Acute Fulminating Myasthenia Gravis in a Shih-tzu Dog

강병택,유종현,박효진,정동인,박철,구수현,전효원,김주원,김하정,임채영,조수경,허라영,이소영,김정현,한성국,성주헌,박희명 한국임상수의학회 2006 한국임상수의학회지 Vol.23 No.4

A 3-year-old, spayed female Shih-tzu dog was presented due to acute vomiting, diarrhea, and generalized weakness. The dog had generalized weakness, increased respiratory rate, and respiratory muscle effort. Neurologic examination revealed appendicular muscular weakness and decreased in tone of the anal sphincter. Megaesophagus was confirmed by radiographic examinations. Other than type 2 fiber atrophy, no specific abnormalities were identified in histopathologic examinations of muscle biopsies from the left pelvic limb. Serum acetylcholine receptor (AChR) antibody titer was increased (0.78 nmol/L; reference range, less than 0.6 nmol/L), confirming a diagnosis of acute fulminating myasthenia gravis. The dog dramatically responded to pyridostigmine bromide and had marked improvement in muscle strength, megaesophagus, and respiratory function. The dog has been successfully managed for 7 months after initial treatment.

Retrospective study of 23 dogs with meningoencephalomyelitis of unknown etiology

강병택,김준희,구윤회,윤태식,채연,이도희,차시진,김지윤,김학현,양만표 충북대학교 동물의학연구소 2022 Journal of Biomedical and Translational Research Vol.23 No.4

This study aimed to identify prognostic factors and describe the treatment outcomes of multidrug therapy in dogs with meningoencephalomyelitis of unknown etiology (MUE). A total of 23 dogs diagnosed with MUE were treated with prednisolone in combination with cyclosporine, cytosine arabinoside (CA), leflunomide, and mycophenolate mofetil. Based on the survival time, these dogs were divided into two groups: group A (n = 10), surviving for < 100 days, and group B (n = 13), surviving for > 100 days. Signalment, seizure activity, cerebrospinal fluid (CSF) analysis results, and magnetic resonance (MR) imaging findings were reviewed. Survival studies were conducted to investigate the association of each prognostic factor and treatment with the clinical outcome. There were no significant differences in age, sex, body weight, occurrence of seizures, cell number and protein concentration in the CSF, or location of lesions between groups A and B. Abnormal MR features were more frequently observed in group A than in group B. It was identified that the longest median survival time was administration of multi-drug therapy including CA. In conclusion, abnormal MR features were associated with poor prognosis in dogs with MUE and CA-based multi-drug therapy could be considered the most effective treatment of MUE.

JBIG2 부호화에서의 한글의 효율적 처리에 관한 연구

강병택,김현민,고형화 한국통신학회 2000 韓國通信學會論文誌 Vol.25 No.6

In this paper, we propose a method to improve JBIG2 compression ratio which can be applied to Hangul text. Hangul character is composed of a few symbols which is called JASO, which needs inevitable increase of position information to be transmitted. To reduce this disadvantage, we have proposed an algorithm that generate aggregated symbol in combination of JASO symbols. Proposed algorithm shows better performance in Huffman coding than in arithmetic coding. In lossless coding, proposed algorithm showed 4.5∼16.7(%) improvement for Huffman coding and 2.9∼10.4(%) improvement for arithmetic coding. In lossy coding, proposed algorithm showed 3.7∼17.0(%) improvement for Huffman coding and 2.1∼10.5(%) improvement for arithmetic coding.

Cutaneous Epitheliotropic T-Cell Lymphoma in a Dog: Clinical Responses to Lomustine and Gemcitabine

강병택,김대영,강지훈,장동우,정동인,조규완,양만표 한국임상수의학회 2013 한국임상수의학회지 Vol.30 No.4

A 5-year-old, spayed female Maltese dog presented with generalized multifocal pruritic erythema and alopecia for a month. Initial skin biopsy suggested cutaneious histiocytosis. The dog had been treated with the immunosuppressive therapy for a month, but multifocal erythematous patches and plaques were newly observed. Direct imprint smear of cutaneous lesions suggested a lymphoma and rebiopsy was performed. Microscopic examination demonstrated a round cell tumor with epitheliotrophism to the epidermis and adnexal structures. The neoplastic round cells were strongly positive for CD3 yet negative for CD79a, indicting the tumor was cutaneous epitheliotropic Tcell lymphoma. After 2 cycles of oral administration of lomustine (70 mg/m2, once every 2-3 weeks), only partial response was observed. Alternative chemotherapy with gemcitabine (500 mg/m2, 30-minute IV infusion, once every week) was initiated. A total 3 cycles of gemcitabine failed to control the progression of disease, and the dog was euthanized on Day 69 after the 1st lomustine treatment.

Bilateral Congenital Deafness in a White Bull Terrier; Brainstem Auditory Evoked Response Findings

강병택,이소영,정동인,김형중,우응제,박희명 한국임상수의학회 2008 한국임상수의학회지 Vol.25 No.6

A 2-month-old, intact female white Bull Terrier presented because of suspected deafness. The coat color was predominantly white and the iris color, of both eyes, was brown. The dog did not respond to the owner’s voice when the sound stimuli were presented outside of the visual field; however, the dog responded to visual gestures. The other physical, neurological, otoscopic, radiographic, and blood examinations were unremarkable. To assess the apparent deafness, brainstem auditory evoked responses (BAER) were recorded and analyzed in the dog with suspected deafness as well as a normal littermate. The response in the normal littermate consisted of a series of five wave peaks (I-V) with decreased amplitude and prolonged latency as the stimulus intensity decreased. The BAER from the dog suspected of deafness appeared as a flat line and did not reveal identifiable peaks that corresponded to those found in the normal littermate. Thus, congenital, sensorineural and bilateral deafness was confirmed by the BAER.

Juvenile cellulitis in a 7-month-old Shih-Tzu dog

강병택,강지훈,정동인,양만표,이지혜,서정향,장동우 충북대학교 동물의학연구소 2013 Journal of Biomedical and Translational Research Vol.14 No.3

A-7-month-old, intact male Shih-Tzu dog was referred with facial dermatitis and stifle pain with 7 days duration. Erythema, hemorrhage, and crusted nodular lesions of the face, swollen eyelids, and otitis externa were observed. A painful response was noted on palpation of the right stifle joint. Impression smears and skin biopsies revealed pyogranulomatous inflammation consistent with canine juvenile cellulitis (CJC). Skin lesions and pain were greatly improved following immunosuppressive corticosteroid therapy. This report firstly describes clinical and histopathological findings as well as treatment responses of CJC in a 7-month-old, domestic dog.

일반적인 불안 증상에 대한 약리학적 치료

강병택,이소영,김주원,정동인,김하정,박철,박희명 로얄에이알씨 주식회사 2005 로얄동물임상의학 Vol.3 No.4

Effect of Conjugated Linoleic Acid on Nuclear Factor-κB Activation and Tumor Necrosis Factor-α Production in RAW 264.7 Cells Exposed to High Concentration of Glucose

이민지,강병택,강지훈,양만표 한국임상수의학회 2012 한국임상수의학회지 Vol.29 No.5

Diabetes-related complications in human and veterinary medicine have been shown to be associated with hyperglycemia-induced inflammation. It has been recently suggested that the onset of insulin resistance may be caused by over-production of inflammatory cytokines such as tumor necrosis factor (TNF)-α from immune cells. Conjugated linoleic acid (CLA) regulates inflammatory response through modulation of TNF-α expression. The objective of this study was to examine the effect of CLA on nuclear factor kappaB (NF-κB) p65 binding activity, inhibitory kappaB (IκB)-α expression, and TNF-α production from high glucose-treated RAW 264.7 cells. CLA was added to RAW cells that had been previously cultured with low or high concentration of glucose. The levels of TNF-α protein in the culture supernatant of RAW cells exposed to high concentrations of glucose were higher than those of cells exposed to low concentrations of glucose. The treatment with the high concentration of glucose in RAW cells increased levels of NF-κB p65 binding activity and the decreased IκB-α expression when compared with those of low glucose. The treatments in combination with CLA and glucose (low and high) glucose in RAW cells increased TNF-α production when compared with that glucose alone. These treatments with CLA increased TNF-α production in high glucosetreated RAW cells than those with low glucose. These treatments of CLA also showed higher NF-κB p65 binding activity and lower IκB-α expression in high glucose than those in low glucose condition. This suggests that CLA can increase NF-κB p65 binding activity and TNF-α production from high glucose-treated RAW 264.7 cells and is likely to promote hyperglycemia-induced inflammation.

Zinc Increases Chemotactic Activity of Porcine Peripheral Blood Polymorphonuclear Cells

서동희,강병택,강지훈,양만표 한국임상수의학회 2018 한국임상수의학회지 Vol.35 No.5

Zinc is necessary for normal functions in the immune system. The objective of the study is to examinethe effect of zinc on the chemotactic activity of porcine peripheral blood polymorphonuclear cells (PMNs). A modifiedBoyden chamber was used to determine the directional migration distance of PMNs. Various concentrations of zincshowed no chemotactic activity to PMNs. However, culture supernatant from peripheral blood mononuclear cells(PBMCs) treated with zinc remarkably increased the chemotactic activity of PMNs when compared with culturesupernatant from PBMCs treated without zinc. Culture supernatant from PBMCs treated without zinc also increasedthe migration distance of PMNs relative to vehicle control (medium alone). Increasing effect in chemotactic activityof PMNs by culture supernatant from PBMCs treated with zinc was inhibited by treatment of porcine anti-interleukin(IL)-8 polyclonal antibody (pAb). This effect was not affected by heat treatment (4-85oC). This corresponded withheat stable physical characteristics of IL-8. These results suggest that zinc can upregulate the chemotaxis of PMNs,which is primary mediated by IL-8 chemotactic factor released from PBMCs treated with zinc.

A Retrospective Study of 94 Hypercalcemic Dogs (2002-2004)

조태형,강병택,박철,정동인,김주원,김하정,임채영,이소영,김정현,우응재,박희명 한국임상수의학회 2007 한국임상수의학회지 Vol.24 No.4

A retrospective study of 94 hypercalcemic dogs was performed to find out most comon causes that leadto hypercalcemia through investigating dogs refered to the Veterinary Teaching Hospital of Konkuk University from2002 to 2004. During the study period, hypercalcemia was found in 94 dogs of 19 breeds, and they were evaluatedstudy period. For general signalments, there were no significant diferences between case and control group with theexception of age distribution. Shih-tzu (17.02%) and Yorkshire terrier (26.60%) was the most common breed in caseand control group, respectively. The most common diseases associated with hypercalcemia were chronic renal failure(18.09%), acute renal failure (14.89%), and renal calculi (6.38%). Malignant neoplasia (lymphoma, hemangiosarcoma,chronic lymphocytic leukemia, mamary gland tumor, and multiple myeloma) and endocrinopathies (hyperad-renocorticism, hyperthyroidism, hypoadrenocorticism, and hypothyroidism) occupiedreport is a first retrospective study of hypercalcemic dogs in South Korea.