후두 및 하인두 암종에서 p53단백 발현과 Espstein-Barr Virus 검출

최영환,도남용,나한조,이도용,노용훈,김완수,최종선 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : When p53 cancer suppressor gene, occurs gene deletion or point mutation, malignancy develops by loss of p53 function with abnormal p53 protein. The Epstein-Barr virus (EBV) is the causative agent of certain type of lymphoma and undifferentiated nasopharyngeal carcinoma. However, the role of EBV as a causative factor in other head &eck tumors is not fully elucidated except nasopharyngeal carcinoma. This study, the author examined that p53 expression and detection rate of EBV correlate to development of laryngeal and hypopharyngeal squamous cell carcinoma(SCC) and play the possible role of prognostic indicators. Materials and Methods : Formalin-fixed, paraffin-embedded tissue specimen from 32 cases of larynx and hypopharyngeal squamous cell carcinomas were studied by immunohistochemical staining for p53 and EBV. The results of analysis were compared with clinicopathological parameters. Results : p53 expression was 56.3% (18 cases) and the detection rate of EBV was 43.6% (14 cases) of 32 cases in laryngeal and hypopharyngeal squamous cell carcinomas. p53 expression was correlate with histologic grade (p<05) only. Detection of EBV was not correlate with clinicopathological parmeters. Conclusion : These results suggest p53 expression and the detection of EBV may be related with development of laryngeal and hypopharyngeal squamous cell carcinoma. And, the expression of p53 protein can be used as a prognosticator in laryngeal and hypopharyngeal squamous cell carcinoma under certain limitation.

수중의 영양염류 제거를 위한 세라믹 소재 개발

이용환(Yong-Hwan Lee),최인호(In-Ho Choi) 한국환경관리학회 2006 環境管理學會誌 Vol.12 No.4

본 연구는 수중에 용해된 인과 질소 제거효과를 갖는 세라믹소재를 개발하기 위하여 수행되었다. 감람석을 이용한 인의 제거효과는 “이”와 “최”의 연구에서 수행된바 있으며, 제올라이트를 이용한 질소제거에 관한 연구는 국내외적으로 많이 수행되어 왔다. 본 연구에서는 감람석(Olivine)과 제올라이트(Zeolite)를 서로 다른 부피 혼합비에 따라 혼합한 후 소성하여 얻어진 세라믹을 이용하여 수중에 용해된 총인(Total-Phosphorus)과 총질소(Total-Nitrogen)의 제거효과를 회분식 실험(batch reactor system)을 통해 분석하였다. 연구결과 총인의 경우 감람석과 제올라이트의 부피 혼합비가 1:2의 경우 최고의 제거효율을 보였으며, 시험개시 30분 일 때 96.0%, 4시간일 때 95.1% 의 인이 제거되었다. 총질소의 경우 감람석과 제올라이트가 1:6일 때 시험개시 30분일 때 93.6%, 4시간일 때 97.4%의 질소가 제거되었다. This study was performed to develop ceramic material to be able to eliminate phosphorus and nitrogen in water. Olivine was found to remove phosphorus in aqueous phase, which was demonstrated by Lee and Choi.1) The nitrogen removal using zeolite has been demonstrated by many researchers.2,3) Hence, utilization of mixed-typed material of Olivine and Zeolite is expected to achieve simultaneous elimination of phosphorus and nitrogen in water. In this study, the removal efficiencies of T-P(Total phosphorus) and T-N(Total nitrogen) were investigated using ceramic material in batch reactor system, which was produced by incinerating after mixing Olivine and Zeolite with different ratio. The highest removal efficiency of phosphorus was achieved under the condition of 1: 2 mixing volume ratio of Olivine to Zeolite. The phosphorus of 93.6% and 97.4% (as T-P) was removed for 0.5hr and 4hr, respectively. For the nitrogen, the nitrogen removal efficiencies of 93.6% and 97.4% (as T-N) were obtained under the condition of 1:6 mixing volume ratio of Olivine and Zeolite.

사회복지에 있어서 자원봉사활동의 실태와 활성화 방안

최용호,김종환,박근수,노병수 朝鮮大學校 社會科學硏究所 2004 社會科學硏究 Vol.25 No.1

3個의 耕耘날을 利用한 平衡振動式 耕耘裝置(Ⅴ) : 運動解析과 要因分析

金成泰,金容煥,崔圭洪,金成泰 慶尙大學校 1988 論文集 Vol.27 No.1

This is the fifth part of series of reports on the study on a blanced-type oscillating tillage implement using triple blades system. Previous reports were made on the characteristics of power requirement and vibration with which tillage implements were oscillated parappep and perpendicular to the travelling direction. In this paper, the locus and motion analysis of the tillage blade and factor analysis were carried out. Obtained results are as follows : 1. The loci od the blade edge were described as helix curve at vertical oscillation and as lacerated curve at horizontal oscillation to the soil bin movement. 2. The motion equations of blade edge are estimated as follows. Vertical forced vibration ?? ?? Horizontal forced vibration ?? ?? 3. The multiple regression equations for resultant oscillating acceleration draft, specific resistance, and torque were established by using frequency, amplitude, life angle of tillage blade, and velocity of carriage as indepentent vibrations, respectively. 4. By reducing the velocity ratio is increased providing higher effect of the reduced draft. But this effect contradicted to achieve the reduced osillating acceleration. Both effects should be considered simultaneously to find out the optimum operating condition. 5. The reduction effect of the oscillating acceleration was slightly favoured to the horizontal forced vibration type, but traction efficiency could be lowered due to the increased slippage. Therefore, it can be concluded that the vertical forced vibration type is more appropriate considering overall performances. 6. From the experimental results, the optimum operating conditions of the vertical forced vibration type are recommended as follow ; life angle 30 degree, operation velocity 0.15 metre per second, amplitude 4-6 millimetre, and frequency 22.5 hertz.

SS41 용접재의 피로크랙 진전거동에 관한 연구

최병기,권택용,정환규 朝鮮大學校 機械技術硏究所 2000 機械技術硏究 Vol.3 No.1

SS41 is welded automatically and is investigated some effects of the welding residual stress in the growth and propagation of fatigue crack, so as to study the fatigue behaviour in the welding residual stress field. The summarized results are as follows; 1) In case of the load range is constant, as the stress ratio is changing to 0.1, 0.33 and 0.5 the propagation life is constant but the growth life decreases. And than, when maximum load or minimum load is constant, as the stress ratio increases the growth life and propagation life. 2) It was shown that the fatigue crack propagation ratio da/dN was almost constant regardless of the stress ratio change at constant load amplitude and that the larger stress ratio, the slower was the fatigue crack propagation ratio. 3) The opening ratio U is influenced by Kmax but it isn't only the function of Kmax because data range is very large. 4) The growing and propagation fatigue crack in the welding residual stress field is similar to original specimen after passing the original residual stress field.

FCL(5-FU, Carboplatin, Leucovorin) 항암 화학요법에서 Gm-CSF의 효과

최지영,김현수,김종숙,박상준,윤환중,조덕연,남상륜,김삼용 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

Background: One of the major side effects of cancer chemotherapy is myelosuppression. Neutropenia and/or thrombocytopenia are dose-limiting factors in chemotherapy. Colony-stimulating factor induces proliferation and functional maturation of hematopoietic progenitor cells. GM-CSF is primarily active on progenitor cells of granulocytic and monocytic lineage. Methods: Fifteen patients with histologically proven malignancy diagnosed at Chungnam National University Hospital from January 1993 to August 1995 were included in this study. We could evaluate the clinical efficacy of GM-CSF in 13 patients undergoing FCL(5-FU, Carboplatin and Leucovorin) chemotherapy; the first cycles involved no GM-CSF while the second cycles involved GM-CSF on day 6 through 15 of chemotherapy. Results: 1) The subjects were fifteen patients in all, there were five patients with head and neck cancer, which was the most common types of maligancy. There were four patients with colon cancer, two patients with stomach cancer, and one patient with breast cancer, gallbladder cancer, cervix cancer and cholangiocarcinoma respectively, two patients, who did not complete two cycles of chemotherapy were excluded. 2) Age distribution was from 38 years to 78 years with a median age of 57. 3) In FCL chemotherapy cycles with GM-CSF, the duration of neutropenia(<500/μL) was 0.5±0.3 day, while FCL chemotherapy cycles without GM-CSF, it was 2.9±0.7 day(P=0.008). 3) There was no significant difference in platelet count between the two chemotherapy cycles(P=0.133). 4) Febrile duration without GM-CSF was 4.9±2.1 day, but with GM-CSF the duration was 1.3±0.7 day, which was significantly different(P=0.003). The duration of antibiotics use with GM-CSF was 1.7±1.2 day and without GM-CSF was 6.8±3.2 day, also significantly different(P=0.002). But hospital stay between the two cycles were not significantly different(P=0.064). Conclusion: GM-CSF was effective in preventing or restoring bone marrow depression after FCL chemotherapy.

손등 정맥 패턴의 회전 왜곡을 보상한 개인 식별 알고리즘의 연구

최환수,안장용 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-

This paper proposes an enhanced algorithm for person identification system utilizing hand vein pattern. The conventional algorithm does not cope with distortion caused by image rotation caused by misplaced hands on the imaging device. A straightforward approach to consider the rotaional compensation required too much computational load, thus, we devised an approach to expect the rotation direction along with image translation, reducing the compuational requirement dramatically. In this paper, we present the detail of the algorithm with experimental results with the new algorithm.

rhBMP-2가 저칼슘식이 투여 백서의 골결손부 이유에 미치는 영향

최용석,황의환,이상래 大韓口腔顎顔面 放射線學會 2004 Imaging Science in Dentistry Vol.34 No.1

Purpose : To investigate the effect of rhBMP-2 on the healing of bone defect in the low calcium diet rat. Materials and Methods : To prepare the experimental model, control group was fed a normal diet and experimental group was fed a low calcium diet for 3 weeks. And then, 4 mm bicortical perforated bone defect was made on mandibular body of each rats. Experimental group was subdivided into two groups; experimental group 1 (rats given a low calcium diet before and after bone defect) and experimental group 2 (rats given a low calcium diet before and after bone defect with rhBMP-2 application). At 1, 3, 5 and 7 weeks after bone defect formation, the rats Were terminated. The healing of bone defect was assessed by three-dimensional computerized tomography, soft xray radiography, and histopathological examination. Results : The wound healing of the bone defect for control group, experimental group 1, and experimental group 2 showed a increase from 3 weeks after bone defect formation. The experimental group 2 showed a more increase in healing amount than control group and experimental group 1 from 5 weeks after bone defect formation and the experimental group 2 showed a complete recovery of bone defect at 7 weeks after bone defect formation. Conclusion : The healing process of bone defect is accelerated by rhBMP-2 application in the low calcium diet rats.

용도지역 적용방식별 비교ㆍ평가 연구 : 도시지역내 2이상의 용도지역에 걸치는 대지를 대상으로 A Case of the Lots Divided by Zoning-Line in the Urban Area

최찬환,황용연,최준순 대한건축학회 2004 대한건축학회논문집 Vol.20 No.2

This study is focusing on analyzing the effect and meaning of the zone on the lot divided by zoning line which is run by the current law to get rational solutions. Each evaluation applies to realistic and applicable methods according to regulations. The three ways of application methods on the zone of the selected lot divided by zoning appear are Land Area Method, Building Area Method, and Zone Method. All three ways have their own meanings and limitations to apply, but according to the analysis result, we could decide that Region Method is the most effective way. However, it has sever limitations when we design site plan, building-use and building form in a land, so complements are required for each of provisions. Therefore, We suggest new approach about the building development scale, and for building-use and a right to enjoy sunshine, We suggest complementary methods for each case. First, We apply for a complex method for deciding on the building development scale. Second, for determination of the building uses, We permit the mixed-usage when a building sets on the lot divided by zoning line, and for a right to enjoy sunshine, We select the application method for the bigger land.

클래스 유사도에 의한 분류방법에 관한 연구

최영신,김용환,최성 호서대학교 반도체제조장비국산화연구센터 2001 반도체장비학술심포지움 Vol.2001 No.-

게임 제작 도구의 핵심 구성 요소가 되는 클래스 라이브러리 개발을 위해 게임 객체와 수 있는 클래스 분류방법이 필요하다.클래스 분류방법에는 Enumerative 분류 방법과 클러스터링 방법을 적용한다.본 논문에선 클래스의 시공간 개념 분석을 하고 유사도 값에 의한 클러스터링을 한다.유사도 값에 의한 클래스 클러스터링이 게임 클래스 객체들의 행위들을분류할 카테고리에 없는 경우 Enumerative분류 방법을 하여 게임 클래스 라이브러리를 연구하였다.