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金完吉 中央醫學社 1976 中央醫學 Vol.30 No.5
Na sopharyngeal; angiofibroma is an uncommon benign tumor of vascular fibrotic nature. It is found mainly in the adolescent male and clinically malignant because of bleeding tendency in surgical procedures and resistance to treatment. Author met an eighteen years old male, who had a huge nasopharyngeal angiofibroma invading the cranium. He got turbinectomy and transpalatal excision of the tumor at the other hospital three and two years prior to the first visit to our clinic, respectively. Besides the child fist sized pinkish tumor mass in the nasopharynx extending to the right nasal vestibule, marked exophthalmos with visual disturbance and retraction of the eardrum were seen on the right side. Carotid angiorgram revealed that the tumor mass destructed the sella turcica and, grew into the temporal lobe of brain.
김완길 전북대학교 의과학연구소 1980 全北醫大論文集 Vol.4 No.1
For the establishment of the knowledge of enzyme activities of the pathologic mucosa, attempts were made to investigate the enzyme activities such as phosphatases, transaminases, ATPase and Adenosine deaminase(ADA) in the pathologic using the normal maxillary mucosa as control. The results of this study were as follows ; 1. Alkaline phosphatase activities of the normal mucosa, mucocele and maxillary polyp were similarly appeared. But in the nasal polyposis and in the chronic maxillary sinusitis the enzyme acitivities were appeared 16% and 50% compared to that of control. 2. GPT activity was very low in the nasal polyposis, maxillary mucocele and normal mucosa. In the maxillary polyposis the enzyme activities were 5 unit/mg protein and 7 unit/mg protein. 3. ATPase showed nearly the same activity both in pathologic and normal maxillary mucosa. in the nasal polyposis the enzyme activity was relatively lower than that of the otheres. 4. The patterns of the relative activities of acid phosphatase, GOT and ADA were simi-lar in each experimental materal. Especially all the experimental enzyme activities were detected much lower in nasal polyp and muceceele compared to the others. 5. The further study of these results which show us that the activities of all the above enzymes in the maxillary polyp were much higher than those of nasal polyp may bring us the good indication for the better understanding of the pathogenesis of these diseases in the biochemical aspect.
특정음역에서의 초강음이 몰못트의 내이 유모세포에 미치는 영향에 관한 연구
김완길 전북대학교 의과학연구소 1978 全北醫大論文集 Vol.2 No.-
To know the extending area and degree of damage of the cochlear hair cells involved by super high intensity of sound, 12 guinea pigs were exposed to very high intensity of pure tone with frequency of 4000 Hz at 130 dB S.P.L. and 100 dB S.P.L. 12 guinea pigs were devided into 4 groups ; Group A_l was exposed to pulsating sound of 130 dB S.P.L. for 8 hours, Group A_2 was exposed to continuous sound of 130 dB S.P.L. for 4 hours. Group B_1 was exposed to pulsating sound of 100 dB S.P.L. for 8 hours. Group B_2 was exposed to continuous sound of 100 dB S.P.L. for 4 hours.
口蓋扁挑의 Mg^2+ dependent Adenosine Diphosphate Rihose Pyrophosphohydrolase의 精製와 性狀
金完吉 전북대학교 의과학연구소 1981 全北醫大論文集 Vol.5 No.1
The Mg^2+-dependent adenosine diphosphate ribose pyrophosphohydrolase(Mg^2+-depen-dent ADDPRase) which repuires Mg^2+ for its catalytic action of ADPR hydrolysis to AMP and ribose-5' -phosphate has been urified and its properties were characterized. Mg^2+-dependent ADPRase has been purified 180-fold to have the specific activity of 30.5u moles per mg protein. hr from human palatine tonsillar cytoplasm by aammonium sulfate fractionation, DEAE-cellulose chromatography and Sephadex G-100 gel filtration. The enzyme repuiring divalent ions such as Mg^2+ for its activity had Km value of 0.23 mM for ADPR and was competitively inhibited by ADP with its inhibitor constant(KI) of 0.87mM. The enyyme was so specific to ADPR as substrate that its true substrate in vivo is ADPR.
金完吉 전북대학교 의과학연구소 1979 全北醫大論文集 Vol.3 No.-
For the establishment of a better therapy for chronic otitis media, an exact knowledge of its pathogenesis is necessary. Among many kinds of the pathologic state of the chronic otitis media, cholesteatoma and chronic inflammation are very important because they may bring both intra and extra-cranial complications. Since the usual mechanism of cholesteatoma on bone can be explained by the mechanical or enzymatic theory, attempts were made to investigate the enzyme activities wuch as ATPase, phosphatases and transaminases in the cholesteatoma matrix and the pathologic granulation tissue in the middle ear cavity using the normal epithelial tissue taken from the post auricular region of the patients as control. Results of this study were as follows. 1. Both the acid and alkaline phosphatase activities were much higher in the pathologic state than in normal epithelial skin, showing more than six times higher in the pathologic state than in normal epithelial skin, showing more thatn six times higher activities were found in case of acid phosphatase. It seemed to be very interesting finding that alkaline phosphatase activity was one hundred time higher in chronic inflammation and was twenty times higher in cholesteatoma than control. 2. ATPase activity was also increased 9 times and 7 times in the chronic inflammation and in the cholesteatoma respectively compared to that of control. 3. Glutamate oxaloacetate transaminase(GOT) activity was two times higher in the chronic inflammation than in control, while glutamate pyruvate tranaminase(GPT) showed nearly the same activity both in pathologic and normal tissues. The further study of these results which show us much higher activity of ATPase and phosphatases in the pathologic state of the chronic otitis media than normal skin may bring us the good indication for the better understanding of the patogenesis of this disorder in the biochemical aspect.