문화공간에 나타난 재생디자인 공간적 특성 연구 -서울시 박물관·미술관을 중심으로-

박세희 ( Park¸ Sehee ),윤재은 ( Yoon¸ Jaeeun ) 한국공간디자인학회 2021 한국공간디자인학회논문집 Vol.16 No.7

(연구배경 및 목적) 서울시는 ‘비전 2030, 문화시민도시 서울’을 목표로 시민의 행복한 삶과 삶을 위한 문화발전이라는 방향성을 가지고 사업을 추진하고 있다. 본 사업은 크게 개인, 공동체, 지역, 도시라는 범주로 나누어, 문화 주권, 문화 공생, 문화재생, 문화 창조를 목표로 한다. 특히 여러 정책의 추진과제 중 문화사업은 문화재생의 범위 안에 속해 문화를 새롭게 만들어내는 것이 아닌, 재생하는 것에 초점을 맞춘 문화예술 사업으로 진행했다. 이 중 ‘박물관·미술관 도시, 서울’은 서울시 곳곳에 방치된 유휴공간을 재생하여 문화공간으로 활용한다. 본 연구는 해당 문화공간을 파악하여, 각각의 사례들이 재생디자인의 범주에서 어떠한 방식으로 보존되며, 특성은 무엇인지 연구하였다. (연구방법) 본 연구는 우선 문화예술 및 관련 유사 공간의 공간재생 및 디자인에 관한 이론적 고찰을 수행하고, 서울특별시에서 ’17년~’23년까지 진행하는 ‘박물관·미술관 도시, 서울’ 프로젝트의 14개 문화시설 개관 사업 중 재생디자인에 해당하는 문화공간을 사례 연구의 대상으로 한다. 서울시가 진행하는 프로젝트의 사업은 연구자 본인이 직접 방문 또는 사업부서 문의를 통해 진행하였다. (결과) 연구 결과, 서울시 도시재생사업 중 문화공간 개관 사업의 특성을 분석하여 서울시 문화공간에 나타난 재생사업 체계적 유형을 도시 생활·문화 재생형, 콘텐츠 개발 및 특화형, 역사 보존형, 문화·예술 영유형 이렇게 네 가지로 분류하여 각 사례에 나타난 재생디자인 공간적 특성을 분석하였다. 재생공간의 공간적 특성을 살펴보면, 모두 유휴지에 새로운 용도를 부여하는 부활형 공간 활용을 하고 있으며, 되도록 원형보존을 목표로 하나, 안전도나 사업의 특성에 따라 구조적으로 원형보존 및 부분 개조하였다. 사업 규모에 따라 신관을 증축하여 신구건물을 연결한 사례도 있었으나, 대부분 건축물은 증축하지 않았다. 재생디자인의 특성은 보존성, 활용성이 기본으로 나타나되, 앞으로의 공간 활용성이나, 사업특징에 따라 역사성, 예술성, 사회·문화성, 장소성, 참여성, 연계성, 경관성 등이 다양하게 나타나고 있다. (결론) 이미 개관한 건축물뿐만 아니라, 앞으로 개관을 앞둔 건물 역시 서울시가 추구하는 도시재생의 목표에 따라 진행하되, 공간과 콘텐츠가 조화를 이룰 수 있는 방향성을 추구하여 지속 가능한 문화 재생공간으로 구현될 수 있기를 기대한다. (Background and Purpose) The Seoul Metropolitan Government is promoting a cultural development project for citizens’ lives and happiness levels under the "Vision 2030, Cultural Citizen City Seoul." This project is largely divided into categories of individuals, communities, regions, and cities, and aims to achieve cultural sovereignty, cultural symbiosis, cultural heritage, and cultural creation. In particular, this cultural and artistic project focused on regenerating culture, rather than creating a new culture within the context of the city’s cultural heritage. Among the project’s initiatives, "Museum, Art Museum City, Seoul" aimed to regenerate abandoned places across Seoul by transforming them into cultural spaces. This study identifies such cultural spaces and examines how each case is preserved under the banner of regenerative design. (Method) To this end, a theoretical review was conducted on the regeneration and design of cultural and artistic spaces, with a focus on the 14 cultural facility openings that happened in Seoul. The project was conducted by the Seoul Metropolitan Government and involved the researcher of this paper through inquiries from the relevant department. (Results) As a result of the study, the systematic types of regeneration projects in the cultural space of Seoul were classified into four categories: urban life and culture regeneration; content development and specialization; historical preservation; and culture and art. Following this, the spatial characteristics of reproduction design were analyzed for each case. All of them utilized resurrection-type spaces that gave new use to abandoned areas, while still preserving their original form as much as possible. In addition, they were structurally preserved and partially modified according to the safety level or the characteristics of each project. In some cases, new and old buildings were connected by expanding new buildings according to the size of the project. However, most of the buildings were not expanded. The characteristics of regenerative design are based on conservation and usability, but historical, artistic, social and cultural, place, participation, connection, and landscape appear in various ways depending on future space utilization and business characteristics. (Conclusions) In accordance with the goals of urban regeneration pursued by the Seoul Metropolitan Government, this research considered not only buildings that have already been opened, but also buildings that are about to be opened. In addition, this is expected to be implemented as a sustainable cultural reproduction space by harmonizing both the space itself and its content.

Increased Sclerostin Levels after Further Ablation of Remnant Estrogen by Aromatase Inhibitors

김원진,Yoon Jung Chung,Se Hwa Kim,Sehee Park1,Jae Hyun Bae,Gyuri Kim1,Su Jin Lee1,Jo Eun Kim1,박병우,임승길,이유미 대한내분비학회 2015 Endocrinology and metabolism Vol.30 No.1

Background: Sclerostin is a secreted Wnt inhibitor produced almost exclusively by osteocytes, which inhibits bone formation. Aromatase inhibitors (AIs), which reduce the conversion of steroids to estrogen, are used to treat endocrine-responsive breast cancer. As AIs lower estrogen levels, they increase bone turnover and lower bone mass. We analyzed changes in serum sclerostin levels in Korean women with breast cancer who were treated with an AI. Methods: We included postmenopausal women with endocrine-responsive breast cancer (n=90; mean age, 57.7 years) treated with an AI, and compared them to healthy premenopausal women (n=36; mean age, 28.0 years). The subjects were randomly assigned to take either 5 mg alendronate with 0.5 μg calcitriol (n=46), or placebo (n=44) for 6 months. Results: Postmenopausal women with breast cancer had significantly higher sclerostin levels compared to those in premenopausal women (27.8±13.6 pmol/L vs. 23.1±4.8 pmol/L, P<0.05). Baseline sclerostin levels positively correlated with either lumbar spine or total hip bone mineral density only in postmenopausal women (r=0.218 and r=0.233; P<0.05, respectively). Serum sclerostin levels increased by 39.9%±10.2% 6 months after AI use in postmenopausal women; however, no difference was observed between the alendronate and placebo groups (39.9%±10.2% vs. 55.9%±9.13%, P>0.05). Conclusion: Serum sclerostin levels increased with absolute deficiency of residual estrogens in postmenopausal women with endocrine-responsive breast cancer who underwent AI therapy with concurrent bone loss.

Towards the Application of Human Defensins as Antivirals

Park, Mee Sook,Kim, Jin Il,Lee, Ilseob,Park, Sehee,Bae, Joon-Yong,Park, Man-Seong The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.3

Defensins are antimicrobial peptides that participate in the innate immunity of hosts. Humans constitutively and/or inducibly express ${\alpha}$- and ${\beta}$-defensins, which are known for their antiviral and antibacterial activities. This review describes the application of human defensins. We discuss the extant experimental results, limited though they are, to consider the potential applicability of human defensins as antiviral agents. Given their antiviral effects, we propose that basic research be conducted on human defensins that focuses on RNA viruses, such as human immunodeficiency virus (HIV), influenza A virus (IAV), respiratory syncytial virus (RSV), and dengue virus (DENV), which are considered serious human pathogens but have posed huge challenges for vaccine development for different reasons. Concerning the prophylactic and therapeutic applications of defensins, we then discuss the applicability of human defensins as antivirals that has been demonstrated in reports using animal models. Finally, we discuss the potential adjuvant-like activity of human defensins and propose an exploration of the 'defensin vaccine' concept to prime the body with a controlled supply of human defensins. In sum, we suggest a conceptual framework to achieve the practical application of human defensins to combat viral infections.

Monolithic Hybridization of Diverse Carbon Nanotubes with Controlled Structures and Three Dimensional Graphene Foams for Supercapacitor Applications

Park, Sehee,Song, Wooseok,Kim, Seong Ku,Han, Jin Kyu,Chae, Heeyeop,Myung, Sung,Lee, Sun Sook,Lim, Jongsun,An, Ki-Seok American Scientific Publishers 2016 Journal of Nanoscience and Nanotechnology Vol.16 No.8

<P>Diverse carbon nanotubes (CNTs) with controlled structures and graphene hybrid nanostructures were synthesized for supercapacitor electrode applications. Three-dimensional multilayer graphene foams were synthesized via thermal chemical vapor deposition (TCVD). The diameter and density of the synthesized CNTs were controlled through the use of two different CVD systems in addition to adjusting the thickness of the Fe catalyst used in the production of these nanomaterials. We thereby fabricated single-walled CNTs/graphene, multi-walled CNTs/graphene, and vertically aligned CNTs/graphene hybrid nanostructures, which was confirmed via scanning electron microscopy and resonant Raman spectroscopy. Additionally, the electrochemical properties of the CNTs/graphene hybrid nanostructures were studied by cyclic voltammetry.</P>

MicroRNA clustering on the biogenesis of suboptimal microRNAs

Park Sehee,Kang Igojo,Shin Chanseok 한국응용생명화학회 2021 Applied Biological Chemistry (Appl Biol Chem) Vol.64 No.S

Most microRNAs (miRNAs) are processed by two ribonuclease III enzymes. The first cleavage is performed by Microprocessor that is composed of RNase III enzyme Drosha and DGCR8, and the second by another RNase III enzyme Dicer. There are many examples of miRNAs that are poor substrates for Drosha and Dicer, owing to their suboptimal structures. However, a number of these suboptimal miRNAs are known to be expressed at the same or higher level as their neighboring structurally-optimal miRNAs. Recent studies suggest that the clustered orientation of these suboptimal miRNAs is the explanation for this phenomenon. It has been observed that the biogenesis of these suboptimal miRNAs can be affected by the expression of their neighboring optimal miRNAs. This principle is expected to apply more broadly, as it has been shown that a large percentage of suboptimal miRNAs reside within operons.

Antiviral Agents Against Influenza Viruses

Park, Sehee,Kim, Jin Il,Park, Man-Seong 대한미생물학회 2012 Journal of Bacteriology and Virology Vol.42 No.4

In annual epidemics and occasional pandemics, influenza viruses cause acute respiratory illnesses in infected humans. Vaccines and antiviral drugs are two main arsenals available for a fight against influenza viruses. However, vaccines often exhibit a limited efficacy in high risk populations, and antiviral drugs are always concerned for mutations, which confer viral resistance. Here we review current advances and knowledge in relation to the usage of antiviral drugs as a prophylactic or therapeutic and the mechanism of resistant variants mainly against the neuraminidase inhibitors. Comprehensive understanding of the resistant mechanism will pave a road for developing new antivirals and/or finding medical or natural alternatives inducing less frequent resistance, and application of combination therapy using two or three different kinds of antivirals can suggest a useful medical intervention against both of seasonal and highly pathogenic influenza viruses including resistant variants. In this review, we provide insights of antiviral drugs for the control and prevention of influenza viruses.

Effects of heat-killed Lactobacillus plantarum against influenza viruses in mice

Park, Sehee,Kim, Jin Il,Bae, Joon-Yong,Yoo, Kirim,Kim, Hyunung,Kim, In-Ho,Park, Man-Seong,Lee, Ilseob MICROBIOLOGICAL SOCIETY OF KOREA 2018 JOURNAL OF MICROBIOLOGY -SEOUL- Vol.56 No.2

The potential use of dietary measures to treat influenza can be an important alternative for those who lack access to influenza vaccines or antiviral drugs. Lactobacillus plantarum (Lp) is one of many lactic acid bacteria that grow in 'kimchi', an essential part of Korean meal, and several strains of Lp reportedly show protective effects against influenza. Using heat-killed Lp (nF1) isolated from kimchi, which is known for its immunomodulatory effects, we investigated whether regular oral intake of nF1 could influence the outcome of influenza virus infection in a mouse model. In a lethal challenge with influenza A (H1N1 and H3N2 subtypes) and influenza B (Yamagata lineage) viruses, daily oral administration of nF1 delayed the mean number of days to death of the infected mice and resulted in increased survival rates compared with those of the non-treated mice. Consistent with these observations, nF1 treatment also significantly reduced viral replication in the lungs of the infected mice. Taken together, our results might suggest the remedial potential of heat-killed Lactobacillus probiotics against influenza.

Antiviral Agents Against Influenza Viruses

Sehee Park,Jin Il Kim,Man-Seong Park 대한미생물학회 2012 Journal of Bacteriology and Virology Vol.42 No.4

Directed self-assembly of rhombic carbon nanotube nanomesh films for transparent and stretchable electrodes

Ahn, Sehee,Choe, Ayoung,Park, Jonghwa,Kim, Heesuk,Son, Jeong Gon,Lee, Sang-Soo,Park, Min,Ko, Hyunhyub The Royal Society of Chemistry 2015 Journal of materials chemistry. C, Materials for o Vol.3 No.10

<P>The development of a transparent and stretchable electrode is critical to the realization of stretchable optoelectronic devices. In this study, a template-guided self-assembly is demonstrated for the integration of carbon nanotubes into 2D rhombic nanomesh films, where the deformation of the rhombic structure accommodates the strain, greatly improving the stretchability. In addition, the regular 2D nanomesh patterns greatly reduce the contact resistance and light scattering. Our rhombic carbon nanotube nanomesh films exhibited significantly lower sheet resistance (∼10 times) at a similar optical transmittance (78%), greater stretchability (∼8 times less resistance increase at 30% strain), and better mechanical durability (∼42 times less resistance increase after 500 stretching cycles at a strain of 30%) than those of random-network carbon nanotube films.</P>

연속적인 공정에서 시간 제약을 고려한 단조 공정 작업 계획 최적화

박세희(Sehee Park),김세영(Seyoung Kim),류광렬(Kwang Ryel Ryu) 한국정보과학회 2021 한국정보과학회 학술발표논문집 Vol.2021 No.12