사례보고 : 하수오 복용 후 발생한 재발성 독성 간염 1예

배상훈 ( Sang Hoon Bae ),김동현 ( Dong Hyun Kim ),배영석 ( Young Seok Bae ),이광재 ( Kwang Jae Lee ),김동완 ( Dong Wan Kim ),윤정빈 ( Jeoung Bin Yoon ),홍준호 ( Joon Ho Hong ),김상현 ( Sang Hyun Kim ) 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.2

Toxic hepatitis has been reported as a major cause of acute hepatitis, but its potential induction by herbal remedies and/or health foods is usually neglected. We experienced a case of toxic hepatitis associated with Polygoni multiflori, a Chinese herb commonly known as Ho-Shou-Wu. A 54-year-old woman consumed Ho-Shou-Wu for 1 month, after which she experienced fatigue and overall weakness. A diagnosis of toxic hepatitis was made based on her clinical history, the findings for viral markers and other laboratory data, and ultrasonography. Her condition improved considerably after she stopped taking Ho-Shou-Wu. However, she resumed taking Ho-Shou-Wu immediately after discharge from hospital, which aggravated her symptoms and liver function. She was immediately readmitted and stopped taking Ho-Shou-Wu. Her relapse into hepatitis immediate after resuming consumption of the herb is strongly indicative of the validity of Koch`s postulate in this case.

요통 환자의 기립위 및 좌,우 외측굴곡시 방사선 사진을 통한 요추 회전변위 분석

허동석 ( Dong Seok Heo ),박석우 ( Seok Woo-park ),박영회 ( Young Hoi Park ),금동호 ( Dong Ho Keum ) 한방재활의학과학회 2003 한방재활의학과학회지 Vol.13 No.2

Objectives : Rotation on vertebra body is common reason causing low back pain and leg radiating pain patients. The present study investigated analysis of the radiological findings on lumbar vertebra rotation between erect position and erect both lateral bending position lumbar AP views in low back pain patients. Method : The study population consisted of 70 patients(outpatients and inpatients clinic of the Dept. of Oriental Rehabilitation Medicine, Dong-Guk Oriental Medical Hospital in Bundang) who were evaluated with X-ray findings of erect position and erect both lateral bending position lumbar AP views. First, patients were measured erect position lumbar AP views by Nash-Moe`s degree. Second, patients were measured erect both lateral bending position lumbar AP views by intervertebral disc space at convexity region and rotation on lumbar vertebral body. They divided into four groups by type of Grice and Cassidy`s classification. Results : 1. The distribution of sex in the low back pain with leg radiating pain was male 30(42.86%) cases, female 40(57.14%) cases. According to age, 30-40s 23(32.9%) cases, 40-50s 15(21.4%) cases, 20-30s 13(18.6%) cases, 50-60s 9(12.9%) cases, 60-70s 5(7.1%) cases, 70-80s 3(4.3%) cases, each 10-20s and 80-90s one case (1.4%). 2. According to Nash-Moe`s degree by erect position lumbar AP view, the grade 0 was male 8(11.4%) cases, female 10(14.3%) cases, the grade Ⅰ was male 17(24.3%) cases, female 22(31.4%) cases, the grade Ⅱ was male 5(7.1%) cases, female 8(11.4%) cases. 3. According to symptoms, first, patients with low back pain were male 22(31.4%) cases, female 20(28.6%) cases. second, patients with leg radiating pain were male 8(11.4%) cases, female 20(28.6%) cases. 4. According to type of Grice and Cassidy`s classification by erect both lateral bending position lumbar AP views, the type Ⅰ was normal group 7(10.0%) cases, the type Ⅲ and Ⅳ were abnormal group each 15(21.4%) cases, 48(68.6%) cases. 5. According to abnormal group in Nash-Moe`s degree by erect position lumbar AP view, the grade Ⅰ was 39(55.7%) cases and then abnormal type Ⅲ, Ⅳ of Grice and Cassidy`s classification were 5(7.1%) cases, 33(47.1%) cases, the grade Ⅱ was 13(18.6%) cases and then abnormal type Ⅲ, Ⅳ of Grice and Cassidy`s classification were 1(1.4%) case, 12(7.1%) cases. So the relationship between rotation of vertebra by erect position lumbar AP view and type of Grice and Cassidy`s classification by erect both lateral bending position lumbar AP views had significant correction(p<0.05). 3 6. According to analysis of symptoms and X-ray findings by erect both lateral bending position at convexity region, patients with leg radiating pain were 28 cases. In the total of 28 cases, 25 cases had shown rotation of vertebra and intervertebra disc space narrowed at convexity region, while 3 cases didn`t have shown. 7. According to abnormal rotation of vertebral body on erect position, the number of group L4 was 48(32.7%) cases the most, group L3 was 43(29.3%) cases, the next group L2 was 30(20.4%) cases. Group L4, L3, L2 had significantly connection with fixation group on erect both lateral bending position(p<0.05). Conclusions : We concluded that the abnormal rotation of lumbar vertebral body had connection with the low back pain and leg radiating pain patients. So we must regard functional X-ray such as erect both lateral bending position lumbar AP views to early find cause.

정상인 및 신기능장애환자에서 Carumonam(AMA-1080)의 약동학

임동석,이경훈,엄재호,한진석,김성권,장인진,신상구 大韓臨床藥理學會 1994 臨床藥理學會誌 Vol.2 No.1

자기 공명 영상을 이용한 뇌척수액 순환의 역학 분석

김동석,치중언,윤펑호,김동익,박승우 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.5

PC12세포에서 Reserpine에 의한 Preproenkephalin 유전자 발현의 조절

박석호,임동윤,최철희,김상훈,박상학,김학렬 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.1

In cultured PCl2 celIs, prepronkephalin gene expression was studied by measuring preproenkephalin mRNA levels as well as enkephalin content after the treatment of reserpine. Reserpine(0.5 uM) elicited and increased enkephalin peptide levels within 6-24 hrs, which was not inhibited by cycloheximide(2ug /ml), a protein synthesis inhibitor. In addition, reserpine-induced increase of enkephalin was not inhinited by dactinomycin(5ug / ml), which was found to decrease preproenkephalin mRNA. When preproenkephalin mRNA was measured by Northern blot hybridization with cDNA probe, reserpine elicited a slightly increased preproenkephalin mRNA in PCl2 cells as well as in the rat adrenal glands. From the present experimental data it is thought that reserpine-induced enhancement of cellular enkephalin content in cultured PCl2 cells may be mediated through the post translational processing along with a slightly increased transcription.

웹기반의 가축전염병 발생자료 관리시스템(AIMS) 개발

박병호,김석재,황인진,김시동,남향미,위성환 한국농업정보과학회 2003 농업정보과학 Vol.4 No.1

The AIMS(Anima1 Infectious Disease Data Management System) was developed to collect and analyze data on animal infectious disease outbreak (62 diseases). When an animal infectious disease is confirmed at a diagnostic laboratory, the disease outbreak is then reported to the regional government through AIMS. After the regional government confirms the number of animals infected or dead, outbreak date and etc, this information is reported to the Ministry of Agriculture & Forestry and the National Veterinary Research & Quarantine Service through AIMS. The AIMS analyzes the outbreak data and reports the outbreak statistics by region, month and year to them. In addition, the AIMS can identify the farm where there was an outbreak of the animal infectious disease. There are four user roles : 1) Administrator, responsible for the overall operation of the system. 2) Inspector, responsible for confirmation of the animal infectious disease outbreak. 3) Pathologist, responsible for input to an animal infectious disease at first. 4) Gallery, only able to read the outbreak statistics. The AIMS has been implemented using the ASP technology and is operated on the web to allow easy access. The data, middle and presentation tier are based on MS-SQL 2000 server, Microsoft transaction server and Internet Explorer, respectively. The database's stored procedure was used to improve the performance. In addition to above software, the dextupload software is used to upload the files. By using the AIMS, a more accurate statistics for the animal infectious disease outbreak is expected.

고주파수용 필터 설계를 위한 자이레이터 회로에 관한 연구

金石鎬,趙成翊,金東龍 全北大學校 1991 論文集 Vol.33 No.-

Switched-capacitor(SC) circuits have already been established in audio frequency range. However, SC circuits are not suitable for high frequency filters, because of the necessity of anti-aliasing filters and the limitation of high-frequency characteristics due to GBW(Gain-Band-Width) products of operational amplifiers. To overcome those disadvantages, a gyrator filtering techniques have been proposed. LC simulation method using gyrators is readily available to abtain low-sensitivity active RC filters. In this paper, highly linear MOS transconductor with the gain factor controllable by offering offset voltage is presented, and to validate transconductor characteristics, computer simulation using PSPICE was performed. Gyrator circuit is designed using MOS transconductor circuits, and for filter design, floating inductor, floating resistor and grounded resistor which are simulated by gyrator circuits are presented.

농가용 저온저장고의 제어변수에 따른 성능평가

김석우,김성만,현명택,최동호,고정삼,박영하 제주대학교 공과대학 첨단기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.2

The low temperature storage method has been used to increase the value of agricultural products by reducing quality deterioration and controlling respiration rate. The respiration rate of agricultural products depends on several factors such as temperature, moisture, gas composition and microbe inside the storage room. Among that temperature is the most important factor, which affects respiration rate and causes severe damage. The results obtained from these experiments are that electric consumption is decreased as setting temperature is decreasing and temperature deviation is increasing. In the ventilation experiment, the case ventilated four times a day(every six hours a day) with ten minutes operation each time, was inspected require as much electric consumption as non-ventilation case.

상수도 배관의 부식감지시스템 개발 (Ⅱ)

최윤석,신동호,김상현,김정구 대한금속재료학회 2005 대한금속·재료학회지 Vol.43 No.4

In order to develop a new corrosion sensor for detecting and monitoring the corrosion of buried pipeline, the electrochemical property of sensors and the correlation of its output to corrosion rate of steel pipe, were evaluated by electrochemical methods in synthetic groundwater, two soils of varying resistivity (5,000 ohm-cm, 10,000 ohm-cm), and synthetic tap water. In this paper, two types of electrochemical probes were used: galvanic cells containing of pipeline steel-copper and pipeline steel-stainless steel (Type 304). The results of EIS measurement indicated that the sensor current was inversely related to sensor resistance, which was governed by the corrosion behavior of cathode. In galvanic corrosion tests, the galvanic current of Cu-CS probe was higher than that of SS-CS probe. The comparison of the sensor output and corrosion rates revealed that a linear relationship was found between the probe current and the corrosion rates. A good linear quantitative relationship was found between the Cu-CS probe current and the corrosion rate of pipeline steel coupons in the soil resistivity of 5,000 ohm-cm, and synthetic tap water. In the case of the soil resistivity of 10,000 ohm-cm, although the SS-CS probe showed a better linear correlation than that of Cu-CS probe, the Cu-CS probe is more suitable than SS-CS probe, due to the high current output. (Received February 1, 2005)

정신재활 치료가 정신분열병 환자의 재발율, 입원횟수, 입원일수 그리고 치료 경비에 미치는 효과 : 2년 추적조사 연구

조진석,공지현,김진원,심경순,하준선,김철권,강동호,장정희,변원탄 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.5

목 적 : 사회기술훈련, 환자교육, 가족교육, 집단치료, 예술치료, 작업치료와 같은 포괄적인 정신재활 치료를 약물치료와 병행할 경우 약물치료만 시행할 때에 비해 정신분열병 환자의 재발율, 입원횟수, 입원일수, 직접 치료경비 등에 어떤 효과가 있는 지를 알아보기 위함이다. 연구방법 : 1993년 9월부터 1995년 2월까지 양산 신경정신병원의 폐쇄병동에서 퇴원한 20∼35세 사이의 정신분열병 환자 173명을 대상으로 46명에게는 6개월동안 정신재활 치료를 시행하였고 127명에게는 통상적인 외래치료만 시행한 후 연구시작 시점을 포함하여 2년동안 양군에 속한 환자들을 대상으로 재발율, 입원횟수, 입원일수, 직접 치료경비 등을 1년 단위로 추적 조사하였으며, 연구시작 시점을 기준으로 전과 후의 매년 평균 입원횟수, 입원일수, 직접 치료경비도 서로 비교하였다. 결 과 : 정신재활 치료를 약물치료와 병행할 경우 약물치료만 시행할 때에 비해 재발율, 입원횟수, 입원일수, 직접 치료비용이 현저히 감소되었다. 그리고 정신재활 치료를 받은 군에서는 치료 전에 비해 치료 후에 재발율, 입원횟수, 입원일수, 직접 치료비용이 유의하게 감소하였지만 통상적인 외래치료만 받은 군에서는 치료 전과 후간에 유의한 변화를 보이지 않았다. 결 론 : 정신분열병 환자들에게 정신재활 치료를 약물치료와 병행할 경우 약물치료만 시행할 때에 비해 환자의 임상적 경과를 호전시킬 뿐 아니라 가족의 경제적 부담도 줄일 수 있다. Objective : We evaluated the clinical efficacy of a comprehensive psychiatric rehabilitation of schizophrenia, including family psychoeducation, patient education, social skills training, group psychotherapy, art therapy, and occupational therapy. Method : From September 1993 to February 1995, 173 chronic schizophrenics who met DSM-IV criteria and were discharged from a locked ward were assigned into the psychiatric rehabilitation service group(psychiatric rehabilitation group, n=46) or the customary out-patient service group(out-patient group, n=127) prospectively, but not randomly. Assignment was based on preferences of patients and their relatives, Each subject included in the psychiatric rehabilitation group received twice weekly patient education, social skills training, family psychoeducation, group psychotherapy, art therapy, occupational therapy and maintenance chemotherapy during a 6-month period. Those in the out-patient group received individual supportive psychotherapy and maintenance chemotherapy according to their clinical needs for 10-20 minutes once per week. After entry into the study, all subjects were assessed for the number of readmission, days of hospitalization, and the direct treatment costs through the first and second year of follow-ups. These outcome variables were also compared pre-and post-2 years at the time point of entry into the study. Aftercare chemotherapy on a weekly to monthly basis continued for the remainder of the two year follow-up period. Results : With regard to the mean number of hospital admissions per year, the mean days of hospitalization per year, and the direct treatment costs per year, the psychiatric rehabilitation group had significantly decreased all clinical outcomes 2 years after compared with before receiving psychiatric rehabilitation. But there were no significant differences in the all clinical outcomes between before and after study intake in the out-patient group. For the number of relapse regardless of drug compliance, 4 patients(9%) during first year and 14 patients(30%) during second year were relapsed in the 46 subjects of the psychiatric rehabilitation group. In contrast, 75 patients(59%) during first year and 90 patients (71%) during second year relapsed in the out-patient group. When considering the effect of drug noncompliance to relapse, 4(9%) and 14 patients(30%) were relapsed while on medication respectively during the first and second year in the 46 of the psychiatric rehabilitation group, vs. 27(34%) of 79 patients on medication during the first year and 31(46%) of 68 patients on medication during the second year were relapsed in the out-patient group. Conclusions : These results indicate that the comprehensive psychiatric rehabilitation can be useful therapeutic intervention both to improve the clinical outcomes of schizophrenic patients and to reduce the economical burden of their relatives.