http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
고지원,박하영,배정모,강준,조의주,이승은,강혜윤,홍민의,원재경,최윤라,김완섭,이아원,The Molecular Pathology Study Group of the Korean Society of Pathologists 대한병리학회 2023 Journal of Pathology and Translational Medicine Vol.57 No.5
Background: The importance of molecular pathology tests has increased during the last decade, and there is a great need for efficient training of molecular pathology for pathology trainees and as continued medical education. Methods: The Molecular Pathology Study Group of the Korean Society of Pathologists appointed a task force composed of experienced molecular pathologists to develop a refined educational curriculum of molecular pathology. A 3-day online educational session was held based on the newly established structure of learning objectives; the audience were asked to score their understanding of 22 selected learning objectives before and after the session to assess the effect of structured education. Results: The structured objectives and goals of molecular pathology was established and posted as a web-based interface which can serve as a knowledge bank of molecular pathology. A total of 201 pathologists participated in the educational session. For all 22 learning objectives, the scores of self-reported understanding increased after educational session by 9.9 points on average (range, 6.6 to 17.0). The most effectively improved items were objectives from next-generation sequencing (NGS) section: ‘NGS library preparation and quality control’ (score increased from 51.8 to 68.8), ‘NGS interpretation of variants and reference database’ (score increased from 54.1 to 68.0), and ‘whole genome, whole exome, and targeted gene sequencing’ (score increased from 58.2 to 71.2). Qualitative responses regarding the adequacy of refined educational curriculum were collected, where favorable comments dominated. Conclusions: Approach toward the education of molecular pathology was refined, which would greatly benefit the future trainees.
대한민국 의료의 발전을 위하여: 젊은의사들이 새 정부에 바라는 다섯 가지
고지원,문우리,남기훈,이상형,김현지,기동훈 대한의사협회 2017 대한의사협회지 Vol.60 No.6
Residents who are currently in the process of completing graduate medical education (GME) will eventually become independently practicing professionals; therefore, the quality of GME is of enormous importance for our society. To improve the quality of GME in Korea, we, as young doctors, suggest that the government support funding for GME; make all possible efforts to ensure reasonable and sustainable working conditions for residents; implement adequate maternity plans; prohibit all kinds of unauthorized medical practice by other healthcare providers; and prevent all kinds of workplace violence toward residents. These measures to improve the quality of GME will surely benefit patient safety and the overall quality of healthcare in the future.
고지원,정다운,김의진,김동규 대한교통학회 2017 대한교통학회 학술대회지 Vol.76 No.-
본 논문에서는 고속도로 사고 속보자료를 이용하여 2차 사고의 심각도에 미치는 요인을 분석한다. 고속도로 사고의 분석은 그간 정형 데이터를 분석하는 연구가 주를 이루었다. 하지만 사고 속보자료인 비정형 텍스트는 사고의 정황과 과정을 알 수 있다는 점에서 매우 중요하다. 특히 2차 사고의 경우, 1차 사고와 이어지는 인과관계가 중요한 사고이므로 2차 사고를 추출해내는 것은 정형데이터만으로 구현하기 힘들었고, 때문에 많은 선행연구에서 시간과 공간의 매칭을 통해 2차 사고를 구별했다. 본 연구는 비정형 데이터를 근간으로 하여 사고 속보자료가 반복적으로 2차사고의 경우에 도출해내는 키워드를 발견하여 키워드를 찾는 방식으로 2차 사고를 구별할 수 있었다. 또한 정형데이터에 없는 변수를 비정형 데이터에서 찾을 수 있었다. 이를 바탕으로 2차 사고의 심각도에 미치는 요인을 회귀분석을 통해 분석했다. Ordered logit 모형을 사용하여 분석을 한 결과, 운전자의 도로 보행 여부, 사고가 일어난 장소, 운전자의 연령이 유의미하게 심각도에 영향을 끼쳤다. 2차 사고를 분리해내는 것은 비정형 데이터 분석의 첫 단계로서, 향후 연구에서는 변수 또한 비정형 데이터에서 완전히 추출해 낼 수 있는 연구를 진행할 수 있을 것으로 기대된다.
Effects of Systemic Glucocorticoid Use on Fracture Risk: A Population-Based Study
고지원,김준강,조혜민,하용찬,김태영,이영균,김하영,장선미 대한내분비학회 2020 Endocrinology and metabolism Vol.35 No.3
Background: Long-term glucocorticoid use increases fracture risk by reducing bone mass. This study evaluated the relationship between hip and vertebral fractures and the total amount of systematic glucocorticoid use. Methods: We randomly selected 1,896,159 people aged 20 to 100 years who participated in the National Health Checkup programin 2006. The amount of glucocorticoids prescribed was calculated based on the defined daily dose (DDD). The total DDD was obtained by adding oral and parenteral glucocorticoids for 6 months from the index date. Subjects were categorized into four groupsaccording to total glucocorticoid DDDs: non-users (DDDs=0), low users (0< DDDs ≤45), intermediate users (45< DDDs ≤90),and high users (90< DDDs). We followed them for 2 years. A multivariate Cox proportional hazard model was used to evaluate theeffects of the total amount of glucocorticoid use on hip and vertebral fractures. Results: Higher glucocorticoid use was associated with a higher risk of vertebral fracture. Relative to non-users, the vertebral fracturerisk was 1.39 times higher in the low-user group, 1.94 times higher in the intermediate-user group, and 2.43 times higher in the highuser group. The risk of hip fracture was 1.72 times higher in intermediate users and 3.28 times higher in high users than in non-users. Conclusion: As the amount of glucocorticoid use for 6 months increased, the risk of hip and vertebral fractures became higher. Inorder to prevent fractures, it is necessary for doctors to evaluate the total amount of glucocorticoid prescribed to the patient and toprovide appropriate treatment.
High-Throughput Multiplex Immunohistochemical Imaging of the Tumor and Its Microenvironment
고지원,곽윤진,김진,김우호 대한암학회 2020 Cancer Research and Treatment Vol.52 No.1
Purpose The aim of this study was to develop a formalin-fixed paraffin-embedded (FFPE) tissue based multiplex immunochemistry (mIHC) method for high-throughput comprehensive tissue imaging and demonstrate its feasibility, validity, and usefulness. Materials and Methods The mIHC protocol was developed and tested on tissue microarray slides made from archived gastric cancer (GC) tissue samples. On a single FFPE slide, cyclic immunochemistry for multiple markers of immune cells and cytokeratin for tumor cells was performed; hematoxylin staining was used for demarcation of nuclei. Whole slides were digitally scanned after each cycle. For interpretation of mIHC results, we performed computer-assisted image analysis using publicly available software. Results Using mIHC, we were able to characterize the tumor microenvironment (TME) of GCs with accurate visualization of various immune cells harboring complex immunophenotypes. Spatial information regarding intratumoral and peritumoral TME could be demonstrated by digital segmentation of image guided by cytokeratin staining results. We further extended the application of mIHC by showing that subcellular localization of molecules can be achieved by image analysis of mIHC results. Conclusion We developed a robust method for high-throughput multiplex imaging of FFPE tissue slides. The feasibility and adaptability of mIHC suggest that it is an efficient method for in situ single- cell characterization and analysis.
컨테이너 항만 하역장비별 대기오염물질 배출 특성에 관한 연구
고지원,김필수,김호정,박건진,표정관,유철,김진식 한국대기환경학회 2021 한국대기환경학회 학술대회논문집 Vol.2021 No.10
최근 부산, 인천 등의 주요 항만도시의 미세먼지 농도가 서울, 대구 등 육상 대도시만큼 심각해짐에 따라 항만 지역 미세먼지 등의 대기오염물질 배출을 저감하고 효율적인 관리를 위해 「항만지역 등 대기질 개선에 관한 특별법」(이하 항만대기질법)이 시행 중이다. 항만도시의 효율적인 대기오염 관리를 위해서는 항만 배출원(선박, 하역장비 등) 관리가 필수적이다. 현재, 국가대기정책지원시스템(Clean Air policy Support System, 이하 CAPSS) 중 선박 부문(화물, 여객, 어선, 레저 등) 대기오염물질 배출량을 산정하고 있으나, 하역장비(야드트랙터 등)는 배출량을 산정하지 않고 있다. 국립환경과학원(2019) 연구에 의하면 항만 내에서 운영 중인 하역장비는 총 30종으로 분류가 가능하고, 이 중 「항만대기질법」에서는 야드트랙터, 갠트리크레인, 트랜스퍼 크레인, 스트래들 캐리어 4종만을 하역장비로 정의하였다. 이에 본 연구에서는 부산항, 인천항, 여수광양항, 울산항 등 국내 4개 항만을 대상으로 현장조사를 통해 수집한 하역장비 활동자료(2018년 기준)를 활용하여 「항만대기질법」에서 정의하고 있는 4종의 하역장비와 기타 하역장비 구분하여 컨테이너 항만에서 운영 중인 하역장비별 대기오염물질 배출 특성을 분석하였다.