding. In advanced Group II and/or Class C of CT scan patients, neoadjuvant treatment and reevaluation could be recommended.
김봉석 ( Kim Bong Seog ),김승진 ( Kim Seung Jin ),정윤수 ( Jeong Yun Su ),임성운 ( Im Seong Un ),노철균 ( No Cheol Gyun ),원철호 ( Won Cheol Ho ),조진호 ( Jo Jin Ho ),이건일 ( Lee Geon Il ) 한국센서학회 2003 센서학회지 Vol.12 No.3
본 연구에서는 택배물의 분류를 위한 자동화 시스템에서 주소 영역 검출 알고리즘을 제안하였다. 주소 영역 검출을 위한 알고리즘에서는 대상 영상이 매우 크기 때문에 수행 시간의 단축을 위하여 택배 라벨부분을 포함하는 제한된 범위인 관심영역(Region of interesting: ROI)을 구한 후 관심 영역내에서 모든 알고리즘이 수행되도록 한다. 주소 영역 검출을 위하여 택배 라벨의 특징인 주소 영역을 둘러싸고 있는 테두리선을 이용한다. 이진화(thresholding) 과정과 라벨링 (Labeling) 과정을 통하여 획득된 영상에서 주소 영역의 테두리선과 그 밖의 성분들을 각각 독립된 연결성분들(connected components)로 검출한다. 주소 영역을 둘러싸는 테두리선의 기하학적인 특징을 이용하여 여러 개의 연결성분들 중에서 주소 영역을 둘러싸는 테두리선을 분리한다. 마지막으로 윈 영상과 분리된 테두리선 부분과의 논리적 곱을 이용하여 주소 영역을 최종적으로 검출하게 된다. In this paper, we proposed the algorithm for locating destination address block (DAB) from automatic system to classify packages. For locating DAB, because the size of obtained images is are very large, we select the region of interesting (ROI) to reduce time carrying into algorithm. After selecting the ROI, proposed algorithm is carried out within the ROI. We extract the outline of the handwriting part of the DAB and the rest components within the obtained ROI using thresholding. We carry out labeling to extract each connected component for extracted outline and the rest components. We extract the outline of the handwriting part of the DAB using the geometrical characteristic of the outline of the handwriting part of the DAB among many connected components. The last, we extract the locating DAB using the outline of the handwriting part of the DAB.
진성다혈구증에 병발한 미세변화신증을 동반한 IgA 신병증
정영종 ( Young Jong Jung ),김범 ( Beom Kim ),조영미 ( Yong Mee Cho ),김희섭 ( Hee Sup Kim ),김지호 ( Ji Ho Kim ),김수연 ( Soo Yeun Kim ),김봉석 ( Bong Seog Kim ),최윤미 ( Youn Mi Choi ),문경협 ( Kyoung Hyoub Moon ) 대한신장학회 2008 Kidney Research and Clinical Practice Vol.27 No.6
Polycythemia vera is a hematopoietic stem cell disease, characterized by sustained and excessive proliferation of erythrocytic, granurocytic and megakaryocytic cells in the bone marrow resulting in pancytosis in peripheral blood. There have been a few reports of glomerulonephritis with polycythemia vera, most of which were IgA nephropathy. We report a case of a polycythemia vera associated with proteinuria. We confirmed the polycythemia vera according to World Health Organization criteria. Renal pathology showed IgA nephropathy and minimal change disease. Periodic phlebotomy was done and hydroxyurea was administered without specific managements for renal disease. After 3-month treatment, hemoglobin level decreased and proteinurea disappeared.
정태영,최영민,김봉석,이동우,김민숙,박준현,Jeong, Tae-Yeong,Choi, Young-Min,Kim, Bong-Seog,Lee, Dong-Woo,Gim, Min-Sook,Park, Jun-Hyun 대한생물정신의학회 2012 생물정신의학 Vol.19 No.2
Objectives : The purpose of this study was to examine the changes in metabolic parameters and Positive and Negative Syndrome Scale (PANSS) scores of patients previously treated with atypical antipsychotic drugs other than paliperidone, after 8 weeks of treatment with paliperidone. Methods : Changes in body weight, body mass index, leptin, lipid levels, fasting glucose, and PANSS scores of patients who switched from other atypical antipsychotic drugs to paliperidone were measured after 8 weeks of treatment with paliperidone. We compared these results with those of patients who had not been treated with antipsychotic drugs for at least 2 weeks prior to treatment with paliperidone (antipsychotic drug-free patients). Results : The antipsychotic drug-free group (n = 9) did not show significant changes in metabolic parameters, but showed a significant improvement in total and subscale scores of PANSS. In the group that switched from other atypical antipsychotic drugs to paliperidone (n = 13), body weight, body mass index and fasting glucose level significantly increased, while total and subscale scores of PANSS significantly improved. Conclusions : Paliperidone treatment will benefit patients with schizophrenia who have been antipsychotic drug-free or who have had difficulty with other atypical antipsychotic drugs, with regard to their psychopathological state. However, if patients have been treated with other atypical antipsychotic drugs before switching to paliperidone, they could gain body weight or their fasting glucose level could increase over a short period because of a change in receptor number and sensitivity caused by the previously prescribed antipsychotic drugs, and hence, paliperidone should be prescribed with caution for these patients.
만성면역혈소판감소자색반에서의 Anti-D immunoglobulin 치료
김혜정 ( Hye Jeong Kim ),정윤진 ( Yun Jin Jung ),황의남 ( Eui Nam Hwang ),김영훈 ( Young Hoon Kim ),최진성 ( Jin Sung Choi ),남승현 ( Seung Hyun Nam ),김봉석 ( Bong Seog Kim ),오도연 ( Do Yeon Oh ),윤성수 ( Sung Soo Yoon ),박선양 대한내과학회 2008 대한내과학회지 Vol.74 No.2
목적: 성인 만성 면역혈소판감소자색반 환자에서 anti-D 면역글로불린을 투여하여 혈소판 상승에 대한 효과와 부작용을 확인하고자 본 연구를 시행하였다. 방법: 이전 치료에 반응을 하지 않거나 재발한 전체 14명의 성인 만성 면역혈소판감소자색반 환자를 대상으로 하였다. 14명 환자가 스테로이드 요법을 받았고, 10명의 환자는 비장절제술을 시행 받았다. Anti-D 면역글로불린의 주입량은 50~70 μg/kg이었으며 단 한번 주입하여 반응을 확인하였고, 치료 반응의 평가는 혈소판 및 혈색소 수치를 추적 검사하였다. 결과: 치료 반응이 확인된 경우는 전체 환자의 36% 인 5명이었고, 혈소판 상승이 지속된 기간은 평균 7일이었으며 심각한 합병증은 없었다. 결론: 본 연구에서는 성인의 만성 면역혈소판감소자색 반증에서 Fc 수용체 차단제인 anti-D 면역글로불린을 이용한 치료가 임상적 유용성이 있는 것으로 나타났다. Background/Aims: Immune thrombocytopenic purpura (ITP) is an autoimmune disease that is mediated by anti-platelet antibodies. Based on the pathogenesis of ITP we evaluated the efficacy of intravenous anti-D immunoglobulin for adult chronic ITP. Methods: Fourteen patients (4 without splenectomy and 10 with splenectomy) with refractory chronic ITP were treated with 50-70μg/kg of intravenous anti-D immunoglobulin only once. Treatment effects were evaluated by measuring the platelet counts and hemoglobin levels. Results: Five patients (36%) showed a response; improvement in the platelet count lasted for on average 7 days (range: 2~24 days). There were no serious adverse effects. Conclusion: Anti-D immunoglobulin, which is associated with an Fc receptor blockade, appeared to be safe and effective for the treatment of adults with chronic ITP. Further studies are needed to confirm these findings and define further potentially effective treatment protocols with intravenous anti-D immunoglobulin. (Korean J Med 74:176-180, 2008)
REAL 분류상 B-미만성 대세포 림프종에서 조직학적 아형 분류의 임상적 의의
류민희 ( Min Hee Ryu ),김봉석 ( Bong Seog Kim ),김태원 ( Tae Won Kim ),박연희 ( Yeon Hee Park ),허주령 ( Joo Ryung Huh ),이승숙 ( Seung Sook Lee ),김철우 ( Chul Woo Kim ),류백렬 ( Baek Yeol Ryoo ),김노경 ( Noe Kyeong Kim ),이규형 대한내과학회 2003 대한내과학회지 Vol.65 No.1
목적 : REAL 분류상 B-미만성 대세포 림프종은 다양한 임상경과를 보이는 이질적인 림프종을 포함하고 있는데, 일부 연구에서는 B-미만성 대세포 림프종 중immunoblastic lymphoma (IBL)가 다른 조직아형에 비해 예후가 좋지 않음을 시사하고 있다. 본 연구에서는 B-미만성 대세포 림프종을 형태학적으로 IBL과 non-IBL로 세분화할 필요가 있는지 알아보고자 하였다. 방법 : 1989년부터 1995년까지 3개 병원에서 치료 받은 비호지 Background : Diffuse large B-cell lymphoma (DLBL) category in the REAL classification includes histologically heterogeneous subtypes in Working Formulation or Kiel classification. Some investigators insist that the prognosis of B-cell immunoblastic lympho
황인철 ( Hwang In Cheol ),김봉석 ( Kim Bong Seog ),김종수 ( Kim Jong Su ),선우재근 ( Seonu Jae Geun ),배동한 ( Bae Dong Han ),김현철 ( Kim Hyeon Cheol ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.11
Liver hematomas, infarction and ruptures complicated with preeclampsia are fatal to pregnant woman and fetus. So, close observation and proper diagnosis are demanded for treatment. Although the incidence of HELLP syndrome in severe preeclampsia and eclamp