엔로플록사신 액제의 닭 호흡기 및 소화기 감염증에 대한 예방 및 치료효과

윤효인,박병권,조준형,정상희,박경환,장범수,김종춘,황윤환,임종환,이내경,박승춘 충남대학교 수의과대학 동물의과학연구소 2000 動物醫科學硏究誌 Vol.8 No.-

We evaluated the efficacy of the liquid form of enrofloxacin against poultry respiratory and digestive infections, the major problems in the poultry industry, from diverse diagnosis viewpoints. Results obtained through this study were as follows: 1. The liquid form of enrofloxacin showed good acceptability to poultry owing to no abhorrence to the drug by chickens, which indicated its suitability for mixing in drinking water. 2. The application of the enrofloxacin formulation improved the productivity of the chicken farm to a great extent by lowering the death toll of chicken raised in the farm. 3. The use of the drug shortened the days to the market, and increased the body weight at the time of marketing. 4. Preventive and therapeutic effects of the liquid enrofloxacin were observed higher than ampicillin, a major antibiotic used in poultry farming. From above results, the liquid form of enrofloxacin would find its use for the prevention and treatment of digestive and respiratory infections, let alone the growth promotion and feed efficiency, especially in the chicken farming practice.

엔로플록사신 액제의 닭유래 병원세균에 대한 시험관내 항균효과 시험

윤효인,박병권,조준형,정상희,박경환,장범수,김종춘,황윤환,임종환,이내경,박승춘 충남대학교 수의과대학 동물의과학연구소 2000 動物醫科學硏究誌 Vol.8 No.-

In this study the antimicrobial spectrum and sensitivity of a liquid formulation of enrofloxacin against the major six pathogenic bacteria isolated from the diseased poultry in Korea were evaluated in comparison with ciprfloxacin (CFX), gentamicin (GM) and penicillin (PC). A liquid form of enrofloxacin, a test material and ciprofloxacin showed at least 83% antibacterial activity against all of six test pathogenic microorganisms at the fixed concentration of 10 ㎍/㎖. Gentamicin and penicillin revealed much lower antibacterial activity at the same condition. We evaluated the liquid form of enrofloxacin as having widespread antibacterial spectrum against poultry infections. The liquid form of enrofloxacin showed potent antibacterial activity, with the MIC range being 0.12∼2 ㎍/㎖ against Gram positives, 0.06∼2 ㎍/㎖ against Gram negatives and 0.5∼2 ㎍/㎖ against Mycoplasma spp. These values were equivalent to or somewhat higher than those of ciprofloxacin, but much lower than those of gentamicn and penicillin. This new liquid form of enrofloxacin would find its way in application of mixing with drinking water for the prevention and treatment of diverse infections in chickens.

데이터 연관 필터를 이용한 자율이동로봇의 환경지도 작성

임종환,이유철,강철웅 제주대학교 공과대학 첨단기술연구소 2005 尖端技術硏究所論文集 Vol.16 No.2

This paper describes a method of building the probability grid map for an autonomous mobile robot using the ultrasonic DAF(data association filter). The DAF, which evaluates the association of each datum with the rest and removes the data affected by the specular reflection effect, can improve the reliability of the data for the probability grid map. This method is based on the evaluation of possibility that the acquired data are all from the same object. Namely, the data from specular reflection have very few possibilities of detecting the same object, so that they are excluded from the data cluster during the process of the DAF. Therefore, the uncertain data corrupted by the specular reflection and/or multi-path effect, are not used to update the probability map, and hence building a good quality of a grid map is possible even in a specular environment. In order to verify the effectiveness of the DAF, it was applied to the Bayesian model and the orientation probability model which are the typical ones of a grid map. We demonstrate the experimental results using an real mobile robot in a real world.

치환 Terpyridine 리간드를 가진 옥소루테늄 착물에 의한 알켄산화반응의 반응속도론적 연구

임종완,여환진 慶北大學校 師範大學 科學敎育硏究所 1998 科學敎育硏究誌 Vol.22 No.-

The 4'-substituted terpyridines(Xtpy; Phtpy, EtOtpy, Cltpy, Me_(2)Ntpy) were synthesized. Their spectral properties have been investigated by means of ^(1)H-NMR and mass spectrometer. Also, a series of new aqua- of oxo-ruthenium complexes containing the tridentate meridonal ligand Xtpy ligand substituted in the 4' positions with electron-donating and electron withdrawing groups of general formula [Ru(Y)(Xtpy)(bpy)]^(2+)(X = ph, EtO, Cl, Me_(2)N ; Y = H_(2)O, O) have been prepared and characterized. Their specral properties have been investigated by means of UV-Vis, ^(1)H-NMR and FT-IR spectrometer. The kinetics of styrene oxidation by [RuO(Xtpy)(bpy)]^(2+) complexes were studied spectrophotometrically by monitoring the increasing of the 400-500nm of oxo ruthenium complexes in acetonitrile. The results of the oxidation reaction clearly demonstrate that the rate of oxidation is dependent on the electronic properties of the oxoruthenium complexes. The oxidation reactions were studied at three different temperatures(15, 25, 35℃). The experimental data support the operation of an associative interchange mechanism in which cleavage of the Ru=O bond and formation of an O-styrene bond have equal importance.

초음파 센서를 이용한 형상기준지도 작성에 관한 연구

임종환,강병수 濟州大學校 産業技術硏究所 2000 산업기술연구소논문집 Vol.11 No.2

This paper presents a sonar based map building method. The environment is a room or an area inside a building. which is composed of four types of geometric primitives(corners. edges. cylinders. and walls). We also assume the environment can be modeled into two dimensional map in terms of planes(wal1s). pointdcorner and edge). and circle(cy1inder). In a real world where most of the object surfaces are specular ones. a sonar sensor suffers from a multipath effect which results in a wrong interpretation of the location of an object. To reduce the effect and uncertainty. the method employs a simple thresholding technique for extracting circular arc features called regions of constant depth(RCD) from scanning sonar data. The usefulness of the approach is illustrated with the results produced by sets of experiments.

단순화된 Bayes 확률이론에 의한 초음파 환경지도 형성

임종환,강승균 濟州大學校 産業技術硏究所 1999 산업기술연구소논문집 Vol.10 No.2

An Autonomous Mobile Robot(AMR) is a mobile system capable of interpreting. planning and executing a given task without any external support. One of the prerequisites for AMR is the ability to perceive and generate a self consistent representation of the environment from sensor data in order to use them for solving a given task. For this purpose. Bayesian map building model is known as sound and effective method for construction of a probabilistic map of a robot's surroundings. It, however, needs a large amount of memory capacity. and would suffer from heavy computation costs when a real time execution is to be done on an on board computer. This study explorers a simple and fast map building method by simplifying the existing Bayesian model. This model will drastically reduce the computation costs and hence can be used in a real time execution.

모세관 전기영동법을 이용한 프로프라놀올-시클로덱스트린 포접화합물의 안정도상수 결정

임환미,최종혁,박경래,강종성 충남대학교 약학대학 의약품개발연구소 2002 藥學論文集 Vol.17 No.-

The stability constants (K_st) for the inclusion complexes between propranolol and three types of cyclodextrin (CD) such as β-CD, methyl (ME)-β-CD and hydroxypropyl (HP)-β-CD were determined by capillary electrophoresis (CE). The enantiomers of propranolol possess relatively high affinity towards ME-β-CD with stability constants of 78 and 76 M^-1 for (R)- and (S)-propranolol, respectively. The affinity of propranolol in HP-β-CD was relatively low compared with that in ME-β-CD, i.e. 39 and 36 M^-1 for (R)- and (S)-propranolol, respectively. In spite of the lower affinity, the K_R/K_S ratio of propranolol in HP-β-CD (K_R/K_S = 1.08) was higher than that in ME-β-CD (K_R/K_S = 1.03) indicating that HP-β-CD would be more efficient than ME-β-CD or β-CD in chiral separation of propranolol by CE.

AMESim를 이용한 유압 굴삭기용 Main Control Valve의 해석에 관한 연구

임태형,최종환,양순용,이병룡,안경관 한국공작기계학회 2003 한국공작기계학회 춘계학술대회논문집 Vol.2003 No.-

The hydraulic excavator has been a popular research object for automation because of its multi-workings and economic efficiency. When it works crane tasks, most of disasters happen. The objective of this paper is to design each components and to construct boom, arm, bucket circuit. These models modeled with AMESim show us change of variables and behavior of excavator. Simulation model will be used for simulator of excavator.

하지수술시 Fentanyl과 병용한 0.75% 등비중 Ropivacaine을 이용한 척추마취

임일환,이상곤,반종석,민병우 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.5

Background: Opioids and local anesthetics administered together intrathecally have a potent synergistic analgesic effect and less hypotention using a minidose of local anesthetic. This study was designed to investigate the safety and efficacy of two doses of intrathecal isobaric ropivacaine/fentanyl in patients undergoing an operation of the lower extremities. Methods: Thirty patients undergoing an elective orthopedic surgical operation of the lower extremities were randomly assigned to two groups for spinal anesthesia. Patients in group Ⅰ (n = 15) received 0.75% ropivacaine 14 mg/fentanyl 20㎍, and patients in group Ⅱ (n = 15) received 0.75% ropivacaine 16 mg/fentanyl 20㎍. After spinal anesthesia, we measured the time to T10, peak dermatomal level, time to peak sensory level, time to maximum motor blockade, duration of complete motor block and duration of complete sensory block using the pin prick test and Bromage motor scale. Also circulatory variables were monitored every 5 min and side effects were measured for 3 day after spinal anesthesia. Results: There were no significant differences between the groups in time to T10, peak dermatomal level, time to peak sensory level, time to maximum motor blockade and duration of complete motor block, but duration of complete sensory block was significantly longer in the 0.75% ropivacaine 16 mg/fentanyl 20㎍ group than the 0.75% ropivacaine 14 mg/fentanyl 20㎍ group. Conclusions: Intrathecal 0.75% ropivacaine 14 mg/fentanyl and 0.75% ropivacaine 16 mg/fentanyl were equally suitable for a lower extremity operation. (Korean J Anerthesiol 2002; 43: 600~605)

모세관 전기영동법을 이용한 베타차단제 광학이성질체의 분석

임환미,린팜두안,강종성 충남대학교 약학대학 의약품개발연구소 2000 藥學論文集 Vol.16 No.-

The effects of type of chiral selectors, pH and concentration of electrolyte on the resolution of the enantiomers of β-blockers by capillary electrophoresis were examined and the analysis of β-blocker enantiomer was attempted using various chiral selectors, such as carboxymethyl-, methyl-, succinyl, hydroxypropyl and dimethyl-β-cyclodextrin. Among the used chiral selectors, carboxymethyl-β-cyclodextrin (CM-β-CD) was the best for the separation of β-blockers. The optimum separation of the enantiomers of β-blocker was achieved on fused silica capillary (75 um i.d.×47 cm, 40 cm to detector) with phosphate buffer (pH 6, 70 mM) containing 10 mM of CM-β-CD as electrolyte at 10 KV running voltage. Injection was hydrodynamically for 3 psi×s and detection was carried out at UV 210nm.