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항진균제 Naftifine 구조와 관련된 알릴아민류의 합성
김욱(Wook Kim),박은주(Eun Ju Park),서희경(Hee Kyong Seo),신부안(Boo Ahn Shin),최보길(Bo Gil Choi),정병호(Byung Ho Chung) 대한약학회 1993 약학회지 Vol.37 No.3
Eight new derivatives of allylamine which are related to naftifine and expected to have antifungal activity were synthesized. Schiff base 2a-2d and 2''e-2''h were obtained by conventional methods using trans-cinnamylamine or trans-cinnamaldehyde. The reduction of azomethine linkage with NaBH4 yielded secondary amine 3a-3h, which were then methylated by means of HCHO and excess NaBH4 or hcooh to give 4a-4h.