http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Ah-Ram Lee (검색결과 216 건)
- 무료
- 기관 내 무료
- 유료
-
DR-LSTM: Dimension reduction based deep learning approach to predict stock price
Lee Ah-ram,Ahn Jae Youn,Choi Ji Eun,Kim Kyongwon 한국통계학회 2024 Communications for statistical applications and me Vol.31 No.2
In recent decades, increasing research attention has been directed toward predicting the price of stocks in financial markets using deep learning methods. For instance, recurrent neural network (RNN) is known to be competitive for datasets with time-series data. Long short term memory (LSTM) further improves RNN by providing an alternative approach to the gradient loss problem. LSTM has its own advantage in predictive accuracy by retaining memory for a longer time. In this paper, we combine both supervised and unsupervised dimension reduction methods with LSTM to enhance the forecasting performance and refer to this as a dimension reduction based LSTM (DR-LSTM) approach. For a supervised dimension reduction method, we use methods such as sliced inverse regression (SIR), sparse SIR, and kernel SIR. Furthermore, principal component analysis (PCA), sparse PCA, and kernel PCA are used as unsupervised dimension reduction methods. Using datasets of real stock market index (S&P 500, STOXX Europe 600, and KOSPI), we present a comparative study on predictive accuracy between six DR-LSTM methods and time series modeling.
-
Lee, Seul Ah,You, Ga Rim,Choi, Ye Won,Jo, Hyun Yong,Kim, Ah Ram,Noh, Insup,Kim, Sung-Jin,Kim, Youngmee,Kim, Cheal The Royal Society of Chemistry 2014 Dalton Transactions Vol.43 No.18
<P>A multifunctional fluorescent and colorimetric receptor <B>1</B> ((<I>E</I>)-<I>N</I>′-((8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-<I>ij</I>]quinolin-9-yl)methylene)benzohydrazide) for the detection of both Al<SUP>3+</SUP> and CN<SUP>−</SUP> in aqueous solution has been developed. Receptor <B>1</B> exhibited an excellent selective fluorescence response toward Al<SUP>3+</SUP>. The sensitivity of the fluorescent based assay (0.193 μM) for Al<SUP>3+</SUP> is far below the limit in the World Health Organization (WHO) guidelines for drinking water (7.41 μM). In addition, receptor <B>1</B> showed an excellent detection ability in a wide pH range of 4–10 and also in living cells. Moreover, receptor <B>1</B> showed a highly selective colorimetric response to CN<SUP>−</SUP> by changing its color from colorless to yellow immediately without any interference from other anions.</P> <P>Graphic Abstract</P><P>A new multifunctional Schiff-base receptor <B>1</B> which exhibits an excellent cell-permeable fluorescence for Al<SUP>3+</SUP> and a color change for CN<SUP>−</SUP> in aqueous media has been prepared. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4dt00361f'> </P>
-
Lee, Ah-Ram,Yim, Je-Min,Kim, Won-Il KOREAN PHARMACOPUNCTURE INSTITUTE 2012 Journal of pharmacopuncture Vol.15 No.1
Objectives: The aim of this study was to investigate the safety and the efficacy of Korean herbal, western and combination medicine use in patients with abnormal liver function tests. Methods: We investigated nerve disease patients with abnormal liver function tests who were treated with Korean herbal, western and combination medicine at Dong-Eui University Oriental Hospital from January 2011 to August 2011. We compared aspartic aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and total bilirubin (T-bil) levels before and after taking medicine and excluded patients who had liver-related disease when admitted. Results: AST and ALT were decreased significantly in patients who had taken herbal, western medicine. AST, ALT and ALP were decreased significantly in patients who had taken combination medicine. Compare to herbal medicine, AST, ALT and ALP were decreased significantly in patients who had taken western medicine, and ALT and ALP were decreased significantly in patients who had taken combination medicine. There were no significant differences between western and combination medicine. Conclusions: This study suggests that prescribed Korean herbal medicine, at least, does not injure liver function for patients', moreover, it was shown to be effective in patients with abnormal liver function tests.
-
-
Differential Role of Central GABA Receptors in Nociception of Orofacial Area in Rats
Ah-Ram Lee,Nak-hyung Lim,Hye-Jin Kim,Min-Ji Kim,Jin-Sook Ju,Min-Kyoung Park,Min-Kyung Lee,Kui-Ye Yang,Dong-Kuk Ahn 대한구강생물학회 2015 International Journal of Oral Biology Vol.40 No.3
The present study investigated the role of central GABAA and GABAB receptors in orofacial pain in rats. Experiments were conducted on Sprague-Dawley rats weighing between 230 and 280 g. Intracisternal catheterization was performed for intracisternal injection, under ketamine anesthesia. Complete Freund's Adjuvant (CFA)-induced thermal hyperalgesia and inferior alveolar nerve injury-induced mechanical allodynia were employed as orofacial pain models. Intracisternal administration of bicuculline, a GABAA receptor antagonist, produced mechanical allodynia in naive rats, but not thermal hyperalgesia. However, CGP35348, a GABAB receptor antagonist, did not show any pain behavior in naive rats. Intracisternal administration of muscimol, a GABAA receptor agonist, attenuated the thermal hyperalgesia and mechanical allodynia in rats with CFA treatment and inferior alveolar nerve injury, respectively. On the contrary, intracisternal administration of bicuculline also attenuated the mechanical allodynia in rats with inferior alveolar nerve injury. Intracisternal administration of baclofen, a GABAB receptor agonist, attenuated the thermal hyperalgesia and mechanical allodynia in rats with CFA treatment and inferior alveolar nerve injury, respectively. In contrast to GABAA receptor antagonist, intracisternal administration of CGP35348 did not affect either the thermal hyperalgesia or mechanical allodynia. Our current findings suggest that the GABAA receptor, but not the GABAB receptor, participates in pain processing under normal conditions. Intracisternal administration of GABAA receptor antagonist, but not GABAB receptor antagonist, produces paradoxical antinociception under pain conditions. These results suggest that central GABA has differential roles in the processing of orofacial pain, and the blockade of GABAA receptor provides new therapeutic targets for the treatment of chronic pain.
-
Ah-Ram Lee,김원일,Je-Min Yim 대한약침학회 2012 Journal of pharmacopuncture Vol.15 No.1
Objectives: The aim of this study was to investigate the safety and the efficacy of Korean herbal, western and combination medicine use in patients with abnormal liver function tests. Methods: We investigated nerve disease patients with abnormal liver function tests who were treated with Korean herbal,western and combination medicine at Dong-Eui University Oriental Hospital from January 2011 to August 2011. We compared aspartic aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and total bilirubin (T-bil) levels before and after taking medicine and excluded patients who had liver-related disease when admitted. Results: AST and ALT were decreased significantly in patients who had taken herbal, western medicine. AST, ALT and ALP were decreased significantly in patients who had taken combination medicine. Compare to herbal medicine, AST, ALT and ALP were decreased significantly in patients who had taken western medicine, and ALT and ALP were decreased significantly in patients who had taken combination medicine. There were no significant differences between western and combination medicine. Conclusions: This study suggests that prescribed Korean herbal medicine, at least, does not injure liver function for patients’, moreover, it was shown to be effective in patients with abnormal liver function tests.
-
A survey of the use of veterinary anesthetics in Korea
Lee, Jae-Won,Lee, Jeong Ik,Cho, Yoon Ju,Lee, Young-Ah,Kim, Jong-In,Hwang, Bo Ram,Kim, Hyung Joon,Jhun, Hyunjhung,Han, Jin Soo The Korean Society of Veterinary Science 2014 大韓獸醫學會誌 Vol.54 No.2
This study was conducted to investigate actual conditions associated with veterinary anesthetic drug use in Korea, and to obtain responses from Korean veterinarians and researchers pertaining to the use of anesthetic drugs. To accomplish this, a nationwide survey was issued to veterinarians working at animal hospitals and to researchers in the Korean Association for Laboratory Animal Science (KALAS). A self-administered questionnaire-based survey was then conducted in which respondents were asked questions about actual conditions associated with the use of animal anesthetic drugs. The survey revealed that the distribution and management of animal medicines in Korea was quite vulnerable to misuse or abuse due to a variety of factors. Therefore, a relevant regulatory system should be strictly enforced to protect vulnerable individuals from abuse or misuse.
-
Lee, Hyun Ah,Song, Bo Ram,Kim, Hye Ryeong,Kim, Ji Eun,Yun, Woo Bin,Park, Jin Ju,Lee, Mi Lim,Choi, Jun Young,Lee, Hee Seob,Hwang, Dae Youn D.A. Spandidos 2017 Experimental and therapeutic medicine Vol.14 No.5
<P>Roots of <I>Asparagus cochinchinesis</I> have been widely used to treat fever, cough, kidney disease, breast cancer, inflammatory and brain disease, although the effects of their fermented products have not been assessed until now. To investigate the anti-inflammatory effects on macrophages of a butanol extract from <I>A. cochinchinensis</I> roots fermented with <I>Weissella cibaria</I> (BAW), alterations in the inducible nitric oxide synthase (iNOS)-mediated cyclooxygenase-2 (COX-2) induction pathway and inflammatory cytokine expression were measured in lipopolysaccharide (LPS)-activated RAW264.7 cells following pretreatment with BAW. Briefly, <I>W. cibaria</I> was selected from two bacterial strains for the fermentation of <I>A. cochinchinensis</I> roots based on its hyaluronidase inhibition and NO suppression rates. Following fermentation with <I>W. cibaria</I>, the level of various key components including total phenols and protodioscin were significantly enhanced in BAW. In addition, BAW exhibited high free radical scavenging activity (IC<SUB>50</SUB>=31.62 µg/ml) and induced a decrease of intracellular ROS production in RAW264.7 cells following DCFH-DA staining. Significant suppressions in the expression level of important members of the iNOS-mediated COX-2 induction pathway and the phosphorylation of mitogen-activated protein kinase members were detected. The expressions of pro-inflammatory and anti-inflammatory cytokines were recovered in BAW pretreated RAW264.7 cells. Overall, these results suggest that BAW may suppress inflammatory responses through differential regulation of the iNOS-mediated COX-2 induction pathway and inflammatory cytokine expressions in LPS-activated RAW264.7 cells.</P>
-
Lee, Ah Ram,Kwon, Seok Young,Choi, Du Hyung,Park, Eun Seok Elsevier 2017 International journal of pharmaceutics Vol.534 No.1
<P><B>Abstract</B></P> <P>A bilayer tablet, which consisted of telmisartan and amlodipine besylate, was formulated based on a Quality by Design (QbD) approach. The control and response factors were determined based on primary knowledge and the target values of the control tablet (Twynsta<SUP>®</SUP>). A D-optimal mixture design was used to obtain the optimal formulations in terms of D-mannitol, crospovidone, and MCC for the telmisartan layer, and CCM-Na, PVP K25, and Prosolv for the amlodipine layer. The quantitative effects of the different formulation factors on the response factors were accurately predicted using the equations of best fit and a strong linearity was observed between the predicted and actual values of the response factors. The optimized bilayer tablet was obtained using a numeric optimization technique and was characterized compared with a control (Twynsta<SUP>®</SUP>) by using various physical evaluations and <I>in vivo</I> pharmacokinetic parameters. The physical stability of Telmiduo<SUP>®</SUP> was greater than that of Twynsta<SUP>®</SUP> owing to the improvement of formulation factors. The <I>in vivo</I> pharmacokinetic parameters suggested that Telmiduo<SUP>®</SUP> might have pharmaceutical equivalence and bioequivalence with Twynsta<SUP>®</SUP>. Therefore, the bilayer tablet that consisted of telmisartan and amlodipine besylate could be produced using a more economical and simpler method than that used to produce Twynsta<SUP>®</SUP>. Moreover, the suitability of QbD for effective product development in the pharmaceutical industry was shown.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
-
거울을 활용한 미러링 코칭이 자유형 스트로킹 변화에 미치는 영향
이보람(Lee, Bo-Ram),윤소미(Yun, Somi),정아름(Jung, Ah-Reum),이윤빈(Lee, Yun Bin),이희진(Lee, Hee Jin),이대택(Lee, Dae Daek) 한국웰니스학회 2020 한국웰니스학회지 Vol.15 No.4
본 연구는 자유형 스트로크를 교정하기 위해 수영장 바닥 거울을 사용한 코칭이 효과적인지 분석하는데 목적이 있다, 1년 이상 수영 강습을 받은 성인 30명을 무작위로 Mirror group(MG)과 No mirror group(NMG)으로 나누어 실시하였다. MG(men=12, 32.25±8.2 yrs, 175±5.5 ㎝, 70.9±9.2 ㎏; women=3, 37.6±13.7 yrs, 160.0±3.4 ㎝, 55.6±3.5 ㎏), NMG(men=7, 28.7±6.1 yrs, 176.2±3.7 ㎝, 72.4±14.4 ㎏; women=8, 38.8±14.6 yrs, 162.1±4.4 ㎝, 54.1±7.3 ㎏)은 2.43 m x 4.57 m x 1.37 m 크기의 인공 수조에서 자유형 1분을 실시하였다. 거울제공 여부와 시간의 상호작용이 스트로크 기준점과의 차이에 미치는 효과는 1차 검사에서 NMG: 6.0±3.982 ㎝, MG: 7.67±3.266 ㎝로 집단 간 차이가 1.67 ㎝인 반면, 2차 검사결과 NMG: 5.07±3.788 ㎝, MG: 2.47±3.502 ㎝ 로 집단 간 차이가 2.6 cm 로 나타나 통계적으로 유의하였다(F=20.627, p<.001). 거울 제공 여부와 시간에 따른 스트로크 빈도에 대한 분산분석 결과, 피드백 종류와 1차, 2차 검사의 상호작용이 스트로크 빈도에 미치는 효과는 1차 결과 NMG: 57.67±6.821 score, MG: 60.73±7.294 score에서 2차 결과 NMG: 56.33±6.586 score, MG: 53.67±5.447 score로 통계적으로 유의한 차이가 있는 것으로 나타났다(F=24.807, p<.001). 거울 제공 여부와 사전사후 검사 따른 스트로크 시간에 대한 분산분석을 실시한 결과, 피드백 종류와 1차, 2차 검사의 상호작용이 스트로크 시간에 미치는 효과는 1차 NMG: 2.04±.208 sec, MG: 2.05±.250sec에서 2차 NMG: 2.15±.287 sec, MG: 2.39±.307 sec로 통계적으로 유의한 차이가 나타났다(F=10.813, p<.01). This study analyzed whether coaching recreational swimmers using pool bottom mirror for correcting front crawl stroke is effective in achieving an intended stroke. Thirty adults who enrolled swimming lessons for more than 1 year participated and were randomly divided into two groups; mirror group (MG: 12 men; 32.3±8.2 yrs, 175.0±5.5 ㎝, 70.9±9.2 ㎏: 3 women; 37.6±13.7 yrs, 160.0±3.4 ㎝, 55.6±3.5 ㎏) and control group (CG: 7 men; 28.7±6.1 yrs, 176.2±3.7 ㎝, 72.4±14.4 ㎏: 8 women; 38.8±14.6 yrs, 162.1±4.4 ㎝, 54.1±7.3 ㎏). They performed front crawl twice in a swimming flume (2.43 × 4.57 × 1.37 meter) at their chosen speed (pace of 87.9±4.2 for men, 102.7±4.7 sec/100 meter for women). Their stroke was video recorded by an underwater camera (xnb-6001, Samsung, Korea) and dry land camera (gnd-6020R, Samsung, Korea). After their first trial and recording, individual stroke was evaluated and verbal feedback was given for correction targeting full arm range stroking. During second trial, MG had a mirror (81 × 151 ㎝) installed under the bottom of flume so that they could check their stroke. CG did not use mirror during second trial. An image analyzer (Dartfish, Swiss) was used to analyze the distance between reference point (RP: where fingertip was reached over Vastus lateralis during standing till on land) and fingertip as well as stroke time (time between left hand immersion cycle). Stroke frequency was counted cycles of both arms. Two trials were compared. The distance between RP and fingertip was 7.7±3.3 and 2.5±3.5 ㎝ in MG in 1st and 2nd trial, respectively (p<0.001) while it was 6.0±4.0 and 5.1±3.8 ㎝ in CG. The stroke frequency was 60.7±7.3 in MG and 57.7±6.8 freq/min in CG at 1st trial. It was decreased to 53.7±5.4 in MG (p<0.001), but not in CG (56.3±6.6 freq/min). The stroke time was increased from 2.1±0.3 to 2.4±0.3 sec in MG (p<0.01), but it was not changed in CG (2.1±0.2 vs. 2.2±0.3 sec)(F=10.813, p<.01).
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
