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폐염간균에 대한 Quinolone계 약제의 항균작용에 미치는 Rifampin의 영향
류필열,정문태,신부안,정선식,안태휴 대한화학요법학회 1990 대한화학요법학회지 Vol.8 No.2
Antimicrobial activities of nalidixic acid(NA),norfloxacin(NX), oxolinic acid(OA), pefloxacin(PX), pipemidic acid(PA), oxacillin, cefotaxime(CFT), cephaloridine, cefazoline, moxalactam(MX), gentamicin, amikacin(AK) and rifampin(RP) were compared by the agar dilution method against 31 strains of K. pneumoniae isolated from various clinical spectimens. And then combined activities of RP with each of the quinolones (NA, MX, OAA, PX, and PA) against the test strains were measured by checkerboard dilution and time-killing methods. The growth inhibitory activities of PX, NX, OA, MX and AK were exellent, and those of PA, NA, RP and CFT were moderate, while the other's being almost negligible. The bactericidal activity of PX was more active than that of the other quinolones. Increasing concentrations of the quinolones resulted in a parallel increment of killing rate. However, when levels of quinolones were excessive beyond the most effective bactericidal ones, the bactericidal activity was decreased. In the combined growth inhigitory tests of RP with quinolones by checkerboard agar dilution method, synergistic and additive effects were rarely observed, and antagonism was noticed among the combinations in the following order: RP-NA, 22 strains (71%); RP-PA, 21 strains (67.7%); RP-OA, 17 strains (54.8%); RP-PX, 15 strains (48.4%) and RP-NA, 14 strains (45.2%). In the combined bactericidal tests measured by time-killing method, RP was found to reduce the activities of all five quinolones tested. And the gradual increasing of RP dose was revealed to reduce progressively the bactericidal action of the quinolones. But when RP was added to quinolones after 1 hour of incubations, the bactericidal activities were not affected.
Ahn, Shin-Hye,Cheong, Hee-Tae,Yang, Boo-Keun,Kim, Dae-Young,Park, Choon-Keun The Korean Society of Animal Reproduction 2009 Reproductive & developmental biology Vol.33 No.4
The present study was performed to identify changes of plasminogen activator (PA) and plasminogen activator inhibitor (PAI) in porcine oviduct epithelial cells (POECs) during the estrous cycle. POECs obtained from ovary in pre-ovulatory (Pre-Ov), early to mid-luteal stage (Early-mid L) and post-ovulatory stage (Post-Ov). For the examine of PA activity, $1{\times}10^5$ fresh cells of POECs were cultured in DMEM/Ham F-12 containing 10% FBS and 0.2% amphotericin under humidified atmosphere of 5% $CO_2$ in air and $38^{\circ}C$. The urokinase-type PA (uPA) was observed at 7 days of POECs culture. PA activity was measured with culture prolonged of 0, 3, 6, 12 and 24 h after culture of 7 days. The PA activity were high significantly (p<0.05) at 12 h of culture, but PA activity were decreased with culture periods increased. The PA activity in POECs of Post-Ov stage were higher significantly (p<0.05) than that of Early-mid L and Pre-Ov stage. When PAI-1 and PAI-2 were added during the POECs culture, the PA were observed significant low activity (p<0.05). The PA activity and protein expression were decreased by PA inhibitor. This results suggest that PAI-1 and PAI-2 have a suppressive action on change of PA activity during the estrous cycle of pigs. Specifically, this study using PA inhibitor was effect the PA activity and PAI expression in oviduct epithelial cells in pigs.