Water-soluble Genistin Glycoside Isoflavones Upregulate Antioxidant Metallothionein Expression and Scavenge Free Radicals

Chung, Mi-Ja,Kang, Ah-Young,Jun, Hee-Jin,Kim Sang-Yeon,Moon, Tae-Hwa,Park, Kwan-Hwa,Lee, Sung-Joon 생명자원연구 2005 생명자원연구 Vol.13 No.-

NaCl이 보리(Hordeum vulgare L.) 잎의 엽록소 형광에 미치는 영향

정화숙,임영진,박강은,박신영 한국환경과학회 2004 한국환경과학회지 Vol.13 No.12

This study was conducted to investigate the changes of chlorophyll contents and chlorophyll fluorescence in barley(Hordeum vulgare L.) 7 day old seedling treated with 0.2M, 0.4M, 0.6M, 0.8M, and 1.0M NaCl concentration containing Hepes buffer(pH 7.5). Barley was affected by NaCl treatment. The chlorophyll a, b and carotenoid of barley decreased with an increase in NaCl concentration. However, chlorophyll a, b and carotenoid of barley were not greatly influenced by o.8M and 1.0M NaCl. Fv, Fv/Fm and qP were gradually decreased by higher concentration of NaCl. qP, qNP, qR and qE were gradually decreased by 6hr. During barley chloroplast was development NaCl affected chlorophyll synthesis than photosynthetic activity. Whereas barley seedling leaves were more influenced photosynthetic activity than chlorophyll contents by NaCl.

뉴헤브리디스 해분의 지질학적 특징에 관한 연구

박충화 大田大學校 環境問題硏究所 1997 환경문제연구소 논문집 Vol.2 No.-

The New Hebrides Basin is an inactive non back-arc basin located at the convergent boundary of the Pacific and Indo-Australian plates. This basin was formed from 46 Ma to 60Ma. The basin has two spreading episodes with rates of 34 mm/a for 42 to 47 Ma and 17 mm/a for 47 to 60 Ma. The sediments covered in the basin has uniform thickness of 0.65 sec. The age-depth correlation curve of the New Hebrides Basin can be represented by the following equation: Depth (m) = 2689 + 312 √Age (Ma) The coefficient of 312 in this equation is close to that for major oceans, 350. This suggests that the cooling processes of the lithospheres in the New Hebrides Basin and major oceans are similar to each other. Free-air gravity anomalies of the basin varying from -22.3 mgal to 59.0 mgal. The mean value is 30.2 mgal higher than those of the normal oceans. Moderately large free-air gravity anomalies in the New Hebrides Basin are presumably owing to its location on a marginal swell along the New Hebrides Trench. It is generally observed of the trench axis. Positive free-air gravity anomalies amounting to 50-60 mgal are usually observed on the crest of the swell. This topography is presumably by bending of the oceanic lithosphere so as to dynamically maintain nonisostatic states for some duration.

Head-Space SPME에 의한 생체시료 중 메스암페타민류 분석(Ⅲ)

박미정,최상길,손행자,최화경,최영남,허상철,박종서,정희선 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

활동적 배호상 해분의 Zero Age Depth의 변화에 관한 연구

박충화 대전대학교 환경문제연구소 2001 환경문제연구소 논문집 Vol.5 No.-

Equations of the linear relationship including zero age depths between the basement depth and the square root of age for 6 active back-arc basins, were obtained from the statistical analysis of a great number of underway bathymetric profiles. Active back-arc basins show a large variety of zero age depths ranging from the shallowest Manus Basin to the deepest Mariana Trough. Variations in zero age depth appear to show glood correlations ulith the dipping angle of slab, convergence rate, spreading rate, and cooling coefficient. The dipping angle of subducting slab increases with the increase of the zero age depth. As the convergence rate decreases, the zero age depth also becomes deeper. The variation in zero age depth of active back-arc basin seems to be caused by the mechanical supporting of the subduction slab. Zero age depths are deeper with the decrease of spreading rates and cooling coefficients.

의약품의 효능별 안전성·유효성 평가에 관한 조사연구(Ⅰ) : 항균제 Antiboiotics

박윤주,최기환,김동섭,박인숙,정면우,임화경,오우용,강주희,박찬웅,김주일 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

새로운 물질이 개발되어 신약으로 탄생하기까지 많은 시간과 노력, 예산이 필요하다. 최근, 우리 나라에서도, 신약캐발이 어릴고 힘든 분야이지만 새로운 신약개발을 총해 얻어지는 분가가치가 막대함을 인식, 연구에 박차를 가하 있는 실정이다. 본 연구는, 의약품 개발 선진국인 미국 FDA에서 발행하는 참고자료 중 항균제 임상편가에 대한 가이드라인 및 주요 임상적응증별 항균제 기발(지역사획회득성 폐렴, 원내감염성 계렴, 급성기관지염의 2차세균감염, 만성기지염의 급성세균성 악화, 연쇄구균에 의한 인두영 및 편도염 , 단순성 요로감염증, 복합성 요로감염증 및 신우신영, 급성 세균성 부비동옆, 항 바이러스제 개발시 전임상단계에서 고려사항, 항 바이러스제 허가와 된련 잉상적 고려사항, 카레타 괸련 혈류감염)에 있어서의 파이드라인 등의 자료를 소개함으로져, 향후 제약사의 항균제 신약개발 및 허가 신청된 의악품의 전임상차료 및 잉상시험자료의 검토 평가업무에 참고자료로 활용될 수 있을 것이다. Changing or unclear interpretations of clinical trial data needed to demonstrate the effectiveness and safety of antimicrobial drug products have a times led to confusion and frustration on the part of both applicants and division of these drug products reviewers. The FDA published guidance on desing clinical protocols, implementing, and analyzing data from clinical trials for antimicrobial drug products has been presented and additional companion guidances introduced specific issues to individual infections. This document provides applicants and reviewers with minimal information appropriate for the clinical development of routine antimicrobial drug products and identifies issues common to many antimicrobial drug applications. The agency can use the kind of information to determine whether the antimicrobial drug product under study is safe and effective in the treatment of the specific infection studied.

만성 골수성 백혈병 환자에서 발생한 거대 후복막강내 혈종 1예

박기령,김영선,박사영,최진혁,이순남,정화순 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.1

Thrombohemorrhagic complications in chronic myeloproliferative disease(CMPD) including chronic myelogenous leukemia(CML) are not rare. Lower incidence of disordered hemostasis is reported in CML compared with other CMPD. The mechanism of thrombohemorrhagic complications might be a consequence of qualitative platelet abnormalites and prolonged bleeding time rather than that of thrombocytosis. Although defect of platelet function has been extensively investigated, there was no established consistent correlation between clinical bleeding and number and function of platelet. The most common site of bleeding complications in the CMPD is superficial mucosa. Bleeding in deep tissue and viscera is very unusual. We report a case of CML which developed a huge spontaneous retroperitoneal hematoma.

多層神經回路網 學習方法의 一般化性能에 대한 考察

박두일,윤충화 명지대학교 공학기술연구소 1991 공학기술연구소 논문집 Vol.6 No.-

Artificial neural network has offered distributed processing power, error correcting capability and structural simplicity of the basic computing element. Basically, neural nets are self-adaptive systems that try to configure themselves to store new information. The Error Backpropagation Algorithm is one of the most widely-used learning algorithms for multi-layered neural networks, but it has a serious drawback that it requires a lengthy learning time, even for a moderate number of input patterns. In this paper, we proposed a specific definition of generalization concept and comparatively analyzed methods which enhance the generalization property and techniques which reduce the learning time, based on this definition.

엽수 및 줄기수 제한이 무등산수박의 생장 및 과실품질에 미치는 영향

박순기,정순주,박화성 全南大學校 農業科學技術硏究所 1997 農業科學技術硏究 Vol.32 No.-

본 실험은 무등산에서 재배되어온 지역 특산물인 무등산수박의 생장촉진과 과실품질의 개선을 위하여 1996년 7월 2일에 해발 10, 150 및 500m인 지대에 정식하여 엽수 및 줄기수를 제한하여 표고별로 재배한 결과는 다음과 같다. 본 실험의 처리 범위내에서는 엽수를 증가시킬수록 방임구보다 당도가 현저히 증가하였으며, 줄기수도 많을수록 당도, 과중, 과고 및 과경이 높아지는 경향이었다. 그리고 표고가 상승함에 따라 온도, 습도 환경에 큰 차이가 나타났고 과실크기, 당도 및 감미 등이 향상되었고 과피두께도 두꺼웠다. 과육부위별 당도의 분포를 보면 무등산수박은 중심부와 종자사이의 부분이 가장 높았고, 과육심부에서 화흔방향이 과병방향보다 더 높았으며 과병, 화흔 및 과피방향으로 갈수록 당도는 낮았다. This study was carried out to promote plant growth and fruit quality of Mudeungsan Watermelon (Citrullus lanatus (Thunb.) Mansf. cv.) by restricting leaf and stem numbers. Seedlings were transplanted to diferent elevations of Mt. Mudeungsan range at 10, 150 and 500 meters above sea level on July 2, 1996. Leaf number was restricted to 20, 23, 25, 28 and 31 and stem number to 1, 2 and 3 along with control, replicated three times. The growth characteristics and fruit quality were recorded and analyzed. Substantial differences in both growth characteristics and fruit quality were found among different elevations. At the site 500m above sea level, soluble solid content, fruit weight, fruit shape index, fruit flesh quality and flavor were improved as the leaf number increased excluding control. At the site 150m above sea level, soluble solid content, fruit weight and flavor also increased as the stem number increased. As the cultural site was higher above sea level, fluctuation in temperature and relative humidity became greater, which might have improved fruit quality in terms of size, soluble solid content and pericarp thickness. Soluble solid content in a fruit of Mudeungsan Watermelon was highest in the center followed by in the order of blossom end and stem end.

女子老人의 衣服購買行爲에 관한 實態分析

박화순,배정숙 대구대학교 기초과학연구소 1984 基礎科學硏究 Vol.1 No.-

The purpose of this study were to explore the present conditions of ready-made, purchasing behavior, and satisfaction of old women who were more than sixty years old in Daegu City, and to aid the development of old women's clothing by analyzing to compare popular old women with College for the Aged. The participants consisted of 145 popular old women and 137 College for the Aged. The data were collected by questionnaires. The statistical analysis of the obtained data included Percentage Method. The specific findings of this study were as follows: 1. The percent of clothing concern showed higher College for the Aged than popular old women. 2. In the purchasing channel and discussion College for the Aged highly depended on their sons (daughters) and popular old women their own purchasing. 3. The ready made were more important in saving of effort and time. 4. Old women were not advertizing but effected a little by showwindow. 5. Old women chose more convenient, less expensive, and sellected the better things in color and style. 6. More than half of the old women were relevant from 20, 000 won to 50, 000 won in price. 7. On the ready made old women were highly satisfied with its textile, color, pattern, and purchasing-place and dissatisfied with comodities of bargain sale, sewing, waist-line, and sleeve-length in size.