남자 알코올 의존 환자의 기질적 특성에 관한 연구

김성곤,민영기,이덕기,김미영,송영상,권도훈,고영훈,박제민,정병선 대한생물치료정신의학회 2003 생물치료정신의학 Vol.9 No.1

목 적: 본 연구의 목적은 한국인 남자 알코올 의존 환자의 기질적 특성을 Temperament and Character Inventory(TCI)를 이용하여 조사하는 것이다. 방 법: DSM-Ⅳ 진단 기준에 맞는 알코올 의존 환자 30명과 정상인 36명을 대상으로 연구학적 특성을 조사하고, 기질적 특성을 한글판 TCI를 이용하여 조사하였다. 모든 대상자의 나이는 30~60세였다. 결 과: 1) 두 군간 평균 나이는 유의한 차이가 없었으나, 교육 정도와 결혼을 유지하고 있는 비율 및 취업률은 알코올 의존군이 정상 대조군에 비해 유의하게 낮았다. 2) 알코올 의존군에서는 정상 대조군에 비해 Harm Avoidance(HA) 점수와 Self-transcendence(ST)점수는 유의하게 높았으며, Self-directiveness(SD)점수는 유의하게 낮았다. 3) 알코올 의존군 내에서의 각 척도들 간의 상관관계는, HA와 SD 점수, HA와 Persistence(PE) 점수, ST와 SD 점수는 각각 유의한 음의 상관관계, ST와 PE 점수, SD 점수와 Cooperativeness(CO) 점수, Reward Dependence(RD)와 CO 점수는 양의 상관관계를 보였다. 결 론: 이러한 본 연구의 결과는 한국인 남성에서 수줍음을 잘 타며, 걱정도 많고, 염세적이고 쉽게 피로해지는 기질적 특성이 알코올 의존과 연관성이 있음을 의미한다. Objectives : The purpose of this study was to assess the temperament of male parients with alcohol dependence. Methods : The subjects were 30 patients who met DSM-Ⅳ criteria for alcohol dependence and 36 normal controls. All subjects completed Temperament and Character Inventory(TCI) which was developed by Cloninger. Results : 1) The educational level, marital status, and occupation in alcohol dependence group were significantly lower than those of normal control group, but there was no difference in the age between two groups. 2) Among the scores of TCI, the score of harm avoidance(HA) and self-transcendence(ST) were significantly higher in the alcohol dependence group than in the normal control group. 3) In the alcohol dependence group, a significant negative correlation among the scores of TCI was between HA and SD, HA and Persistence(PE), ST and SD, and positive correlation between ST and PE, SD and Cooperativeness(CO), Reward Dependence(RD) and CO. Conclusion : These results suggest that shy, fearful, pessimistic and fatigable temperament are related to developing alcohol dependence in Korean males.

급성 하지 동맥폐색증의 치료

고영관,박호철,고석환,김도균,주홍재 대한혈관외과학회 1999 Vascular Specialist International Vol.15 No.1

Background: Arterial emboli remain an important cause of acute arterial ischemia. Despite simplification of operative techniques, the substantial morbidity and mortality still associated with an acute embolus remain a challenge to the vascular surgeon. We wanted to know the adequate evaluation and treatment modality for this limb threatened condition, and to evaluate the results according to etiology, location, time interval before starting treatment, clinical conditions, and limb survival rate. Material and Methods: A retrospective review was conducted on 91 patients who treated for acute lower leg thromboembolism between Jan. 1992 and Dec. 1997. Results: There were 73 men and 18 women and most prevalent age group was in the 5th and 6th decades (53.8%). Over all amputation rate was 25.3% and mortality rate was 5.5%. Cardiac problem was the most common etiologic factor. Associated diseases were cardiac problem (37.4%), hypertension (35.2%), cerebrovascular accident (17.6%), and diabetes (15.4%). Interval from attack to definite therapy, within 24 hours in 14 cases (15.4%), 1 ∼3 days in 23 (25.3%), after 4 days in 54 (59.3%) were noted. The locations were aorta and iliac in 25.3%, femoral in 38.5%, popliteal in 19.8%, tibial in 4.4%, and 15.4% in graft site in other of frequency. Clinical categories were grade I in 9.9%, IIa in 40.7%, IIb in 30.8%, and III in 18.7%. According to Eagle' s criteria, low risk group were 34 cases (37.4%), moderate risk group were 39 cases (42.9%), and high risk group were 18 cases (19.8%). Of the 91 patients, conservative treatment in 2 (2.2%), thrombolytic therapy in 33 (36.3%), thromboembolectomy in 56 (61.5%), bypass in 16 (17.6%), endarterectomy and vessel ligation were performed. The 1-month and 1-year limb salvage rates were 73.4% and 71.1%, respectively. Especially, salvage rates in the Department of Vascular Surgery were 84.9% and 83.7%, whereas that of Thoracic and Orthopedic Surgery were 44.4% and 33.0% (p=0.0001). Conclusions: Cardiac problem especially atrial fibrillation was the most common etiologic factor. Prompt balloon catheter embolectomy performed under local anesthesia is a safe, simple, and effective method of treatment and the preferred mode of management in the great majority of patients. Nonoperative management with thrombolytic agents or high-dose heparin therapy alone is occasionally indicated in highly selected patients. The prognosis of acute arterial thromboembolism of lower extremity can be improved by early detection, early adequate treatment, and the involvement of a qualified vascular surgeon.

氣溫變化가 쌀보리와 麥酒보리의 初期生育 및 葉特性에 미치는 影響

高官秀,吳現道,姜榮吉 濟州大學校 亞熱帶農業硏究所 1995 亞熱帶農業硏究 Vol.12 No.-

氣溫變化와 쌀보리와 麥酒보리의 初期生育 및 葉特性에 미치는 영향을 구명하기 위하여 쌀보리 3품종 (늘쌀보리, 새쌀보리, 향천과 1호)과 麥酒보리 3품종 (두산 8호, 사천 6호, 진광보리)을 공시하여 4, 8, 12, 16, 20, 24, 28℃의 생장상에서 4엽기까지 재배하여 분얼수, 건물중, 엽신장, 엽신폭, 엽록소를 조사한 결과를 요약하면 다음과 같다. 1. 늘쌀보리와 향천과 1호는 각각 16℃와 12℃에서 分蘖數가 個體當 3.1개로 가장 많았고 새쌀보리와 맥주보리 3품종은 모두 8℃에서 개체당 4.5개 내외로 가장 많았다. 2. 쌀보리 3품종의 개체당 乾物重은 16∼24℃에서 가장 무거웠으며 늘쌀보리는 1.5g 내외였고 새쌀보리와 향천과 1호는 2.0g 내외였다. 맥주보리 3품종은 16℃와 20℃에서 건물중이 가장 무거웠으며 사천 6호가 1.6g, 두산 8호와 진광보리가 모두 1.9g이었다. 3. 葉伸長은 모든 엽위에서 공시품종 모두 16∼24℃에서 가장 넓었고 새쌀보리, 향천과 1호, 맥주보리 3품종, 늘쌀보리 순으로 적었다. 4. 葉身幅은 모든 엽위에서 공시품종 모두 16∼24℃에서 가장 넓었고 새쌀보리, 향천과 1호, 맥주보리 3품종, 늘쌀보리 순으로 적었다. 5. 葉綠素 SPAD값은 8, 12℃에서 가장 컸던 늘쌀보리와 향천과 1호의 엽을 제외하고는 모든 엽위에서 4℃에서 가장 컸었다. Three naked (Nulssalbori, Saessalbori, Hyangcheongwa 1) and three malting barley cultivars (Doosan 8, Sacheon 6, Jinkwangbori) were grown at constant temperatures of 4, 8, 12, 16, 20, 24, and 28℃ through the fourth-leaf stage in growth chambers to determice the effects of air temperature on growth and leaf characteristics of naked and malting barley seedlings. The results obtained are summarized as follows: 1. The greatest number of tiller per plant at fourth-leaf stage was 3.1 at from 16 to 20℃ for Nussalbori and Hyangcheongwa 1 and about 4.5 at 8℃ for Saessalbori and three malting barley cultivars. 2. The above-ground dry weight per plant at fourth-leaf stage was heaviest (about 1.5g for Nulssalbori and about 2.0g for Saessalbori and Hyangcheongwa 1) at from 16 to 24℃ for three naked barley cultivars and was heaviest (abort 1. g for Sacheon 6 and 1.9g for Doosan 8 and Jinkwangbori) at 16 and 20℃ for three malting barley cultivars. 3. Blade length of the first four leaves was longest at about 24℃ regardless of cultivars and was smaller for Saessalbori, Hyangcheongwa 1, three malting barley cultivars, and Nulssalbori in order. 5. Chlorophyll SPAD values of the first four leaves were greatest at 4℃ except of the first leaf on Nulssalbori and Hyangcheongwa 1 which showed the highest values at 8 and 12℃.

말더듬 아동과 일반 아동의 유창성 특성 비교

고영옥,전희숙,권도하 대구대학교 특수교육재활과학연구소 2007 再活科學硏究 Vol.25 No.2

The purpose of this study was to investigate characteristics of stutter children on the speech task. The speech task was automatic speech, reading, and monologue. we collect speech sampling during of task. In the study participated seven stuttering children of 7 to 12years old(4 males, 3 females) and seven nonstuttering children(5 males, 2 females). The results of this study were as following. First, there was not significant difference between stuttering children and nonstuttering in the articulation rate. On the automatic speech task, stuttering children articulation rate was mean 171.60(SPM) and nonstuttering children articulation rate was mean 168.34(SPM). On the reading task, stuttering children articulation rate was mean 225.82(SPM) and nonstuttering children articulation rate was mean 218.09(SPM). On the monologue task, stuttering children articulation rate was mean 195.58(SPM) and nonstuttering children articulation rate was mean 191.95(SPM). Second, In the stutter children, dysfluency syllable number varied on the speech task. Also, stutter children, dysfluency syllable rate varied on the speech task. On the automatic, monologue task, dysfluency syllable number was mean 8.57syllable (SD=9.71), 20.71syllable (SD=13.47). On the automatic, monologue task, dysfluency syllable rate was mean 15.85%(SD=32.98), 29.00%(SD=19.74). 본 연구의 목적은 말더듬 아동이 각기 다른 구어 과업에서 유창하게 말할 때의 구어 특성을 알아보는 것이었다. 본 연구의 대상은 7~12세의 말더듬 아동 7명(남자 4명, 여자 3명)과 일반 아동7명(남자 5명, 여자 2명)이었다. 자동구어와 독백 과업을 실시하는 동안 구어샘플 수집하였다. 연구의 결과는 다음과 같다. 첫째, 말더듬 아동과 일반 아동의 유창한 구어의 속도에는 차이는 없었다. 자동구어 및 독백 과업 모두 유의한 차이가 없었다. 둘째, 과업별 말더듬 아동의 비유창한 음절수는 구어과업에 따라 다양하게 나타났다. 그리고 비유창한 음절 비율도 구어과업에 따라 다양하게 나타났다. 자동구어, 읽기, 독백과업에서 말더듬 아동의 비유창한 음절수는 평균 8.57음절(SD=9.71), 27.57음절(SD=23.47), 20.71음절(SD=13.47)이었다. 비유창한 음절비율은 자동구어, 독백과업에서 평균 15.85%(SD=32.98), 61.35%(SD=106.08), 29.00%(SD=19.74)이었다.

도토리澱粉이 흰쥐의 脂質代謝에 미치는 影響

崔到点,金載營,高鎭福 新羅大學校 1984 論文集 Vol.16 No.-

In an attempt to observe the lipid metabolism of acorn starch, five different diets were made: one rice diet (control group) and four diets in which acorn starch was mixed with rice at the rate of 10%, 20%, 30% and 40% respectively. These five diets controlled in such ways are the same level in calorie and protein content. The acorn starch used was cleared from tannin by being heated 20 hours. These diets were each fed to different groups of male albino rats for 6 weeks, during which various items were measured on these rats such as total lipid, total cholesterol, triglyceride, phospholipid and HDL-cholesterol contents. The results obtained through this study are summarized as follow: The content of total lipid in liver of each group was lower in the 2nd week, and that of 30% acorn starch group was lower in the 4th week, and that of 20% acorn starch group was lower in the 6th week, compared with control group. The content of total cholesterol in liver of each group except 10% acorn starch group was lower than that of the control group in the 2nd week, but in the 4th and the 6th week, there was no particular difference in content between each group and the control group. The centents of total lipid, triglyceride, phospholipid, total cholesterol and HDL-cholesterol in serum are almost the same between each group and the control group during each period of feeding. Therefore acorn starch diets mixed with rice at the rate of 10%, 20%, 30% and 40% had little effect on the serum lipid contents.

Methylprednisolone 및 Levamisole 투여가 Bovine Gamma-Globulin으로 초래된 생쥐의 IgA 신병증에 미치는 영향

이광도,노은석,고철우,구자훈,송경은,김용진 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.4

목적 : 본 연구는 생쥐를 대상으로 실험적 IgA 신병을 유발시키고 부신피질제재 및 levamisole 등의 면역제재를 투여하여 이들 약제의 IgA 신병증에 미치는 영향을 알아보고자 시행하였다. 대상 및 방법 : 실험동물은 체중 20-30gm 생쥐로서 암수 구별없이 사용하였다. 실험에 사용한 Bovine Gamma-Globulin (BGG, Sigma, U.S.A.)은 0.1% 농도로 식수에 섞어 매일 섭취시켰으며 제Ⅰ군은 BGG만을 섭취시켰고, 제Ⅱ군은 BGG섭취와 같은 시기부터 methylprednisolone을 격일로 존대를 통하여 경구 투여하였으며, 제Ⅲ군은 BGG 섭취와 같은 시기부터 levamisole을 격일로 존대를 통하여 경구 투여하였다. 실험 제 100일째 실험동물을 도살하고 신장을 적출하여 병리조직학적 검사를 시행하였다. 결과 : 실험개시후 100일째에 채취한 혈액검사상 혈청 BUN과 creatinine치는 각군간에 유의한 차이가 없었다. 병리조직학적 변화는 광학현미경 소견상 세군 모두에서 사구체의 미세한 변화만이 관찰되었다. 전자현미경적 소견은 세군 모두에서 기저막의 비후는 없었으며 족돌기도 잘 유지되어 있었다. 기저막쪽으로 향한 메산지움 영역에서 전자밀도가 높은 침착물이 흔히 관찰되었다. 면역형광현미경적 소견은 형광물질의 강약에 따라 약양성 (+), 중등도 양성 (++) 및 강양성(+++) 으로 구분하였다. 제Ⅰ군에서 형광물질은 IgA에서만 실험동물 9마리 모두에서 관찰되었다. 반면 IgM. IgG및 C_3는 모두 음성이었다. 면역형광물질은 모두 메산지움 및 기저막 일부에서 관찰되었으며 과립형이었다. 특히 강양성으로 보인 경우는 5마리였다. 제Ⅱ군에서도 결과는 같았으나 강양성은 20마리중 8마리였다. 역시 IgG, IgM, C_3는 음성이었다. 제 Ⅲ군에서도 결과는 같았으며 강양성은 20마리중 11마리였다. IgG, IgM은 모두 음성이었으며 단지 1마리에서 C_3가 약양성이었다. 결론 : 본 연구결과에 의하면 BGG투여로 초래되는 생쥐에서의 IgA 신병증의 실험모델에서는 methylprednisolone과 levamisole은 신장조직 소견상 IgA 침착정도나 병변의 경중에는 그 차이를 보이지 않았다. The pathogenesis of IgA nephropathy, first described by Berger and Hinglais in 1968. has not been defined clearly and appropriate treatment modality also not established. Present study has been conducted to induce IgA nephropathy in experimental animal and to see the effectiveness of methylprednisolone and levamisole on the experimentally induced IgA nephropathy. Mice weighing 20-30gm were used as experimental animal and Bovine gamma-globulin (BGG) (Sigma U.S.A.) was given as 0.1% drinking solution (Group Ⅰ). Group Ⅱ received methylprednisolone (5㎎/㎏) and Group Ⅲ levamisole (5㎎/㎏) on alternate day in addition to BGG-containing solution. On the 100th day of experiment, animals were sacrificed and blood chemistries and renal histopathologic examinations were done. Histopathologic examination: In all three groups, light microscopic, electron-microscopic and immunofluorescent microscopic findings were similar. Light microscopy showed mild focal mesangial proliferation and electron microscopy showed electron-dense materials deposited in the mesangial area near the basement membrane. Immuriofluorescent stain using fluorescin isothiocyanate goat anti-mouse IgA (Biodesign, U.S.A.) demonstrated prominent IgA staining in the mesangial area in all three group. Staining with IgG, IgM and C_3 were all negative. In conclusion, present experiment did not show any effectiveness of methylprednisolone nor levamisole on the BGG-induced IgA nephropathy in mice. And the effectiveness and its acting mechanism of methylprednisolone on human IgA nephropathy has to be studied further.

定着村癩患者의 再發實態에 關한 調査硏究

金道一,高英勳,金潤元,李惠映,金學鵬,金起會 大韓癩學會 1982 癩學 會誌 Vol.15 No.1

사료제조공정에서 발생된 악취처리에 관한 연구

박영구,김승호,최선도,고재철 三陟大學校 2000 論文集 Vol.33 No.2

Methods for the treatment of foul odor was physical, chemical and biological. In this study, we utilized biofilter for the treatment of foul odor. Importance factors of a microbe is nutrients, temperature, moistrure and pH. As the results, it was found that matter of the odor was trimethylamine, removal rate(η(%)) fo (CH₃)N₃ appeared 19.7%∼96.5%(site-1), 20%∼95.5%(site-2) after treated to the biofilter, and tended to decrease from 7 months later by a biofilter compaction. Also size of the tree chip was 2cm, degree of the foul odor was degree of 3∼4, propriety temperature was 20∼40℃, the rate of contained moisture was 60∼70%, acidity was pH=8.

신환과 재발환자에서 나균에 대한 DDS및 RMP의 감수성에 관한 마우스족저접종실험 연구

정구원,고영훈,김도일 大韓癩學會 1990 癩學 會誌 Vol.23 No.1

마우스足底 接種實驗에 의한 抗癩劑耐性 特히 Rifampicin耐性에 關한 硏究

鄭求元,高英勳,金道一 大韓癩學會 1986 癩學 會誌 Vol.19 No.1