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      • KCI등재

        현대시 비평문의 구성 형식과 교육적 활용 방향 - 작품 재기술(再記述) 유형을 중심으로 -

        강민규 서울대학교 국어교육연구소 2014 국어교육연구 Vol.33 No.-

        This study discusses a format of written criticism about modern poetry and presents an educational application direction of the format as a method to develop poetry criticism writing ability of students. To achieve this, aimed to discuss the structure of poetry-redescription because redescripion is basic function of criticism. According to the analysis result of criticism written by critics, poetry-redescription is performed on the basis of ‘repertory’ which is a resource or a ground of interpretation. And the type of poetry-redescription is classified into three categories: Story organization based on time axis, Analytic description and synthesis, Deductive appication of main interpretative logic. To utilize the format of written criticism about modern poetry in the classroom, it is required to make the students be conscious of critical writing procedure, and be well-informed of poetry-redescription types. The format of written criticism discussed in this study will lighten the burden of students who write critical essay, and offer a frame which enables students to demonstrate their critical originality in a confident attitude. 이 연구는 학습 독자의 시 감상문 쓰기 능력을 신장시키기 위한 방안의 일환으로 현대시 비평문의 구성 형식을 밝히고 그 교육적 활용 방향을 제시하고자 하였다. 시 감상문의 장르적 관습에 익숙하지 않은 학습 독자들이 비평문을 포함한 수용 텍스트의 일반적인 구성 형식을 이해할 경우 감상문의 체계성이 높아지고 해석 내용도 풍부해질 수 있다는 것이 이 연구의 전제이다. 비평문의 여러 기능 중 ‘작품에 대한 재기술’이 가장 기본적인 기능이라는 점에 착안하여 먼저 작품 재기술의 구조를 논구하고자 하였다. 비평가들의 비평문을 검토한 결과 해석의 자원이나 근거가 되는 ‘레퍼토리’를 바탕으로 본격적인 재기술이 수행됨을 확인할 수 있었다. 그리고 작품 재기술의 방식은 시간축에 준거한 이야기 구성, 분석적 기술과 종합, 주요 해석 논리의 연역적 적용이라는 세 유형으로 대별할 수 있었다. 이와 같이 밝힌 현대시 비평문의 구성 형식을 문학 교실에서 활용할 수 있는 가능성을 타진하기 위해 학습 독자들의 감상문 자료를 수집하여 검토하였다. 그 결과 레퍼토리의 발견에서부터 시에 대한 나름의 의미 부여, 궁극적인 메시지 제시에 이르는 일련의 단계와 재기술 유형별 활용 방법을 숙지하도록 할 필요가 있음을 확인하였다. 이 연구에서 밝힌 시 비평문의 구성 형식은 학습 독자가 감상문을 쓸 때 느끼는 인지적 부담을 경감시키고, 주체적이고 자신 있는 태도로 비평적 상상력을 발휘하는 틀을 제공할 수 있다는 점에서 의의가 있다.

      • KCI등재
      • KCI등재

        Effects of candesartan cilexetil and amlodipine orotate on receptor for advanced glycation end products expression in the aortic wall of Otsuka Long-Evans Tokushima Fatty (OETFF) type 2 diabetic rats

        강민규,정우백,홍슬기,김옥란,임상현,장기육,승기배 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.4

        The receptor for advanced glycation endproducts (RAGE) plays a key role in the development ofvascular inflammation and acceleration of atherosclerosisin type 2 diabetes. We investigated the effect of candesartancilexetil (CDRT) and amlodipine orotate (AMDP)on the expression of RAGE in the aortic walls of OtsukaLong-Evans Tokushima Fatty (OLETF) rats and AGEtreatedendothelial cells. Twenty five-week-old OLETFrats were randomized to 8 week treatments consisting ofCDRT (n = 8), AMDP (n = 8) or saline (control, n = 8). Immunohistochemical and dihydroethidine stainingrevealed reduced RAGE and reactive oxygen species(ROS) signals in rats treated with CDRT or AMDP comparedwith control rats. Both CDRT and AMDP suppressedthe expression of p22phox and p47phox NADPH oxidasesubunits. However, only CDRT significantly reducedexpression of phosphorylated extracellular signal regulatedkinase (pERK)1/2 in the aortic wall of OLETF rats. Inaddition, both drugs reduced RAGE expression and totaland mitochondrial ROS production in the AGE-treatedendothelial cells. Both ARBs and CCBs reduced RAGEexpression in the aortic walls of OLETF rats, which wasattributed to decreased ROS production through inhibitionof NADPH oxidase. In addition, only CDRT reduced aorticexpression of RAGE via suppression of the ERK1/2 pathwayunlike AMDP.

      • KCI등재

        Biodegradable Stereocomplex Polylactide Having Flexible ε-Caprolactone Unit

        강민규,정영미,김수현 한국고분자학회 2013 Macromolecular Research Vol.21 No.9

        Stereocomplex formation between poly(L-lactide-co-ε-caprolactone) (PLLCL) and poly(D-lactide-co-ε-caprolactone) (PDLCL) is known to be disturbed when their molecular weights increase to >105 g/mol. Here, Strong and biodegradable stereocomplexes of copolymers (S-PLCL) were studied using a supercritical fluid and co-solvent system. Mechanical properties such as tensile strength were ~2.5 times increased due to high degree of stereocomplex than those of PLGA20. The addition of the flexible ε-caprolactone units to the polylactide increased its thermal stability which significantly enhanced 100% degree of stereocomplex after 2nd melt processing through DSC due to the increased mobillity of the polylactide’s chains. The degradation behavior of resulting biodegradable S-PLCL showed slow degradation with increasing CL content in 0.13 M, pH 4.3 phosphate buffers.

      • KCI등재

        Role of Chemotherapy in Stage II Nasopharyngeal Carcinoma Treated with Curative Radiotherapy

        강민규,오동렬,조관호,문성호,우홍균,허대석,안용찬,박근칠,박효정,박준수,금기창,차지혜,김준원,김연실,강진형,오영택,김지윤,김성환,김진희,이창걸 대한암학회 2015 Cancer Research and Treatment Vol.47 No.4

        Purpose To define the role of neoadjuvant and concurrent chemotherapy in stage II nasopharyngealcarcinoma, we compared the treatment outcomes of patients treated with curative radiotherapywith or without chemotherapy. Materials and MethodsFrom 2004 to 2011, 138 patients with American Joint Committee on Cancer (AJCC) 2002stage II nasopharyngeal carcinoma were treated with curative radiotherapy in 12 hospitalsin South Korea. Treatment methods included radiotherapy alone in 34 patients, neoadjuvantchemotherapy followed by radiotherapy alone in seven, concurrent chemoradiotherapy in80, and neoadjuvant chemotherapy followed by concurrent chemoradiotherapy in 17. Adjuvant chemotherapy was used in 42 patients. Total radiation dose ranged from 64 Gyto 74.2 Gy (median, 70 Gy). ResultsMedian follow-up was 48 months (range, 7 to 97 months) for all patients. At the last followup,13 patients had died and 32 had experienced treatment failure; locoregional failureoccurred in 14, distant failure in 16, and both in two. Five-year locoregional relapse-freesurvival, distant metastasis-free survival, progression-free survival, and overall survival were86.2%, 85.5%, 74.4%, and 88.2%, respectively. Multivariate analyses showed that thesignificant prognostic factors were concurrent chemotherapy and N stage for locoregionalrelapse-free survival, concurrent chemotherapy for progression-free survival, and age andN stage for overall survival. Neither neoadjuvant nor concurrent chemotherapy improveddistant metastasis-free survival. ConclusionConcurrent chemotherapy significantly improved 5-year locoregional relapse-free survivaland progression-free survival in stage II nasopharyngeal carcinoma. However, neoadjuvantchemotherapy failed to improve either

      • KCI등재

        Intraoperative Radiotherapy for Locally Advanced Rectal Cancer

        강민규,김명세,김재황 대한대장항문학회 2010 Annals of Coloproctolgy Vol.26 No.4

        Purpose: Although intraoperative radiotherapy (IORT) is known to be a method that can reduce local recurrence in locally advanced colorectal cancer, it is not widely used. The aim of this study was to report our experience with IORT for locally advanced rectal cancer. Methods: From 1991 to 1994, nine patients with locally advanced rectal cancer received IORT. External beam radiotherapy was given postoperatively in five patients and preoperatively in three. Seven patients received chemotherapy. IORT was done with 6-MeV or 9-MeV electrons, and 12 Gy was irradiated at the tumor bed. The median follow-up period was 84 months (range, 15 to 208 months). Results: The median age of patients was 51 years (range, 42 to 73 years). All patients had advanced clinical T-stage (cT3/4)cancer. The overall and the disease-free survival rates were 66.7% and 66.7% at 5 years, respectively. One patient developed a local recurrence near the anastomosis site, which was out of the IORT field. Four patients died before the last follow-up;three from distant metastasis and one from secondary primary cancer. Adverse effects related to IORT did not occur. Conclusion: Although the number of patients was small in this study, IORT is thought to be safe and effective in reducing local recurrence in locally advanced rectal cancer. However, the role of IORT should be refined in the era of preoperative radio-chemotherapy followed by total mesorectal excision.

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