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A Case of Visceral T Cell Lymphoma with Prominent Histiocyte Infiltration in a Dog
Myung-Chul Kim,Du-Min Go,Sang-Ho Woo,Jeong-Seop Oh,Dae-Yong Kim,Na-Yon Kim,Yeseul Yang,Jae-Ha Jung,Hwa-Young Youn,Yongbaek Kim 한국임상수의학회 2023 한국임상수의학회지 Vol.40 No.5
A 13-year-old intact male English Springer Spaniel presented with anorexia. Physical examination revealed a palpable abdominal mass without peripheral lymphadenopathy. Ultrasonography revealed hepatosplenomegaly and a markedly enlarged hepatic lymph node. Fine-needle aspiration of the splenic and nodal lesions revealed atypical round cells admixed with numerous histiocytes. The dog was euthanized owing to deteriorating condition despite a month of chemotherapy with lomustine. Histopathology revealed obliteration of the normal architecture of the liver, spleen, kidney, and hepatic and mesenteric lymph nodes by CD3+ neoplastic lymphocytes, accompanied by extensive F4/80+ histiocytic infiltration. This report describes a rare presentation of T-cell lymphoma with prominent histiocytic infiltration that may initially be misdiagnosed as histiocytic neoplasia in a dog.
진료수행시험에서 시험 시간 경과에 따른 표준화 환자 채점의 정확도 분석
박완범(Wan Beom Park),김아름(Ah Reum Kim),이성아(Sung A Lee),김은아(Eun A Kim),장선영(Sun-young Chang),김연수(Yon Su Kim),김석화(Suk Wha Kim),신좌섭(Jwa -Seop Shin),이윤성(Yoon Sung Lee) 한국의학교육학회 2007 Korean journal of medical education Vol.19 No.1
Purpose: The purpose of this study is to evaluate the accuracy of standardized patients’ (SP) rating according to the order of examinees in clinical performance examination. Methods: In the clinical performance examination which was administered in 2005 at Seoul National University College of Medicine, each SP evaluated 16 students consecutively. For all 16 SPs (2 SPs per station), accuracy of rating was evaluated by comparing the individual records of each SP to the ‘recording keys’ made by two SPs from reviewing a video recording of performances by examinees. Results: The average number of items incorrectly rated by SP was 3.8 (range, 0~12), 2.8 in female SPs and 4.8 in male SPs (p<0.001). No statistical correlation was observed between the number of errors and the order of examinees (p=0.843). Even after stratification by gender or age of the SPs or domains of examination, the number of items incorrectly rated did not differ significantly according to the order of examinees. Conclusion: An increase in SP’s rating error with time after the start of examinations was not observed within the 16 consecutive encounters in clinical performance examination. The effect of SP’s fatigue on the accuracy of simulation as an examination progresses remains to be studied.
알레르기 ; 천식증상으로 내원한 성인에서 운동유발성 천식과 아토피의 상관관계
한진형 ( Jin Hyung Han ),권병운 ( Byung Woon Kwon ),현경희 ( Kyung Hee Hyun ),김용현 ( Young Hyun Kim ),이현숙 ( Hyun Suk Lee ),김도형 ( Do Hyung Kim ),김윤섭 ( Yon Seop Kim ),박재석 ( Jae Suk Park ),김경묵 ( Kyung Mook Kim ),지 대한내과학회 2011 대한내과학회지 Vol.81 No.6
목적: 아토피는 천식과 밀접한 관련이 있으며, 천식의 발생과 악화의 위험인자로 알려져 있다. 이 연구에서는 천식으로 내원한 환자들을 대상으로 아토피와 운동유발성 천식사이의 연관성을 알아보고자 하였다. 방법: 2002년 1월부터 2010년 1월까지 천식증상으로 단국 대학교병원 호흡기-알레르기내과를 방문하여 운동유발 검사를 시행한 환자들을 대상으로 하였다. 진단적 검사로 피부단자시험, 메타콜린 기관지유발 검사를 함께 시행하였다. 과거에 흡연을 하였거나 현재 흡연 중인 환자들은 모두 제외하였다. 결과: 총 40명의 성인 환자들을 분석하였다. 기도과민성을 보인 환자는 운동유발성 천식 양성군에서 음성군에 비해 더많았다(85.7 vs. 42.1%, p=0.007). 아토피는 운동유발성 천식군에서 대조군에 비해 더 흔히 관찰되었고(85.7 vs. 47.4%, p=0.017), 아토피 점수(16.5±3.0 vs. 6.5±2.0, p=0.011) 및 아토피 지수(2.1±0.3 vs. 1.0±0.3, p=0.004)는 운동유발성 천식군에서 대조군에 비해 높았다. 총 40명의 환자들 중기도과민성이 있는 26명의 천식 환자들과 기도과민성이 없는 14명의 환자들 각각을 대상으로 운동유발성 천식 유무에 따른 특성을 비교하였다. 26명의 천식 환자들 중 운동유발성천식은 18명(69.2%)에서 관찰되었으며, 이들에서 아토피 빈도, 아토피 점수 및 아토피 지수가 높은 경향이 관찰되었지만 유의한 차이는 없었다. 기도과민성이 없는 14명의 환자들중 운동유발성 천식은 3명(21.4%)에서 관찰되었으며 아토피빈도는 운동유발성 천식 양성군과 음성군 사이에 유의한 차이가 없었으나 아토피 점수(22.3±3.3 vs. 5.9±2.3, p=0.007) 및 아토피 지수(2.3±0.3 vs. 1.0±0.4, p=0.028)는 운동유발성천식 양성군에서 유의하게 높았다. D. pteronyssinus (76.2% vs. 42.1%, p=0.028)와 D. farinae (76.2% vs. 36.8%, p=0.012) 양성률은 운동유발성 천식군에서 대조군에 비해 높았다. 이분형로지스틱회귀분석을 시행한 결과 메타콜린에 대한기도과민성(위험비[OR]: 14.3, 95% 신뢰구간[CI]: 1.86-109.4)과 아토피(OR; 16.9, 95% CI; 2.04- 140.74)는 운동유발성 천식의 유의한 위험인자였다. 결론: 아토피는 운동유발성 천식과 연관된 위험인자로 생각된다. 운동유발성 천식 환자에서 대조군에 비해 D. pteronyssinus와 D. farinae의 양성률이 높아 집먼지진드기 항원이운동유발성 천식의 발생과 악화와 관계가 있을 가능성을 확인하였다. Background/Aims: Atopy is closely related to asthma and is a risk factor for the development and exacerbation of asthma. The aim of this study was to evaluate the association between exercise-induced asthma (EIA) and atopy in adult patients with asthma-like symptoms. Methods: Forty young male patients with asthma-like symptoms were enrolled. Skin prick, methacholine bronchial provocation, and exercise provocation tests were performed. Current and ex-smokers were excluded. Results: Exercise provocation tests were positive in 21 patients (52.5%). Airway hyperresponsiveness (AHR) to methacholine (85.7% vs. 42.1%, p=0.007) and atopy (85.7% vs. 47.4, p=0.017) was found more frequently in patients with EIA than in those without EIA. EIA was significantly associated with atopy score (16.5±3.0 vs. 6.5±2.0, p=0.011), atopy index (2.1±0.3 vs. 1.0±0.3, p=0.004), and positive responses to Dermatophagoides pteronyssinus (76.2% vs. 42.1%, p=0.028) and Dermatophagoides farinae (76.2% vs. 36.8%, p=0.012), but not with positive responses to pollen allergens. AHR to methacholine (odds ratio [OR]: 14.3, 95% confidence interval [CI]: 1.86-109.4) and atopy (OR: 16.9, 95% CI: 2.04-140.74) were significant risk factors for EIA. Conclusions: Atopy was a risk factor for EIA in young adult men, and sensitization to house dust mites was associated with EIA. (Korean J Med 2011;81:723-728)
Yon, Jung-Min,Kim, Jae Seung,Lin, Chunmei,Park, Seul Gi,Gwon, Lee Wha,Lee, Jong-Geol,Baek, In-Jeoung,Nahm, Sang-Seop,Nam, Sang-Yoon The Korean Society of Veterinary Science 2019 大韓獸醫學會誌 Vol.59 No.2
We investigated whether ${\beta}$-carotene (${\beta}-CA$) or ellagic acid (EA), originating from various fruits and vegetables, has a preventive effect against male infertility induced by exogenous scrotal hyperthermia. ICR adult mice were intraperitoneally treated with 10 mg/kg of ${\beta}-CA$ or EA daily for 13 days consecutively. During this time, mice were subjected to transient scrotal heat stress in a water bath at $43^{\circ}C$ for 20 min on day 7, and their testes and blood were obtained on day 14 for histopathologic and biochemical analyses. Heat stress induced significant testicular weight reduction, germ cell loss and degeneration, as well as abnormal localization of phospholipid hydroperoxide glutathione peroxidase (PHGPx) and manganese superoxide dismutase (MnSOD) in spermatogenic and Leydig cells. Heat stress also altered the levels of oxidative stress (lipid peroxidation, SOD activity, and PHGPx, MnSOD, and $HIF-1{\alpha}$ mRNAs), apoptosis (Bax, Bcl-xL, caspase 3, $NF-{\kappa}B$, and $TGF-{\beta}1$ mRNAs), and androgen biosynthesis (serological testosterone concentration and $3{\beta}$-hydroxysteroid dehydrogenase mRNA) in testes. These changes were all improved significantly by ${\beta}-CA$ treatment, but only slightly improved by EA treatment. These findings indicate that ${\beta}-CA$, through modulations of oxidative stress, apoptosis, and androgen biosynthesis, is a potent preventive agent against testicular injuries induced by scrotal hyperthermia.
김재영,강성구,이권전,고광섭,김소연 대한핵의학회 1987 핵의학 분자영상 Vol.21 No.1
The stress fracture is a disease caused by and abnormal stress to the normal bone with constant, repeated pull. Early detection of stress fracture plays an important role in treatment and prevention of its complication. Bone scintigraphy was performed to evaluate 18 patients with stress fracture of the lower extremities from May, 1985 to April, 1987, in the Department of Internal Medicine of National Police Hospital. The results were as follows: 1) Seventeen of the 18 cases showed positive bone scans at the initial study performed from 1 week to 5 months after the onset of symtom. 2) Ten of the18 patients had findings of stress fracture at the initial X-ray film. Two out of 8 negative case revealed positive findings in the follow-up studies. 3) The bone scans in the 2 cases taken 5 months after the onset of symtom; the one showed only slightly increased radiouptake, the other showed no abnormal findings. In conclusion, bone scanning is a more sensitive indicator of early stress fracture than radiologic study, The healing phase is characterized by a gradual decline in radioactivity at the fracture site in concordance with subsidence of symptom.
이라크 파병이 "한국이미지"에 미친 영향에 관한 연구 : 중동지역 5개국을 중심으로
이인섭 ( In Seop Lee ),유홍식 ( Hong Sik Yu ),김능우 ( Neung Woo Kim ),윤용수 ( Yong Su Youn ),장세원 ( Se Won Chang ),황성연 ( Sung Yon Hwang ) 부산외국어대학교 지중해연구소 2006 지중해지역연구 Vol.8 No.2
This study explored whether the dispatch of Korean troops to Iraq had detrimental influences on image of Korea. In addition, the study examined whether the attitudes of Arab media in dealing with Korea- related issues played an important role in shaping Arab people`s attitude toward Korea and image of Korea. Data collected at the 5 Arab countries(Egypt, Iraq, Lebanon, Jordan, & Arab Emirate) from June 2005 to August 2005. The results showed that the respondents of the countries, especially the ones of Arab Emirate, had a good impression on image of Korea. The comparative analysis of South Korea, Japan, China, and North Korea on image of country was conducted. The results revealed that Japan had the best image, and China had the second best image. The image of South Korea was recognized at the third place. The Arab respondents, who thought that Korea sent their troops to Iraq for getting any kinds of profits in relations to America, showed lower scores on image of Korea. Although Arab media didn`t cover Korea-related news much, the Arab respondents` perception toward the attitude of the Arab media in dealing with Korea-related issues and image of Korea had a positive correlation. The third person effects was also identified. Findings are discussed in relations to third person effect theory, public relations and image of country.