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(Tong Kun Pai 한국응용생명화학회 2000 Journal of Applied Biological Chemistry (J. Appl. Vol.43 No.4
The effects of high relative humidity (RH) on the physicochemical properties and microbial activity of mature green tomatoes (`Dombito`) during refrigerated storage were determined at three temperatures (5, 10, and 15℃) and four different RH levels (91, 94
Tong Kun Pai 한국응용생명화학회 2002 Journal of Applied Biological Chemistry (J. Appl. Vol.45 No.4
The optimum condition of rat hepatocyte primary cell culture for use as a model system to study the role of various fatty acids on cholesterol and glycerol lipid metabolism was determined. Up to 1.5×10 exp (6) cells/well, a linear relationship (r=0.96) was
(Tong Kun Pai 한국응용생명화학회 2000 Journal of Applied Biological Chemistry (J. Appl. Vol.43 No.3
The effects of storage temperature and high relative humidity (RH) on the weight loss, color change, and microbial activity of a mushroom (`Sylvan` hybrid white) were investigated. The experiment was performed at three temperature (5, 10 and 15℃) and four
Mineral-rich Solar Sea Salt Generates Less Oxidative Stress in Rats than Mineral-deficient Salt
Tiancheng Gao,조정용,Ling-Yun Feng,Saoraya Chanmuang,박선영,오정균,Tong-Kun Pai,함경식 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.3
Certain solar sea salts have a high content ofessential minerals other than NaCl. The effects of mineralsin sea salts on oxidative stress in rats were investigated. Mineral-rich salt (MRS) and mineral-deficient salt (MDS)did not scavenge DPPH radicals. When MRS and MDS(equivalent to 1.8 g NaCl/kg/day) and a saline control wereorally administered to rats for 7 weeks, MRS group ratsshowed lower levels of plasma lipid oxidation than MDSgroup rats. MRS group rats exhibited significantly lowerlevels of protein carbonyls and 8-hydroxy-2'-deoxyguanosinein the liver than MDS group rats. MRS group rats showedlower protein expression of NF-κB p65 in adipose tissuethan MDS group rats. Intake of MRS may generate lessoxidative stress than intake of MDS.
Son, Kyung-No,Song, In-sung,Shin, Yong-Hyun,Pai, Tong-Kun,Chung, Dae-Kyun,Baek, Nam-In,Lee, Jung Joon,Kim, Jiyoung Korean Society for Molecular Biology 2005 Molecules and cells Vol.20 No.1
<P>Mannasantin B, a dilignan structurally related to manssantin A, is an inhibitor of NF-kappaB transactivation. In the present study, we found that it inhibited PMA-induced expression of IL-1beta, IL-1beta mRNA, and IL-1beta promoter activity in U937 cells with IC50 values of about 50 nM. It also inhibited NF-IL6- and NF-kappaB-induced activation of IL-1beta, with IC50 values of 78 nM and 1.6 microM, respectively, revealing a potent inhibitory effect on NF-IL6. Electrophoretic mobility shift assays showed that manassantin B had an inhibitory effect on DNA binding by NF-IL6, but not by NF-kappaB. Further analysis revealed that transactivation by NF-IL6 was also inhibited. Our results indicate that manassantin B suppresses expression of IL-1beta in promonocytic cells by inhibiting not only NF-kappaB but also NF-IL6 activity. Furthermore, our observations suggest that manassantin B may be clinically useful as a potent inhibitor of NF-IL6 activity.</P>
김지영,Kyung-No Son,송인성,Yong-Hyun Shin,Tong-Kun Pai,Dae-Kyun Chung,Nam-In Baek,Jung Joon Lee 한국분자세포생물학회 2005 Molecules and cells Vol.20 No.1
Mannasantin B, a dilignan structurally related to manssantin A, is an inhibitor of NF-κB transactivation. In the present study, we found that it inhibited PMAinduced expression of IL-1β, IL-1β mRNA, and IL-1β promoter activity in U937 cells with IC50 values of about 50 nM. It also inhibited NF-IL6- and NF-κBinduced activation of IL-1β, with IC50 values of 78 nM and 1.6 μM, respectively, revealing a potent inhibitory effect on NF-IL6. Electrophoretic mobility shift assays showed that manassantin B had an inhibitory effect on DNA binding by NF-IL6, but not by NF-κB. Further analysis revealed that transactivation by NF-IL6 was also inhibited. Our results indicate that manassantin B suppresses expression of IL-1β in promonocytic cells by inhibiting not only NF-κB but also NF-IL6 activity. Furthermore, our observations suggest that manassantin B may be clinically useful as a potent inhibitor of NF-IL6 activity.