State Indicator of Water Quality for Surface Water and Groundwater in Agriculture

Min-Kyeong Kim,Goo-Bok Jung,An-Sung Ro,Seung-Chul Choi,Won-Il Choi,Eun-Jeong Kim,Jong-Eun Lee,Yeo-Uk Yun,Kab-Cheol Kim,Do-Young Ko,Byeong-Ho Kim,Hyeon-Ji Kim,Sang-Jo Park,Seong-Tae Lee,Jae-Young Heo,S 한국토양비료학회 2015 한국토양비료학회지 Vol.48 No.5

Indicators of environmental conditions qualitatively and quantitatively describe the state of the environment and natural resources, and the OECD (Organization for Economic Cooperation and Development) has initiated and suggested AEIs (Agri-Environmental Indicators) to assess trends over time of the effects of agriculture on the environment and the effectiveness and efficiency of agricultural and environmental policy measures since 1990’s. This study aims to develop the state indicators of water quality for agricultural water, surface and groundwater, to evaluate the environmental impacts of agricultural activities and policies by qualifying the environmental levels of a nation. Status indicators were calculated according to the agricultural water quality standards of OECD and Korea, and their trends were analyzed over time. Particularly, nitrate(NO₃<SUP>-</SUP>) status indicators of ground water in 2013 were significantly lower than the ones in 2000. Overall, the water quality indicators of surface water in 2013 were higher than the ones in 2012, except for pH and DO. The groundwater quality indicators in 2013 were lower than those of previous years. The optimal management indicators were calculated to assess agricultural surface water and groundwater quality. The findings of this study indicated that the state indicators could play a significant role to establish policies and procedures for managing and conserving water resources. This study also discussed water pollution caused by agricultural and industrial effluents.

State Indicator of Water Quality for Surface Water and Groundwater in Agriculture

Kim, Min-Kyeong,Jung, Goo-Bok,Ro, An-Sung,Choi, Seung-Chul,Choi, Won-Il,Kim, Eun-Jeong,Lee, Jong-Eun,Yun, Yeo-Uk,Kim, Kab-Cheol,Ko, Do-Young,Kim, Byeong-Ho,Kim, Hyeon-Ji,Park, Sang-Jo,Lee, Seong-Tae,H 한국토양비료학회 2015 한국토양비료학회지 Vol.48 No.5

Indicators of environmental conditions qualitatively and quantitatively describe the state of the environment and natural resources, and the OECD (Organization for Economic Cooperation and Development) has initiated and suggested AEIs (Agri-Environmental Indicators) to assess trends over time of the effects of agriculture on the environment and the effectiveness and efficiency of agricultural and environmental policy measures since 1990's. This study aims to develop the state indicators of water quality for agricultural water, surface and groundwater, to evaluate the environmental impacts of agricultural activities and policies by qualifying the environmental levels of a nation. Status indicators were calculated according to the agricultural water quality standards of OECD and Korea, and their trends were analyzed over time. Particularly, nitrate ($NO_3{^-}$) status indicators of ground water in 2013 were significantly lower than the ones in 2000. Overall, the water quality indicators of surface water in 2013 were higher than the ones in 2012, except for pH and DO. The groundwater quality indicators in 2013 were lower than those of previous years. The optimal management indicators were calculated to assess agricultural surface water and groundwater quality. The findings of this study indicated that the state indicators could play a significant role to establish policies and procedures for managing and conserving water resources. This study also discussed water pollution caused by agricultural and industrial effluents.

A case of nevus comedonicus occurred along Blaschko`s line

( Won Kyung Lee ),( So Hee Park ),( Do Hyeong Kim ),( In Ho Park ),( Jeong Nan Kang ),( Jung Eun Seol ),( Hyojin Kim ),( Ho Suk Sung ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

A 13-year-old male presented with linearly-clustered erythematous to hypopigmented patches with comedones on his left arm. The lesions were occurred at birth and spread linearly over time. With histopathologic examination, nevus comedonicus was diagnosed. Nevus comedonicus is a rare kind of epidermal nevus that hamartomatously differentiated from pilosebaceus unit. appears as dilated hair follicles filled with hyperkeratotic plug mimicking comedone. It usually occurs on the face and neck and can show various patterns. One of patterns is blaschkoid arrangement. Blaschko’s line is dorso-ventral migratory pathways of the neuroectoderm during embryogenesis, and epidermal nevi including nevus comedonicus can occurred along the line. But there were few reports of nevus comedonicus distributed along Blaschko’s line in Korean dermatologic literatures. Herein, we report a rare case of nevus comedonicus along Blaschko’s line.

Effects of Aerobic Exercise on Serum Blood Lipids, Leptin, Ghrelin, and HOMA-IR Factors in Postmenopausal Obese Women

Jeong-Ah Lee(이정아),Ji-Hyeon Kim(김지현),Jong-Won Kim(김종원),Do-Yoen Kim(김도연) 한국산학기술학회 2017 한국산학기술학회논문지 Vol.18 No.2

본 연구는 체지방률이 32% 이상인 폐경 후 비만여성 36명을 대상으로 유산소운동이 혈청지질, 렙틴, 그렐린 및 인슐린저항성지수에 미치는 영향을 구명하기 위하여 운동집단(18명)과 통제집단(18명)으로 나누어 유산소운동인 라인댄스를 16주간 실시한 후 체조성, 혈청지질, 렙틴, 그렐린 및 인슐린저항성지수를 운동전과 후로 측정하여 비교분석하였다. 본 연구의 결과 운동 후에 운동집단에서 체중, 체지방률(%BF), 체질량지수(BMI), 내장지방면적(VFA), 렙틴(Leptin), 인슐린(Insulin), 글루코스(Glucose), 인슐린저항성지수(HOMA-IR), 총콜레스테롤(TC), 중성지방(TG), 아포리포프로틴(Apolipoprotein) B, 저밀도지단백 콜레스테롤(LDL-C) 및 수축기혈압(SBP)이 유의하게 감소하였다. 또한 아포리포프로틴(Apolipoprotein) A-1, 그렐린(Ghrelin) 및 고밀도지단백 콜레스테롤(HDL-C)이 유의하게 증가하였다. 유산소운동집단의 내장지방면적에 영향을 미치는 에너지대사조절인자의 회귀분석결과에서 주요요인으로 그렐린, 인슐린, 글루코스 및 HOMA-IR 나타났다. 따라서 규칙적이고 지속적인 유산소운동이 폐경 후 비만여성의 체조성, 내장지방, 혈청지질, 렙틴, 그렐린 및 HOMA-IR을 개선시키는 데 효과가 있을 것으로 생각된다. The aim of this study was to analyze the effects of aerobic exercise on the blood lipids, leptin, ghrelin, and HOMA-IR factors in obese postmenopausal Korean women. Thirty-six healthy postmenopausal women (mean age, 54.47 ± 2.50 years) with >32 % body fat were assigned randomly to an aerobic exercise group (n = 18) or to a "no exercise" control group (n = 18). The subjects" body composition, blood lipid, leptin, ghrelin levels, and HOMA-IR were measured before and after a 16-week line-dancing program. The exercise group showed a significant decrease in body weight, percent body fat, body mass index, visceral fat area, leptin, insulin, glucose, HOMA-IR, total cholesterol, triglycerides, apolipoprotein B, low-density lipoprotein cholesterol, and systolic and diastolic blood pressure. In addition, this group exhibited a significant increase in the apolipoprotein A-I, ghrelin, and high-density lipoprotein cholesterol levels. The energy metabolic factors that influenced the visceral fat included ghrelin, leptin, insulin, glucose, and HOMA-IR. The t-value, which determined the statistical significance of the independent variables, was significant for ghrelin, glucose, insulin, and HOMA-IR (p < 0.05). Regular and continuous aerobic exercise (e.g., line dancing) effectively improved the body composition, visceral fat, serum blood lipids, leptin, ghrelin, and HOMA-IR factors in obese postmenopausal Korean women.

Clinical Impact of Hepatic Steatosis in Patients with Chronic Hepatitis B Infection on Tenofovir Therapy

( Jeong Eun Song ),( Young Eun Cheon ),( Hye Won Lee ),( Beom Kyung Kim ),( Seung Up Kim ),( Do Young Kim ),( Sang Hoon Ahn ),( Seong Gyu Hwang ),( Kwang-hyub Han ),( Jun Yong Park ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: To further observe and identify the effect of nonalcoholic fatty liver disease (NAFLD) on the response to tenofovir disoproxil fumarate (TDF) treatment in patients with chronic hepatitis B (CHB). Methods: From 2012-2014, consecutive antiviral-naïve CHB patients who started TDF and underwent controlled attenuated parameter (CAP) measurement were enrolled from two tertiary medical center. Based on CAP score, patients were divided into groups with NAFLD (CAP score ≥ 250) and non-NALFD (CAP score < 250). The demographic, anthropometric and clinical data was investigated at baseline, 24wk, 48wk, and 96wk. Results: A total of 159 patients (mean age 47.23±11.61 years, 90 (56.6%) males) were involved in the study, with overall percentages of NAFLD as 35.8% (n=57). The two groups were not significantly different in terms of age, sex, biochemical parameters and the status of compensated liver cirrhosis. Moreover, HBV DNA level and the status of HBeAg positive were equally distributed in both two groups. However, the NAFLD group showed a higher level of BMI compared with non-NAFLD group (p < 0.05). Although the HBV DNA undetectable rate increased gradually after treatment with TDF in both two groups, non-NAFLD group showed a higher virological response rate compared to NAFLD group (54.4% vs. 41.1%, 80.6% vs. 69.6%, 95% vs. 72.7%; week 24, week 48, week 96, respectively). However, there was significant difference between two groups only at week 96 (p<0.001). The rate of ALT normalization was higher in non-NAFLD group throughout the whole time spot, but reached no statistical significance. Multivariate analysis indicated that a higher HBV DNA level was associated with early virological non-response and that hepatic steatosis may influence long-term virological non-response. Conclusions: NAFLD significantly affected long-term virological response in CHB patients treated with TDF. Further investigation is needed in the future, which calls for a specific antiviral strategy in CHB patients with NAFLD.

Integrated Analysis of Elbasvir/Grazoprevir Clinical Trials in Korean Participants with Hepatitis C Virus Genotype 1b Infection

( Do Young Kim ),( Youn Jae Lee ),( Jeong Heo ),( Woo Jin Chung ),( Won Young Tak ),( Yoon Jun Kim ),( Seung Woon Paik ),( Eungeol Sim ),( Susila Kulasingam ),( Rohit Talwani ),( Barbara Haber ),( Peg 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: All-oral direct-acting antiviral medications have transformed the treatment of hepatitis C virus (HCV) infection; however, local evidence is limited in some regions, including Korea. We conducted an integrated analysis of the efficacy of elbasvir (EBR)/grazoprevir (GZR) in Korean participants with HCV infection enrolled in EBR/GZR phase 3 clinical studies. Methods: Participants with HCV GT1b infection enrolled at Korean study centers who received EBR/GZR 50 mg/100 mg for 12 weeks were included. The primary endpoint of all studies was sustained virologic response (HCV RNA < 15 IU/mL) 12 weeks after end of therapy (SVR12) in the full analysis set (all participants who received ≥1 dose of study medication). Results: A total of 74 Korean participants were included. Mean age was 55 years (SD, 11 years), 25 (33.8%) had cirrhosis, and 70 (94.6%) were treatment-naïve. There were no participants with HCV/HIV coinfection. SVR12 was achieved by 73 of 74 (98.6%) participants; and only 1 participant, who withdrew consent, failed to achieve SVR12. Therefore, in the modified full analysis set (excluding participants who discontinued for reasons unrelated to study medication), SVR12 was 100% (73/73). SVR remined high among participants with cirrhosis (25/25, 100%), baseline viral load >2,000,000 IU/mL (34/34 (100%), and age >65 years (16/16, 100%). Baseline NS5A resistance associated substitutions (RASs) were detected in 16 of 73 participants (22%) who had a treatment outcome of SVR or virologic failure; all 16 achieved SVR12. Rates of SVR12 among Korean participants in this analysis (73/74, 98.6%) were similar to those in non-Korean Asian participants with GT1b infection (378/388, 97.4%), and to non-Asian participants with GT1b infection (589/608, 96.9%) enrolled in phase 2/3 EBR/GZR clinical trials. Conclusions: The combination of EBR/GZR was highly effective in Korean participants with HCV GT1b infection, with high rates of SVR12 across all subgroups examined, including those with NS5A RASs.

A caes of eruptive lichen planus

( Jeong Won Jo ),( Hae Bong Jeong ),( Yun Sun Moon ),( Do Seon Jeong ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Eruptive lichen planus is a rare variant of lichen planus and variety of rapidly spreading and extensive form of lichen planus. Lichen planus is a common and chronic inflammatory disease of the skin and mucous membranes. It typically manifests as pruritic, faintly erythematous to violaceous, flat-topped, polygonal papules distributed mainly over the flexural areas of wrists, arms, and legs. It usually resolves after a variable period of time, ranging from a few months to years, leaving behind pigmentation and/or scarring. The exact pathogenesis of lichen planus is not clear. Association of a chronic active hepatitis C virus infection with lichen planus and triggering of lichen planus following a hepatitis B virus vaccination has been previously described. So we report the eruptive lichen planus in patients who have received treatment with hepatitis B infection.

Sweet-like syndrome induced by bortezomib

( Do Seon Jeong ),( Jeong Won Jo ),( Hae Bong Jeong ),( Yun Sun Moon ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Sweet syndrome is characterized by fever, tender, erythematous skin lesions, neutrophilia, high levels of serum inflammatory markers, and diffuse mature neutrophil infiltration typically localized to the upper dermis. Many drugs have been found to be associated with Sweet’s syndrome. Various drugs used in hematology and oncology such as immunomodulating drugs, differentiation-inducing agents, and anti-neoplastic agents have been found to be associated. Bortezomib is a proteasome inhibitor, which was approved in 2008 to treat progressive multiple myeloma. Bortezomib can cause cutaneous side effects such as erythema, pruritus, periorbital edema, eczemas and rarely erythema multiforme-like skin changes or vasculitis. A 65-year old man used bortezomib for multiple myeloma. Using about 3 cycles and the multiple nodular lesion was repeated three times for a period of relief and aggravation of the symptoms. The diagnosis was reported Sweet syndrome by incisional biopsy. Symptoms improved after the bortezomib was discontinued. In conclusion, even though there are not many reports, we have to be aware of the possibility of sweet-like syndrome due to bortezomib.

P098 A clinical study on herpes zoster during the last 5-year-period (2011-2015)

( Jeong Won Jo ),( Hae Bong Jeong ),( Yun Sun Moon ),( Do Seon Jeong ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Herpes zoster is a common dermatologic disease. But there has not been any report on the clinical characteristics of herpes zoster in the Province of Gyeongsangnam-do. Objectives: The purpose of this study was the elucidation of the clinical characteristics of herpes zoster in the Province of Gyeongsangnam-do. Methods: The study was conducted between 2011 and 2015 at our hospital outpatients. 901 patients with herpes zoster were evaluated in regard to age, sex, dermatomic distributions, associated diseases and complications. Results: Out of 901 cases, 396 were males and 505 were females. The maximum incidence was in the over 70 year-old group (26.4%). The most frequent involved dermatome was the trigeminal dermatome (28.7%). Associated diseases were observed in 679 patients (75.3%), which included hypertension (21.2%), malignancy (11.4%) and so on. Out of 901 patients, 443 (49.2%) developed complications. The most common complication was postherpetic neuralgia (27.1%). It is noteworthy that skin edema was accompanied from 43 patients (4.8%). Fourty patients showed edematous change on herpes zoster lesion. But other 3 patients showed facial edema in spite of involving herpes zoster in other area. Conclusion: Most of the results are similar to those previously reported, except for a higher incidence in trigeminal dermatome. The most interesting part of this study is herpes zoster can cause skin edema. We need to take further studies in future by others to explain causes in detail.

Notes : Screening and Characterization of Secretion Signals from Lactococcus lactis ssp. cremoris LM0230

( Do Won Jeong ),( Youn Chul Choi ),( Jung Min Lee ),( Jung Min Seo ),( Jeong Hwan Kim ),( Jong Hoon Lee ),( Kyoung Heon Kim ),( Hyong Joo Lee ) 한국미생물 · 생명공학회 2004 Journal of microbiology and biotechnology Vol.14 No.5