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이주영,류수진,박예진,황순호,이마세,김인종,김동현,김신규 慶熙大學校 1996 論文集 Vol.25 No.-
Sythesis of β-naphthol derivatives and their anti-tumor activity were investigated. Binaphthol 1 obtained from β-naphthol by oxidative C-C bond formation(phenoloxydation) was converted into its derivatives. Treatment of 1 with POCl_3 followed by aziridine introduction gave phosphoryl aziridine 3. Also, diaziridine 5 was obtained from 1 by chlorination and successive aziridine introdution. Typical chemical transformation of 1 to obtain ester-type afforded compound 7 and 8. Compound 5 was the most effective derivative of the tested compounds on their anti-tumor activity.
방창훈,이진호,예용택 한국산업안전학회 2002 한국안전학회지 Vol.17 No.3
The purpose of this study was to present the thermal characteristics of the working uniform exposed to the radiation heat. The effect of exposure time and exposure distance on the changes and the relationship between physical properties were investigated experimentally. Regardless of the kind of working uniform, the surface temperature of the working uniform with exposed time sharply increases as exposed distance is more close and the reaching tie of steady state is shorter. The surface temperature of working uniform exponentially decreases as exposed distance become more distant. For the safety of the working man, it is necessary that he work far away at a fixed standard distance from the radiant heat source.
Phytochemical Constituents from the Stem Bark of Phellodendron amurense Rupr.
Lee, Jin-Hwan,Lee, Byong-Won,Moon, Yea-Hwang,Yang, Min-Suk,Jang, Ki-Chang,Park, Ki-Hun The Korean Society for Applied Biological Chemistr 2005 Journal of Applied Biological Chemistry (J. Appl. Vol.48 No.2
Three limonoids and two phenolics were isolated from stem bark of Pellodendron amurense Rupr. (Rutaceae) and were defined clearly as calodendrolide (1), obacunone (2), limonin (3), methyl 4-hydroxybenzoate (4), and syringin (5) based on NMR spectroscopy results obtained with the aid of X-ray crystallographic analysis. This is the first report on the isolation of calodendrolide (1) from this plant.
Lee, Yea Ram,Park, Daehwan,Choi, Sang Koo,Kim, Miju,Baek, Heung Soo,Nam, Jin,Chung, Chan Bok,Osuji, Chinedum O.,Kim, Jin Woong American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.36
<P>Cellulose fibrils, unique plant-derived semicrystalline nanomaterials with exceptional mechanical properties, have significant potential for rheology modification of complex fluids due to their ability to form a physically associated semiflexible fibrillary network. Here, we report new associative cellulose nanocrystals (ACNCs) with stress-responsive rheological behaviors in an aqueous solution. The surface-mediated living radical polymerization was employed to graft poly(stearyl methacrylate-co-2methacryloxyethyl phosphorylcholine) brushes onto the nanofibrils, and then 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-mediated oxidation was conducted to produce nanoscale ACNCs in the aqueous solution. The ACNCs displayed interfibril association driven by the hydrophobic interaction that resulted in the formation of a nanofibrillar crystalline gel phase. We observed that the viscosity of the ACNC fluid showed reversible shear thinning and temperature-induced thickening in response to applied shear stress and thermal shock. Moreover, thanks to generation of a mechanically robust nanofibrillar crystalline gel network, the ACNC suspension showed extraordinary stability to changes in salinity and pH. These results highlighted that the interfibril hydrophobic association of ACNCs was vital and played an essential role in regulation of stimulireVonsive sol gel transitions.</P>
Protective Effect of Carnosine Against Zn-Mediated Toxicityin Cortical Neuronal Cells
Jin-Joo Hue,Ah-Ram Lee,Yea Eun Lee,Min-Hang Cho,Ki-Nam Lee,남상윤,윤영원,Jae-Hwang Jeong,Sang-Hwa Lee,이범준 한국독성학회 2007 Toxicological Research Vol.23 No.1
Zinc is an endogenous transition metal that can be synaptically released during neuronal activity. However, zinc may contribute to the neuropathology associated with a variety of conditions. Carnosine expressed in glial cells can modulate the effects of zinc on neuronal excitability as a zinc chelator. We hypothesize that carnosine may protect against neurotoxicity of zinc in cortical neuronal cells. The cortical neuronal cells from newborn rats were prepared and exposed to zinc chloride and/or carnosine at various concentrations. Zinc at the doses of 0 to 500 μM decreased neuronal cell viability in a dosedependent manner. Additionally, at the concentrations of 100 and 200 μM, it significantly decreased cell viability in an exposed time-dependent manner (p < 0.05). Treatment with carnosine at the concentrations of 20 and 200 μM significantly increased neuronal cell proliferation by approximately 14% and 20%, respectively, compared to the control (p < 0.05). At the concentrations of 100 and 200 μM zinc, 20 μM carnosine significantly increased the viability of neuronal cells by 18.3% and 12.1%, and 200 μM carnosine also increased it by 33.5% and 28.6%, respectively, compared to the normal control group (p < 0.01). These results suggest that carnosine at a physiologically relevant level may protect against zinc-mediated toxicity in neuronal cells as an endogenous neuroprotective agent