키영상을 이용한 영상검색시스템 구현

이경자,정성환 國立 昌原大學校 産業技術硏究所 1998 産技硏論文集 Vol.12 No.-

In this paper, we implement an image retrieval system using key image. We use key image to reduce time-consuming for calculating similarity distance in a large image database. We extract and store feature values using, texture and color. The similarity distance values between each image and key image are calculated and stored in the database. We first filter images in the database using color feature. Next we retrieve the candidate images using texture feature hierarchically. Our system shows better retrieval result than in the case of using texture and color feature respectively. In the experiment with 200 real images, the results of 95% recall and 73% precision are shown.

장기입원환자 관리 방해요인

이경석,윤석만,권희,이호,김혜경,조미자,한규남,김명성 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Background: Recently the health insurance review agency tried to cut off the cost of unnecessary hospital stay. It is important to reduce the prolonged occupation of the hospital beds. However, there are some obstacles of the management for the prolonged bed occupation. We report our experiences and the problems of bed-control. Methods: To increase the rate of effective bed-usage, a task force was made. This team was consisted of 4 dctors, 2 nurses and 2 personnel of the administrative department. From December 20th 2001 to May 17th 2002, the task force analysed the rate, number and causes of the prolonged (more than 60 days, regardless of the disease entities) bed occupation. We announced and explained the necessity of bed-control and actively pressed to reduce the prolonged bed occupation. Results: The number of the prolonged bed occupation was 71 at the beginning of the management. It was reduced to 46 at best, then turned back to 65 at the end. It seems to be impossible to reduce the prolonged bed occupation until there are sufficient numbers of long-term care facilities. Aggressive bed control makes the sick patients to move every two or three months, it is never desirable. Conclusion: We cannot expect any Quality Improvements without improvement of the wrong system. Prior to the management for the prolonged bed occupation, it is necessary to build a sufficient number of long-term care facilities.

북미 양서류의 치사종간 핵치환 개체의 염색체 이상과 발생 능력에 관한 연구

이자경,정해문 A.R. Liss 1990 ENVIRONMENTAL MUTAGENS AND CARCINOGENS Vol.10 No.1

독성물질의 세포사 기전 및 세포사 유발물질의 검색법 개발에 관한 연구(Ⅰ) : 독성물질로 인한 파킨슨병 모델에서의 세포사 기전 연구 Study on the cell-death mechanisms of toxin-induced parkinsonism

강태석,김종민,서경원,김영옥,김준규,오재호,이윤동,김규봉,오정자,송연정,임종준,전범석,문전옥,최광식 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

MPTP 독성물질이 도파민성 신경세포에 선택적으로 작용하여 산화성 손상에 의한 신경세포사를 일으키는 것을 이용하여 파킨슨병의 동물모델을 만들고, 이를 통해서 아폼토시스를 비롯한 포사의 기전에 대한 연구 및 너코틴의 신경세포 보호효과 여부를 판정하는 실험을 병행하고자 하였다. 파킨슨꾐의 동물모델을 MPTf 독성 물질을 이용하여 확립하였으며, MPTP(30mgag, i.p.)를 투여한 후 1, 2,3, 4, 5일째 흑질 조직을 채춰하여 tarm로 박걸하여 tyrosine hydroxylase 면역조직화학염색을 수행하여 cell countif우한 결과, control은 57.635ce11s, 1일째 친.OfDells,2일째 57.9±6cells,3일릴 없.3±죠ells, 4일째 49.0츠3cells, 5일째 39.4±Scells료 4, 3일째 뚜렷한 신경세포 수의 감소를 보였다. 신경세포사 기전 규명을 위한 아폼토시스 분걱에서는 벼PTP 투여 후 1, 2, 3, 4, 5일째 조직을 채취하여 Hoechst staining, TUNEL staining을 수곡하였는데 양성 반응을 보인 신경세포는 관찰되지 않아. 아폼토시스로 인한 세포사가 관찰되지 않았다. bIPTP 파킨슨병 동물모델에서 nicotine 보호효과 탐색에 관한 실험은 nicat푸e 0.2mgAg을 5일 퐁안 투여 후 리『fP(30mgag)를 CS7Bt/6 마은스에 복강 내주사로 nicotine과 병용 투여한 후 1, 2, 3, 4, 5일째 뇌를 적출하땄다. 신경세포사가 뚜렷이 관찰되기 시작하는 4, 5일째의 신경세포 수의 감소 정도를 20. 30% 정도 약화시키는 경향을 보였으나, nicotine 보호효과에 대한 추가 실헝이 현재 수행 중에 있다. The cause of Parkinson's disease (PD) is largely unknown. However, free radical toxicit? may plaf a role ip. the degeneration of substantia nigra, which is the Hajorfocus of pathological damages in PD. Recently, a neuroprotective effect of nicotine in PD has been suggested. Therefore, the mechanism of neurodegenerafion and protective potential o( nicotine in PD were investigated in the experimental modeB of Pll using a neurotoxin, C57BL/6mice were administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30 mg/kg,j.p.). The degree of neurodegenerafion was determined by immunohistochemical stainiHB oftyrosine hydroxylase (TH). TH-positive cells on nigral sections were found 56.0 ±4, 57.9 ±6,52.315ce11s, 49.0±3cells, and 39,4±Scells at days 1, 2, 3, 4, 5, respectively (controls : 57.6±Scells). Hoechst and TUNEL staining showed no evidence of apoptosis. The exandnation on themice co-adrunistered with nicotine(0.2mgAg) and MPTP(30mgag) revealed a tendency ofnicotine protective effects. At days 4 and 5, the degree of TH-positive cells was decreased by20-30%, In corclusiffn, the role of apoptosis was not evidenced in this MPTP modeB of PB.The possible proteccon by nicotine should be elucidated with further studies.

전래동요놀이가 만 2세 영아의 의사소통 및 사회정서발달과 놀이성에 미치는 영향

이영자(Lee Yeong-Ja),곽경화(Kwak Kyeong-Hwa),최진숙(Choi Jin-Suk) 한국어린이미디어학회 2022 어린이미디어연구 Vol.21 No.2

본 연구는 전래동요놀이가 만 2세 영아의 의사소통 및 사회정서발달과 놀이성에 어떤 영향을 미치는지 알아보고자 한 것이다. 연구대상은 전라남도 N시에 소재한 A어린이집과 B어린이집에 재원 중인 만 2세 영아 28명을 대상으로 하였다. 본 연구의 프로그램은 1주에 2회씩, 8주간 전래동요놀이 활동을 실시한 실험집단과 표준보육과정에 기초한 음률신체활동을 실시한 비교집단으로 나누어 실시하였다. 연구도구는 영아의 의사소통능력 및 사회정서발달과 놀이성을 측정하기 위해 이영자, 이종수, 신은수, 곽향림, 이정욱(2002)의 ‘1, 2세 영아발달 평가도구’ 중에서 의사소통에 해당하는 부분을 발췌하여 사용하였고, 김호인(2010)의 사회정서발달 척도와, 이화용(2012)의 놀이성 척도를 사용하였다. 수집한 자료는 SPSS 23.0 Windows program을 통해 독립표본 t-검증을 실시하였다. 연구결과 전래동요놀이는 만 2세 영아의 의사소통 및 사회정서발달과 놀이성에 긍정적인 영향을 미치는 것으로 나타났다. 이러한 연구의 결과는 만 2세 영아의 의사소통, 사회정서발달, 놀이성을 증진시키기 위한 전래동요놀이의 효과를 검증한 연구로서 현장에서 전래동요놀이가 지속적으로 활용되길 기대한다. The purpose of this study is to investigate the effect of traditional nursery rhymes on communication, social-emotional development and playfulness of 2-year-old children. The subjects of this study were 28 2-year-old children who were enrolled in daycare center A and day care center B located in N city, Jeollanam-do. The study was conducted by dividing the groups into a comparison group where rhythmic physical activities were completed based on the national childcare curriculum and an experimental group where traditional nursery rhyme play were implemented twice a week for 8 weeks. As for research instruments, the part corresponding to communication among the ‘1st and 2nd-year-old children development evaluation tools’ of Lee Young-ja, Lee Jong-su, Shin Eun-su, Kwak Hyang-rim, and Lee Jeong-wook(2002) was extracted and used as a research tool to measure the communication ability of toddlers, and Kim Ho-in(2010) and the playability scale of Lee Hwa-yong(2012) were used. The collected data was subjected to independent sample t-test through SPSS 23.0 Windows program. As a result of the study, it was found that traditional nursery rhymes have a positive effect on communication, social-emotional development and playability of 2-year-old children. This study verified the effects of traditional nursery rhyme play to enhance communication, social emotional development, and playfulness of 2-year-old children, and it is expected that traditional nursery rhyme play can be used continuously in the day care center.

Gamma-ray Full Spectrum Analysis for Environmental Radioactivity by HPGe Detector

Meeyoung Jeong,Kyeong Beom Lee,Kyeong Ja Kim,Min-Kie LEE,Ju-Bong HAN 한국우주과학회 2014 Journal of Astronomy and Space Sciences Vol.31 No.4

Odyssey, one of the NASA’s Mars exploration program and SELENE (Kaguya), a Japanese lunar orbiting spacecraft have a payload of Gamma-Ray Spectrometer (GRS) for analyzing radioactive chemical elements of the atmosphere and the surface. In these days, gamma-ray spectroscopy with a High-Purity Germanium (HPGe) detector has been widely used for the activity measurements of natural radionuclides contained in the soil of the Earth. The energy spectra obtained by the HPGe detectors have been generally analyzed by means of the Window Analysis (WA) method. In this method, activity concentrations are determined by using the net counts of energy window around individual peaks. Meanwhile, an alternative method, the so-called Full Spectrum Analysis (FSA) method uses count numbers not only from full-absorption peaks but from the contributions of Compton scattering due to gamma-rays. Consequently, while it takes a substantial time to obtain a statistically significant result in the WA method, the FSA method requires a much shorter time to reach the same level of the statistical significance. This study shows the validation results of FSA method. We have compared the concentration of radioactivity of 40K, 232Th and 238U in the soil measured by the WA method and the FSA method, respectively. The gamma-ray spectrum of reference materials (RGU and RGTh, KCl) and soil samples were measured by the 120% HPGe detector with cosmic muon veto detector. According to the comparison result of activity concentrations between the FSA and the WA, we could conclude that FSA method is validated against the WA method. This study implies that the FSA method can be used in a harsh measurement environment, such as the gamma-ray measurement in the Moon, in which the level of statistical significance is usually required in a much shorter data acquisition time than the WA method.

Induction of Nerve Injury-Induced Protein 1 (Ninjurin 1) in Myeloid Cells in Rat Brain after Transient Focal Cerebral Ischemia

Lee, Hye-Kyung,Lee, Hahnbie,Luo, Lidan,Lee, Ja-Kyeong The Korean Society for Brain and Neural Science 2016 Experimental Neurobiology Vol.25 No.2

<P>Nerve injury-induced protein-1 (Ninjurin-1, Ninj1) was initially identified as a novel adhesion molecule in rat sciatic nerve and to be up-regulated in neurons and Schwann cells of distal nerve segments after nerve transection or crush injury. Recently, Ninj1 was found to act as a modulator of cell migration, angiogenesis, and apoptosis. Accumulating evidence indicates that innate immune response plays beneficial and deleterious roles in brain ischemia, and the trans-endothelial migration of blood-derived immune cells is key initiator of this response. In the present study, we examined the expression profile and cellular distribution of Ninj1 in rat brain after transient focal cerebral ischemia. Ninj1 expression was found to be significantly induced in cortical penumbras 1 day after 60 min of middle cerebral artery occlusion (MCAO) and to increase gradually for 8 days and then declined. In infarction cores of cortices, patterns of Ninj1 expression were similar to those observed in cortical penumbras, except induction was maintained for 10 days. At 1 day post-MCAO, Ninj1 inductions were detected mainly in neutrophils and endothelial cells in both infarction cores and penumbras, but reactive macrophages were the major cellular expressers of Ninj1 at 4 days post-MCAO. Expressional induction in reactive macrophages was maintained in infarction cores after 12 days post-MCAO but not in penumbras. These dynamic expressions of Ninj1 in different immune cells at different times suggest that this protein performs various, critical roles in the modulation of acute and delayed immune responses in the postischemic brain.</P>

Enhanced Transparency for Physical Human-Robot Interaction Using Human Hand Impedance Compensation

Lee, Kyeong Ha,Baek, Seung Guk,Lee, Hyuk Jin,Choi, Hyouk Ryeol,Moon, Hyungpil,Koo, Ja Choon IEEE 2018 IEEE/ASME transactions on mechatronics Vol.23 No.6

<P>In a physical human-robot interaction (pHRi) system, improving transparency that allows humans to move as if there is no robot is a challenging topic. In general pHRi, usage of the multiaxial force sensor for robot control is the norm. However, the signal measured from the force sensor contains not only the force applied to the robot by the human motion intention but also the influence of the natural force feedback between the robot and the human hand produced by the robot motion. Therefore, in order to improve the transparency, it is necessary to characterize the dynamics of the human hand as well as the dynamics of the robot. In this paper, an algorithm to improve the transparency is proposed. The proposed algorithm uses only a multiaxial force sensor and compensates the natural force feedback by using the human hand impedance. And it further improves the transparency of the pHRi system, which has a limitation adjusting admittance parameters. In order to verify the algorithm, a device that can measure the impedance of the human hand is introduced, and a system model analysis and experiments using the hydraulic upper limb exoskeleton are carried out.</P>

Anti-Inflammatory and Neuroprotective Effects of DIPOPA (N,N-Diisopropyl-2-Oxopropanamide), an Ethyl Pyruvate Bioisoster, in the Postischemic Brain

Lee, Hye-Kyung,Park, Ju-Young,Lee, Hahnbie,Kim, Il-Doo,Kim, Seung-Woo,Yoon, Sung-Hwa,Lee, Ja-Kyeong Springer-Verlag 2019 Neurotherapeutics Vol.16 No.2

Proangiogenic functions of an RGD-SLAY-containing osteopontin icosamer peptide in HUVECs and in the postischemic brain

Lee, Hahnbie,Jin, Yin-Chuan,Kim, Seung-Woo,Kim, Il-Doo,Lee, Hye-Kyung,Lee, Ja-Kyeong Nature Publishing Group 2018 Experimental and molecular medicine Vol.50 No.1

<P>Osteopontin (OPN) is a phosphorylated glycoprotein secreted into body fluids by various cell types. OPN contains arginine-glycine-aspartate (RGD) and serine-leucine-alanine-tyrosine (SLAY) motifs that bind to several integrins and mediate a wide range of cellular processes. In the present study, the proangiogenic effects of a 20-amino-acid OPN peptide (OPNpt20) containing RGD and SLAY motifs were examined in human umbilical vein endothelial cells (HUVECs) and in a rat focal cerebral ischemia model. OPNpt20 exerted robust proangiogenic effects in HUVECs by promoting proliferation, migration and tube formation. These effects were significantly reduced in OPNpt20-RAA (RGD->RAA)-treated cells, but only slightly reduced in OPNpt20-SLAA (SLAY->SLAA)-treated cells. Interestingly, a mutant peptide without both motifs failed to induce these proangiogenic processes, indicating that the RGD motif is crucial and that SLAY also has a role. In OPNpt20-treated HUVEC cultures, AKT and ERK signaling pathways were activated, but activation of these pathways and tube formation were suppressed by anti-α<SUB>v</SUB>β<SUB>3</SUB> antibody, indicating that OPNpt20 stimulates angiogenesis via the α<SUB>v</SUB>β<SUB>3</SUB>-integrin/AKT and ERK pathways. The proangiogenic function of OPNpt20 was further confirmed in a rat middle cerebral artery occlusion model. Total vessel length and vessel densities were markedly greater in OPNpt20-treated ischemic brains, accompanied by induction of proangiogenic markers. Together, these results demonstrate that the 20-amino-acid OPN peptide containing RGD and SLAY motifs exerts proangiogenic effects, wherein both motifs have important roles, and these effects appear to contribute to the neuroprotective effects of this peptide in the postischemic brain.</P>