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Prognostic Value of Vascular Endothelial Growth Factor Expression in Resected Gastric Cancer
Liu, Lei,Ma, Xue-Lei,Xiao, Zhi-Lan,Li, Mei,Cheng, Si-Hang,Wei, Yu-Quan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7
Background and Aims: Vascular endothelial growth factor (VEGF) is a potential prognostic biomarker for patients with resected gastric cancer. However, its role remains controversial. The objective of this study was to conduct a systematic review and meta-analysis of published literature. Methods: Relevant literature was identified using Medline and survival data from published studies were collected following a methodological assessment. Quality assessment of eligible studies and meta-analysis of hazard ratio (HR) were performed to review the correlation of VEGF overexpression with survival and recurrence in patients with gastric cancer. Results: Our meta-analysis included 44 published studies with 4,794 resected patients. VEGF subtype for the prediction of overall survival (OS) included tissue VEGF (HR=2.13, 95% CI 1.71-2.65), circulating VEGF (HR=4.22, 95% CI 2.47-7.18), tissue VEGF-C (HR=2.21, 95% CI 1.58-3.09), tissue VEGF-D (HR=1.73, 95% CI 1.25-2.40). Subgroup analysis showed that HRs of tissue VEGF for OS were, 1.78 (95% CI 0.90-3.51) and 2.31 (95% CI 1.82-2.93) in non-Asians and Asians, respectively. The meta-analysis was also conducted for disease free survival (DFS) and disease specific survival (DSS). Conclusion: Positive expression of tissue VEGF, circulating VEGF, VEGF-C and VEGF-D were all associated with poor prognosis in resected gastric cancer. However, VEGF demonstrated no significant prognostic value for non-Asian populations. Circulating VEGF may be better than tissue VEGF in predicting prognosis.
Spatial Regionalization on Surface Ozone in the Yangtze River Delta of China
Lei Tong,Hang Xiao,Hui Yi,Yu Liu,Jie Zheng,Cenyan Huang,Mengmeng He 한국기상학회 2022 Asia-Pacific Journal of Atmospheric Sciences Vol.58 No.2
In order to better understand the tempo-spatial characteristics of surface ozone (O3) on the regional scale of Yangtze River Delta (YRD), China, cluster analysis was applied to surface O3 monitored from 2016 to 2017 at 110 state-controlled stations. Eight spatial regions with distinct patterns of O3 variations were identified. The exceedances over the Grade I (100 μg/m3) andGrade II (160μg/m3) National Ambient Air Quality Standard of maximum daily average 8 h O3 (MDA8 O3) varied within 99~192 and 1~41 days, respectively, for different subregions. The central and east YRD were the most polluted subregions with higher incidence of O3 episodes, while the southwest and southeast YRD were relatively clean. The spatial disparity of O3 over YRD was strongly affected by local emissions, with larger precursor emissions contributing to higher frequencies of O3 pollution and larger amplitudes of temporal variations. The regionalO3 pollution mainly occurred in spring, with higher peaks ofMDA8O3 being observed duringApril ~May for most subregions. While for east YRD, O3 pollution was most serious in summer, when its monthly MDA8 O3 reached the highest value (141.0 μg/m3). During thewhole study period, the spatial differences of weekly/monthly amplitudes ofMDA8O3 were similar to those of NO2 among the eight subregions, indicating the significant influence of NO2 on O3 over YRD on the yearly timescale. This influence was especially evident in warm seasons for the coastal subregions, where O3 production was controlled by NOx. While for the west inland subregion, O3was less affected by NO2 variation, indicating a NOx-saturated characteristic of O3 formation.
Structural and Thermal Characteristics of a High-Nitrogen Energetic Material: G(AHDNE)
Lei Lü,Kangzhen Xu,Hang Zhang,Gang Wang,Jie Huang,Bozhou Wang,Fengqi Zhao 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.7
A high-nitrogen energetic salt, 1-amino-1-hydrazino-2,2-dinitroethylene guanidine salt [G(AHDNE)], was synthesized by reacting of 1-amino-1-hydrazino-2,2-dinitroethylene (AHDNE) and guanidine hydrochloride in sodium hydroxide aqueous solution. The theoretical investigation on G(AHDNE) was carried out by B3LYP/ 6-311+G* method. The thermal behaviors of G(AHDNE) were studied with DSC and TG-DTG methods, and the result presents an intense exothermic decomposition process. The enthalpy, apparent activation energy and pre-exponential constant of the process are −1060 J g−1, 148.7 kJ mol−1 and 1015.90 s−1, respectively. The critical temperature of thermal explosion of G(AHDNE) is 152.63 °C. The specific heat capacity of G(AHDNE) was studied with micro-DSC method and theoretical calculation method, and the molar heat capacity is 314.69 J mol−1 K−1 at 298.15 K. Adiabatic time-to-explosion of G(AHDNE) was calculated to be a certain value between 60-72 s. The detonation velocity and detonation pressure were also estimated. G(AHDNE) presents good performances.
Lei-Chen Lin,Wan-Rou Lin,Yu-Chen Hsu,Hung-Yu Pan 한국원예학회 2020 원예과학기술지 Vol.38 No.5
Rhododendron kanehirae Wilson is an endemic species of Taiwan that is listed as extinct in the wild by the Red List of Vascular Plants of Taiwan. R. kanehirae seedlings can form mycorrhizae with the ericoid mycobiont Oidiodendron maius. A completely randomized experimental design was conducted to investigate the effects of three different O. maius isolates (strains CBS110450, RhYM3, and RooDK1) as well as nitrate and ammonium (inorganic nitrogen) on the growth of R. kanehirae by evaluating height and shoot, root, and total fresh weight. Three isolates of O. maius showed different colony morphology and growth rate, which was further verified by molecular analysis. The results showed that application of ammonium fertilizer improved the height and shoot, root, and total fresh weight of all of the R. kanehirae seedlings. Among them, seedlings inoculated with RhYM3 had the highest fresh weights and heights. By applying an appropriate amount of nitrogen combined with RhYM3 inoculation, the rhizome of R. kanehirae grew well. The information provided here is crucial for the conservation of R. kanehirae, as this species is on the verge of extinction.
Song Lei,Qiu Xiaoming,Zhang Cun,Zhou Hang,Guo Wenmin,Ye Yu,Wang Rujia,Xiong Hui,Zhang Ji,Tang Dongfang,Zou Liwei,Wang Longsheng,Yu Yongqiang,Guo Tingting 대한영상의학회 2024 Korean Journal of Radiology Vol.25 No.2
Objective: This study aimed to determine the predictive performance of non-contrast CT (NCCT) signs for hemorrhagic growth after intracerebral hemorrhage (ICH) when stratified by onset-to-imaging time (OIT). Materials and Methods: 1488 supratentorial ICH within 6 h of onset were consecutively recruited from six centers between January 2018 and August 2022. NCCT signs were classified according to density (hypodensities, swirl sign, black hole sign, blend sign, fluid level, and heterogeneous density) and shape (island sign, satellite sign, and irregular shape) features. Multivariable logistic regression was used to evaluate the association between NCCT signs and three types of hemorrhagic growth: hematoma expansion (HE), intraventricular hemorrhage growth (IVHG), and revised HE (RHE). The performance of the NCCT signs was evaluated using the positive predictive value (PPV) stratified by OIT. Results: Multivariable analysis showed that hypodensities were an independent predictor of HE (adjusted odds ratio [95% confidence interval] of 7.99 [4.87–13.40]), IVHG (3.64 [2.15–6.24]), and RHE (7.90 [4.93–12.90]). Similarly, OIT (for a 1-h increase) was an independent inverse predictor of HE (0.59 [0.52–0.66]), IVHG (0.72 [0.64–0.81]), and RHE (0.61 [0.54– 0.67]). Blend and island signs were independently associated with HE and RHE (10.60 [7.36–15.30] and 10.10 [7.10–14.60], respectively, for the blend sign and 2.75 [1.64–4.67] and 2.62 [1.60–4.30], respectively, for the island sign). Hypodensities demonstrated low PPVs of 0.41 (110/269) or lower for IVHG when stratified by OIT. When OIT was ≤ 2 h, the PPVs of hypodensities, blend sign, and island sign for RHE were 0.80 (215/269), 0.90 (142/157), and 0.83 (103/124), respectively. Conclusion: Hypodensities, blend sign, and island sign were the best NCCT predictors of RHE when OIT was ≤ 2 h. NCCT signs may assist in earlier recognition of the risk of hemorrhagic growth and guide early intervention to prevent neurological deterioration resulting from hemorrhagic growth.
Structural and Thermal Characteristics of a High-Nitrogen Energetic Material: G(AHDNE)
Lu, Lei,Xu, Kangzhen,Zhang, Hang,Wang, Gang,Huang, Jie,Wang, Bozhou,Zhao, Fengqi Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.7
A high-nitrogen energetic salt, 1-amino-1-hydrazino-2,2-dinitroethylene guanidine salt [G(AHDNE)], was synthesized by reacting of 1-amino-1-hydrazino-2,2-dinitroethylene (AHDNE) and guanidine hydrochloride in sodium hydroxide aqueous solution. The theoretical investigation on G(AHDNE) was carried out by B3LYP/$6-311+G^*$ method. The thermal behaviors of G(AHDNE) were studied with DSC and TG-DTG methods, and the result presents an intense exothermic decomposition process. The enthalpy, apparent activation energy and pre-exponential constant of the process are $-1060J\;g^{-1}$, $148.7kJ\;mol^{-1}$ and $10^{15.90}s^{-1}$, respectively. The critical temperature of thermal explosion of G(AHDNE) is $152.63^{\circ}C$. The specific heat capacity of G(AHDNE) was studied with micro-DSC method and theoretical calculation method, and the molar heat capacity is $314.69J\;mol^{-1}K^{-1}$ at 298.15 K. Adiabatic time-to-explosion of G(AHDNE) was calculated to be a certain value between 60-72 s. The detonation velocity and detonation pressure were also estimated. G(AHDNE) presents good performances.