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전상훈,허규찬,박혜원,이석근,허정욱,안성훈,박승국 계명대학교 의과학연구소 2001 계명의대학술지 Vol.20 No.1
Hepatocellular carcinoma with sarcomatous component has rarely been reported. The clinicopathologic characteristics, histogenesis, and prognosis after hepatic resection have yet to be clarified. We experienced a case of hepatocellular carcinoma with sarcomatous component. A 58-year-old woman had suffered from the liver cirrhosis due to chronic hepatitis B. She complained of dull abdominal discomfort in the right upper quadrant and general weakness. Abdominal computed tomography scan revealed a 4.2 × 3.8 cm sized mass with central low density and peripheral enhancement. The microscopic findings of the segementally resected liver mass showed hepatocelluar carcinoma with foci of pleomorphic spindle cell proliferation and transitional zone. The tumor cells revealed prominent nucleoli and frequent mitosis. The sarcomatous component reacted positivily for cytokeratin, vimentin and partially α-fetoprotein. Findings suggest that sarcomatous components represent sarcomatous changes of hepatocellular carcinoma cells rather than the collision tumor of hepatocellular carcinoma and sarcoma.
Jeon, Eun Su,Song, Hae Young,Kim, Mi Ra,Moon, Hyun Jung,Bae, Yong Chan,Jung, Jin Sup,Kim, Jae Ho American Society for Biochemistry and Molecular Bi 2006 Journal of lipid research Vol.47 No.3
<P>Sphingosylphosphorylcholine (SPC) has been implicated in a variety of cellular responses, including proliferation and differentiation. In this study, we demonstrate that d-erythro-SPC, but not l-threo-SPC, stereoselectively stimulated the proliferation of human adipose tissue-derived mesenchymal stem cells (hADSCs), with a maximal increase at 5 microM, and increased the intracellular concentration of Ca(2+) ([Ca(2+)](i)) in hADSCs, which do not express known SPC receptors (i.e., OGR1, GPR4, G2A, and GPR12). The SPC-induced proliferation and increase in [Ca(2+)](i) were sensitive to pertussis toxin (PTX) and the phospholipase C (PLC) inhibitor U73122, suggesting that PTX-sensitive G proteins, Gi or Go, and PLC are involved in SPC-induced proliferation. In addition, SPC treatment induced the phosphorylation of c-Jun and extracellular signal-regulated kinase, and SPC-induced proliferation was completely prevented by pretreatment with the c-Jun N-terminal kinase (JNK)-specific inhibitor SP600125 but not with the MEK-specific inhibitor U0126. Furthermore, the SPC-induced proliferation and JNK activation were completely attenuated by overexpression of a dominant negative mutant of JNK2, and the SPC-induced activation of JNK was inhibited by pretreatment with PTX or U73122. Treatment of hADSCs with lysophosphatidic acid (LPA) receptor antagonist, Ki16425, had no impact on the SPC-induced increase in [Ca(2+)](i). However, SPC-induced proliferation was partially, but significantly, attenuated by pretreatment of the cells with Ki16425.These results indicate that SPC stimulates the proliferation of hADSCs through the Gi/Go-PLC-JNK pathway and that LPA receptors may be responsible in part for the SPC-induced proliferation.</P>
( Chan-mi Lim ),( Min-jung Choi ),( Hae-rin Jeon ),( Sun-young Jung ),( Suk-young Kim ) 대한주산의학회 2020 Perinatology Vol.31 No.2
Objective: Chronic kidney disease (CKD) is a known risk factor of pregnancy that increases the rates of preterm birth, intrauterine growth restriction, and preeclampsia. And maternal CKD may worsen due to pregnancy itself. However, few studies have examined these problems in Korea. Methods: The cases of 29 women with CKD who delivered singleton at our institute between 2006 and 2018 were retrospectively reviewed. Cases with major fetal malformation, intrauterine fetal death, a history of kidney transplantation, or insufficient information for the parameters were excluded. The subjects were divided into early-stage (stages 1 and 2) and late-stage (stages 3 to 5) groups according to the midterm glomerular filtration rate (GFR). Demographic profiles, renal function, perinatal complications, and changes in GFR from pre-conception to postpartum were compared and analysed. Results: The incidence of preeclampsia (28.6% vs. 75.0%; P=0.038), anemia (28.6% vs. 75.0%; P=0.038), cesarean section (42.9% vs. 100.0%; P=0.009), small for gestational age (14.3% vs. 62.5%; P=0.019) and the need for neonatal intensive care unit (38.1% vs. 87.5%, P=0.035) were significantly higher in the late-stage group than those in the early-stage group. Gestational age at delivery (38.1 vs. 35.4 weeks, P=0.021) and birth weight (2,970 vs. 2,200 g, P=0.006) were significantly lower in the late-stage group than those in the early-stage group. GFR decreased significantly after delivery compared to pre-conception in both group (P=0.028, both). Conclusion: Late-stage CKD is a poor prognostic factor for pregnancy outcomes. Pregnancy deteriorates renal function even in early-stage. Close monitoring and management are required for pregnant women with any stage of CKD.
( Hae Sun Jeon ),( Seung Mi Lee ),( Young Mi Jung ),( Jin Kyun Park ),( Eun Bong Lee ),( Chan-wook Park ),( Jong Kwan Jun ),( Joong Shin Park ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: Pregnancy in patients with systemic lupus erythematosus (SLE) is associated with an increased risk for maternal and fetal adverse outcomes. Defective placentation plays an important role in the pathogenesis of these adverse outcomes. Also, it has been reported that angiogenic proteins are altered even before the onset of clinical manifestations. In this regard, this study aimed to evaluate the usefulness of the soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) ratio in second trimester plasma of patients with SLE for the prediction of adverse outcomes. Methods: This retrospective cohort study included 30 SLE patients and 9 normal pregnancy controls, who were matched for gestational age at sample collection and for maternal age. The study population was divided into three groups: SLE patients with normal pregnancy outcome (Group 1, n=18), SLE patients with adverse outcomes (Group 2, n=12), and healthy controls (Group 3, n=9). The definition of adverse outcomes was at least one of the followings: intrauterine fetal death, preeclampsia, neonatal death prior to hospital discharge, indicated preterm delivery before 36 weeks, and small for gestational age (<5th percentile) at birth. Second trimester maternal plasma was analyzed for sFlt-1/PlGF ratio using high-sensitive multiplex array. Results: Among 30 women with SLE (Group 1 and 2), adverse outcomes developed in 12 (40%) and the rate of intrauterine fetal death, preeclampsia, neonatal death, indicated preterm delivery, and small for gestational age were 25%, 58%, 0%, 67%, and 54.5%, respectively. The median concentration of the sFlt-1/PlGF ratio was significantly higher in Group 2 compared with Group 1 or Group 3. Receiver operating characteristic analysis revealed the predictability for adverse outcomes based on the sFlt-1/PIGF ratio with AUC of 0.847. Conclusion: Our findings indicate that sFlt-1/PIGF ratio in second trimester maternal plasma can be used to predict the development of adverse outcomes in patients with SLE.
A New Bacterial Blight Resistant, High-Quality Cultivar, "Seogjeongbyeo" Adaptable to Reclaimed Area
Hae Chune Choi,Hung Goo Hwang,Ha Cheol Hong,Yeon Gyu Kim,Hong Yeol Kim,Moon Tae Song,Yong Hwan Choi,Chang In Yang,Jong Doo Yea,Young Chan Cho,Man Kee Baek,Eung Gi Jeong,O Young Jeon 한국육종학회 2005 한국육종학회지 Vol.37 No.3
Park, Chan Seok,An, Gun-Hee,Kim, Young-Woon,Park, Youn-Jung,Kim, Mi-Jeong,Cho, Eun Joo,Ihm, Sang-Hyun,Jung, Hae-Ok,Kim, Hee-Yeol,Jeon, Hui-Kyung,Youn, Ho-Joong,Kim, Jae-Hyung Korean Society of Echocardiography 2011 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.19 No.4
<P><B>Background</B></P><P>Non-dippers were reported as showing different left atrial function, compared to dippers, but no study to date investigated the changes in the left atrial function according to the diurnal blood pressure pattern, using tissue Doppler and strain imaging.</P><P><B>Methods</B></P><P>Forty never treated hypertensive patients between 30 and 80 years of age were enrolled in this study. Patients were classified as non-dippers when, during night time, they had a blood pressure decrease of less than 10%. Strain of the left atrium was measured during late systole, and peak strain rates of the left atrium were measured during systole, early and late diastolic periods.</P><P><B>Results</B></P><P>The left atrial expansion index, left atrial active emptying volume and left atrial active emptying fraction were all significantly increased in non-dippers. They also had increased values of mean peak left atrial strain (dippers = 21.26 ± 4.23% vs. non-dippers = 24.91 ± 5.20%, <I>p</I> = 0.02), strain rate during reservoir (dippers = 1.29 ± 0.23 s<SUP>-1</SUP> vs. non-dippers =1.52 ± 0.27 s<SUP>-1</SUP>, <I>p</I> = 0.01) and contractile period (dippers = -1.38 ± 0.24 s<SUP>-1</SUP> vs. non-dippers = -1.68 ± 0.32 s<SUP>-1</SUP>, <I>p</I> < 0.01).</P><P><B>Conclusion</B></P><P>Strain and strain rate acquired from color Doppler tissue imaging demonstrate exaggerated reservoir and booster pump function in never-treated, non-dipper hypertensive patients. These methods are simple and sensitive for the early detection of subtle changes in the left atrial function.</P>